• Title/Summary/Keyword: Maternal age

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Effects of paternal age on human embryo development in in vitro fertilization with preimplantation genetic screening

  • Kim, Min Kyoung;Park, Jae Kyun;Jeon, Yunmi;Seok, Su Hee;Chang, Eun Mi;Lee, Woo Sik
    • Clinical and Experimental Reproductive Medicine
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    • v.46 no.1
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    • pp.22-29
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    • 2019
  • Objective: As paternal age increases, the quality of sperm decreases due to increased DNA fragmentation and aneuploidy. Higher levels of structural chromosomal aberrations in the gametes ultimately decrease both the morphologic quality of embryos and the pregnancy rate. In this study, we investigated whether paternal age affected the euploidy rate. Methods: This study was performed using the medical records of patients who underwent in vitro fertilization (IVF) procedures with preimplantation genetic screening (PGS) from January 2016 to August 2017 at a single center. Based on their morphological grade, embryos were categorized as good- or poor-quality blastocysts. The effects of paternal age were elucidated by adjusting for maternal age. Results: Among the 571 total blastocysts, 219 euploid blastocysts were analyzed by PGS (38.4%). When the study population was divided into four groups according to both maternal and paternal age, significant differences were only noted between groups that differed by maternal age (group 1 vs. 3, p= 0.031; group 2 vs. 4, p= 0.027). Further analysis revealed no significant differences in the euploidy rate among the groups according to the morphological grade of the embryos. Conclusion: Paternal age did not have a significant impact on euploidy rates when PGS was performed. An additional study with a larger sample size is needed to clarify the effects of advanced paternal age on IVF outcomes.

Lifestyle, nutrient intake, iron status, and pregnancy outcome in pregnant women of advanced maternal age

  • Bae, Hyun-Sook
    • Nutrition Research and Practice
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    • v.5 no.1
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    • pp.52-59
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    • 2011
  • The purpose of this study was to investigate how advanced maternal age influences lifestyle, nutrient intake, iron status, and pregnancy outcomes in pregnant women. The subjects of this study were 112 pregnant women who were receiving prenatal care at gynecologists located in Seoul. The subjects were divided into two groups according to their ages: those over age 35 were the advanced age group of pregnant women (AP) and those under age 35 were the young age group of pregnant women (YP). General factors, nutrient intakes, iron status, and pregnancy outcomes of the two groups were then compared. It was found that 72.5% of the YP group and 51.2% of the AP group had pre-pregnancy alcohol drinking experience; indicating that the YP group had more pre-pregnancy alcohol consumption than the AP group (P<0.05). The only difference found in nutrient intake between the two groups was their niacin intakes which were $16.83{\pm}8.20\;mg$/day and $13.76{\pm}5.28\;mg$/day, respectively. When gestational age was shorter than 38.7 weeks, the average infant birth weight was $2.95{\pm}0.08\;kg$, and when gestational age was longer than 40 weeks, it averaged at about $3.42{\pm}0.08\;kg$. In other words, as gestational age increased, infant birth weight increased (P<0.0001), and when maternal weight increased more than 15 kg, the infant birth weight increased significantly (P<0.05). In conclusion, in order to secure healthy human resources, with respect to advanced aged women, it is necessary to intervene by promoting daily habits that consist of strategic increases in folate and calcium intake along with appropriate amounts of exercise.

Bone Mineral Density, with Anthropometric Measurement, and Maternal Factors for Postmenopausal Women in Chungnam (폐경 후 여성들의 골밀도와 신체 측정치 및 모성 요인과의 관련성 연구 -충남 일부 지역을 중심으로-)

  • Park, Mie-Ja
    • The Korean Journal of Food And Nutrition
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    • v.20 no.4
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    • pp.450-459
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    • 2007
  • This study was performed to assess the relationships between bone mineral density(BMD), anthropometric measurements, and maternal factors in postmenopausal women. The anthropometric measurements were taken by a trained practitioner, and the maternal factors of the 85 subjects in Chungnam were acquired by an interview questionaire. The BMDs of the lumbar $spines(L_2-L_4)$, femoral necks(FN), ward's triangles(WT), and trochanters(TR) were measured by dual energy X-ray absorptiometry(DEXA). The BMDs(T-score) for $L_2-L_4$, FN, and WT were 0.996 $g/cm^2$(-1.601), 0.697 $g/cm^2(-1.657)$, and 0.793 $g/cm^2(-1.512)$ respectively, which were assessed as osteopenia by the T-score ; TR was noma1 at 0.718 $g/cm^2(-0.675)$. The 85 subjects in Chungnam were divided into three groups according to their BMD measurements for $L_2-L_4$ and FN, assessed by the T-score. The percentages in the osteoporosis, osteopenia, and normal groups were 32.9%, 42.4, and 24.7%, respectively. The average age was significantly the highest in the osteoporosis group than in the other two osteopenia and normal group(p<0.001). The subjects' BMDs were positively correlated with weight, height, BMI, waist, WHR, OBR and hip circumference, and negatively correlated with the age, duration time after menopause, lactation, the age of last delivery, menarche age, and number of children. The average age at menopause was 48.8. The osteoporosis group's average age at menopause was lower than those of the other groups. However, the BMD of the lumbar spine positively correlated with duration time after menopause and the BMD of the femoral neck with lactation, last delivery, menarch age, number of children. Therefore, researches are needed to find out the effective way to minimize the effect of age and other physiological conditions on the decrease of bone mass density.

