• 제목/요약/키워드: Lignans

검색결과 190건 처리시간 0.027초

Two New Lignans from Lindera obtusiloba Blume

  • Kwon, Hak-Cheol;Choi, Sang-Un;Lee, Jung-Ock;Bae, Ki-Hwan;Zee, Ok-Pyo;Lee, Kang-Ro
    • Archives of Pharmacal Research
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    • 제22권4호
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    • pp.417-422
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    • 1999
  • Two new furanolignans (3, 5), together with three known lignans (1, 2, 4,), were isolated from the stem of Lindera obtusiloba (Lauraceae). The structures of the compounds were determined as actifolin (1), pluviatilol (2), 5,6-dihydroxymatairesinol (3), (+)-syringaresinol (4), and $(+)-9^{l}$-O-trans-feruloyl-5,51-dimethoxylariciresinol (5) on the basis of physicochemical and spectroscopic evidences. Compounds 1, 2, 3, and 5 showed cytotoxicity against a small panel of human tumor cell lines with values of $3.40{\sim}19.27 {\mu}g/ml$.

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Lignans from the Flower Buds of Magnolia fargesii

  • Lee, Jun;Yang, Min-Suk;Nam, Sang-Hae;Shon, Mi-Yae;Hwang, Seon-Woo;Park, Ki-Hun
    • Bulletin of the Korean Chemical Society
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    • 제26권6호
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    • pp.913-915
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    • 2005
  • The three new lignans 1-3 were isolated from the methanol extracts of the flower buds of Magnolia fargesii. They were elucidated as (7S,8R)-1-(3,4-dimethoxyphenyl)-2-O-(2-methoxy-4-omegahydroxypropylphenyl) propane-1,3-diol, (7S,8S)-1-(4-hydroxy-3-methoxyphenyl)-2-O-(6-hydroxy-2-methoxy-4-omegahydroxypropylphenyl) propane-1,3-diol, and [tetrahydro-4-hydroxy-2-(3,4,5-trimethoxyphenyl)furan-3-yl]methyl 3,4-dimethoxy benzoate by spectral analysis.

HPLC에 의한 오미자 리그난 성분의 정량분석 (Quantitative Determination of Lignans from Schizandra chinensis by HPLC)

  • 구동칠;서원세;백소윤;심상희
    • 생약학회지
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    • 제42권3호
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    • pp.233-239
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    • 2011
  • A reversed phase HPLC method was established for quantitative determination of lignans including schizandrin (1), gomisin A (2), deoxyschizandrin (3), gomisin N (4), and wuweizisu C (5) from Schizandra chinensis using a binary gradient of acetonitrile and water as a mobile phase with UV detection at 254nm. In result, contents of schizandrin (1), gomisin A (2), deoxyschizandrin (3), gomisin N (4), and wuweizisu C (5) in Schizandra chinensis from Moonkyung were 8.41${\pm}$0.30, 3.01${\pm}$0.13, 1.06${\pm}$0.05, 7.69${\pm}$0.30, and 1.68${\pm}$0.06 mg/g, respectively.

Lignans from Lonicerae caulis

  • Yean, Min-Hye;Kim, Ju-Sun;Lee, Je-Hyun;Kang, Sam-Sik
    • Natural Product Sciences
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    • 제16권1호
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    • pp.15-19
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    • 2010
  • A new 2,7'-cyclolignan named lonicerinol (1) along with eight known lignans, (-)-epipinoresinol (2), (-)-pinoresinol (3), $9{\alpha}$-hydroxypinoresinol (4), 7R,8S-dihydrodehydrodiconiferyl alcohol (5), ($\pm$)-neo-olivil (6), (+)-isolariciresinol (7), 3-methoxy-8,4'-oxyneoligna-3',4,7,9,9'-pentol (8), and (-)-pinoresinol 4-O-glucoside (9), were isolated from the caulis of Lonicera japonica THUNB. (Caprifoliaceae). All of these constituents except for (-)-pinoresinol (3) and $9{\alpha}$-hydroxypinoresinol (4) are reported for the first time from the genus Lonicera. The structures and absolute configurations of these compounds were determined on the basis of spectroscopic analysis, including CD and 1D- and 2D-NMR techniques and chemical methods.

