• Korean Journal of Acupuncture
• /
• 제22권2호
• /
• pp.25-41
• /
• 2005

Objectives : Bambusae Caulis in Liquamen(BCL) has been used to medication for early stroke in the Oriental Medicine. So this study was planned to investigate the effects of BCL on the focal ischemia-induced by intraluminal filament insertion in the rats. Materials and methods: The focal ischemia was induced by Intraluminal Filament insertion into middle cerebral artery. BCL herbal acupuncture at ST36 was carried out during 3 weeks after focal ischemia-induced. Eight-arm radial maze was used for the behavioral task and neuroprotective effect of BCL acupuncture was observed by Cresyl violet, AchE, ChAT-stain Results : The error rate in the eight-arm radial maze task was significantly decreased in BCL1(0.89mg/kg) herbal acupuncture group compared to control group on 3,4,5days, compared to saline acupuncture group on 3,5days. The rate of correct choice was significantly increased in saline acupuncture, BCL1 herbal acupuncture group, BCL2(0.089mg/kg) herbal acupuncture groups compared to control group. The density of neurons in the hippocampal CA1 was the most increased in BCL1 herbal acupuncture group compared to the others. The density of AchE in the hippocampal CA1 was significantly increased in BCL1 herbal acupuncture, BCL2 herbal acupuncture groups compared to control group, and in BCL2 herbal acupuncture groups increased compared to saline acupuncture, control groups. The density of ChAT in the hippocampal CA1 was significantly increased in BCLl herbal acupuncture group compared to saline acupuncture, control groups. Conclusions : These results suggest that BCL herbal acupuncture could be used as a medication for controlling the early stroke.

• Journal of Acupuncture Research
• /
• 제27권4호
• /
• pp.137-146
• /
• 2010

Objectives & Methods : The purpose of this study is to observe the effects of Cnidii Rhizoma Herbal solution at $GB_{34}$(Yangleungchean) on hyperlipidemia in rats. The author performed several experimental items to analyze the levels of various components and enzymes in serum, urine and liver, as well as the histological change of liver and aorta. Results : 1. In the Cndii Rhizoma Herbal-acupuncture group, The levels of total cholesterol were significantly decreased, and the ratio of HDL to Total cholesterol, Phospholipid/total cholesterol were significantly increased as compared with those of the control group. 2. In the Cndii Rhizoma Herbal-acupuncture group, HMG-CoA reductase activity was significantly decreased than those of the control group NP(needle prick) group and saline group. 3. In the Cndii Rhizoma Herbal-acupuncture group, phathohistological change of liver was suppressed as compared with the control group. Conclusions : From the above results, it is suggested that Cndii Rhizoma Herbal-acupuncture at $GB_{34}$ has a therapeutic effect on hyperlipidemia.

• 대한약침학회지
• /
• 제7권2호
• /
• pp.91-96
• /
• 2004

Objective : Alopecia areata is a common disease and the difficulty of its medical management is well known. This study was designed to investigate the effect of bee venom and Carthami Flos herbal acupuncture. Method : The patient was managed by bee venom, carthami-flos herbal acupuncture and General acupunture. Herbal acupuncture was injected subcutaneously into the lesion. We checked involvement in plaque, according to evaluation of the effect on alopecia areata. Results : After 5 month of treatment, the lesion had been replaced with new terminal hair. Evaluation of the effect on alopecia areata The score changed from 0 to 3 point. Conclusion : These result suggest that bee venom and Carthami Flos herbal acupuncture has good effect on alopecia areata. But further studies are required to concretely prove the effectiveness of bee venom and Carthmi Flos herbal acupuncture for treating alopecia areata.

• Korean Journal of Acupuncture
• /
• 제21권3호
• /
• pp.89-96
• /
• 2004

Objectives : In order to prove the effect of Phospholipase $A_2(PLA_2)$ Herbal-acupuncture, this experimental studies were performed by using rats that had neuronal damage due to the Middle Cerebral Artery Occulsion(MCAO). Methods : Microdialysis probes were implanted into the coordinate of striatum of anesthetized rats which consist of sham-operated 8 rats, MCAO-operated 8 rats and $PLA_2$ Herbal-acupuncture administrated 8 rats before MCAO operating. The $PLA_2$ Herbal-acupuncture(0.5mg/kg) was administrated to rats 30 minutes before having an operation causing the MCAO. The surgical excision lead the cross resected brain to the acute ischemic state. The brain was sliced in 2mm thickness and stained with cresyl violet buffer for the measurement of cerebral infarcted area and volume. Results : Based on the result of the tissue inspection for the cerebral ischemic cell, $PLA_2$ Herbal-acupuncture significantly protect neurocytes. Conclusions : We suggest $PLA_2$ Herbal-acupuncture produces protective effects against the neuronal damage induced by MCAO. Therefore, $PLA_2$ Herbal-acupuncture may prevent delayed neuronal death(DND) in selectively vulnerable focal areas of the brain effectively.

