• Genomics & Informatics
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• v.6 no.4
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• pp.231-234
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• 2008

Precise and reliable identification of CNV is still important to fully understand the effect of CNV on genetic diversity and background of complex diseases. SNP marker has been used frequently to detect CNVs, but the analysis of SNP chip data for identifying CNV has not been well established. We compared various normalization methods for CNV analysis and suggest optimal normalization procedure for reliable CNV call. Four normal Koreans and NA10851 HapMap male samples were genotyped using Affymetrix Genome-Wide Human SNP array 5.0. We evaluated the effect of median and quantile normalization to find the optimal normalization for CNV detection based on SNP array data. We also explored the effect of Robust Multichip Average (RMA) background correction for each normalization process. In total, the following 4 combinations of normalization were tried: 1) Median normalization without RMA background correction, 2) Quantile normalization without RMA background correction, 3) Median normalization with RMA background correction, and 4) Quantile normalization with RMA background correction. CNV was called using SW-ARRAY algorithm. We applied 4 different combinations of normalization and compared the effect using intensity ratio profile, box plot, and MA plot. When we applied median and quantile normalizations without RMA background correction, both methods showed similar normalization effect and the final CNV calls were also similar in terms of number and size. In both median and quantile normalizations, RMA backgroundcorrection resulted in widening the range of intensity ratio distribution, which may suggest that RMA background correction may help to detect more CNVs compared to no correction.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.24 no.1
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• pp.57-65
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• 2018

Background: This study examined the effects of nerve mobilization exercise and scapula postural correction exercise and scapula postural correction exercise after applying conservative physical therapy to frozen shoulder. Methods: Thirty-four outpatients were divided into a nerve mobilization exercise and scapula postural correction exercise group and scapula postural correction exercise group. Each group performed its own exercise 30 minutes per day, three times per week, for 6 weeks. Pain intensity was measured by the visual analogue scale. Range of motion was measured by the goniometer. The scapular position was measured by scapular index. Grasping power was measured by the Grip Track Commander. Measurements were made at baseline and six weeks after the intervention. Results: the visual analogue scale, range of motion (except lateral rotation), and grasping power for each group showed significant changes at baseline and six weeks after the intervention (p<.05). Significant differences were also evident between the two groups for these three measurements (p<.05). Conclusions: Nerve mobilization exercise & scapula postural correction exercise is more effective than scapula postural correction exercise for reducing pain intensity and increasing grasping power, scapular index and range of motion (except lateral rotation) in frozen shoulder syndrome patients.

• Bulletin of the Korean Chemical Society
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• v.32 no.3
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• pp.805-808
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• 2011

We have determined the urea concentration in an aqueous solution using Raman spectroscopy by incorporating a Teflon tube as an effective intensity correction standard as well as sample container. A non-overlapping Teflon band was used as the reference peak to correct Raman intensity variations that occasionally resulted from changes in laser power. To increase the sensitivity, we positioned a copper reflector inside the Teflon tube to maximize the collection of Raman scattering. The obtained accuracy using Raman spectroscopy was 0.53 mM, close to the range of accuracy of previous NIR studies (0.15-0.52 mM).

• Transactions of the Korean Society of Mechanical Engineers
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• v.11 no.1
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• pp.132-144
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• 1987

This paper presents the theroetical analysis of the crack tip stress intensity factor for a center crack in a finite width plate with variable thickness. The analyses were based on Laurent's expansions of complex stress potentials where the expansion coefficients are determined from the boundary conditions. The perturbation method was employed in numerical calculations. The correction factor F(.lambda.)is given in the form of power series of .lambda. [a numerical formula] where .lambda.=a/w$^{1}$; Dimensionless crack length, .betha.=t$_{2}$/t; Thickness ratio .omega.=w$_{2}$/w$_{1}$; width ratio The correction factor values vary with the width ratio .omega. and the maximum variation occurs around .betha.=1. For the case of .betha.=1 or .betha.=0 (uniform thickness plate0, the correction factor values agree well with Feddersen's formula. In all cases, as .lambda. approaches to 1 (thickness interface), the correction factor values are decreased rapidly for .betha.>1, and increased rapidly for .betha.<1.