Inhibitory Lignans against NFAT Transcription Factor from Acanthopanax koreanum

  • Cai, Xing-Fu;Lee, Im-Seon;Dat, Nguyen-Tien;Guanghai-Shen;Kang, Jong-Seong;Kim, Dong-Hyun;Kim, Young-Ho
    • Archives of Pharmacal Research
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    • 제27권7호
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    • pp.738-741
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    • 2004
  • Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E(1), tortoside A(2), and hemiariensin(4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (($IC_{50}$ : 36.3${\pm}2.5{\mu}\textrm{M}$). However, the activities of 1 (($IC_{50}$:>500 11M) and 2 (($IC_{50}$: 136.1 ${\pm}9.4\mu\textrm{M}$), which possess bisaryldioxabicy-clooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and(+)-syringaresinol (3) with a bisaryldioxabicy-clooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.

삼백초 근경의 저장방법에 따른 품질과 Lignans 함량 변화 (Qualities and Lignans Contents of Saururus chinensis Baill. Rhizome by Storage Methods)

  • 김인재;김민자;남상영;윤태;김홍식;정승근
    • 한국식품저장유통학회지
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    • 제13권3호
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    • pp.279-284
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    • 2006
  • 저장방법에 따른 삼백초 생근경의 품질과 유효성분 함량의 변화를 조사하였다. 감모율과 부패율 및 맹아수는 저장기간이 경과할수록 증가하거나 많았다. 감모정도와 맹아수는 저온저장에서 가장 적었으며, 부패율은 창고 내 흙 충진 저장에서 낮았다. 삼백초 근경의 chromatogram상 각 성분의 머무름시간(RT)은 $18{\sim}36$분대로 saucernetin>sauchinone>manassantin A>saucerneol D>manassantin B의 순으로 나타났다. Lignans의 함량은 저장방법 모두 저장 후 30일에 비해 120일에 낮았으나, 저장방법간에는 차이가 없었고 manassantin B>manassantin A>saucernetin>sauchinone>saucerneol D의 순으로 함량이 높았다.

Inhibition of Phospholipase $C{\Upsilon}1$ and Cancer Cell Proliferation by Lignans and Flavans from Machilus thunbergii

  • Lee, Ji-Suk;Kim, Jin-Woong;Yu, Young-Uck;Kim , Young-Choong
    • Archives of Pharmacal Research
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    • 제27권10호
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    • pp.1043-1047
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    • 2004
  • Thirteen compounds were isolated from the $CH_2Cl_2$ fraction of Machilus thunbergii as phospholipase $C{\Upsilon}1\;(PLC{\Upsilon}1)$ inhibitors. These compounds were identified as nine lignans, two neolignans, and two flavans by spectroscopic analysis. Of these, 5,7-di-O-methyl-3',4'-methylenated (-)-epicatechin (12) and 5,7,3'-tri-O-methyl (-)-epicatechin (13) have not been reported previously in this plant. In addition, seven compounds, machilin A (1), (-)-sesamin (3), machilin G (5), (+)-galbacin (9), licarin A (10), (-)-acuminatin (11) and compound 12 showed dose-dependent potent inhibitory activities against $PLC{\Upsilon}1$ in vitro with $IC_{50}$ values ranging from 8.8 to 26.0 ${\mu}M$. These lignans, neolignans, and flavans are presented as a new class of $PLC{\Upsilon}1$ inhibitors. The brief study of the structure activity relationship of these compounds suggested that the benzene ring with the methylene dioxy group is responsible for the expression of inhibitory activities against $PLC{\Upsilon}1$. Moreover, it is suggested that inhibition of $PLC{\Upsilon}1$ may be an important mechanism for an antiproliferative effect on the human cancer cells. Therefore, these inhibitors may be utilized as cancer chemotherapeutic and chemopreventive agents.