• Journal of Menopausal Medicine
• /
• v.24 no.3
• /
• pp.183-187
• /
• 2018

Objectives: The present mini review aimed to summarize the existing knowledge regarding the beneficial and adverse effects of raloxifene in menopausal women. Methods: This study is a review of relevant publications about the effects of raloxifene on sleep disorder, depression, venous thromboembolism, the plasma concentration of lipoprotein, breast cancer, and cognitive function among menopausal women. Results: Raloxifene showed no significant effect on depression and sleep disorder. Verbal memory improved with administration of 60 mg/day of raloxifene while a mild cognitive impairment risk reduction by 33% was observed with administration of 120 mg/day of raloxifene. Raloxifene was associated with a 50% decrease in the need for prolapse surgery. The result of a meta-analysis showed a significant decline in the plasma concentration of lipoprotein in the raloxifene group compared to placebo (standardized mean difference, -0.43; 10 trials). A network meta-analysis showed that raloxifene significantly decreased the risk of breast cancer (relative risk, 0.572; 95% confidence interval, 0.327-0.881; P = 0.01). In terms of adverse effects of raloxifene, the odds ratio (OR) was observed to be 1.54 (P = 0.006), indicating 54% increase in the risk of deep vein thrombosis (DVT) while the OR for pulmonary embolism (PE) was 1.05, suggesting a 91% increase in the risk of PE alone (P = 0.03). Conclusions: Raloxifene had no significant effect on depression and sleep disorder but decreased the concentration of lipoprotein. Raloxifene administration was associated with an increased risk of DVT and PE and a decreased risk of breast cancer and pelvic organ prolapse in postmenopausal women.

• The Journal of the Korea Contents Association
• /
• v.19 no.10
• /
• pp.45-58
• /
• 2019

As modern people's daily lives are becoming more harsh in Korea, the so-called Kidults generation has appeared since a few years ago as adults have come back to their childhood sensibility and are exposed to various cultures online, and there are many people who have a hobby for collecting toys. However, as there is currently no formalized system for individual toy trade online, it is difficult to acquire expertise and share information with each other through a major portal site's $caf{\acute{e}}$, and is exposed to security or fraud while trading toys. In this paper, we design and implementation of a web-based toy trading system. Analyzing the advantages and disadvantages of the various trading and relay systems currently in use, it will provide opportunities for professional toy knowledge and information exchange to many users who have a hobby of collecting toys, and will greatly help vitalize the toy market through a secure and convenient trading environment between individuals.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• 2008.03a
• /
• pp.680-685
• /
• 2008

The ejector is a simple device which can transport a low-pressure secondary flow by using a high-pressure primary flow. In general, it consists of a primary driving nozzle, a mixing section, and a diffuser. The ejector system entrains the secondary flow through a shear action generated by the primary jet. Until now, a large number of researches have been made to design and evaluate the ejector systems, where it is assumed that the ejector system has an infinite secondary chamber which can supply mass infinitely. However, in almost all of the practical applications, the ejector system has a finite secondary chamber implying steady flow can be possible only after the flow inside ejector has reached an equilibrium state after the starting process. To the authors' best knowledge, there are no reports on the starting characteristics of the ejector systems and none of the works to date discloses the detailed flow process until the secondary chamber flow reaches an equilibrium state. The objective of the present study is to investigate the starting process of an ejector-diffuser system. The present study is also planned to identify the operating range of ejector-diffuser systems where the steady flow assumption can be applied without uncertainty. The results obtained show that the one and only condition in which an infinite mass entrainment is possible is the generation of a recirculation zone near the primary nozzle exit. The flow in the secondary chamber attains a state of dynamic equilibrium at this point.

• Korean Medical Education Review
• /
• v.23 no.3
• /
• pp.160-167
• /
• 2021

Rapid developments in technology as part of the Fourth Industrial Revolution have created a demand for educational technology (EdTech) and a gradual transition from traditional teaching and learning to EdTech-assisted learning in medical education. EdTech is a portmanteau (blended word) combining the concepts of education and technology, and it refers to various attempts to solve education-related problems through information and communication technology. The aim of this study was to explore the use of key EdTech applications in medical education programs. A scoping review was conducted by searching three databases (PubMed, CINAHL, and Educational Sources) for articles published from 2000 to June 2021. Twenty-one studies were found that presented relevant descriptions of the effectiveness of EdTech in medical education programs. Studies on the application and effectiveness of EdTech were categorized as follows: (1) artificial intelligence with learner-adaptive evaluation and feedback, (2) augmented/virtual reality for improving learning participation and academic achievement through immersive learning, and (3) social media/social networking services with learner-directed knowledge generation, sharing, and dissemination in medical communities. Although this review reports the effectiveness of EdTech in various medical education programs, the number of studies and the validity of the identified research designs are insufficient to confirm the educational effects of EdTech. Future studies should utilize suitable research designs and examine the instructional objectives achievable by EdTech-based applications to strengthen the evidence base supporting the application of EdTech by medical educators and institutions.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.54 no.6
• /
• pp.1045-1051
• /
• 2021

Eighty-nine different types of commercially salt-fermented fishery products comprising various raw materials were analyzed for total aerobic bacteria, number of coliform bacteria, fecal coliform, and Escherichia coli. The food-poisoning bacterial content of the samples was investigated using next-generation sequencing. The mean mass of total aerobic bacteria in Jeotgal was 6-1.8×10⁹ CFU/g, and that in Aekjeot and Sikhae was 4-2.2×10⁵ CFU/mL and 1.9×10⁵-8.4×10⁸ CFU/g, respectively. Coliform bacteria were detected in 9 (28.1%) of 32 Jeotgal samples; 15 (46.8%) of 32 seasonal Jeotgal samples; and in 5 (55.5%) of 9 Sikhae samples. Fecal coliform and E. coli were not detected in 86 of the 89 samples. Yersinia enterocolitica was detected only in Galchi jeot (salt-fermented hairtail) (1 type) and not in other Jeotgal samples. These results contribute to our knowledge regarding the bacterial stability of salt-fermented fishery products.

