• Proceedings of the Korea Information Processing Society Conference
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• 2023.11a
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• pp.1033-1034
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• 2023

현대 사회에서 정신건강이 중요한 문제로 부상하고 있으나 국내 정신건강 서비스 이용률은 7.2%에 그친다. 코로나 발생 이후 이동성 제약 등의 요인에 따라 디지털 정신건강 관리 시장이 크게 성장할 것으로 보인다. 이에 본 논문에서는 AI 챗봇을 활용한 고민 상담을 통해 위로 및 제안을 제공하고, 대화 내용을 기반으로 영화를 추천하는 시스템을 제안한다. KoBert 모델을 이용하여 사용자의 감성을 분석하고, KoGPT 모델을 활용해 챗봇 응답을 생성한다.

• The Journal of Korean Medicine
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• v.16 no.1 s.29
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• pp.209-226
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• 1995

In order to investigate the protective effects of Jiyusaenggan-Tang by F-I(Jiyusaenggan-Tang aspirated by distilled water), F-II(Non-polysaccharides in Jiyusaenggan-Tang) and F-III(Polysaccharides in Jiyusaenggan-Tang), experimental studies were performed in mice with liver injury induced by $CCI_4$, and d-galactosamine. The results were summarized as follows : 1. The increases of the serum GOT activities in mice induced by $CCI_4$ were inhibited significantly by the administration of highly concentrated FIII. The increases of the serum GPT, LDH, and ALP activities in mice induced by $CCI_4$ were inhibited significantly by the administration of highly concentrated FI and FIII. 2. The increases of the serum total-cholesterol and triglyceride activities in mice induced by $CCI_4$ were inhibited significantly by the administration of highly concentrated FI, FII and FIII. 3. On liver injury induced by the $CCI_4$, the activities of GOT, GPT, ALP, LDH were inhibited by highly concentrated FIII, F-I, F-II, and F-I, F-II, F-III on total cholesterol level and F-III, F-I, F-II on triglyceride level in order of their efficacies. And F-III is considered to be the most effective component. 4. The increases of the serum GOT, GPT activities in mice induced by d-galactosamine were inhibited significantly by the administration of FI and FIII. The increases of the serum LDH, ALP activities in mice induced by d-galactosamine were inhibited significantly by the administration of FI and FIII. 5. The increases of the serum Total-cholesterol, Triglyceride activities in mice induced by d-galactosamine were inhibited significantly by the administration of FI, FII and FIII. 6. The increases of the serum GOT, GPT activities in mice induced by d-galactosamine were inhibited significantly in F-III administrated group and then F-I in order of efficacies. FII does not showed significant effect, on inhibiting the activities of serum GOT and GPT levels. The activity of ALP was inhibited by F-III, F-I, F-II, LDH by F-III, F-I in order of efficacies, and F-II did not showed significant effect on LDH activity. The triglyceride level was decreased significantly by F-III, F-II, F-I and the total cholesterol level by F-II, F-I, F-III in order of their efficacies. Judging from the above results, it is considered that Jiyusaenggan-Tang has protective effect against liver injury, and that Polysaccharides in Jiyusaenggan-Tang is more effective.

• Proceedings of the Korea Information Processing Society Conference
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• 2023.11a
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• pp.1092-1093
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• 2023

본 논문에서는 한국무역협회(KITA)의 오픈상담 자료들을 바탕으로, 딥러닝 기술을 이용하여 구현한 해상물류 대화형 챗봇 ShipMate를 제안한다. 챗봇 ShipMate는 KoGPT2를 활용한 답변과 Doc2Vec 기반의 유사 상담사례 추천이 가능하고, 무역상담을 시간제약 없이 진행할 수 있기 때문에, 기존 해상물류 서비스의 접근성을 한층 더 높일 수 있으며 이를 실험을 통해 입증하였다.

• Proceedings of the Korea Information Processing Society Conference
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• 2021.11a
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• pp.741-744
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• 2021

본 논문은 사전 학습된 심층생성모델을 기반으로 가수 별 가사의 특성을 반영하여 새로운 가사를 생성하는 모델을 소개한다. 베이스 모델로 한국어 사전 학습 모델 KoGPT-2 를 사용하였으며, 총 가수 10 명의 노래 823 곡을 수집하여 미세조정 기법을 바탕으로 학습하였다. 특히, 가수 별로 구분한 가사를 학습 데이터로 구축하여, 가수 별로 독특하게 나타나는 가사 스타일이 전이되도록 하였다. 가수의 이름과 시작 단어를 입력으로 주고 작사를 수행한 실험 결과, (i) 가수 별로 생성되는 가사의 어휘와 스타일이 그 가수의 기존 곡들의 가사와 유사함을 확인하였고, (ii) 작사 결과 가수 별 차이를 확인하였다. 추후 설문을 통해, 개별 가수들의 가사와 생성된 가사의 어휘와 스타일 유사성을 확인하고, 가수 별 차이 또한 확인하고자 한다.

