• BMB Reports
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• v.55 no.6
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• pp.281-286
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• 2022

Hepatocellular carcinoma is a major health burden, and though various treatments through much research are available, difficulties in early diagnosis and drug resistance to chemotherapy-based treatments render several ineffective. Cancer stem cell model has been used to explain formation of heterogeneous cell population within tumor mass, which is one of the underlying causes of high recurrence rate and acquired chemoresistance, highlighting the importance of CSC identification and understanding the molecular mechanisms of CSC drivers. Extracellular CSC-markers such as CD133, CD90 and EpCAM have been used successfully in CSC isolation, but studies have indicated that increasingly complex combinations are required for accurate identification. Pseudogene-derived long non-coding RNAs are useful candidates as intracellular CSC markers - factors that regulate pluripotency and self-renewal - given their cancer-specific expression and versatile regulation across several levels. Here, we present the use of microarray data to identify stemness-associated factors in liver cancer, and selection of sole pseudogene-derived lncRNA ZNF204P for experimental validation. ZNF204P knockdown impairs cell proliferation and migration/invasion. As the cytosolic ZNF204P shares miRNA binding sites with OCT4 and SOX2, well-known drivers of pluripotency and self-renewal, we propose that ZNF204P promotes tumorigenesis through the miRNA-145-5p/OCT4, SOX2 axis.

• Journal of The Korean Association For Science Education
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• v.2 no.1
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• pp.16-30
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• 1980

In is a recent trend of the world to study the integrated science curriculum development. This study aims at pursuing how to integrate physics and earthscience in high school course and forming a tentative plan as to an integrated process between both the subjects. The one was compared with the other accor ding to the basic concepts and theteaching objecties. The contents of these two subjects were analysed, the overlapping parts being chosen, and so in the hierachy of the curriculum, some mistakes were found in eaching these two two subjects. It proved valid to in tegrate these two subject. A concrete scheme was offered to in tegrate these two subjects-physics and earthscience, when a tentative plan concerning, the integra ted process was made. This new plan can make the time required for teaching decrease by 5% The better study on the basic structure of the integrated concepts between these two subjects will go on further in this respect. It is necessary to train again the teachres concerned with this new subject and to put an emphasis on the elective course between physics and earthscience in the teacher's college curriculum.

• Journal of the Korean Society of Earth Science Education
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• v.12 no.3
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• pp.224-238
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• 2019

The purpose of this study is to analyze the perception of integrated school education and education for sustainable development of secondary school science teachers, judging that the existence of a common science teacher qualification certificate is related to the expertise of the common science map. To that end, the survey was conducted for three months from June to August 2018 for secondary school science teachers, and multiple choice questions were analyzed as statistical processing and descriptive questions as topical modeling. According to the analysis, teachers with a common science teacher qualification certificate had a high awareness of integrated school education, and the response average was high in all areas of value, direction and success condition of integrated school education. In addition, the average response of teachers with a common science teacher qualification certificate was also found to be higher than those with a common science teacher qualification. There were no major differences in perception between the two groups on the strength of science education and ESD integration, but the difference was that teachers with a common science teaching certificate focused on science in all topics and recognized science as a medium for each topic compared to teachers who did not.

• Transactions of the Korean hydrogen and new energy society
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• v.31 no.3
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• pp.276-283
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• 2020

Alcohol-based solvents including ethanol (EtOH) and tert-butyl alcohol (TBA) are investigated instead of isopropanol (IPA), which is a common solvent for polytetrafluoroethylene (PTFE), as an alternative solvent for preparing the catalyst slurry with PTFE binder. As a result, the performance at 0.2 A/㎠ from the single cells from using catalyst slurries based on EtOH and TBA showed very similar value to that from the slurry using IPA, which implies the EtOH and TBA can be used as a solvent for the catalyst slurry. It is also confirmed by the very close values of the total resistance of the membrane electrode assemblies from the slurries using different solvents. In the energy dispersive spectrometry (EDS) image, the shape of crack and dispersion of PTFE are changed according to the vapor pressure of the solvent.

• JSTS:Journal of Semiconductor Technology and Science
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• v.11 no.4
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• pp.329-335
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• 2011

In this paper, a dual-band integer-N frequency divider is proposed for 2.4/5.2 GHz multi-standard wireless local area networks. It consists of a multi-modulus imbalance phase switching prescaler and two all-stage programmable counters. It is able to provide dual-band operation with high resolution while maintaining a low power consumption. This frequency divider is integrated with a 5 GHz VCO for multi-standard applications. Measurement results show that the VCO with frequency divider can work at 5.2 GHz with a total power consumption of 22 mW.

