• Journal of the Society of Cosmetic Scientists of Korea
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• v.32 no.2 s.57
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• pp.81-88
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• 2006

Amino acid complex was made with the composition of amino acids quite similar to that of stratum corneum on the skin. In order to evaluate the efficacy of amino acid complex on the skin as an active cosmetic ingredient, we measured cytotoxicity. TIMP-1 expression, moisturizing effect and the amount of horny substance. In cytotoxicity assay, amino acid complex did not show any cytotoxicity. In moisturizing effect test using corneometer, it showed very good moisturizing effect. In TIMP-1 mRNA assay using RT-PCR, moo acid complex showed the increase of TIMP-1 expression, suggesting that amino acid complex have anti-wrinkle effect. Therefore, amino acid complex may be useful as an active ingredient for anti-aging.

• Journal of Digital Convergence
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• v.14 no.1
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• pp.163-170
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• 2016

The purpose of this study is to determine the effect of R&D learning organization activities of domestic small and medium-sized businesses on economic/technological results. This study, through investigation on preceding studies of domestic and foreign learning organization researchers, examined the definition, characteristics, and deteriorating factors of learning organization, and learned dependent variables, which are the definition of organizational performance, and relationship between learning organization and organizational performance. Then it performed a survey targeting small- and medium-sized businesses in Gumi and grasped the relationship between R&D capability (study planning, vision goal adequacy, project management, commercialization of technologies) and learning organization capability (creation of constant learning opportunities, knowledge sharing and utilizing system, strategic learning leadership) by classifying them to seven independent variables, using regression analysis. Because this study grasped the effect of R&D learning organization activities on organizational performance, it is expected to promote forming R&D learning organization for active R&D activities and contribute to enhancing small and medium-sized businesses' recognition on the need of R&D activities.

• Journal of Technology Innovation
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• v.21 no.1
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• pp.59-83
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• 2013

Recently, the importance of the health care industry is increasing due to the rapid changes in the population structure caused by decreasing in fertility rate and aging population. Therefore expansion of government investment in R&D of the health care industry is needed as the demand of health care is increasing. This study attempts to examine the economic impacts of national research and development for the health care industry using an inter-industry analysis. Specifically, the study investigates production-inducing effect, value added inducing effect, and employment-inducing effect of the health care industry based on demand-driven model. These analyses pay particular and close attention to the health care industry by taking it as exogenous rather than endogenous. Here we present results. First, the production-inducing effect and value added inducing effect was high in common real estate and business services and finance and insurance sector. Second, employment-inducing effect of the health care industry showed the highest levels in wholesale and retail sector, followed by the real estate and business services, agriculture sector. Third, the actual 2009 health care industry-related national R&D investment embracing on the production-inducing effect and value added inducing effect. The health care industry R&D induces the production of 4,932 billion won and the value added of 2163 billion won.

• Journal of Technology Innovation
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• v.25 no.1
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• pp.1-34
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• 2017

It is almost impossible for firms to possess all of resources and capabilities needed to create technological innovations in modern competitive environment. This situation forces firms to conduct R&D collaboration. Therefore, this paper analyzes an effect of appropriability protecting knowledge exclusively on R&D collaboration and product innovation performance. In addition, we investigate how the governmental R&D support moderates and influences those relationships through empirical analysis. The results of moderated mediation show that the impact of appropriability on product innovation performance appears to be a common pattern in each conditional indirect effect of appropriability regardless of financial, direct, indirect R&D support of the government. The more governmental R&D supports increase over a certain level, the more conditional indirect effects of appropriability on product innovation performance increase through the vertical R&D collaboration. However, conditional indirect effects of appropriability through horizontal R&D collaboration are not significant in all levels of government R&D supports. If we utilize an analysis of moderated mediation by applying governmental R&D supports as a moderator, it is possible to analyze a significant strength of innovation policies and their performance. Therefore, this paper would make a contribution to an evolution of governmental R&D support and an effective formulation of innovation policy.

• Journal of Information Technology Services
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• v.22 no.3
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• pp.65-83
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• 2023

Due to the development of modern technology and the enlargement of industrial scale, the scale of many projects is expanding and the complexity is also increasing. Individual management of existing projects cannot effectively manage projects in this trend, and it is necessary to systematically manage the entire process from initiation to completion. Accordingly, the need for integrated management and life cycle management that can efficiently manage the entire project is emerging, and for this, a systematic project management system is also required. PMS enables efficient project management by linking business processes such as resource, schedule, scope, and output management of a project with separately separated infrastructure accordingly. In this paper, a research model was proposed to manage the project from the perspective of implementing integrated management and life cycle management, especially during R&D project execution, and to prove the mediating role between PMS and R&D project performance for this purpose. The proposed research model will be able to help companies and organizations that feel the need to implement integrated management and life cycle management and are preparing to build a PMS-type system or that have already been established to efficiently perform project management.

• 한국벤처창업학회:학술대회논문집
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• 2007.04a
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• pp.101-122
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• 2007

In this study, as the result of analyzing the relationship and influence between economic outcome and R&D supporting investment, the number of supporting subjects among the technological innovational areas of SMEs, it is as below. First, as the economic result of analyzing companies from the investment in R&D of technological innovational areas of minor companies, the number of supporting subjects and amount of R&D have relationship with increase of sales and export amount, employee reduction & the effect of new job creation shows positive correlation with the effect of import replacement. Second, as analyzing the influence of the investment in R&D has economic effect from of technological innovational minor companies. This is thought that the financial and R&D support increase a significant effect on economical, technical against SMEs.