• Journal of Applied Biological Chemistry
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• v.58 no.2
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• pp.139-143
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• 2015

In the present study, we investigated the oral toxicity of Amomum tsao-ko Crevost et Lemaire, (Zingiberaceae) extract in Balb/c mice (BALB, n=60) for 3 weeks. Balb/c mice (10 mice/group, 6 group, $20{\pm}2g$, 6 weeks) were orally administered for 21 days, with dosage of 250, 500, 1000, 2000 mg/kg/day. Ethanol extract of A. tsao-ko did not affect any significant change of mortality, clinical signs, organs and body weights. Also, there were not significantly difference from the naive group (control) in hematological and serum biochemical examination. Consequently, these findings indicate that 3-week treatment with the ethanol extract of A. tsao-ko was not any toxic effects in Balb/c mice and the no-observed adverse effect level (NOAEL) for oral toxicity was determined to be 2000 mg/kg/day under our experimental conditions.

• Physical Therapy Korea
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• v.12 no.2
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• pp.90-97
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• 2005

By measuring changes in blood lactate and plasma enzyme (CPK, GOT, GPT) with electrical stimulation applied at two duty cycles, this study is intended to look into which type of duty cycle may have more effects on blood lactate and plasma enzyme constituents through animal experiment so as to determine any duty cycle appropriate for electrical treatment. In this study, electrical stimulation was applied to total 20 Korean house rabbits (weight: 3~3.5 kg) by means of an electrical therapeutic apparatus called TS6000 (made in Netherlands) at duty cycle of 50% and 20% respectively for 30 minutes. Here, 5 cc of blood was collected from their carotid artery before stimulation and in 30 minutes after stimulation respectively to carry out biochemical experiment and analysis. As determined through the above experiment, blood lactate rate was increased to 333.07% at 50% duty cycle after experiment and 185.71% at 20% duty cycle after experiment respectively. In both cases, blood lactate rate was significantly increased to higher level after electrical stimulation than before. Moreover, the rate of change in the average of blood lactate rate at both duty cycles also showed significant differences. CPK rate was boosted to 301.82% at 50% duty cycle after experiment and 321.35% at 20% duty cycle after experiment respectively. In both cases, CPK rate was remarkably boosted to higher level after stimulation than before (p<.05). However, there was not any significant difference in the rate of change in average CPK at both duty cycles (p<.05). GOT rate was significantly boosted up to 38.97% at 50% duty cycle after experiment (p<.05), while it was slightly increased to 1.68% at 20% duty cycle after experiment without any significant difference. Rather, GPT rate dropped slightly at both duty cycles after experiment, but there was not any significant difference. Although blood lactate and GOT were relatively less generated at 20% duty cycle after electrical stimulation than at 50% duty cycle, the change of duty cycle didn't have any significant influence on CPK rate. In this regard, this study failed to come any consistent conclusion about the association between change of duty cycle and muscle fatigue. Therefore, it is advisable that follow-up studies seek various ways to a little more effectively apply electrical stimulation to laboratory animals by avoiding their muscle fatigue. GOT rate was significantly boosted up to 38.97% at 50% duty cycle after experiment (p<.05), while it was slightly increased to 1.68% at 20% duty cycle after experiment without any significant difference. Rather, GPT rate dropped slightly at both duty cycles after experiment, but there was not any significant difference. Although blood lactate and GOT were relatively less generated at 20% duty cycle after electrical stimulation than at 50% duty cycle, the change of duty cycle didn't have any significant influence on CPK rate. In this regard, this study failed to come any consistent conclusion about the association between change of duty cycle and muscle fatigue. Therefore, it is advisable that follow-up studies seek various ways to a little more effectively apply electrical stimulation to laboratory animals by avoiding their muscle fatigue.

• Fisheries and Aquatic Sciences
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• v.22 no.5
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• pp.9.1-9.7
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• 2019

The study investigated the changes in growth performance, hematological parameters, plasma components, and stress indicators of juvenile starry flounder, Platichthys stellatus, depending on varying exposure to hexavalent chromium. P. stellatus was exposed to waterborne chromium at 0, 50, 100, 200, and 400 ppb for 4 weeks. The result showed that Cr exposure resulted in decreased daily length gain (DLG), daily weight gain (DWG), condition factor (CF), and hepatosomatic index (HIS) in P. stellatus. In terms of hematological parameters, red blood cell (RBC) count, hematocrit (Ht), and hemoglobin (Hb) significantly decreased at 400 ppb after 2 weeks. In terms of plasma components, inorganic analysis was unchanged and cholesterol, an organic component, considerably increased at 400 ppb after 4 weeks. Plasma enzyme components including glutamic oxalate transaminase (GOT) and glutamic pyruvate transaminase (GPT) were significantly increased. Stress indicators such as cortisol and glucose were notably increased over 100 ppb after 4 weeks with increasing chromium concentration. The results indicate that exposure to waterborne Cr induced toxic effects on growth, hematological parameters, plasma components, and stress indicators.

