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Double-stranded RNA Induces Inflammatory Gene Expression in Schwann Cells: Implication in the Wallerian Degeneration

  • Lee, Hyun-Kyoung;Park, Chan-Hee;Choi, Se-Young;Oh, Seog-Bae;Park, Kyung-Pyo;Kim, Joong-Soo;Lee, Sung-Joong
    • The Korean Journal of Physiology and Pharmacology
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    • v.8 no.5
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    • pp.253-257
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    • 2004
  • Schwann cells play an important role in peripheral nerve regeneration. Upon neuronal injury, activated Schwann cells clean up the myelin debris by phagocytosis, and promote neuronal survival and axon outgrowth by secreting various neurotrophic factors. However, it is unclear how the nerve injury induces Schwann cell activation. Recently, it was reported that certain cytoplasmic molecules, which are secreted by cells undergoing necrotic cell death, induce immune cell activation via the toll-like receptors (TLRs). This suggests that the TLRs expressed on Schwann cells may recognize nerve damage by binding to the endogenous ligands secreted by the damaged nerve, thereby inducing Schwann cell activation. Accordingly, this study was undertaken to examine the expression and the function of the TLRs on primary Schwann cells and iSC, a rat Schwann cell line. The transcripts of TLR2, 3, 4, and 9 were detected on the primary Schwann cells as well as on iSC. The stimulation of iSC with poly (I : C), a synthetic ligand for the TLR3, induced the expression of $TNF-{\alpha}$ and RANTES. In addition, poly (I : C) stimulation induced the iNOS expression and nitric oxide secretion in iSC. These results suggest that the TLRs may be involved in the inflammatory activation of Schwann cells, which is observed during Wallerian degeneration after a peripheral nerve injury.

A Study on Major Satisfaction and Career Maturity according to the Values of College Students - Majoring in Food Management and Culinary Arts - (대학생들의 가치관에 따른 전공만족도와 진로성숙도에 관한 연구 - 외식.조리 전공 -)

  • Han, Yae-Jung;Lee, Jong-Ho
    • Culinary science and hospitality research
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    • v.19 no.2
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    • pp.76-92
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    • 2013
  • This study aimed to investigate major satisfaction and career maturity according to the values of college students majoring in food management and culinary arts. To do this, frequency analysis, factor analysis, correlation analysis, and multiple regression were conducted and analyzed using SPSS18.0 program. Analysis results indicate that the values of the college students majoring in dining and culinary education have effects on major satisfaction and career maturity. In particular, pragmatic value is a very important factor in increasing major satisfaction and career maturity, and social recognition and curriculum factors are very significant for students to make career decisions. Therefore, in order to enhance college students' major satisfaction and career maturity, it's necessary to teach sound values so that they can build self-esteem value. Also, it's essential to organize subject contents and curriculums in which theory and practice are allocated properly so that students can be interested in their majors and have new experience as well as the community's right recognition for college students majoring in dinning and culinary education and their active interest as the study suggests.

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The Relationship between Academic Stress and Major Satisfaction of University Students: Factors Affecting Self-Effectiveness and Social Support (대학생의 학업스트레스와 전공만족도의 관계 : 자기효능감과 사회적 지지의 영향요인)

  • Park, Hyo-Jin;Yoo, Eun-Ju;Lee, Hwa-Myung
    • The Journal of the Korea Contents Association
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    • v.20 no.2
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    • pp.310-322
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    • 2020
  • This study also examined the influence of academic stress on major satisfaction of college students and the influence of self-efficacy and social support. The subjects of this study were 320 students attending K university in B city. The 295 questionnaires were collected and 291 questionnaires were finally analyzed except for 4 questionnaires that were insufficient. Major satisfaction had a statistically significant negative correlation with academic stress, and major satisfaction had a statistically significant positive correlation with self-efficacy. Also, major satisfaction had a statistically significant positive correlation with social support. Finally, as a result of examining the effects of each factor, academic stress, self-efficacy, and social support had a significant effect on major satisfaction except for informational support in social support. In order to increase the satisfaction of college students, it is necessary to study the factors that can lower academic stress and develop the program accordingly. It is necessary to develop educational methods and programs that can increase self-efficacy and social support. This is considered to have a positive effect on the satisfaction of college students.

