• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09a
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• pp.446-447
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• 2006

Magnetic oxide-coated iron nanoparticles with the mean size ranging from 6 to 75 nm were synthesized by aerosol method using iron carbonyl as a precursor under the flowing inert gas atmosphere. Oxide shells were formed by passivation of asprepared iron particles. The influence of experimental parameters on the nanoparticles' microstructure, phase composition and growth behavior as well as magnetic properties were investigated and discussed in this study.

• Journal of Powder Materials
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• v.28 no.6
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• pp.518-526
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• 2021

This review summarizes the recent progress in iron-oxide-based heat generators. Cancer treatment using magnetic nanoparticles as a heat generator, termed magnetic fluid hyperthermia, is a promising noninvasive approach that has gained significant interest. Most previous studies on improving the hyperthermia effect have focused on the construction of dopant-containing iron oxides. However, their applications in a clinical application can be limited due to extra dopants, and pure iron oxide is the only inorganic material approved by the Food and Drug Administration (FDA). Several factors that influence the heat generation capability of iron-oxide-based nanoparticles are summarized by reviewing recent studies on hyperthermia agents. Thus, our paper will provide the guideline for developing pure iron oxide-based heat generators with high heat dissipation capabilities.

• Journal of Magnetics
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• v.20 no.3
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• pp.215-220
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• 2015

The PVDF fibrous composite filled with iron oxide nanoparticles were prepared by using the electrospinning technique. The electrospun composite have the thickness in the range of $60-80{\mu}m$ with the average fibrous diameters of 500-900 nm. The magnetizations of PVDF fibrous composite filled with iron oxide nanoparticles showed 4.5 emu/g, 3.1 emu/g and 1.6 emu/g at 1.5 T of external magnetic field for 20 wt.%, 10 wt.% and 5 wt.% iron oxide nanoparticles, respectively. The heat elevation of the magnetic composite were measured under various AC magnetic fields, frequency and the ambient temperatures. The temperature reached up to $46.3^{\circ}C$ from $36^{\circ}C$ at 128 Oe and 355 kHz for 20 wt.% iron oxide nanoparticles filled in PVDF fibrous composite sheet. The specific absorption rate of theses sheets increased from 0.041 W/g to 0.236 W/g with the increment of AC magnetic field from 90 Oe to 167 Oe at 190 kHz, respectively.

• Journal of Magnetics
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• v.15 no.4
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• pp.179-184
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• 2010

We have investigated the effects of post annealing on iron oxide nanoparticles synthesized by the novel hydrothermal synthesis method with the $FeSO_4{\cdot}7H_2O$. To investigate the post annealing effect, the as-synthesized iron oxide nanoparticles were annealed at different temperatures in a vacuum chamber. The morphological, structural and magnetic properties of the iron oxide nanoparticles were investigated with high resolution X-ray powder diffraction (XRD), high resolution transmission electron microscopy (HRTEM), Mossbauer spectroscopy, and vibrating sample magnetometer analysis. According to the XRD and HRTEM analysis results, as-synthesized iron oxide nanoparticles were only magnetite ($Fe_3O_4$) phase with face-centered cubic structure but post annealed iron oxide nanoparticles at $700^{\circ}C$ were mainly magnetite phase with trivial maghemite ($\gamma-Fe_2O_3$) phase which was induced in the post annealing treatment. The crystallinity of the iron oxide nanoparticles is enhanced by the post annealing treatment. The particle size of the as-synthesized iron oxide nanoparticles was about 5 nm and the particle shape was almost spherical. But the particle size of the post annealed iron oxide nanoparticles at $700^{\circ}C$ was around 25 nm and the particle shape was spherical and irregular. The as-synthesized iron oxide nanoparticles showed superparamagnetic behavior, but post annealed iron oxide nanoparticles at $700^{\circ}C$ did not show superparamagnetic behavior due to the increase of particle size by post annealing treatment. The saturation of magnetization of the as-synthesized nanoparticles, post annealed nanoparticles at $500^{\circ}C$, and post annealed nanoparticles at $700^{\circ}C$ was found to be 3.7 emu/g, 6.1 emu/g, and 7.5 emu/g, respectively. The much smaller saturation magnetization value than one of bulk magnetite can be attributed to spin disorder and/or spin canting, spin pinning at the nanoparticle surface.

• Journal of Magnetics
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• v.9 no.3
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• pp.83-85
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• 2004

Magnetic nanoparticles have been investigated for use as biomedical purposes for several years. For biomedical applications the use of particles that present superparamagnetic behavior at room temperature is preferred [1-4]. To control the magnetic materials by magnetic field is essential locate particle to the suitable destination on feeding by injection. In order to use them properly, the particles should be nano size. However there are many difficulties in applications, because there is lack of identifications in nano magnetic properties. In our studies, structural and magnetic properties of iron oxide nanoparticles were investigated by XRD, VSM, TEM, and Mossbauer spectroscopy. At 13 K, hyperfine fields of ${\gamma}-Fe_2O_3$ were 516 kOe and 490 kOe, that of $Fe_3O_4$ were 517 kOe and 482 kOe. The saturation magnetizations were 21.42 emu/g and 39.42 emu/g. The particle size of powders is 5～19 nm.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.1-1
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• 2011

