• Molecular & Cellular Toxicology
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• 제3권3호
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• pp.165-171
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• 2007

Mitomycin C (MMC), an antitumor antibiotic isolated from Streptomyces caespitosus, is used in chemotherapy of gastric, bladder and colorectal cancer. MMC is activated in vivo to alkylate and crosslink DNA, via G-G interstrand bonds, thereby inhibiting DNA synthesis and transcription. This study investigates gene expression changes in response to MMC treatment in order to elucidate the mechanisms of MMC-induced toxicity. MMC was admistered with single dose (0.32 and 1.6 ${\mu}M$) to TK6 cells. Applied Biosystem's DNA chips were used for identifying the gene expression profile by MMC-induced toxicity. We identified up- or down-regulated 90 genes including cyclin M2, cyclin-dependent kinase inhibitor 1A (p21, cip1), programmed cell death 1, tumor necrosis factor (ligand) superfamily, member 9, et al. The regulated genes by MMC associated with the biological pathways apoptosis signaling pathway. Further characterization of these candidate markers related to the toxicity will be useful to understand the detailed mechanism of action of MMC.

• 디지털융복합연구
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• 제14권12호
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• pp.245-256
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• 2016

본 연구는 국내 결혼이주여성을 대상으로 한 건강관련중재연구의 동향을 고찰함으로 결혼이주여성의 건강증진을 위한 중재개발의 기초적 자료로 활용하기 위한 문헌분석 연구로 15년간 국내외 학술지에 발표된 결혼이주여성 대상 건강관련 논문 96편 중 9편의 중재연구를 분석하였다. 9편의 실험 연구 중 3편이 임신 분만 관련 중재 연구이고, 영유아 감염예방, 여성 질환 관련 중재연구가 각각 1편이었으며, 신체적 요소만을 다룬 논문은 3편, 정신적 요소만을 다룬 논문은 2편, 4편은 정신 및 신체적 혹은 사회적 요소를 함께 포함하는 중재프로그램을 제공하였다. 신체적 요소를 포함한 결혼이주여성 대상의 연구는 여성이 결혼 후 자녀를 출산하고 양육하는 과정에 이어 생애 전반에 걸친 다양한 문제에의 접근을 고려할 필요가 있으며, 이들을 위한 정신사회적 중재는 여성 개인적 차원과 관계적 차원 모두에서 긍정적 대처와 적응을 돕기 위한 목적으로 계획되어야 할 것이다.

• 수산해양교육연구
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• 제24권2호
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• pp.246-262
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• 2012

This study analyzed the trend of researches regarding parenting involvement of fathers with early childhood children in terms of research period, research content and research method. Forty master's thesis and doctoral dissertation and 22 articles were selected for final analysis. Collected data were analyzed using frequency and percentage ratio. The results of this study showed that research on the parenting involvement of fathers has been rapidly increased since 2005. From the perspective of research content, studies dealing with parenting involvement of fathers as an independent variable focused on early children and social and emotional variables. Most of studies dealing with parenting involvement of fathers as an dependent variable consistently dealt with demographic variables. From the perspective of research method, most researches were quantitative and non-experimental. No research was done using qualitative method and all researches except one were done using non-experimental method. The number of participants in most researches were over 100 and less than 400. Most researches used participants from one particular district. Research instruments validated in Korea were used in most researches. These results were discussed with suggestions for further study.

• 정보기술과데이타베이스저널
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• 제8권2호
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• pp.115-135
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• 2001

The objective of this paper is to develop a knowledge assets measurement model in Korea. There are relatively many researches on measuring knowledge assets of an organization. These previous researches, however, lack of comprehensive view of knowledge management and view of Korean organizational culture. We surveyed and analyzed previous researches, and found common factors to measure knowledge assets. We developed an updated version of knowledge assets index. The developed model has been validated for its fitness with real data of Korean companies. The result of this research can be used as a measurement tool for knowledge assets of public institutions as well as private companies.

