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http://dx.doi.org/10.9721/KJFST.2011.43.6.675

Monitoring of Anti-impotence Drugs and Their Analogues in Food  

Lee, Hyun-Sook (Imported Food Analysis Division, Gyeongin Regional Korea Food and Drug Administration)
Lee, Joon-Goo (Imported Food Analysis Division, Gyeongin Regional Korea Food and Drug Administration)
Kim, Jin-Chul (Imported Food Analysis Division, Gyeongin Regional Korea Food and Drug Administration)
Oh, Jae-Ho (Imported Food Analysis Division, Gyeongin Regional Korea Food and Drug Administration)
Jang, Young-Mi (Imported Food Analysis Division, Gyeongin Regional Korea Food and Drug Administration)
Kim, Mee-Hye (Food Contaminants Division, Korea Food and Drug Administration)
Publication Information
Korean Journal of Food Science and Technology / v.43, no.6, 2011 , pp. 675-682 More about this Journal
Abstract
This study was conducted to monitor the concentrations of 24 anti-impotence drugs and their analogues in various foods and dietary supplements, with the aim of ensuring the safety of the foods and supplements. The measurements were done in 226 samples using high performance liquid chromatography/photodiode array detector (HPLC/PDA) and liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Five male sexual function enhancing products have been detected as follows: acethylvardenafil (21,476 mg/kg; 15 mg/capsule from one sample), sildenafil (52,778 mg/kg, 29 mg/capsule in one sample; 71,535 mg/kg, 48 mg/capsule in one sample), and tadalafil (9,772-55,545 mg/kg, 6-33 mg/capsule in four samples). A sustainable monitoring of anti-impotence drugs and their analogues in various foods and dietary supplement is recommended.
Keywords
anti-impotence drugs; monitoring; food; HPLC/PDA; LC-ESI-MS/MS;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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