• Genomics & Informatics
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• v.10 no.2
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• pp.81-87
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• 2012

Large-scale copy number variants (CNVs) in the human provide the raw material for delineating population differences, as natural selection may have affected at least some of the CNVs thus far discovered. Although the examination of relatively large numbers of specific ethnic groups has recently started in regard to inter-ethnic group differences in CNVs, identifying and understanding particular instances of natural selection have not been performed. The traditional $F_{ST}$ measure, obtained from differences in allele frequencies between populations, has been used to identify CNVs loci subject to geographically varying selection. Here, we review advances and the application of multinomial-Dirichlet likelihood methods of inference for identifying genome regions that have been subject to natural selection with the $F_{ST}$ estimates. The contents of presentation are not new; however, this review clarifies how the application of the methods to CNV data, which remains largely unexplored, is possible. A hierarchical Bayesian method, which is implemented via Markov Chain Monte Carlo, estimates locus-specific $F_{ST}$ and can identify outlying CNVs loci with large values of FST. By applying this Bayesian method to the publicly available CNV data, we identified the CNV loci that show signals of natural selection, which may elucidate the genetic basis of human disease and diversity.

• Korean Journal of Social Welfare
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• v.58 no.4
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• pp.37-63
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• 2006

In terms of theory, this study differentiates the definition of collaboration management and provides the different angle to find collaboration determinants. In terms of practice, stressing the necessity of establishing and practicing the plan for collaboration management, it suggests us that promising strategies of management for inter-organizational collaboration in korean children and youth social service arena should be prepared. Through examining the theories, it is found that collaboration management like formal and informal meeting, contract, appointing the staff for collaboration is different from the former organizational factors. Collaboration management is found to be a factor accelerating the collaboration and differentiating from collaboration result itself. It is found that collaboration management factor affects the clients being refereed, providing some kinds of programs, and getting them. It means that the policy of organization which makes the staffs to participate at meetings to obtain various programs that other organizations provide, draws the agreement for collaboration, and arranges internal system for collaboration like appointing special staff activates the collaboration among organizations. Findings of this study provides us some recommendations. The efforts to develop technique, know-how, and management theory should be made in the Korean society. Organizations and the government should encourage organizations to manage the collaboration among them and make an effort to initiate policies and programs.

• Journal of Venture Innovation
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• v.1 no.2
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• pp.75-87
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• 2018

We designed this study for verifying the differences of causes and individual results of job stress between Koreans in Korea and Chinese in China of a same company. The results in the study are as follow. Significant differences between two groups were identified in job stressors: Koreans showed higher levels than Chinese for factors like inter-group conflicts, supervision/evaluation, job overload, task characteristics, socio-demographic factors, and Chinese showed higher levels than Koreans for factors like job conflicts, job ambiguity, family-related factors. We also identified that levels of stress perceived by individuals as anxiety, depression, and physical symptoms of Koreans are higher than those of Chinese. As to the influence of job stressors on stress level, Koreans show significant results for supervision/evaluation, decision making/responsibility, family-related factors, and Chinese show significant results for family-related factors, social support, socio-demographic factors. Based on the results of this study, implications, limitations, and future research topics were discussed.

• The Journal of the Korea Contents Association
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• v.6 no.11
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• pp.8-14
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• 2006

With an analysis of government owned corporations based on Chinese law as a subject and in the light of comparing and assessing intra-company domination called internal management organization with the domination structure of already established advanced nations, the objective of this study is to analyze the reality and possibility of company domination structure of Chinese government owned corporations. Especially, the intra-company domination structure in China from the points of view such as general meeting of stock holders, director and board of directors, and board of auditors, this study examines the direction toward which internal domination organizations in China form. Also, related to chinese corporations, the study proposes the model in which the possession right of general meeting of stock holders, corporation property right of board of directors, corporation representative right of the senior executive and superintendency of board of auditors are mutually restricted and inter-connected.

• Journal of Korean Library and Information Science Society
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• v.24
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• pp.485-517
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• 1996

The purpose of this study is to investigate typical ethical problems found in the technical and public services areas. The followings are the summary of the study. There are three distinct elements that govern ethical problems. One element is legal laws. The copyright law and the privacy act are exact examples. The copyright law has strong influence on the inter library loan service where the majority requests from the users are reproduction of copies. The privacy act also creates difficulties for librarians. Most requests for circulation records infringe on the privacy of library user. And advance online access systems also violates the privacy of library users. The second element is the code or rules that private organization has created. American Library Association created many statements that regulate the conduct of librarians. The bill of right, the professional code of ethics and policy on the confidentiality of library records have strong implications in the obligation of librarian. In the case of censorship at the selection of library materials, the code is a defensive tool against intellectual freedom. Yet self-censoring are prevailing practice among librarians. The thirds element is the competence of librarians. The analyzed table 3 showed that beside two elements, the rest of matters are competence required by librarians. The one aspect of it is humaneness and the other one is technical aspects. Technical aspect of competence are:(l) managerial and operational ability (2) communication skill (3) leadership (4) structure of knowledge and (5) self developing professionalism. Humanity aspect of competence are:(l) trust(fiduciary relationship) gained by diligence, objective judgement, ability, belief, rationality, integrity, kindness) (2) objectiveness (free from bias) (3) user-oriented consideration (need, interest, equal treatment, information gap) (4) caution in providing information (5) pride and (6) ability to distinguish advice and guidance specially in medical and law library.