• 지역사회간호학회지
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• 제15권3호
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• pp.419-437
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• 2004

Purpose: This study aims to analyze the trends of the gerontological nursing researches in Korea and suggest the direction for research in this nation. Method: A total of 241 dissertations and other published articles in Korea from 1997 to 2003 were analyzed in this study focusing on the design of the research, key words, measurement tools for basic concepts, and the intervention outcomes in the case of the experimental research. Result: Of those analyzed researches. it was found that 80.9% accounted for the published articles and 19.1% dissertations. There were no clear criteria for the classification of the old men. The most popular research design was an exploratory/descriptive study (54.4%). The major concepts were about 'physical and mental health'. Most of the measurement tools used were developed by foreigners. which were translated into Korean. Among 56 experimental studies, nursing intervention programs in 22 studies were based on physical exercise programs. Conclusion: It is necessary to analyze the trend of gerontological health research in comparison with multidisciplinary researches for elderly people. In addition, the experimental researches for both development and verification of nursing intervention programs are needed. Also, accumulation of research outcomes and development of a standardized instrument for the measurement of Korean elderly people are required.

• 지역사회간호학회지
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• 제25권2호
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• pp.146-157
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• 2014

Purpose: The objective of this study is to analyze systematically the trends of experimental researches in the area of community health nursing. Methods: This is a study based on literature review, which analyzed 137 experimental research papers in the Journal of Korean Academy of Community Health Nursing, from the first issue in 1989 to those in 2012. Results: 1) The proportion of experimental researches in the total published papers was 14.9%. 2) The mainly used research method was quasi-experiment, which was 60.6% of them, and there was no RCT. 3) Convenient sampling was used in 95.6% of the researches. 4) Only 5.1% were reviewed for keeping the ethical standards for the study objects by the IRB. 5 When classified by the Omaha Classification System, psycho-social researches were most frequent, which were followed by physiological, health-related behavioral, and environmental ones in order of frequency. Conclusion: This study found that the proportion of experimental research papers was increasing in the 2000s and ethical standards were required more rigorously. However, it was suggested that the research design be more elaborated and sampling methods be manifested to reduce research bias and errors.

• 한국주거학회논문집
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• 제23권4호
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• pp.19-31
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• 2012

The main objectives of this research are to compile all the researches published in the registered academic journals to study the trends of researches and analyze the relationships between research contents and the social factors so that the accomplishments of community related researches and future tasks can be identified. For this purpose, 97 papers published between 1973 and July 2011 were chronologically organized and analyzed in terms of research methods, main contents, and their relationship with social factors. The key findings are as follows; 1) Researches on multi-family-housing community started in 1973 mainly focusing on the social factors of neighbors in a complex; since 2000, however, the researches on physical factors were increased the most followed by psychological and social factors accordingly. 2) The research findings were not fully developed to give a guidance for appropriate space programs or an analysis of residents' preference on facilities. The cause of this shortfall is due to the fact that there was a lack of studies on residents' usage of community facilities based on quantified database. 3) More comprehensive researches should be conducted in the future for vitalizations of community through facility supply system and design guidelines, development and operation of community programs and measures to enhance community awareness targeted on public housing and more diverse types of housing being apart from typical multi-family-houisng provide by private sector.

• 대한산업공학회지
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• 제34권2호
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• pp.181-189
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• 2008

Survivability of a network is one of the most important issues in designing present-day communication networks. For the past few decades, a lot of researches have proposed the mathematical models to evaluate the survivability of networks. In this paper, we attempt to survey such researches and classify them based on how these researches measure the survivability of a network.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1994년도 춘계공동학술대회논문집; 창원대학교; 08월 09일 Apr. 1994
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• pp.112-121
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• 1994

Studies on visual fatigues were activated after VDTs were rapidly introduced into the office works in 1980s. Various measurement methods and its measures were developed from those studies. Early studies frequently used simple measures such as near point of accommodation, near point of vergence, and CFF. Current researches focus on dark focus, dark vergence, and VEP which have a good relevance to the visual fatigues. In spite of the merit they also have some limits and disagreements. This survey summarizes the measures, measurement methods and relevant researches. Finally several topics are proposed for the future researches in Korea.

• 한국작물학회지
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• 제23권3호
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• pp.73-82
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• 1978

Researches on weed control in vegetable and fruits are reviewed in the aspects of technical dissemination of research results and problems to be solved for the establishment of integrated weed control measures. The future researches in relation to the possible changes of cultivation pattern in horticultural crops are also discussed. The current situation of weed control in horticulture in general is classed as a primitive stage comparing to other food crops and is well behind of other advanced countries. It is strongly suggested that only steady and extensive researches in this field will produce a significant contribution to the minimization of labor cost in horticultural crop production.