Browse > Article
http://dx.doi.org/10.5653/cerm.2019.46.1.22

Effects of paternal age on human embryo development in in vitro fertilization with preimplantation genetic screening  

Kim, Min Kyoung (Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine)
Park, Jae Kyun (Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine)
Jeon, Yunmi (Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine)
Seok, Su Hee (Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine)
Chang, Eun Mi (Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine)
Lee, Woo Sik (Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine)
Publication Information
Clinical and Experimental Reproductive Medicine / v.46, no.1, 2019 , pp. 22-29 More about this Journal
Abstract
Objective: As paternal age increases, the quality of sperm decreases due to increased DNA fragmentation and aneuploidy. Higher levels of structural chromosomal aberrations in the gametes ultimately decrease both the morphologic quality of embryos and the pregnancy rate. In this study, we investigated whether paternal age affected the euploidy rate. Methods: This study was performed using the medical records of patients who underwent in vitro fertilization (IVF) procedures with preimplantation genetic screening (PGS) from January 2016 to August 2017 at a single center. Based on their morphological grade, embryos were categorized as good- or poor-quality blastocysts. The effects of paternal age were elucidated by adjusting for maternal age. Results: Among the 571 total blastocysts, 219 euploid blastocysts were analyzed by PGS (38.4%). When the study population was divided into four groups according to both maternal and paternal age, significant differences were only noted between groups that differed by maternal age (group 1 vs. 3, p= 0.031; group 2 vs. 4, p= 0.027). Further analysis revealed no significant differences in the euploidy rate among the groups according to the morphological grade of the embryos. Conclusion: Paternal age did not have a significant impact on euploidy rates when PGS was performed. An additional study with a larger sample size is needed to clarify the effects of advanced paternal age on IVF outcomes.
Keywords
Embryo quality; In vitro fertilization; Paternal age; Preimplantation genetic screening;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Ziebe S, Loft A, Petersen JH, Andersen AG, Lindenberg S, Petersen K, et al. Embryo quality and developmental potential is compromised by age. Acta Obstet Gynecol Scand 2001;80:169-74.   DOI
2 Szamatowicz M, Grochowski D. Fertility and infertility in aging women. Gynecol Endocrinol 1998;12:407-13.   DOI
3 Pantos K, Athanasiou V, Stefanidis K, Stavrou D, Vaxevanoglou T, Chronopoulou M. Influence of advanced age on the blastocyst development rate and pregnancy rate in assisted reproductive technology. Fertil Steril 1999;71:1144-6.   DOI
4 Khandwala YS, Zhang CA, Lu Y, Eisenberg ML. The age of fathers in the USA is rising: an analysis of 168 867 480 births from 1972 to 2015. Hum Reprod 2017;32:2110-6.   DOI
5 Dain L, Auslander R, Dirnfeld M. The effect of paternal age on assisted reproduction outcome. Fertil Steril 2011;95:1-8.   DOI
6 Sagi-Dain L, Sagi S, Dirnfeld M. Effect of paternal age on reproductive outcomes in oocyte donation model: a systematic review. Fertil Steril 2015;104:857-65.   DOI
7 Robertshaw I, Khoury J, Abdallah ME, Warikoo P, Hofmann GE. The effect of paternal age on outcome in assisted reproductive technology using the ovum donation model. Reprod Sci 2014;21:590-3.   DOI
8 Kaarouch I, Bouamoud N, Madkour A, Louanjli N, Saadani B, Assou S, et al. Paternal age: negative impact on sperm genome decays and IVF outcomes after 40 years. Mol Reprod Dev 2018;85:271-80.   DOI
9 Campos I, Gomez E, Fernandez-Valencia AL, Landeras J, Gonzalez R, Coy P, et al. Effects of men and recipients' age on the reproductive outcome of an oocyte donation program. J Assist Reprod Genet 2008;25:445-52.   DOI
10 Neri QV, Monahan D, Rosenwaks Z, Palermo GD. Intracytoplasmic sperm injection: technical aspects. In: Gardner DK, Weissman A, Howles CM, Shoham Z, editors. Textbook of assisted reproductive techniques. 4th ed. Boca Raton: Informa Healthcare; 2012. p. 172-82.
11 Silverberg KM, Turner T. Evaluation of sperm. In: Gardner DK, Weissman A, Howles CM, Shoham Z, editors. Textbook of assisted reproductive techniques. 4th ed. Boca Raton: Informa Healthcare; 2012. p. 48-59.
12 Gardner DK, Schoolcraft WB. In vitro culture of human blastocysts. In: Jansen R, Mortimer D, editors. Towards reproductive certainty: fertility and genetics beyond 1999. Carnforth: Parthenon Publishing; 1999. p. 378-88.
13 Eskenazi B, Wyrobek AJ, Sloter E, Kidd SA, Moore L, Young S, et al. The association of age and semen quality in healthy men. Hum Reprod 2003;18:447-54.   DOI
14 Kidd SA, Eskenazi B, Wyrobek AJ. Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 2001;75:237-48.   DOI
15 Wyrobek AJ, Eskenazi B, Young S, Arnheim N, Tiemann-Boege I, Jabs EW, et al. Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm. Proc Natl Acad Sci U S A 2006;103:9601-6.   DOI
16 Kuhnert B, Nieschlag E. Reproductive functions of the ageing male. Hum Reprod Update 2004;10:327-39.   DOI
17 Vagnini L, Baruffi RL, Mauri AL, Petersen CG, Massaro FC, Pontes A, et al. The effects of male age on sperm DNA damage in an infertile population. Reprod Biomed Online 2007;15:514-9.   DOI
18 Schmid TE, Eskenazi B, Baumgartner A, Marchetti F, Young S, Weldon R, et al. The effects of male age on sperm DNA damage in healthy non-smokers. Hum Reprod 2007;22:180-7.   DOI
19 Capelouto SM, Nagy ZP, Shapiro DB, Archer SR, Ellis DP, Smith AK, et al. Impact of male partner characteristics and semen parameters on in vitro fertilization and obstetric outcomes in a frozen oocyte donor model. Fertil Steril 2018;110:859-69.   DOI
20 Begueria R, Garcia D, Obradors A, Poisot F, Vassena R, Vernaeve V. Paternal age and assisted reproductive outcomes in ICSI donor oocytes: is there an effect of older fathers? Hum Reprod 2014;29:2114-22.   DOI
21 Ho J, Noel M, Kao CN, Mok-Lin E, Cedars MI, Huddleston HG. Semen parameters and paternal age do not affect fertilization rate or pregnancy outcomes in oocyte recipient cycles. Fertil Steril 2015;103(2 Suppl):e23-4.
22 Barros B, Domingues TS, Belo AS, Mazetto R, Aquino AP, Motta EL. Influence of seminal quality in donor egg IVF program using vitrified oocytes. Fertil Steril 2015;104(3 Suppl):e195.
23 Tiegs AW, Sachdev NM, Grifo JA, McCulloh DH, Licciardi F. Paternal age is not associated with pregnancy outcomes after single thawed euploid blastocyst transfer. Reprod Sci 2017;24:1319-24.   DOI
24 Garcia-Ferreyra J, Luna D, Villegas L, Romero R, Zavala P, Hilario R, et al. High aneuploidy rates observed in embryos derived from donated oocytes are related to male aging and high percentages of sperm DNA fragmentation. Clin Med Insights Reprod Health 2015;9:21-7.
25 Gutierrez-Mateo C, Colls P, Sanchez-Garcia J, Escudero T, Prates R, Ketterson K, et al. Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos. Fertil Steril 2011;95:953-8.   DOI