We developed a new generalized synthetic procedure, called as "heat-up process," to produce uniform-sized nanocrystals of many transition metals and oxides without a size selection process. We were able to synthesize uniform magnetite nanocrystals as much as 1 kilogram-scale from the thermolysis of Fe-oleate complex. Clever combination of different nanoscale materials will lead to the development of multifunctional nano-biomedical platforms for simultaneous targeted delivery, fast diagnosis, and efficient therapy. In this presentation, I would like to present some of our group's recent results on the designed fabrication of multifunctional nanostructured materials based on uniform-sized magnetite nanoparticles and their medical applications. Uniform ultrasmall iron oxide nanoparticles of <3 nm were synthesized by thermal decomposition of iron-oleate complex in the presence of oleyl alcohol. These ultrasmall iron oxide nanoparticles exhibited good T1 contrast effect. In in vivo T1 weighted blood pool magnetic resonance imaging (MRI), iron oxide nanoparticles showed longer circulation time than commercial gadolinium complex, enabling high resolution imaging. We used 80 nm-sized ferrimagnetic iron oxide nanocrystals for T2 MRI contrast agent for tracking transplanted pancreatic islet cells and single-cell MR imaging. We reported on the fabrication of monodisperse magnetite nanoparticles immobilized with uniform pore-sized mesoporous silica spheres for simultaneous MRI, fluorescence imaging, and drug delivery. We synthesized hollow magnetite nanocapsules and used them for both the MRI contrast agent and magnetic guided drug delivery vehicle.

• Journal of Powder Materials
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• v.20 no.3
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• pp.180-185
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• 2013

The iron oxides nanoparticles and iron oxide with other compounds are of importance in fields including biomedicine, clinical and bio-sensing applications, corrosion resistance, and magnetic properties of materials, catalyst, and geochemical processes etc. In this work we describe the preparation and investigation of the properties of coated magnetic nanoparticles consisting of the iron oxide core and organic modification of the residue. These fine iron oxide nanoparticles were prepared in air environment by the co-precipitation method using of $Fe^{2+}$: $Fe^{3+}$ where chemical precipitation was achieved by adding ammonia aqueous solution with vigorous stirring. During the synthesis of nanoparticles with a narrow size distribution, the techniques of separation and powdering of nanoparticles into rather monodisperse fractions are observed. This is done using controlled precipitation of particles from surfactant stabilized solutions in the form organic components. It is desirable to maintain the particle size within pH range, temperature, solution ratio wherein the particle growth is held at a minimum. The iron oxide nanoparticles can be well dispersed in an aqueous solution were prepared by the mentioned co-precipitation method. Besides the iron oxide nanowires were prepared by using similar method. These iron oxide nanoparticles and nanowires have controlled average size and the obtained products were investigated by X-ray diffraction, FESEM and other methods.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.22 no.3
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• pp.134-138
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• 2012

Recently the preparation magnetic nanoparticles by a pulsed laser ablation in liquid has gained much attention because it is easy to control experimental parameters. Iron oxide magnetic nanoparticles have been prepared by a pulsed laser ablation of ${\alpha}-Fe_2O_3$ target in ethanol at different magnitude of laser energy of 1, 20, 40 and 80 mJ/pulse. It revealed that particle size increases with increasing laser energy. It could be concluded that 40 mJ/pulse is an optimum laser energy for the preparation of iron oxide nanoparticles with uniform size distribution. The nanoparticles are homogeneously dispersed in ethanol and their stability maintained for several months.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.4 no.1
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• pp.36-42
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• 2018

Molecular imaging refers to detect the biochemical process in living organisms at the cellular and molecular levels and to quantify them. Due to several advantages of nanomaterials, various molecular images using nanomaterials are being tried. Attempts have been made to combine nanoparticles, known as micro- or nanosized nanomaterials, with radioactive isotopes for molecular imaging probe. The radiolabeled nanoparticles will expend the molecular imaging due to nanoparticle's size-dependent nature. In particular, iron oxide nanoparticles can be used for magnetic resonance imaging, can be adjusted in size, easily functionalized, and biocompatible, making it a very good platform for molecular imaging. In addition, iron oxide nanoparticles may be the best example for a new approach to molecular imaging techniques. In this paper, we introduce various methods for preparation of iron oxide nanoparticle combined with radioisotope starting from various synthesis methods of iron oxide nanoparticles to utilize iron oxide nanoparticles as a platform for molecular imaging through radioactive labeling.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.133-140
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• 2021

Various iron oxide nanoparticle-based radiomaterials(IO-NRM) can be used for multimodal imaging of magnetic resonance imaging and molecular imaging, can be easily sized, can be easily functionalized, and have biocompatibility, making them a very good platform for molecular imaging. Based on the previously revealed molecular imaging technology of iron oxide nanoparticles, this paper introduces the in vivo distribution and use in various diseases through iron oxide nanoparticles-based radiolabeled compounds for diagnosis and treatment of iron oxide nanoparticles-based molecular imaging platforms. We would like to look forward to its potential as a radiopharmaceutical.