• 자원환경지질
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• 제49권4호
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• pp.269-280
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• 2016

지역에 최적화된 스레피안 구면함수(spherical Slepian function)를 활용하여 남극을 중심으로 반경 $20^{\circ}$ 범위의 지역에 지각 자기이상의 3개의 방향 성분과 6개의 구배성분들을 표현하였다. 2013년 11월 유럽 항공 우주국이 발사한 3개의 자력 위성인 Swarm은 궤도 전개를 통해 동서 방향의 구배값은 물론 남북 및 수직방향의 구배값을 얻을 수 있도록 계획하였다. 이미 발사된 여러 중력위성들(i.e., GRACE and GOCE) 역시 이러한 구배값을 활용하여 보다 정확한 중력 이상값 및 지표에서의 시간에 따른 중력변화 연구등을 수행해 왔으나 자력 위성자료를 통해서는 많은 연구들이 이루어지고 있지 않는 상태이다. 한편 지역화 모델링은 관심 지역 또는 자료 분포의 제한인 지역인 경우에 활용될 수 있다. 또한 전지구 모델보다 효율적인 연산이 가능하여 위성자료로부터 고해상도의 지각 자기이상값을 표현할 수 있다는 장점을 지니고 있다. 또한 기존의 전지구 구면조화함수의 선형 결합으로 이루어진 기저함수들은 서로 직교성(orthogonality)이 유지되므로 스레피안 구면함수의 계수를 전지구 구면조화함수의 계수로 변환이 가능하여 스펙트럼 분석에 활용할 수 있다. 따라서 Swarm 위성자료의 구배 성분을 이용한 지역화 모델링 방법은 앞으로 많은 활용이 기대되며 여기서는 Swarm 위성자료로부터 얻어진 지각 자기이상값의 전지구 조화함수 계수 모델을 사용하여 자기이상의 방향성분과 구배성분을 유도하고 이를 스레피안 구면 조화함수에 적용하여 관심지역인 남극지역의 방향 성분과 구배 성분을 표현하고 이에 대한 결과를 토의 하고자 한다.

• 한국식품위생안전성학회지
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• 제13권2호
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• pp.171-187
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• 1998

Garlic occupies a special position among the many foods of vegetable origin because it is the sole food for Koreans during the their lives. And vitamin A has been ingested by forms of food or additives. Cadmium has been described as one of the most dangerous trace elements in the food and environment of man and livestocks. Since the de novo synthesis of stress proteins can be detected early after exposure to some agents, analysis of cadmium-induced changes in gene expression , ie. alterations in patterns of protein synthesis, may be useful to develop as biomarkers of exposure and damage for food hygiene. He acute and chronic combine effects of cadmium (Cd, CdCl2 20mg/kg), garlic oil(Dds: diallyl disulfide 50mg/kg, 3 times a week) and vitamin A(Ra: retinol acetate 50,000 IU/kg, 3 times a week) on Wistar male rats were evaluated concerning cadmium contents, tissues enzyme activity, HSP expression histopathological and electron microscopical examinations. The results of the study are as follows ; 1. Less cadmium was absorbed through the digestive tracts, but the ratio of contents in tissue were not changed by the simultaneous adminstration of diallyl disufide or retinol acetate. 2. ALT(alanine aminotransferase) , AST(aspartate aminotransferase), glucose, BUN (blood urea nitrogen), creatinine, the key indices of the clinical changes in hepatic and renal function were significantly hanged by the cadmium treatment after 1 week in liver, after 4 weeks in kidney. 3. Histopathological changes in cadmium treated rats were appeared at 8 weeks age treatment in kidneys. Homogenous eosinophilic material was accumulated in cortical and collecting tubular lumens at 16 weeks. Degenerated or necrotized tubular cells were observed in cortex and medulla. Degenerated seminiferous tubules and homogeneous eosinophilic material was seen in interstitial tissue of rat treated with cadmium for 16 weeks. Calcium deposits were seen in degenerated seminiferous tubules and the tubules showed severe calcification of rat treated with cadmium for 16 weeks. Electron microscope changes in kidney were observed in rats treated with CdCl2 20 mg/kg. Proximal convoluted tubule cells showed selling of cytoplasm and narrow lumen. Capillary endothelial cells showed cytoplasmic vacuoles and swelling. Degenerated epithelial cells were accumulated in tubular lumen of kidney. 4. Enhanced synthesis of 70 KDa relateve molecular mass proteins were detected in 2 hours after cadmium, exposure, with maximum activity occurring at 8~48 hours. Induction of HSP 70 was evident at proximal tubules and glomeruli in kidney. Testicular cells produced enough HSP to be detected normally. From the above results, it could be concluded that HSP70 induction by the cadmium treatment was a rapid reaction to indicated the exposure of xenobiotics, and retinol acetate reduced the cadmium induced nephrotoxicity.