• The Korean Journal of Archival Studies
• /
• no.21
• /
• pp.355-383
• /
• 2009

The greatest mission of archival community lies in collecting records to document past and present Korean society and in safeguarding them to pass over to the next generation. For the last decade, Korean archival community has actively pursued this mission and accomplished it to the certain extent. A series of events occurred during the last year urged the community to regretfully accept that the so-called accomplishment was by no means satisfactory. The present study aims to review what has been achieved against what should be if the community is to be truthful to the fundamental mission. It begins with addressing attributes of electronic records. To be specific, attributes of electronic records as 'records' are compared against those as 'digital objects.' Current state of long-term preservation of electronic records is reviewed. Suggestions follow in terms of four directions: establishing a policy framework based on principles of electronic records management, building integrated electronic records management system, researching and developing functionalities for long-term preservation, and finally, knowledge transfer and coordination.

• Journal of Microbiology and Biotechnology
• /
• v.28 no.12
• /
• pp.2113-2120
• /
• 2018

Cross-reactive material 197 ($CRM_{197}$) is a non-toxic mutant of diphtheria toxin containing a single amino acid substitution of glycine 52 with glutamic acid. $CRM_{197}$ has been used as a carrier protein for poorly immunogenic polysaccharide antigens to improve immune responses. In this study, to develop a sandwich ELISA that can detect $CRM_{197}$ and $CRM_{197}$ conjugate vaccines, we generated a human anti-$CRM_{197}$ monoclonal antibody (mAb) 3F9 using a phage-displayed human synthetic Fab library and produced mouse anti-$CRM_{197}$ polyclonal antibody. The affinity ($K_D$) of 3F9 for $CRM_{197}$ was 3.55 nM, based on Bio-Layer interferometry, and it bound specifically to the B fragment of $CRM_{197}$. The sandwich ELISA was carried out using 3F9 as a capture antibody and the mouse polyclonal antibody as a detection antibody. The detection limit of the sandwich ELISA was <1 ng/ml $CRM_{197}$. In addition, the 3F9 antibody bound to the $CRM_{197}$-polysaccharide conjugates tested in a dose-dependent manner. This ELISA system will be useful for the quantification and characterization of $CRM_{197}$ and $CRM_{197}$ conjugate vaccines. To our knowledge, this study is the first to generate a human monoclonal antibody against $CRM_{197}$ and to develop a sandwich ELISA for $CRM_{197}$ conjugate vaccines.

• Korean Journal of Construction Engineering and Management
• /
• v.22 no.2
• /
• pp.80-87
• /
• 2021

Shortage of SOC budget and inappropriate initial construction cost planning have worsened the economic sentiment of the construction firm. Construction VE can be one of the solutions for improving the profitability of construction projects. This study identifies the strong and weak points of construction firms for establishing the strategy of effective construction VE by using importance-performance analysis. As a result, construction firms have strong points on support, cooperation, and knowledge about construction VE, but have weak points on 'VE experience of VE leader', 'Detailed cost estimation', and 'Idea generation and evaluation'. This paper contributes to establishing the strategy of effective construction VE from the perspective of the construction firm, which is differentiated from previous studies that have focused on the institutional approach for construction VE.

• The Journal of the Convergence on Culture Technology
• /
• v.7 no.3
• /
• pp.571-576
• /
• 2021

This study was carried out to overcome the problems of the existing fitness business and to build a fitness system that can meet the increased demand in the Corona situation. As a platform technology for non-face-to-face fitness edutainment service, it is a next-generation fitness exercise device that can use various body parts and synchronize network-type information. By synchronizing the exercise information of the fitness equipment, it was composed of learning contents through MR-based avatars. A quantified result was derived from examining the applicability of the customized evaluation system through momentum analysis with A.I analysis applying the LSTM-based algorithm according to the cumulative exercise effect of the user. It is a motion capture and 3D visualization fitness program for the application of systematic exercise techniques through academic experts, and it is judged that it will contribute to the improvement of the user's fitness knowledge and exercise ability.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.16 no.7
• /
• pp.2209-2224
• /
• 2022

The Internet of Things (IoT) is being used in a wide variety of fields due to the recent 4th industrial revolution. In particular, research is being conducted that combines IoT with the medical field such as telemedicine. Among them, the field of shock detection is a big issue in the medical field because the causes of shock are diverse, treatments are very complex, and require a high level of medical knowledge and experience. The transmission of infectious diseases is common when treating critically ill patients, especially patients with shock. Thus, to effectively care for shock patients, we propose an architecture that continuously monitors the patient's condition, and automatically recommends a drug injection treatment according to the patient's shock condition. The patient's hemodynamic information is continuously monitored, and the patient's shock generation information is recorded periodically. With the recorded patient information, the patient's condition is determined and automatically injected with necessary medication. The medical team can find out whether the patient's condition has improved by checking the recorded information through web applications. The study can help relieve the shortage of medical personnel and help prevent transmission of infectious disease in medical staff. We look forward to playing a role in helping medical staff by making recommendations for the diagnosis and treatment of complex and difficult shocks.