A Study on the EPL using Instructional Model of SW Major's Programming Class (EPL 기반의 SW전공자를 위한 프로그래밍 수업 모형에 관한 연구)

  • KO, Kwangil
    • Journal of Digital Contents Society
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    • v.19 no.5
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    • pp.891-898
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    • 2018
  • Although programming language is a core education area of software that is becoming increasingly important in the age of the fourth industrial revolution, as it requires logical thinking skills, it is recognized as a difficult subject even for SW major students. This difficulty occasionally causes SW major students to lose interest and confidence in their major during the introductory course of a programming language; making them change their majors, or give up their studies. In this study, we designed an instructional model using Scratch for educating C language which is a typical programming introductory language. To do this, we analyzed the concepts that can be trained by Scratch among the programming concepts supported by C language, and developed the examples of Scratch for exercising the concepts. The instructional model supports the progress model of learning first the programming concepts through Scratch and then expand the learning content into C language. We also conducted an experiment on the SW major freshman students of a local private university to verify the effectiveness of the model.

A Study on College Nursing Students' Volunteering Activities, Volunteering Motivation and Needs, Sociability and Satisfaction in their Major (간호대학생의 봉사활동 특성에 따른 욕구충족, 사회성, 전공만족도 연구)

  • Kwon, Young-Mi;Joo, Hye-Joo;Cho, Kyung-Mi
    • The Journal of Korean Academic Society of Nursing Education
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    • v.10 no.1
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    • pp.20-32
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    • 2004
  • Purpose: The purpose of this study is to investigate undergraduate nursing students' volunteering activities, volunteering motivation- needs, sociability and satisfaction in their major for those who take the social service activities, and to provide basic information for operating the credit system of social service activity as service-learning system. Method: This study is a descriptive study and the participants were 363 of 2nd- and 3rd-year students at a nurses' college in I City, who completed the basic course of volunteering, and the survey was conducted during April 2004. Result: The group who participated in counseling service as a volunteering activity was high in volunteering motivation-needs, sociability and satisfaction in their major. In the group who performed volunteering through circle activities, those who volunteered for children, who participated longer and who had an active attitude showed high volunteering motivation-needs. In the group who had volunteering activities during weekdays, those who took an active attitude toward volunteering showed high sociability. Those who were somewhat dissatisfied with volunteering activities, however, showed significantly high sociability. Satisfaction in the major, namely, nursing was higher in senior students, in those who participated in volunteering activities for the first time at college, those who had religion, those who are active in volunteering activities and those who were highly satisfied with volunteering activities. Considering that active attitude toward volunteering activities and high volunteering motivation-needs enhance nursing students' satisfaction in their major, it is necessary to upgrade the current volunteering activities to the level of service learning. That is, it is necessary to develop new service learning in nursing curriculum that utilizes volunteering activities as well as what they learn in major for community societies.

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An evaluation of the accuracy of Root ZX according to the conditions of major apical foramen (주근단공의 조건에 따른 Root ZX의 정확성 평가)

  • Park, Shin-Young;Lee, Dong-Kyun;Hwang, Ho-Keel
    • Restorative Dentistry and Endodontics
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    • v.37 no.2
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    • pp.68-73
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    • 2012
  • Objectives: The purpose of this study was to assess the accuracy of Root ZX (J. Morita Corp.) according to the location of major foramen and open apex. Materials and Methods: 81 mandibular premolars with mature apices were selected. After access preparation, 27 teeth were instrumented to simulate open apices. 54 teeth were classified according to location of major foramen under surgical microscope (${\times}16$). The file was fixed at the location of apical constriction by Root ZX using glass ionomer cement .The apical 4 mm of the apex was exposed and photo was taken and the distance from file tip to the major foramen was measured by calibrating metal ruler on graph paper. The results were statistically analyzed using ANOVA and Scheffe test at p < 0.05 level. Results: Mean distance from file tip to major foramen was 0.308 mm in Tip foramen group (I), 0.519 mm in Lateral foramen group (II) and 0.932 mm in open apex group (III). Root ZX located apical constriction accurately within ${\pm}0.5mm$ in group I of 85.71%, in group II of 59.09%, and in group III of 33.33%. There was a statistically significant difference between group I and III (p < 0.05). Conclusion: Root ZX located apical constriction accurately regardless of location of major foramen. However, Root ZX couldn't find it in open apex. Clinicians have to use a combination of methods to determine an appropriate working length at open apex. It may be more successful than relying on just electronic apex locator.