• Annual Conference on Human and Language Technology
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• 2022.10a
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• pp.71-76
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• 2022

목적 지향 대화 시스템은 사용자가 원하는 목적을 달성하기 위해 사용하는 시스템으로 일상 대화와 다르게 시스템이 정보를 명확히 전달하는 것이 중요하다. 따라서 최근 연구에서 목적 지향 대화 시스템을 위한 자연어 생성 모델은 정해진 대화 정책에 따라 알맞은 응답을 생성할 수 있도록 의도와 슬롯 정보를 담은 대화 행위(Dialog Act)를 활용한다. 하지만 대화 행위는 생성하는 문장을 탁월하게 제어하는 반면에 대화의 흐름과 상황에 맞게 다양한 문장을 생성하기 어렵다는 문제점을 가지고 있다. 이러한 문제점을 해소하고자 본 논문에서는 목적에 부합하는 내용을 명확하게 자연어로 생성하기 위해 대화 행위를 사용하면서 동시에 일상 대화 생성 모델과 같이 문맥을 고려하여 대화 흐름에 어울리는 자연스러운 문장을 생성할 수 있는 문맥 기반의 제어 가능한 자연어 생성 모델을 제안한다. 실험에서는 KoGPT2 사전 학습 모델과 한국어 대화 데이터셋을 사용하였으며 실험을 통해 대화 행위 기반의 자연어 생성 모델과 본 연구에서 제안한 문맥 기반의 제어 가능한 자연어 생성 모델을 비교하였다. 결과적으로 대화 행위를 단독으로 학습한 모델보다 일정 문맥을 함께 학습한 모델이 유의미한 BLEU 점수 향상을 보인다는 점을 확인하였다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.17 no.4
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• pp.336-340
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• 1988

This study was performed to investigate the influence of mixtures of 0(control), 1, 2 and 3% ethanol and water respectively on growth and various blood parameters of growing broiler chicks. At the end of the 7 weeks' experiment, body weight gain in 1% ethanol group and liver weight in 3% ethanol group were significantly higher than those of control group. It was found that the levels of red blood cell, hemoglobin, hematocrit, and serum protein were within normal ranges. Serum GOT and r-GTP activities were significantly increased in 2 and 3% ethanol groups compared with those in control group. But serum CPT activity was slightily decreased in all ethanol groups. Serum LDH activity was increased in all ethanol groups compared with that In control group. Serum alkaline phosphatase was not affected by the ethanol. Serum glucose concentration in 3% ethanol group was significantly lower than that in control group.

• The Journal of Korean Medicine
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• v.20 no.3 s.39
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• pp.105-114
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• 1999

To investigate the anti-complementary and cytotoxic effects of oriental prescription, Kuseonwangdogo, on the proliferation of preadipocyte 3T3- L1 cells, we examined biological effects of Kuseonwangdogo. The results obtained were as follows. 1. After 14 days, the body weight of rats treated with Kuseonwangdogo decreased more than that in the control group (p<0.05). However, the weights of liver, spleen and kidney were unchanged. In serum biochemical test, we examined the level of glucose (GLU) and glutamic pyruvic transaminase (GPT). The levels of GOT and CHOL in serum were decreased remarkably by the administration of Kuseonwangdogo (p<0.05). The haematological examination of the tested group showed significant increment of white blood cells (WBC), hemoglobin concentration (HGB), mean corpuscular hemoglobin (MCH) and monocyte (MO). 2. The effect of Kuseonwangdogo on the proliferation of 3T3-L1 cells was tested by the sulforhodamin B(SRB) assay. The high concentration ($100{\mu}l\;and\;200{\mu}l$) of extracts inhibited the proliferation of 3T3- L1 cells. The p-value was <0.01, respectively. 3. The extract of Kuseonwangdogo showed a potent anti -complementary activity. It was suggested that the active principle may be a kind of polysaccharide molecule. 4. The cytotoxic effects of Kuseonwang dogo and its composing herbs in human liver cells (WRL68) and monkey kidney cells (Vero) were examined by the SRB and 3- (4,5- Dimethylthiazol-2-yl) -2,5 diphenyl-2H- tetrazolium bromide (MTT) assay. Cytotoxic effects were not observed.