• Korean Institute of Interior Design Journal
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• v.14 no.2 s.49
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• pp.112-119
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• 2005

This study attempts to suggest new directions of urban multi-family housing design in the recent era of information, in which the representation of publicity and privacy of the housing reflects new meanings and relationships of the current digital society. The study examines cases of Dutch multi-family housing and investigates the meanings and relationships of publicity and privacy in the building as well as unit design of the housings. Borneo-Sporenburg housing development is a good example that suggests new interpretation and design solution for low-rise, high-density multi-family housing. Thus, this study analyzes street patterns, facade design, and ways of housing unit combination in Borneo-Sporenburg housing and concludes as follows. First, public space in Borneo-Sporenburg housing, which was designed differently from hierarchical and centripetal organization of modern architecture, is divided into small units and spread into the inside, which provides high potential for personal control of space and personal programming of space by space choices. Second, street pattern and facade design of Borneo-Sporenburg housing provide visual publicity and privacy simultaneously as they maintain unity as a whole as well as articulate individual unit in many different ways and provide clues to neighboring. Streets as a public domain have self-controlled boundaries for residents and introduce voluntary use-programs for residents. Third, facades of the housing have no inter-mediate space or common space, and confront streets directly. Space in-between is composed inside the facade and extends into the streets by residents' own choices. Fourth, privacy and individuality of the housing is strengthened. Units of the housing have individual entrances, unique plan type and complicated combination of space that all together emphasize individuality of units, however they are not often notified from the outside.

• Journal of the Economic Geographical Society of Korea
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• v.15 no.4
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• pp.628-641
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• 2012

This research investigates a dynamic mechanism underlying the co-evolution between network and space by applying hype-curve model, typical phenomenon which shows how new technologies and ideas initially adapted in the society. This study analysis the knowledge intensive industry of digital contents using social network analysis (SNA) in terms of structural, spatial, and temporal aspects, year of 2000, 2005, and 2010 focused on Seoul area. First of all, network and space establish 'inter-feedback' as a result of evolution and differentiation process. Second, it happen temporal 'delay' through the learning process stage of 'peak of inflated expectation' and 'trough of disillusionment.' As a result, Seoul develops with the technology commercialized-orient strategy affect government policy. This trend changes to technology-oriented development in Seoul area in the late of 2000 established 'self-organization' with geographical proximity organizations through learning process.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.23 no.4
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• pp.5-24
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• 2012

The aim of this study is 1) to analyse the historical development and current condition of the subject based classification(SBC), 2) to clarify the function and to categorize the specific kind of SBC, for its conceptualization and the development plan. For this purpose, almost 30 cases, for the period 1937 through now, were analyzed concerning their terms used in the names and the specific kinds as SBC. In addition, the analysis was made regarding how the SBC fulfill the selected main functions as a classificatory scheme and how SBC is inter-related with the other knowledge organization systems(KOS) such as classification and subject heading. Based on the above analysis, the conclusion addressed that SBC could be defined in consideration of the detailed function, type, information environment, and interconnection among the KOS, and suggested the future development plan of SBC as a classification scheme.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3213-3218
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• 2012

When patients with advanced breast cancer (ABC) are treated with neoadjuvant chemotherapy (NACT), efficacy is monitored by the extent of tumor shrinkage. Since their publication in 1981, World Health Organization (WHO) guidelines have been widely practiced in clinical trials and oncologic practice, for standardized tumor response evaluation. With advances in cancer treatment and tumor imaging, a simpler criterion based on one-dimensional rather than bi-dimensional (WHO) tumor measurement, named Response Evaluation Criteria in Solid Tumors (RECIST) was introduced in 2000. Both approaches have four response categories: complete response, partial response, stable disease and progressive disease (PD). Bi-dimensional measurement data of 151 patients with ABC were analysed with WHO and RECIST criteria to compare their response categories and inter criteria reproducibility by Kappa statistics. There was 94% concordance and 9/151 patients were recategorized with RECIST including 6/12 PD cases. RECIST therefore under-estimates and delays diagnosis of PD. This is undesirable because it may delay or negate switch over to alternate therapy. Analysis was repeated with a new criteria named RECIST-Breast (RECIST-B), with a lower threshold for PD (${\geq}10%$ rather than ${\geq}20%$ increase of RECIST). This showed higher concordance of 97% with WHO criteria and re-categorization of only 4/151 patients (1/12 PD cases). RECIST-B criteria therefore have advantages of both ease of measurement and calculations combined with excellent concordance with WHO criteria, providing a practical clinical tool for response evaluation and offering good comparison with past and current clinical trials of NACT using WHO guidelines.

• Journal of the Korean Association of Geographic Information Studies
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• v.10 no.4
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• pp.35-45
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• 2007

Currently, the necessity of inter-system integration and sharing system increases to additionally construct and efficiently utilize the geographical information data in accordance with the increase in demand for geographical information. The provision of the data within the domestic sharing system is led by the tasks within national geographical information distribution network or intra-local governmental combined system. However, any voluntary geographical information sharing cooperation body is increasingly required with the increase in necessity of administrative cooperation among neighboring metropolitan areas, including space planning and development. Accordingly, this study is aimed at looking into the constitutions and roles of cooperation bodies within metropolitan areas by the composition, distribution, update and management of data with special regard to overseas advanced cases whose sharing systems and their effects are highly evaluated, and at presenting any model of the domestic future voluntary sharing cooperation organization within metropolitan area.