The Structural Relationship among Major Satisfaction, Occupation Value View and Career Decision-Marking Self-Efficacy of Beauty Majoring students (뷰티전공 대학생들의 전공만족도, 직업가치관, 진로결정 자기효능감의 구조적 관계)

  • Pyo, Young-Hee;Yoon, Mi-Yun
    • Journal of Convergence for Information Technology
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    • v.9 no.10
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    • pp.144-153
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    • 2019
  • The purpose of this study is to investigate the structural correlation between career decision making self-efficacy, major satisfaction and occupation value of beauty major students by questionnaire collection and statistical analysis. Major satisfaction was found to be statistically significant at the significance level of .05 with respect to coccupation value and career decision making self-efficacy at p<.001. Occupation value was found to be statistically significant at p<.001 for career decision and job decision of career decision making self-efficacy and significance level .05. Therefore, it has been confirmed that the major satisfaction and job value are the factors that play a significant role in the self-efficiency of career decisions, and it is believed that continuous research on various variables that affect the self-efficiency of career decisions of beauty major university students is necessary.

The Relationship between Major Satisfaction, Self-Esteem, Work Values of Nursing Students at one University (일개 대학 간호대학생의 전공만족도, 자기존중감, 직업가치관의 관계)

  • Yang, Hye Kyung
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.1
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    • pp.219-226
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    • 2022
  • This study is a descriptive research study to confirm the degree and correlation of major satisfaction, self-esteem, and work values of nursing students, and was attempted to provide basic data for nursing students' nursing education. The subjects of this study were 224 nursing students from one university in the c region. Data analysis was analyzed using SPSS 22.0 program with frequency and percentage, mean and standard deviation, t-test and ANOVA, and Pearson's Correlation Coefficients. As a result of this study, there was a statistically significant difference in major satisfaction at the time of major decision(F=4.127, P=.004), self-esteem at the motivation for admission(F=7.384, P<.001), and work value at the motivation for admission(F=5.023, P<.001) and the presence or absence of nurses in the family(F=3.501, P<.001). There was a significant correlation between major satisfaction, self-esteem, and work value of nursing college students. Through the results of this study, it is suggested that it is necessary to develop an education and training program that can improve the major satisfaction, self-esteem, and job value of nursing college students.

Effect of Career Decision Making Types on Career Preparation Behavior and Major Satisfaction of Beauty Major College Students (뷰티전공 대학생들의 진로 의사결정유형이 진로준비행동 및 전공만족에 미치는 영향)

  • Lee, Jae-Eun
    • Journal of Convergence for Information Technology
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    • v.12 no.2
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    • pp.221-230
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    • 2022
  • The purpose of this study is to identify career decision-making types of college students majoring in beauty, and to improve career preparation behaviors by analyzing their effects on career preparation behaviors and major satisfaction. It was conducted from November 1 to 30, 2021, and a total of 485 questionnaires were used as analysis data. Frequency analysis, factor analysis, reliability analysis, correlation analysis, and multiple regression analysis were performed as research methods. As a result of the study, first, the type of career decision-making showed a positive (+) correlation between career preparation behavior and major satisfaction, indicating that it was statistically significant. Second, rational career decision-making style was correlated with dependence and intuitive style. As the career preparation behavior, the career preparation behavior of time effort, ability activity, and information collection, and the satisfaction of the major showed a statistically significant positive (+) correlation in class satisfaction and subject satisfaction. Third, among career decision-making types, rational and dependent types were found to have a statistically significant effect on ability activity, which is a sub-factor of career preparation behavior.

A Study on the Relationship Between Digital Literacy and Major Satisfaction of Nursing Students: Intermediary Role of LMS Learning Effects (간호대학생의 디지털 리터러시와 전공만족도의 관계에서 LMS 학습효과의 매개역할 연구)

  • KIM, EUN JAE
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.4
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    • pp.27-35
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    • 2022
  • This study In order to understand the mediating role of the LMS learning effect between digital literacy and major satisfaction of nursing students, data were collected from 241 students enrolled in the nursing college of J city. The collected data were analyzed using SPSS WIN 23.0. The study results show that digital literacy of nursing students has a positive effect on the LMS learning effect (B=.65, p<.001) and major satisfaction (B=.62, p<.001), and the LMS learning effect on the major satisfaction There was a positive (B = .19, p < .001) correlation between the results, and it was found that the LMS learning effect plays a mediating role in the relationship between digital literacy and major satisfaction of nursing students. Therefore, in order to improve nursing students' major satisfaction, it is necessary to develop and apply a program that can improve not only digital literacy but also LMS learning effects.