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Anti-aging Effect of Amino Acid Complex on the Skin  

Kim, Ki-Ho (R&D Center, Bioland Ltd.)
Kim, Ki-Soo (R&D Center, Bioland Ltd.)
Kim, Young-Heui (R&D Center, Bioland Ltd.)
Ko, Kang-Il (R&D Center, Bioland Ltd.)
Park, Sun-Hee (R&D Center, Bioland Ltd.)
Kim, Jin-Guk (R&D Center, Bioland Ltd.)
Chio, Hyun-Jin (R&D Center, Bioland Ltd.)
Ko, Su-Yeon (R&D Center, Bioland Ltd.)
Bae, Yoon-Joo (Ellead Skin Research Center)
Kim, Yong-Min (R&D Center, Bioland Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.32, no.2, 2006 , pp. 81-88 More about this Journal
Abstract
Amino acid complex was made with the composition of amino acids quite similar to that of stratum corneum on the skin. In order to evaluate the efficacy of amino acid complex on the skin as an active cosmetic ingredient, we measured cytotoxicity. TIMP-1 expression, moisturizing effect and the amount of horny substance. In cytotoxicity assay, amino acid complex did not show any cytotoxicity. In moisturizing effect test using corneometer, it showed very good moisturizing effect. In TIMP-1 mRNA assay using RT-PCR, moo acid complex showed the increase of TIMP-1 expression, suggesting that amino acid complex have anti-wrinkle effect. Therefore, amino acid complex may be useful as an active ingredient for anti-aging.
Keywords
amino acid; moisturizing; TIMP-1; anti-aging; cosmetic active ingredient;
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