• Macromolecular Research
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• v.13 no.3
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• pp.218-222
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• 2005

Transferrin-conjugated liposomes ($T_f$-liposomes) were made and formulated with pCMVluc DNA to form a lipoplex. Among the various formulations studied, the $T_f$-liposome: pCMVluc DNA complex at a ratio of 5: 1 (wt/wt) showed the highest transfection efficiency, which was twice that of $Lipofectin^{TM}$ on HeLa cells. The maxi-mum tolerated dose (MTD) of this lipoplex formulation from a single intravenous injection was over 10 mg/kg in healthy ICR mice. The RT-PCR results showed that the highest level of luciferase mRNA was detected in the lungs, followed by the liver, spleen, heart and kidneys, after an intravenous injection into mice. Two weeks after the injection, the levels of luciferase mRNA decreased gradually in the liver, spleen, heart, and kidney, but not in the lungs. The micro-array study showed that the cancer-related genes, including the bcl 6 gene, were highly up-regulated by the treatment with $T_f$-liposome/ pCMVluc DNA complex on HeLa cells, indicating that there were possible interactions between the host chromosomal DNA and the $T_f$-liposome within the cells. The results obtained from this study are expected to be useful for designing a safe and efficient gene delivery system using transferrin-conjugated liposomes.

• Bulletin of the Korean Mathematical Society
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• v.43 no.4
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• pp.841-846
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• 2006

Suppose that F is a closed t-aspherical PL n-manifold with finite, sparsely abelian ${\pi}_1(F)$ and A is a closed aspherical PL m-manifold with hopfian, normally cohopfian ${\pi}_1(A)$. If $X(F){\neq}0{\neq}X(A)$, then $F{\times}A$ is a codimension-(t+1) PL fibrator.

• Kyungpook Mathematical Journal
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• v.54 no.4
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• pp.639-653
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• 2014

In [9], Kauffman introduced virtual knot theory and generalized many classical knot invariants to virtual ones. For example, he extended the Jones polynomials $V_K(t)$ of classical links to the f-polynomials $f_K(A)$ of virtual links by using bracket polynomials. In [4], M. Goussarov, M. Polyak and O. Viro introduced finite type invariants of virtual knots. In this paper, we give a necessary condition for a virtual knot invariant to be of finite type by using $t(a_1,{\cdots},a_m)$-sequences of virtual knots. Then we show that the higher derivatives $f_K^{(n)}(a)$ of the f-polynomial $f_K(A)$ of a virtual knot K at any point a are not of finite type unless $n{\leq}1$ and a = 1.

• KSBB Journal
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• v.21 no.6 s.101
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• pp.422-427
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• 2006

The culture media from Fomitopsis pinicola were extracted by methanol and examined growth inhibition against Helicobacter pylori. The culture media from 8 days fermentation of F. pinicola showed maximum inhibition activity on H. pylori in 0.25 mg as MIC value. The highest activity against H. pylori by MHCS agar diffusion medium by Fp-P1 in 22.7 mm ID among 3 peaks from methanol fraction of 8 days culture media of Fomitopsis pinicola which purified by ion-exchange chromatography. The Fp-P1 from DEAE-Sephadex A-25 have been analysed by TLC as Fp-T1, Fp-T2 and Fp-T3 by ninhydrin staining. Fp-T3 (Rf value : 0.67) was higher activity against H. pylori in 14.4 mm ID. Fp-T3 was identified as single band by HPLC and TLC. It was assumed to aminosugar by BioLC analysis and TLC staining.

• Ecology and Resilient Infrastructure
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• v.9 no.3
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• pp.183-193
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• 2022

The growth inhibitory effect of Microcystis aeruginosa according to the ultrasonic irradiation time was evaluated using a large algae sample volume (10 L) for various ultrasonic irradiation times (0.5, 1, 1.5, 2, 2.5 and 3 hr) at a laboratory scale. Based on the analysis of Chl-a and cell number of M. aerginosa, algae growth inhibition was observed with the decrease in Chl-a and cell number in all experimental groups after the ultrasonic irradiation. For the experimental group (T_B, T_C, T_D) with an ultrasonic irradiation time of less than 2 hours, rapid regrowth of algae was observed after growth inhibition, but the experimental group (T_E, T_F, T_G) with an irradiation time of more than 2 hours successfully inhibited algal growth lasting one or two more days. Based on the comparison of the recovery time to initial cell number the experimental group (T_B, T_C, T_D) took less than 20 days whereas the experimental group (T_E, T_F, T_G) took about 30 days. Correspondingly, the experimental group showed a high first order decay rate (𝜅) in proportion to the ultrasonic irradiation time during the growth inhibition period. Additionally, the specific growth rates (𝜇) during regrowth in the experimental group with irradiation time of more than 2 hours were relatively low compared to those in the experimental group with less than 2 hours. Therefore, ultrasonic irradiation for more than 2 hours is required for long-term (30 days) inhibition of algal growth in stagnant waters. However, the appropriate ultrasonic irradiation time for algae growth inhibition should be determined according to various field conditions such as the volume of stagnant water, water depth, flow rate, algae concentration, etc. Finally, damages to the algal cell surface and cell membrane were clearly observed, and both destruction and disturbance of gas vesicles of M. aeruginosa in the experimental group were discovered, indicating the growth inhibitory effect of Microcystis aeruginosa according to the ultrasonic irradiation time was confirmed.