• 한국식품과학회지
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• 제39권6호
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• pp.701-707
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• 2007

민간요법에서 항당뇨 및 항비만 효과가 있는 것으로 알려진 길경의 항당뇨 효과가 있는 지 여부를 in vitro에서 조사하기 위해서 길경을 70% 에탄올로 추출한 후 메탄올과 물을 섞은 용액으로 단계별로 XAD-4 column으로 분획하였다. 본 연구에서는 1) 3T3-L1 섬유아세포와 지방세포에서 길경의 추출 분획물이 인슐린처럼 작용하는 인슐린성 물질이거나, 2) 인슐린 작용을 향상시키는 인슐린 민감성 물질이거나, 또는 3) 포도당 자극에 의한 인슐린 분비를 향상시키거나, 4) 베타세포의 기능과 양을 증가시키는데 관여하는 유전자인 IRS-2, glucokinase, PDX-1의 mRNA 발현을 향상시키거나, 5) $\alpha-glucoamylase$ 활성을 억제하는 물질로 작용하는 지 여부를 조사하였다. 길경 추출 분획물은 인슐린성 물질로 작용하지 않았다. 반면에 0, 20와 100%메탄올층은 3T3-L1 지방세포에서 인슐린 자극에 의한 포도당 흡수를 증가시켰다. 이 분획층 중에서 특히 0%과 100% 메탄올 분획층은 분화 유도물질의 작용을 향상시켜 3T3-L1 섬유아세포에서 지방세포로의 분화 및 중성 지방의 축적을 증가시켰다. 그러므로 이들은 $PPAR-{\gamma}$ agonist로 작용하는 물질을 함유할 가능성이 매우 높다. 인슐린을 분비하는 세포인 Min6 세포에서 포도당 자극에 의한 인슐린 분비를 향상시키는 지 여부를 조사하였는데 20, 80 그리고 100% 메탄올층은 포도당 자극에 의한 인슐린 분비를 증가시켰다. 그 기전은 인슐린 분비와 베타세포의 증식에 관여하는 유전자의 IRS-2, glucokinase 그리고 PDX-1의 mRNA의 양을 증가시키는 것과 관련이 있다. 결론적으로 길경은 지방 세포의 분화를 촉진하는 물질, 인슐린 민감성을 향상시키는 물질 그리고 베타세포의 기능과 증식을 촉진시키는 물질을 함유하고 있으므로 우리나라 및 아시아의 사람들에서 많이 유발되는 비만을 동반하지 않은 당뇨병 및 인슐린 저항성의 치료와 예방에 중요한 역할을 할 것으로 사료된다.

• 대한두경부종양학회지
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• 제14권2호
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• pp.228-235
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• 1998