• Management & Information Systems Review
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• v.33 no.1
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• pp.191-217
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• 2014

The Purpose of this study is to find the effect factors of R&D investment in SMEs which plays an important role in the national economy, and the differences of the effect factors by the type of SMEs. The subject of this study is about 3,400 SMEs mentioned in "The survey of technical statistics on SMEs in 2007" by Korea Federation of Small and Medium Business. The effect factors are related with the size of business, the infrastructure of R&D and the activities of R&D which have been studied by many researchers. The methods of analysis are regression analysis, moderating effect analysis and the software package used is SPSS 12.0. The results of the study are as fallow. First, it was found that unlike in previous studies which show the effect of the elements of business's size, research infrastructure, research activities on R&D investment, one element alone can't be considered for meaningful result but the various elements have effect on R&D investment at the same time. In other words, the number of employees and the sales as the elements of business's size, the ratio of researchers, the technical ability, the ratio of equipment possession and the intellectual properties as the elements of R&D infrastructure, the activity of ideas and joint research as the elements of R&D activities have positive(+) effect, whereas the participation of CEO in the activity of R&D as the elements of R&D activities activity has negative(-) one. The number of employees, the ratio of researchers, and the sales had relatively high influence whereas equipment possession, technical ability, intellectual properties, the participation of CEO in the research, the activity of idea, joint research had relatively low influence. Next, it was also found that there are differences of the effect factors over the types of SMEs. SMEs were classified into 19 types by eight criteria such as start-ups and existing business by business age; small business and medium business by size; manufacturing business and service business by product type;independent business and subcontractor business by dealing type; businesses in the entering, growing, maturing and restructuring stage by growth stage; businesses with low, medium and high technology by technological level; pioneering business and non-pioneering business by industrial type; and businesses with state-of-the-art technology and non-advanced business by the level of business activities. The meaning of this study lies in the fact that it found the various effect factors should be considered at the same time when conducting study on SMEs' R&D investment, and the differences by the type should be acknowledged. This study surpassed the limitations of the previous studies which focused on a couple of factors and types. This study result can also be considered for other studies on achievement, organization, marketing and others. Moreover, it shows that a differential policy by business type is needed when formulating SME policy.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.9 no.2
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• pp.71-80
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• 2014

Standard Industrial classification is a key factor of technology spillover effect. It is the result of the empirical study that is the IC(industrial classification) which influences the technology spillover effect by way of interaction term, or moderating effect combing independent variables and moderators. As relatively high technology industry is more important than the low counterpart in R&D management system. And the result of the study says that Government should support SME's considering the IC moderating effect and different subsidies which is appropriated to the SME's IC(industrial classification). This way of Government subsidy will improve the efficiency of industrial policy effect of SME's.

• Korean Journal of Culture and Social Issue
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• v.18 no.2
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• pp.261-278
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• 2012

This study understood the influence of the company R&D researchers' perfectionism on burnout, and also verified if self-efficacy shows the mediated effect in this relation. In order for this, the data was collected for 293 R&D researchers of a research institute in Daejeon while the structural equation was used for hypothesis verification. In the results of analyzing the survey data, self-oriented perfectionism and self-efficacy had negative correlations with burnout while socially-oriented perfectionism showed positive correlation with burnout. Also it was found that self-efficacy mediated in the influence of self-oriented perfectionism on burnout. In case of socially-oriented perfectionism, however, the mediated effect of self-efficacy was not significant while having direct influence on burnout. Such study results show that self-oriented perfectionism and confidence in self ability that sets up goals and carries out things have positive influence on decreasing burnout. In order to decrease burnout, it would be necessary to cognize that the expectation of perfection is the goal for myself, rather than the one by others.

• YAKHAK HOEJI
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• v.40 no.4
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• pp.428-437
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• 1996

The in vitro and in vivo antibacterial activities of a new fluoroquinolone, DWP20364(1-cyclopropyl-5-amino-6,8-difluoro-7-(2,7-diazabicyclo[3.3.0]oto-4-ene-7-yl)-1 ,4-di-hydro-4-oxoquinoline-3-carboxylic acid) were evaluated in comparison with those of ciprofloxacin(CPFX), sparfloxacin(SPFX) and ofloxacin(OFLX). DWP20364 was more potent than CPFX and OFLX against Staphylococcus spp., Streptococcus spp. and Enterococcus faecium MD8b and it was similarly or slightly less active than CPFX against Escherichia spp. and Pseudomonas spp.. For MRSA and OFLX resistant strains (Staphylococcus spp.(14),Enterococcus spp.(4), Acinetobacter spp.(2), Pseudomonas spp.(9), Klebsiella spp.(2) and Serratia spp.(6)),DWP20364(MICs for 90% of strains,0.025 and 12.5${\mu}$g/ml, respectively) was 4 to 32 folds more potent than SPFX and CPFX. The activity of DWP20364 decreased moderately in the presence of 5mM $Mg^{2+}$. However, various pHs and the concentrations of various serum had no effect on the activity of DWP20364. DWP20364 possessed a bacteriocidal effect at the 1MIC against gram positive and gram negative strains. The protective effect of DWP20364 against systemic infections in mice caused by S. aureus Smith or S. aureus L2379 was superior to that of CPFX and SPFX but it was less active than that of CPFX against infection by P. aeruginosa E-2.