Correlations among Perceptions and Practice of Taegyo and Maternal-Fetal Attachment in Pregnant Women (일 지역 임부의 태교인식, 태교실천 및 모-태아애착 간의 상관관계)

  • Jang, Sang-Youn;Bang, Kyung-Sook
    • Child Health Nursing Research
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    • v.25 no.4
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    • pp.398-405
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    • 2019
  • Purpose: This study was conducted to examine the relationships among the perceptions and practice of taegyo (a traditional set of practices and beliefs related to healthy fetal development) and maternal-fetal attachment in pregnant women. Methods: The participants were 136 pregnant women who visited a public health center or maternity hospital for prenatal care. The collected data were analyzed using descriptive statistics, the t-test, analysis of varience, and Pearson correlation coefficients with SPSS version 22.0. Results: The mean age of the pregnant women was $32.24{\pm}3.99$ years. The mean scores for perceptions of taegyo, practice of taegyo, and maternal-fetal attachment were $3.96{\pm}0.53$, $3.74{\pm}0.64$, and $3.94{\pm}0.49$, respectively. Perceptions of taegyo were significantly correlated with the practice of taegyo (r=.72, p<.001), and maternal-fetal attachment (r=.55, p<.001). A significant correlation was also found between the practice of taegyo and maternal-fetal attachment (r=.65, p<.001). Conclusion: Perceptions of taegyo affected the practice of taegyo, and had a positive effect on maternal-fetal attachment. These findings suggest that primary care nurses at hospitals and public health centers should provide nursing intervention programs to improve the perceptions of taegyo, the practice of taegyo, and maternal-fetal attachment.

Relationships among Maternal Psychological Life Position, Involvement in Child-rearing and Child-rearing and Childrens' Emotional Intelligence (어머니의 심리적 자세 및 양육참여도와 유아의 정서지능과의 관계 연구)

  • Yeom, Mi-Ae;Moon, Hyuk-Jun
    • Journal of the Korean Home Economics Association
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    • v.44 no.6 s.220
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    • pp.1-13
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    • 2006
  • This study examined the relationships among maternal psychological life position, involvement in child-rearing and children's emotional intelligence. The subjects were 267 four and five-year-old children and their mothers from five child care centers located in Seoul. Children's emotional intelligence was assessed by the teacher rating scale developed by Kin(1998) and questionnaires were used to assess the maternal psychological life position and involvement in child-rearing. Data was analyzed by t-test, Pearson's correlation, and stepwise multiple regression. Results demonstrated a correlation between the level of the children's emotional intelligence and their gender and age. The strongest predictor of children's emotional intelligence was the child's age.

The Effects of Children's Internal and External Variables on Self-Regulation (유아의 내적$\cdot$외적 변인이 자기규제 발달에 미치는 영향)

  • Kim Mee-Hae;Yoon Ho-Yeol
    • Journal of the Korean Home Economics Association
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    • v.43 no.3 s.205
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    • pp.185-197
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    • 2005
  • The purpose or this study was to investigate the effects of children's internal (age, sex, self-respect) and external (maternal belief, childrearing behavior) variables on self-regulation. The subjects were 2004-and-5-year-olds, their mothers, and teachers. Children's age, sex, and self-respect had m influence on self-regulation; that is 5-year-olds were higher than 4-year-olds for behavioral self-regulation, girls were higher than boys for cognitive and behavioral self-regulation, and the high self-respect group was higher than the low self-respect group for cognitive self-regulation. The psychological controlling and externally directed strategies had a negative influence on children's self-regulation. Maternal affectionate childrearing behavior had an influence on children's self-regulation; that is the high affectionate group had children with higher self-regulation.

Interactions between 2-and-4 year-old Children and their Mothers During a Joint Picture-Book Reading (만 2, 4세 유아와 어머니의 그림책 읽기 상호작용에 관한 연구)

  • 김재순;김희진
    • Journal of the Korean Home Economics Association
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    • v.41 no.3
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    • pp.57-71
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    • 2003
  • The purpose of this research was to find out how the interactions between mothers and their children differed depending on the age of the child and the type of book. The subjects of this study were thirty 2-year-olds and thirty 4-year-olds and their mothers. The number of male and female children was the same. The maternal interactions were analyzed in term of attention gelling, explanation, request, asking questions, and feedbacks, and the children's verbal and nonverbal reactions were also analyzed. The results showed that the characteristics of the mother and child interactions were different according the age of the child and the type of picture books. The results were discussed from the perspective of maternal scaffolding and the quality of mother-child interactions. The implications of the study were suggested in terms of the importance of the picture books and maternal roles in reading pictures books to their child.