• Journal of the Korean Society of Earth Science Education
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• v.13 no.1
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• pp.53-63
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• 2020

The purpose of this study is to analyze the current status of the second year of application of Integrated Science and Science Laboratory Experiments, which are common courses of high school, and to explore suggestions for curriculum development in the future. To this end, the results of the survey of a total of 244 science-core and general high schools were compared with the survey result of 2018 school year. In addition, in-depth interviews were conducted with nine science teachers of the focus group to discuss the current state of curriculum implementation. According to the results, as in the first year, most of the Integrated Science courses were implemented in 6-8 units, and in most schools the number of teachers in charge of Integrated Science per class were 3-4. In the teacher's focus group interview, teachers insisted that Integrated Science requires integrated teaching approaches and is good for generating students' interest, but it is difficult to implement process-based assessment due to issues such as ensuring fairness of assessment. Most of Science Laboratory Experiments courses were implemented in two semesters, one unit per semester, and there was little link between Integrated Science and Science Laboratory Experiments because of the different teaching staff. The school life record entry method of Science Laboratory Experiments has been changed to criterion-based assessment starting in 2019, so students' satisfaction or flow of classes is much better than expected, and teachers can teach without burden. Based on the research results, ways to support the settlement of Integrated Science and Science Laboratory Experiments as common subjects, and ways to improve those subjects in the next curriculum revision were suggested.

• Journal of The Korean Association For Science Education
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• v.33 no.1
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• pp.208-227
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• 2013

The purpose of this study is to analyze secondary science teachers' planning process for an integrated science lesson. For this study, relevant references were collected from various sources, including literatures, previous studies regarding integrated science education, and individual studies. Two teachers (one from middle school and the other from high school) participated and 'the five-step instructional design' was adopted from former studies in this subject. The teachers were asked to develop an instructional plan based on 'the design' provided. While the consultation provided a framework for an instructional plan, the teachers were asked to take a leading role in terms of selecting the chapter to be taught; analyzing the course structure; and making detailed teaching plans. In the course of consultations, discussions, records, and analysis were organized into a journal. Based on the journal, the aspects of the planning process, including difficulties and problems faced by teachers, were analyzed in-depth. From the study, it could be observed that both high school and middle school teachers face various difficulties in preparing for the integrated science lesson. Among other things, the teachers emphasized the difficulties in the stages of selecting the topic, collecting the relevant information, and restructuring and organizing the lecture contents.

• Applied Science and Convergence Technology
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• v.24 no.5
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• pp.196-202
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• 2015

Human blood consists of 55% of plasma and 45% of blood cells such as white blood cell (WBC) and red blood cell (RBC). In plasma, there are many kinds of promising biomarkers, which can be used for the diagnosis of various diseases and biological analysis. For diagnostic tools such as a lab-on-a-chip (LOC), blood plasma separation is a fundamental step for accomplishing a high performance in the detection of a disease. Highly efficient separators can increase the sensitivity and selectivity of biosensors and reduce diagnostic time. In order to achieve a higher yield in blood plasma separation, we propose a novel fluid wing structure that is optimized by COMSOL simulations by varying the fluidic channel width and the angle of the bifurcation. The fluid wing structure is inspired by the inertial particle separator system in helicopters where sand particles are prevented from following the air flow to an engine. The structure is ameliorated in order to satisfy biological and fluidic requirements at the micro scale to achieve high plasma yield and separation efficiency. In this study, we fabricated the fluid wing structure for the efficient microfluidic blood plasma separation. The high plasma yield of 67% is achieved with a channel width of $20{\mu}m$ in the fabricated fluidic chip and the result was not affected by the angle of the bifurcation.

• Journal of electromagnetic engineering and science
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• v.18 no.2
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• pp.101-107
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• 2018

The impedance bandwidth and radiation characteristics of an aperture-coupled microstrip line-fed patch antenna (ACMPA) with a high permittivity (${\varepsilon}_r=10$) feed substrate suitable for integration with a monolithic microwave integrated circuit (MMIC) are investigated for various feed substrate thicknesses through an experiment and computer simulation. The impedance bandwidth of an ACMPA with a high permittivity feed substrate increases as the feed substrate thickness decreases. Furthermore, the front-to-back ratio of an ACMPA with a high permittivity feed substrate increases and the cross-polarization level decreases as the feed substrate thickness decreases. As the impedance bandwidth of an ACMPA with a high permittivity feed substrate increases and its radiation characteristics improve as the feed substrate thickness decreases, the ACMPA configuration becomes suitable for integration with an MMIC.

• Proceedings of the Polymer Society of Korea Conference
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• 2006.10a
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• pp.301-301
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• 2006

The physical properties of well-defined star-shape polystyrenes with high number of arms (6 to 57 arms) in good and theta solvents were studied using synchrotron X-ray scattering. The scattering profiles for multi-armed polystyrenes shown the molecular shape is changed according to increasing of number of arm. From various parameters which were obtained from scattering profiles, the molecular shape was determined more detail. As results, the molecular shape was changed from a fuzzy-ellipsoid for 6-armed PS to a fuzzy-sphere sphere for 57-armed PS according to increasing of number of arm.