• BMB Reports
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• v.38 no.5
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• pp.619-623
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• 2005

The efficacy of chemotherapeutic agents on tumor cells has been shown to be modulated by tumor suppressor gene p53 and its target genes such as Bcl-2 family members (Bax, Noxa, and PUMA). However, various chemotherapeutic agents can induce cell death in tumor cells that do not express the functional p53, suggesting that some chemotherapeutic agents may induce cell death in a p53-independent pathway. Here we showed that etoposide can induce the similar degree of cell death in p53-deficient HCT 116 cells, whereas 5'-FU-mediated cell death is strongly dependent on the existence of functional p53 in HCT 116 cells. Further, we provide the evidence that etoposide can induce the cytochrome c release from isolated mitochondria, and etoposide-induced cytochrome c release is not accompanied with the large amplitude swelling of mitochondria. These data suggest that etoposide can directly induce the mitochondrial dysfunction irrespective of p53 status, and it may, at least in part, account for the p53-independent pathway in cell death induced by chemotherapeutic agents.

• Proceedings of the SAREK Conference
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• 2009.06a
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• pp.309-314
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• 2009

The unpredicted worldwide oil price makes the energy efficiency technology be more importance than any other period. The small cogeneration system is one of the most representative technology among the energy efficiency technologies, and the Stirling engine cogeneration system has been concerned and investigated due to the preferable characteristics - low toxic emission, low noise and vibration level, and the various form of fuel. A tiny, 1kW of electrical output, gas fueled Stirling engine cogeneration system was investigated. The electrical efficiency and thermal efficiency of the system were measured. The experiment was executed at an independent Stirling engine mode, independent secondary burner mode, and the combined mode. Part load characteristics of the Stirling engine cogeneration system were investigated also. With the efficiency characteristics, the $O_2$ and NOx emission characteristics were measured.

• Proceedings of the KIEE Conference
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• 2015.07a
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• pp.645-646
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• 2015

The conventional wheelsets has disadvantages of potential oscillatory instability. In the paper, a design of the permanent magnet synchronous machine of independent-wheel type for near-surface is performed. Also, the lateral displacement control algorithm is proposed. The subcale bogie can maintain the centering by this algorithm. The design of the machine is verified by BEMF. And the validity and usefulness of the lateral displacement control algorithm is verified by experimental results.

• Journal of the Korean Society of Safety
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• v.32 no.5
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• pp.47-53
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• 2017

In this study, we propose a new control system that effectively utilizes the interaction effect of control force through the connection of stiffness member for seismic performance enhancement of two adjacent structures equipped with active tuned mass damper (ATMD). The efficiency of the proposed control system is verified by comparing with the existing independent control system through the numerical simulations of the 10th- and 12th-story buildings. From the numerical results, it is confirmed that the proposed method can show similar or better control performance even with more economical control capacity than the existing independent control system. Another advantage is that the existing system does not exhibit the adaptive control performance in emergency of failure of one control device, whereas the proposed system can achieve successful adaptive control performance by economically and efficiently utilizing the interacting control effect through the connection member.

• Journal of Microbiology and Biotechnology
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• v.13 no.2
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• pp.313-316
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• 2003

Lipomyces starkeyi KSM 22 elaborates an enzyme that has both dextranase and amylase activities in a single protein of 100 kDa. Competition studies, using different amounts of dextran and starch as substrates, gave a competition plot consistent with the hypothesis that the hydrolysis of dextran and starch occurs at two independent active sites, each specific for starch and dextran, respectively.

• Journal of the Korean Mathematical Society
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• v.32 no.2
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• pp.363-370
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• 1995

A famous result of Chow and Robbins [8] asserts that if ${X_n, n \geq 1}$ are independent and identically distributed (i.i.d.) random variables with $E$\mid$X_1$\mid$ = \infty$, then for each sequence of constants ${M_n, n \geq 1}$ either $$ (1) lim inf_{n\to\infty} $\mid$\frac{M_n}{\sum_{j=1}^{n}X_j}$\mid$ = 0 almost certainly (a.c.) $$ or $$ (2) lim sup_{n\to\infty}$\mid$\frac{M_n}{\sum_{j=1}^{n}X_j}$\mid$ = \infty a.c. $$ and thus $P{lim_{n\to\infty} \sum_{j=1}^{n}X_j/M_n = 1} = 0$. Note that both (1) and (2) may indeed prevail.

• Phonetics and Speech Sciences
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• v.4 no.4
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• pp.37-43
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• 2012

This study investigates an independent evaluation of prosody and segmentals with reference to the difference in the foreign accent of Korean, Chinese, and Japanese learners of English. For this study, a set of stimuli were made of English sentences read by male and female Korean, Chinese, and Japanese learners of English by prosody swapping technique. Two groups of American and Korean subjects evaluated the difference in the prosody and segmentals of the stimuli by pairwise difference rating. The results showed that there was no significant difference in the evaluation scores of prosody and segmentals across accents for either subject group. The results also showed that both subject groups indicated a greater score with segmentals than with prosody. The results of the present study are significant in that they are opposite to the claim of some previous studies that prosodic factors could have a greater influence on the foreign accent and intelligibility than segmentals.

• Journal of Korean Society for Quality Management
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• v.17 no.1
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• pp.82-88
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• 1989

This paper has provided a systematic technique, the evaluation of the distribution with the NPV and the derivation of the IRR in the investment alternatives, for the cost estimating analysts, The proposals of investment alternatives are included the venture capital under risk and probabilities at each events, within the cash inflows are occuring at random timing. Therefore, we have considered the followings ; 1) the first cash outflow is deterministic, 2) the cash inflows are random variables with known distributions, 3) the lengths of the time intervals between the cash inflows are independently distributed and independent of the cash inflows. In this paper, the first two moments of the distribution, the Laplace Transforms and the convolutions are computed for both independent cash inflows and mutually exclusive alternatives as in the case of quite correlated cash inflows.

• Proceedings of the KIEE Conference
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• 1988.07a
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• pp.651-654
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• 1988

This paper proposes a microcode generating system which automatically generates the microcode of various target machine by inputing the intermediate language (MDIL) from the machine independent HLML-C (High Level Microprograming Language C) language. The MOP's (Microoperations) which is modeled 7-tuples generate to extend MDIL by table driven method with the information of translation table for each target machine. As compaction being considered and the hardware resource of target machine used, the conflicts of hardware elements are removed possibly. This proposed system is implemented with C language and yacc on VAX-11/750 (UNIX 4.3 BSD).

• Proceedings of the KIEE Conference
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• 2006.07b
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• pp.625-626
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• 2006

This paper presents the new simulation model for the performance analysis of Surface-Mounted Permanent Magnet Synchronous Motor(SMPMSM) Drive System which is integrated with a controller and a power converter. To enhance reusability and compatibility, the system model is expressed by the association of independent sub-modules reflecting the real physical construction. This concept allows another independent sub-module to be effectively inserted in the model for the comprehensive analysis of larger systems such as a Machine Tool and HEV. The developed model which is composed of MATLAB/Simulink's basic blocks can rapidly analyze not only the entire behavior of system, but also the functional relationship between each components for the effective development of controller.