Objectives: Papillary microcarcinoma of the thyroid was evaluated as to the effectiveness of diagnostic modalities, lymphatic spread pattern, and therapeutic decision according to tumor size. Material and Methods: We retrospectively analyzed a clinicopathologic findings of 72 papillary microcarcinoma patients who were treated at the over 11 years between 1985 and 1995. The authors divided papillary microcarcinoma of the thyroid into two subgroups according to tumor size: $0{\leqq}5mm$ and $5<0{\leqq}10mm$. An analysis including age and gender distribution, diagnostic tools(thyroid sonogram, thyroid scan, thyroid function test, fine needle aspiration cytology, frozen section), pathological examination of lymphnode, and surgical procedures was carried out in each subgroups. Results: The carcinoma of smaller than 5mm were found in 32 patients, and of 6 -10mm were in 40 patients. The average age of patients was 45years and all of them were female. Cold nodules on thyroid scan were noticed in 53 patientss and normal findings were in 15 patients. Suspicious malignant lesions(fine calcification, solid mass, irregular margin) on thyroid sonography were detected in 23 patients and the sonography was more useful in detecting $0{\leqq}5mm$ small sized lesions than other diagnostic methods. FNAC were performed in 17 patients, and 7 patients were diagnosed as having thyroid papillary cancer. But diagnotic rate in $0{\leqq}5mm$ small sized lesions was very low(one of eights).Frozen section were performed in all patients, among these 15 patients were diagnosed as being benign diseases and false negative rates were higher in $0{\leqq}5mm$ small sized lesions than in $5<0{\leqq}10mm$ sized lesions(p-value<0.006). Only thyroidectomies were performed in 24 patients and thyroidectomy with node dissections in 48 patients. The lymphnode metastatic rates were much higher in multifocal lesions(61.5%) than in single lesion. The incidence of cervical lymphnode metastasis was 19.4% in $0{\leqq}5mm$ sized lesions and 47.9% in $5<0{\leqq}10mm$ sized lesions. Postoperative management were performed with TSH suppression therapy(T4, synthroid) in all patients and RI therapy in 29 patients. Conclusion: On the basis of our study, improved preoperative diagnostic tools for papillary microcarcinoma of the thyroid was helpful in the choice of surgical treatment. As a result of techninological progress(ultrasonography, FNAC), the pencentage of the discovery of papillary microcarcinoma has been increased. The thyroid ultrasonography was useful in detecting small sized lesions($0{\leqq}5mm$), but FNAC may not be beneficial in detecting small sized lesions($0{\leqq}5mm$). In the surgical procedure, thyroid lobectomy alone should be avoided because of the high rate of bilaterality and multifocality.

• 한국식품과학회지
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• 제43권6호
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• pp.675-682
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• 2011

본 연구는 국내/수입 유통되는 식품과 건강기능식품의 발기부전치료제 및 그 유사물질 혼입 농도를 모니터링하고, 그 결과를 바탕으로 식품의 안전성을 확보하고자 하였다. 전국에서 유통중인 식품 및 건강기능식품 총 226건을 구입하고 24종의 발기부전치료제 및 그 유사물질을 HPLC/PDA 및 LC-ESI-MS-MS를 이용하여 분석하였다. 고체 및 액체 시료의 전처리는 메탄올을 이용하여 추출하였다. 식품 및 건강기능식품 시료에서 확립된 시험법을 이용하여 식품과 건강기능식품 226건을 수거하여 모니터링한 결과, 5건의 성기능 표방 제품에서 acethylvardenafil, sildenafil, tadalafil이 검출되었다. 분석 결과, 검출량은 acethylvardenafil이 1종에서 21,476 mg/kg(15 mg/capsule)이었으며, sildenafil이 2종에서 각각 52,778 mg/kg(29 mg/capsule), 71,535 mg/kg (48 mg/capsule)이었고, tadalafil이 4종에서 9,772 mg/kg(6 mg/capsule) -55,545 mg/kg (33 mg/capsule)이었다. 따라서 식품 및 건강기능식품 중의 발기부전치료제 및 그 유사물질에 대한 지속적인 실태조사가 요구된다.

• 인터넷정보학회논문지
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• 제19권4호
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• pp.53-63
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• 2018