• Journal of the Korean Society of Safety
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• v.12 no.4
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• pp.27-38
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• 1997

The effect of geometry factors on the combined mode stress intensity factor behaviors of a slant crack in a non-uniform thickness material was analysed by 2-dimensional theoretical analysis. The analysis is based on the Laurent's series expansions of complex potentials where the complex coefficients of the series are determined from the compatibility and the equilibrium conditions of the thickness interface and the stress free conditions of the crack surface. In numerical calculations the perturbation technique is employed. The expressions for the crack tip stress intensity factor are given in the form of power series of dimensionless crack length $\lamda$, and the function of crack slant angle $\alpha$ and thickness ratio $\beta$. The results of numerical calculations for each problems are represented as the correction factors F($\lamda$, $\alpha$, $\beta$). The results clearly show the following characteristics : The correction factors of the combined mode stress intensity factors for a non-uniform thickness material can be defined in the form of F($\lamda$, $\alpha$, $\beta$). The stress intensity factor values for a given crack length are decreased with increase of thickness ratio $\beta$.

• Radiation Oncology Journal
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• v.36 no.2
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• pp.171-171
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• 2018

• Journal of the Korea Society of Computer and Information
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• v.20 no.4
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• pp.57-67
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• 2015

The concept of detection and classification of objects based on infrared camera is widely applied to military applications. While the object detection technology using infrared images has long been researched and the latest one can detect the object in sub-pixel, the object classification technology still needs more research. In this paper, we present object classification method based on measured radiant intensity of objects such as target, artillery, and missile using infrared camera. The suggested classification method was verified by radiant intensity measuring experiment using black body. Also, possible measuring errors were compensated by modelling-based correction for accurate radiant intensity measure. After measuring radiation of object, the model of radiant intensity is standardized based on theoretical background. Based on this research, the standardized model can be applied to the object classification by comparing with the actual measured radiant intensity of target, artillery, and missile.

• Journal of Broadcast Engineering
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• v.22 no.2
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• pp.207-213
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• 2017

In order to accurately perform multispectral imaging using a multiplexed illumination, intensity of illumination in a scene must be uniform. For image acquisition that requires accurate color information, even if not multispectral imaging, the illumination information must be accurate, and a flat light source or illumination calibration is performed for accurate illumination characteristics. In this paper, we propose a method of color correction to uniformly illuminate an image with non-uniform illumination intensity. The proposed method uses multispectral imaging instead of illumination calibration for color correction. First of all, we perform multispectral imaging with two images obtained from non-uniformity illumination to acquire spectral reflectance. The obtained reflection spectrum is relit as the illumination characteristic of the image obtained from general planar light such as fluorescent light or sunlight. By comparing the image obtained by relighting with the uniformly illuminated image, the non-uniformity of the illumination is confirmed, and the color correction is performed as the image obtained from the uniform image. It is expected that the experimental results will confirm whether the non-uniformity of the illumination is uniformly corrected and reduce the restriction of illumination in obtaining the color information of the image.

• Bulletin of the Korean Chemical Society
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• v.32 no.12
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• pp.4327-4331
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• 2011

A new method in thermal ionization mass spectrometry (TIMS) was developed to correct peak tailing backgrounds in the isotope ratio measurements of uranium in ultra trace levels for higher accuracy. Two different uranium standard reference materials (U005 and U030) were used to construct databases of signal intensities at mass 234 u and mass 236 u, which correspond to the two uranium minor isotopes, and signal intensity of $^{238}U$. Correlations between peak tailing backgrounds and $^{238}U$ were obtained by least-squares regression on calculated backgrounds at mass 234 u and mass 236 u with respect to the signal intensity of $^{238}U$ followed by separation of the peak tails of the two major isotopes of uranium ($^{235}U$ and $^{238}U$), which enables us to obtain a master equation for peak tailing background correction on all kinds of samples. Verification of the correction method was carried out using U010 and IRMM-040a.

• Transactions of the Korean Society of Mechanical Engineers
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• v.13 no.4
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• pp.625-635
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• 1989

Mixed mode fracture problem is analyzed for the finite orthotropic plate where an inclined crack parallel to the fiber direction is centrally placed. Modified mapping collocation method with both uniform stress and uniform displacement boundary conditions is utilized to calculate stress intensity correction factors for glass/epoxy and graphite/epoxy composites. Computed results are presented for selected combinations of crack length to width ratio L/W and plate aspect ratio H/W with various fiber orientations.