A Study on Bone Mineral Density, Anthropometric Measurements, Maternal Factors, and Exercise and Their Correlation in Premenopausal and Postmenopausal Women in Gyeonggi-do Korea (경기 지역 폐경 전.후 여성들의 골밀도와 신체 계측, 모성요인 및 운동과의 상관성 연구)

  • Choi, Yun-Hee;Kim, Hyun-Oh
    • The Korean Journal of Food And Nutrition
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    • v.24 no.4
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    • pp.630-638
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    • 2011
  • This study was performed to assess the relationships among bone mineral density, anthropometric measurements, maternal factors and exercise in premenopausal and postmenopausal women. Anthropometric measurements were taken by a trained practitioner and the maternal factors of the 78 subjects in Gyeonggi-do were acquired by an interview questionnare. The BMD of the lumbar spine(L2~L4), femoral neck, Ward's triangles and trochanters were measured by dual energy X-ray absorptiometry. The mean age of the premenopausal women was 45.23 years and that of the postmenopausal women whose ase of menopause was 49.37 years was 61.27 years. The age, waist and waist to hip ratio of postmenopausal women were significantly higher than those of premenopausal women. BMD of the lumbar spine(L2~L4) in postmenopausal women was significantly higher than that of premenopausal women. Number of children and age at last delivery were significantly higher in postmenopausal women than those in premenopausal women. The BMDs of the lumbar spine and femoral neck of premenopausal women was positively correlated with weight, body mass index, waist and WHR and the BMDs of these two sites in postmenopausal women were positively correlated with height, and weight. In postmenopausal women, BMD of the lumbar spine was negatively correlated with duration time after menopause and BMD of the femoral neck was positively correlated with age at last delivery. These results suggest that it is necessary to maintain adequate body weight. Health management and education about performing more exercise are recommended for postmenopausal women to prevent osteoporosis.

Multiple births conceived by assisted reproductive technology in Korea

  • Park, Young-Sil;Choi, Sun-Hee;Shim, Kye-Shik;Chang, Ji-Young;Hahn, Won-Ho;Choi, Yong-Sung;Bae, Chong-Woo
    • Clinical and Experimental Pediatrics
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    • v.53 no.10
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    • pp.880-885
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    • 2010
  • Purpose: The recent trends of multiple births (MBs) conceived by assisted reproductive technology (ART) in Korea were analyzed as well as the relationship with maternal age, especially advanced maternal age. Methods: Data were obtained from the Korean Statistical Information Service and annual ART reports from the ART committee of the Korean Society of Obstetrics and Gynecology. Results: MBs increased from the early 1990s; there was a 275% increase by 2008. The number of total live births was 448,153 and MBs accounted for 10,767; the MB rate was 24.0% in 2006. Among 2,326 deliveries conceived by ART, multiple deliveries accounted for 786 (33.8%). The total number of live births with ART was 3,125 and 1,585 (50.7%) of them were MBs. During 2006, 14.7% of the entire MBs in Korea were associated with ART. The proportion of women of advanced maternal age was much higher in the ART group than in the total live birth group. Conclusion: MBs in women of advanced maternal age have been increasing in Korea with the use of ART. The results of this study showed that ART was a significant factor associated with the increase in MBs in Korea.

Severe vitamin D deficiency in preterm infants: maternal and neonatal clinical features

  • Park, Sook-Hyun;Lee, Gi-Min;Moon, Jung-Eun;Kim, Heng-Mi
    • Clinical and Experimental Pediatrics
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    • v.58 no.11
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    • pp.427-433
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    • 2015
  • Purpose: We investigated the vitamin D status of preterm infants to determine the incidence of vitamin D deficiency. Methods: A total of 278 preterm infants delivered at Kyungpook National University Hospital between January 2013 and May 2015 were enrolled. The serum concentrations of calcium, phosphorous, alkaline phosphatase, and 25-hydroxyvitamin D (25-OHD) were measured at birth. We collected maternal and neonatal data such as maternal gestational diabetes, premature rupture of membranes, maternal preeclampsia, birth date, gestational age, and birth weight. Results: Mean gestational age was $33^{+5}{\pm}2^{+2}$ weeks of gestation and mean 25-OHD concentrations were $10.7{\pm}6.4ng/mL$. The incidence of vitamin D deficiency was 91.7%, and 51.1% of preterm infants were classified as having severe vitamin D deficiency (25-OHD<10 ng/mL). The serum 25-OHD concentrations did not correlate with gestational age. There were no significant differences in serum 25-OHD concentrations or incidence of severe vitamin D deficiency among early, moderate, and late preterm infants. The risk of severe vitamin D deficiency in twin preterm infants was significantly higher than that in singletons (odds ratio, 1.993; 95% confidence interval [CI], 1.137-3.494, P=0.016). In the fall, the incidence of severe vitamin D deficiency decreased 0.46 times compared to that in winter (95% CI, 0.227-0.901; P=0.024). Conclusion: Most of preterm infants (98.9%) had vitamin D insufficiency and half of them were severely vitamin D deficient. Younger gestational age did not increase the risk of vitamin D deficiency, but gestational number was associated with severe vitamin D deficiency.