정보를 전달하고 여론을 형성하는 전통적인 매스미디어의 기능이 ICT 기술의 발전으로 소셜미디어를 통해 정보와 의견을 공유하는 환경으로 급격하게 변해 왔으며, 그 영향력을 더욱 강화시키고 있다. 즉, 일반 대중들이 소셜미디어를 통해 정치 사회 경제 변화에 대한 여론을 생산하고 공유하는 여론의 영향력이 갈수록 커지고 있는 것이 확인되고 있으며, 그 변화는 선거활동과 같은 정치 분야에서 활용되고 있다. 소셜미디어를 활용해서 대중들의 의사를 파악하고, 반영하기 위한 노력은 정치 영역뿐만 아니라 공공 영역에서도 활발하게 이루어지고 있다. 본 논문은 교육분야 정책과정에서 소셜미디어 기반 여론을 활용하기 위한 가능성을 탐색하는 것을 목적으로 한다. 이를 위해 교육정책 중 소프트웨어교육에 관한 키워드를 중심으로 데이터를 수집하고, 문서의 주요 토픽과 토픽별 출현 확률, 토픽 트렌드를 분석하였다. 그 결과 '국내 컴퓨터 교육 시간'토픽이 전체의 43.99%를 차지하였으며, '프라임 사업 선정' 토픽이 36.81%, '인공지능 프로그램'토픽이 7.94%의 출현 확률을 나타내어, 대중의 소프트웨어교육 정책에 대한 주요 관심도를 파악할 수 있었다. 또한, 시기별 토픽 추세 및 연관성 있는 토픽간의 트렌드 비교 분석을 통하여 동일한 주제의 정책이라도 교육과정의 시기와 정책의 대상에 따라 유연한 정책수립이 필요하다는 시사점을 도출할 수 있었다.

• 천문학회지
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• 제37권4호
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• pp.199-203
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• 2004

The gas response to a proposed spiral stellar pattern for our Galaxy is presented here as calculated via 2D hydrodynamic calculations utilizing the ZEUS code in the disk plane. The locus is that found by Drimmel (2000) from emission profiles in the K band and at 240 ${\mu}m$. The self-consistency of the stellar spiral pattern was studied in previous work (see Martos et al. 2004). It is a sensitive function of the pattern rotation speed, $\Omega$p, among other parameters which include the mass in the spiral and its pitch angle. Here we further discuss the complex gaseous response found there for plausible values of $\Omega$p in our Galaxy, and argue that its value must be close to $20 km s^{-l}\;kpc^{-1}$ from the strong self-consistency criterion and other recent, independent studies which depend on such parameter. However, other values of $\Omega$p that have been used in the literature are explored to study the gas response to the stellar (K band) 2-armed pattern. For our best fit values, the gaseous response to the 2-armed pattern displayed in the K band is a four-armed pattern with complex features in the interarm regions. This response resembles the optical arms observed in the Milky Way and other galaxies with the smooth underlying two-armed pattern of the old stellar disk populations in our interpretation. The complex gaseous response appears to be related to resonances in stellar orbits. Among them, the 4:1 resonance is paramount for the axisymmetric Galactic model employed, and the set of parameters explored. In the regime seemingly proper to our Galaxy, the spiral forcing appears to be marginally strong in the sense that the 4:1 resonance terminates the stellar pattern, despite its relatively low amplitude. In current work underway, the response for low values of $\Omega$p tends to remove most of the rich structure found for the optimal self-consistent model and the gaseous pattern is ring-like. For higher values than the optimal, more features and a multi-arm structure appears.

• Tuberculosis and Respiratory Diseases
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• 제72권4호
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• pp.367-373
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• 2012

Background: Chronic obstructive pulmonary disease (COPD) is now regarded as a heterogenous disease, with variable phenotypes. Acute exacerbation of COPD is a major event that alters the natural course of disease. The frequency of COPD exacerbation is variable among patients. We analyzed clinical features, according to the frequency of acute exacerbation in COPD. Methods: Sixty patients, who visited Gyeongsang National University Hospital from March 2010 to October 2010, were enrolled. Patients were divided into two groups, according to their frequency of acute exacerbation. Frequent exacerbator is defined as the patient who has two or more exacerbation per one year. We reviewed patients' medical records and investigated modified Medical Research Council (MMRC) dyspnea scale, smoking history and frequency of acute exacerbation. We also conducted pulmonary function test and 6-minute walking test, calculated body mass index, degree of airway obstruction and dyspnea and exercise capacity (BODE) index and measured CD146 cells in the peripheral blood. Results: The number of frequent exacerbators and infrequent exacerbators was 20 and 40, respectively. The frequent exacerbator group had more severe airway obstruction (forced expiratory volume in one second [$FEV_1$], 45% vs. 65.3%, p=0.001; $FEV_1$/forced vital capacity, 44.3% vs. 50.5%, p=0.046). MMRC dyspnea scale and BODE index were significantly higher in the frequent exacerbator group (1.8 vs. 1.1, p=0.016; 3.9 vs. 2.1, p=0.014, respectively). The fraction of CD146 cells significantly increased in the frequent exacerbator group (2.0 vs. 1.0, p<0.001). Conclusion: Frequent exacerbator had more severe airway obstruction and higher symptom score and BODE index. However, circulating endothelial cells measured by CD146 needed to be confirmed in the future.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1998년도 춘계학술발표 논문집
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• pp.255-263
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• 1998

