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Inhibitory Lignans against NFAT Transcription Factor from Acanthopanax koreanum  

Cai, Xing-Fu (College of Pharmacy, Chungnam National University)
Lee, Im-Seon (College of Pharmacy, Chungnam National University)
Dat, Nguyen-Tien (College of Pharmacy, Chungnam National University)
Guanghai-Shen (College of Pharmacy, Chungnam National University)
Kang, Jong-Seong (College of Pharmacy, Chungnam National University)
Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
Kim, Young-Ho (College of Pharmacy, Chungnam National University)
Publication Information
Archives of Pharmacal Research / v.27, no.7, 2004 , pp. 738-741 More about this Journal
Abstract
Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E(1), tortoside A(2), and hemiariensin(4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (($IC_{50}$ ： 36.3${\pm}2.5{\mu}\textrm{M}$). However, the activities of 1 (($IC_{50}$：＞500 11M) and 2 (($IC_{50}$： 136.1 ${\pm}9.4\mu\textrm{M}$), which possess bisaryldioxabicy-clooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and(＋)-syringaresinol (3) with a bisaryldioxabicy-clooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.
Keywords
Acanthopanax koreanum; Araliaceae; Lignan; NFAT transcription factor; Inhibitory effect;
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Times Cited By Web Of Science : 9  (Related Records In Web of Science)
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