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The Pharmaceutical Society of Korea (대한약학회)
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Inhibitory Lignans against NFAT Transcription Factor from Acanthopanax koreanum

  • Published : 2004.07.01
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Abstract

Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E(1), tortoside A(2), and hemiariensin(4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (($IC_{50}$ ： 36.3${\pm}2.5{\mu}\textrm{M}$). However, the activities of 1 (($IC_{50}$：＞500 11M) and 2 (($IC_{50}$： 136.1 ${\pm}9.4\mu\textrm{M}$), which possess bisaryldioxabicy-clooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and(＋)-syringaresinol (3) with a bisaryldioxabicy-clooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.

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References

  1. Abbas, A. K., Lichtman, A. H., and Pober, J. S., Cellular and molecular immunology. W.B. Saunders Company, Philadelphia, pp. 315-338, (1997)
  2. Bensky, D. and Gamble, A., Materia medica. Eastland press, Washington, pp. 161-162, (1986)
  3. Hattori, M., Shu, Y., Shimizu, M., Hayashi, T., Morita, N., Kobashi, K., Xu, G., and Namba, T., Metabolism of paeoniflorin and related compounds by human intestinal bacteria. Chem. Pharm. Bull., 33, 3838-3846 (1985) https://doi.org/10.1248/cpb.33.3838
  4. Jain, J., Loh C., and Rao, A., Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol., 7, 333-342 (1995) https://doi.org/10.1016/0952-7915(95)80107-3
  5. Lalit, P. B., Bharathi, R. P, and Newand, B. M., Lignans of Piper cubeba. Phytochemistry, 26, 2033-2036 (1987) https://doi.org/10.1016/S0031-9422(00)81752-5
  6. Lee, I. S., Dang, T. L. H., Lee, M. S., Kim, J. W, Na, D. S., and Kim, Y. H., NFAT transcription factor inhibitory constituents from Cnidium officinale. Nat. Prod. Sci., 8, 94-96 (2002)
  7. Lee, I. S., Lee, H-K., Nguyen, T. D., Lee, M. S., Kim, J. W, Na, D. S., and Kim, Y. H., Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis. Planta Med., 69, 63-64 (2003) https://doi.org/10.1055/s-2003-37024
  8. Lim, H. M., Kim, Y., Kim, Y. H., Ahn, B. Z., and Kang, J. S., Stereoselective determination of (-)-yatein in the plants of the Cupressaceae family by capillary electrophoresis. J. Sep. Sci., 25, 1070-1072 (2002) https://doi.org/10.1002/1615-9314(20021101)25:15/17<1070::AID-JSSC1070>3.0.CO;2-H
  9. Nguyen, T. D., Lee, I. S., Cai, S. F., Shen, G. H., and Kim, Y. H., Oleanane triterpenoids with inhibitory activity against NFAT transcription factor from Liquidambar formosana. Biol. Pharm. Bull., 27, 426-428 (2004) https://doi.org/10.1248/bpb.27.426
  10. Phan, V. K., Chau, V. M., Nguyen, T. D., Cai, X. F., Lee, J. J., and Kim Y. H., Two new phenylpropanoid glycosides from the stem bark of Acanthopanax trifoliatus. Arch. Pharm. Res., 26, 1014-1017 (2003) https://doi.org/10.1007/BF02994751
  11. Takeshi, D., The constituents of Eucommia ulmoides OLIV. I. Isolation of (+)-medioresinol di-O-$\beta$-D-glucopyranoside. Chem. Pharm. Bull., 31, 2993-2997 (1983) https://doi.org/10.1248/cpb.31.2993
  12. Wang, C. Z. and Jia, Z. J., Lignan, phenylpropanoid and iridoid glycosides from Pedicularis torta. Phytochemistry, 45, 159-166 (1997) https://doi.org/10.1016/S0031-9422(96)00770-4
  13. Winter, G. and Harris, W. J., Humanized antibodies. Immunology Today, 14, 243-246 (1993) https://doi.org/10.1016/0167-5699(93)90039-N
  14. Yang, T. T., Sinai, P, Kitts, P. A., and Kain, S. R., Quantification of gene. expression with a secreted alkaline phosphatase reporter system. Biotechniques., 23, 1110-1114 (1997)