Dust-free garment prevents contamination which otherwise is caused by skin and clothes to protect from dust or dirt. Therefore, it requires high performance and should function as a working clothes. Clothes are a medium between human and thermal environmental system, and it is required to study human enviroment to ensure comfortableness of clothes and to satisfactorily go along with enviroment .This study investigates the physical and physiological features of dust-free garment used in the clean room at a semiconductor factory in oredr to scientifically clarify what the dust-free garmint is as well as to contribute to the design and development of high performance material and clothes. Three kinds of dust-free fabrics (DFG-I, DFG-II, DFG-III) which are being developed by a local company are used to manufacture dust-free garment. These dust-free garments are dressed and tested in such an enviroment as similar to semiconmemts with temperature at 23${\pm}$1$^{\circ}C$ and humidity at 50${\pm}$5%RH in order to investigate the thermo physiological and psychological features of human body. The results of this study are as follows. The results of this study are as follows. 1.The mean skin temperature was significantly different among the clothes, subjects and experimental time. Temperature tends to rise from the time of exercising load. Continuous motion coupled sealed clothes prevents heat transmittance, and temperature rises in the order of DFG-l, DFG-ll and DFG-lll as time course. 2.As for the skin temperature by local timperature is minimun on the head and torso and increares remarkably at the terminal part of human body. 3. As for the body mass loss was significantly higher in DFG-lll than DFG-l and DFG-ll. 4. Though there is no significant difference in the temperature within clothes among the kind of clothes temperature is 1$^{\circ}C$ higher in the back. Temperature within all the dust-free garments 29.7$^{\circ}C$ in the back and 31.3$^{\circ}C$ in the chest which belong to the comfort zone(31-33$^{\circ}C$). The relative humidity is 39.7%RH in the chest and 33.8%RH in the back which is slightly below the comfort zone(40-60%RH) 5. The thermal sensation belong to the comfort zone regardless of the kinds of clothes. The subjects feels a slight fatigue as times goes. As for the subjective sense of subjects the mean skin temperature as well as temperature and humidity within clothes show similar tendency. This means that they relate with each other.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1979년도 제13차 학술대회 연제순서 및 초록
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• pp.7.2-8
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• 1979

음성외과는 발성기능를 취급하는 기능외과이기 때문에 수술적응의 결정 수술효과의 판정 수술성적의 비교를 위하여 발성기능의 검사가 필요하다. 청력을 취급하는 수술에서 청력검사가 필요한 것과 같다. 연자는 구유미대학 이비인후과를 방문한 각종후두환자(56례 즉Recurrent laryngeal nerve paralysis, polyp. polipoid vocal cord. sulcus vocalis, Laryngeal cancer, Benign mass, Epitherial hypertrophy. 등에서 발성지적시간, 폐활량/담성지적시간, 평균호기유율 및 후두 Stroboscopy 검사를 시행하여 다음과같은 결과를 얻었다. 1) 성대의 편측성병변은 35례(62.5%)이고 양측성병변은 21례(37.5%)로 편측성병변이 많았다. 2) 성별로는 남성이 39례(69.8%) 여성이 17례(30.2%)로 남성이 많았다. 3) 발성지적시간은 10초이하가 26례(46.4%) 10초이상이 30례(53.6%)이였다. 4) 폐활양/발성지적시간은 300m1/sec이하가 33례(58.9%) 300m1/sec이상이 23례(41.1%)이였다. 5) 평균호기류율은 300m1/sec이하가 37례(66.1%)300ml/sec 이상이 19례(33.9%)이였다. 6) 후두 stroboscopy 검사에서 성대의 대칭성, 규칙성, 진폭, 점막파동 및 성문패쇄에 대해서 관찰하였다. 7) 후두수술전후의 음성검사와 stroboscopy 검사의 비교는 수술후의 성적이 매우 좋다.