• Kyungpook Mathematical Journal
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• v.48 no.2
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• pp.281-286
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• 2008

In this note we prove that if A and $B^*$ are subnormal operators and is a bounded linear operator such that AX - XB is a Hilbert-Schmidt operator, then f(A)X - Xf(B) is also a Hilbert-Schmidt operator and $${\parallel}f(A)X\;-\;Xf(B){\parallel}_2\;\leq\;L{\parallel}AX\;-\;XB{\parallel}_2$$, for f belonging to a certain class of functions. Furthermore, we investigate the similar problem in the case that S, T are hyponormal operators and $X\;{\in}\;\cal{L}(\cal{H})$ is such that SX - XT belongs to a norm ideal (J, ${\parallel}\;{\cdot}\;{\parallel}_J$) and prove that f(S)X - Xf(T) $\in$ J and ${\parallel}f(S)X\;-\;Xf(T){\parallel}_J\;\leq\;C{\parallel}SX\;-\;XT{\parallel}_J$, for f in a certain class of functions.

• The Journal of Engineering Geology
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• v.6 no.1
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• pp.1-13
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• 1996

The fracture transmissivity($T_f$) is the most important parameter of fracture in assessing groundwater flow in fractured rock masses by using the DFN(Discrete Fracture Network) modeling. $T_f$, the most sensitive parameter m DFN modeling, is dependent upon aperture, size and filling characteristics of each fracture set. In the field test, the accuracy of $T_f$ can be increased with Borehole Acoustic Scanning (Televiewer) and Fixed Interval Length(FIL) test in constant head. $T_f$ values measured from FIL test was modified and estimated by each fracture set on the basis of the Cubic Law and the information of aperture and filling characteristics obtained from Televiewer. The modified $T_f$ results in the increase of confidence and reliability of modeling results including the amount of tunnel inflow.And, this approach would reduce the uncertaintity of the assessment for groundwater flow in fractured rock masses using the DFN modeling.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.6
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• pp.771-780
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• 2010

This paper describes the design process of a six-component force/torque (F/T) sensor. The new six-component F/T sensor having leaf spring ends has been developed using a cross beam structure as the basic sensing element. Fundamental strain analysis of both ends fixed beam having a leaf spring structure is performed by finite element analysis. In order to obtain similar output sensing strains from the six component loads and minimize coupling strains, the optimal location of strain gages is determined and the strain gages are connected so that the bridge circuits with four strain gages would be balanced. Using leaf spring ends instead of rigid fixed ends, remarkable increment in output sensing strain can be achieved for two component forces. Several modifications in design result in a similar sensing strain of approximately $400\;{\mu}m/m$ for the six-component forces and moments, and a reduced coupling strain of $0\;{\mu}m/m$ between the forces and moments.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.36 no.3
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• pp.234-243
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• 2000

This paper is to study population ecological characteristics, including growth parameters, survival rate, instantaneous coefficients of natural and fishing mortalities, and age at first capture of the soft-shelled clam, Mya japonioa in the intertidal zone of South Sea in Korea. For describing growth of the clam a von Bertalanffy growth model was adopted, The von Bertalanffy growth curve had an additive error structure and the growth parameters estimated from a non-linear regression were SH/sub ∞/=79.83mm, K=0.26, and t/sub 0/= -0.01. Survival rate (S) of the soft-shelled clam was 0.26 (SD=0.02). The instantaneous coefficients of natural mortality (M) was estimated to be 0.78/year and fishing mortality (F) 0.57/year for the soft-shelled clam. The age at first capture (t/sub c/) was estimated as 2.69 year. The mean densities of the soft-shelled clam by bottom type were 3.40 inds./m²(SE=0.18) in the sand, 63.4 inds./m²(SE= 0.53) in the muddy sand, and 0 inds./m2 (SE=0) in the gravelly sand. The mean densities of the soft-shelled clam by 3 different areas were 4.88 inds./m²(SE=0.09), 2.61 inds./m²(SE=0.13), 7.20 inds./m²(SE=0.18), respectively and the biomass of the clam were estimated as 131mt, 121mt, 665mt, respectively. An yield-per-recruit analysis showed that the current yield-per-recruit of about 8.30g with F=0.57/year and the age at first capture (t/sub c/) 2.69 year, was lower than the maximum possible yield-per-recruit of 9.60g. Fixing to at the current level and increased fishing intensity (F) could produce an increase in the predicted yield-per-recruit from 8.30g to about 9.40. However, estimated yield-per-recruit increased to 1.30g by decreasing to from the current age (2.69 year) to age two with F fixed at the current level. Yield-per-recruit was estimated under harvest strategies based on F/sub max/ and F/sub 0.1/.

• Journal of the Korean Mathematical Society
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• v.49 no.2
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• pp.265-291
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• 2012

In this paper, we consider the regularity theory and the existence of smooth solution of a degenerate fully nonlinear equation describing the evolution of the rolling stones with nonconvex sides: $\{M(h)=h_t-F(t,z,z^{\alpha}h_{zz})\;in\;\{0<z{\leq}1\}{\times}[0,T] \\ h_t(z,t)=H(h_z(z,t),h)\;{on}\;\{z=0\}$. We establish the Schauder theory for $C^{2,{\alpha}}$-regularity of h.