• 대한약침학회지
• /
• 제7권2호
• /
• pp.29-41
• /
• 2004

Objective : This experimental studies were performed in order to prove the effect of Hirudin Herbal-acupuncture by using rats that had neuronal damage due to the Middle Cerebral Artery Occulsion(MCAO). Method : We observed the change of extracellular concentrations(${\mu}M$) of dopamine, DOPAC, HVA, HIAA, glutamate, aspartate, GABA, glysine, taurine, alanine, and tyrosine as extracted by vivo microdialysis, in the Hirudin Herbal-acupuncture administrated rats($240{\sim}260g$, Sprague-Dawley) subjected to the MCAO. The dialysates were extracted three times before the MCAO and six times after the MCAO every 20 minutes, and analysed by highperformance liquid chromatography(HPLC). Results : Hirudin Herbal-acupuncture significantly inhibited glutamate, aspartate, and tyrosine which are stimulant neurotransmitters at brain ischemia, and it significantly decreased glycine, GABA, taurine, and alanine which are inhibitory neurotransmitters at brain ischemia. Conclusion : Hirudin Herbal-acupuncture may prevent delayed neuronal death(DND) in selectively vulnerable focal areas of the brain effectively.

• 대한약침학회지
• /
• 제8권2호
• /
• pp.91-95
• /
• 2005

Objective : The purpose of this study is to report the patient with radial nerve palsy, who improved by Scolopendrae Corpus Herbal-Acupuncture and other Oriental medical treatments. Methods : The patient was managed by Scolopendrae Corpus Herbal-Acupuncture, body acupuncture, physical theraphy and herbal medicine. We took picture of the patient's wrist and checked the power of muscles. Result : After 4 week treatment, the movement and power of wrist was restored to nearly normal range. Conclusions : The results suggest that combination of Scolopendrae Corpus Herbal-Acupuncture and other Oriental medical treatments is good method for treatment of radial nerve palsy. But further studies are required to concretely prove the effectiveness of this methods.

• 대한약침학회지
• /
• 제9권1호
• /
• pp.109-113
• /
• 2006

Objective : This study is to report the effect of Scolopendrid Herbal Acupuncture on a patient suffering from the pain of Hip Adductors after operation for hip fracture. Methods : First we had treated the patient with the pain of Hip Adductors by acupuncture and herb medication(活絡湯), but we did't get remarkable improvement in condition of patient. So we added to treat his pain site with Scolopendrid Herbal Acupuncture. And then we evaluated his pain by VAS(Visual Analog Scale). Results : 1. Scolopendrid Herbal Acupuncture had a very excellent effect on relieving pain and inflammation of Hip Adductors after operation for hip fracture. 2. It appears that Scolopendrid Herbal Acupuncture is very effective against Trigger Point of muscle and pain site fixed.

• 동의생리병리학회지
• /
• 제18권5호
• /
• pp.1322-1330
• /
• 2004

This experimental studies were performed in order to prove the effect of Phospholipase A₂(PLA₂) Herbal-acupuncture by using rats that had neuronal damage due to the Middle Cerebral Artery Occulsion(MCAO). We observed the change of extracellular concentrations(μM) Of dopamine, DOPAC, HVA, HIAA, glutamate, aspartate, GABA, glysine, taurine, alanine, and tyrosine as extracted by vivo microdialysis, in the PLA₂ Herbal-acupuncture administrated rats(240-260g, Sprague-Dawley) subjected to the MCAO. The dialysates were extracted three times before the MCAO and six times after the MCAO every 20 minutes, and ana lysed by highperformance liquid chromatography(HPLC). PLA₂ Herbal-acupuncture significantly inhibited glutamate and tyrosine which are stimulant neurotransmitters at brain ischemia, and it significantly decreased glycine, GABA, taurine, and alanine which are inhibitory neurotransmitters at brain ischemia. PLA₂ Herbal-acupuncture may prevent delayed neuronal death(DND) in selectively vulnerable focal areas of the brain effectively.

• 대한약침학회지
• /
• 제7권3호
• /
• pp.109-114
• /
• 2004

Objective : This study was designed to investigate the anti-inflammatory effect of Scolopendrid Herbal-Acupuncture. Methods : Scolopendrid Herbal-Acupuncture was administered one time on everyday and A-shi points were selected. Except Scolopendrid Herbal-Acupuncture administration, other therapies(conventional body acupuncture, physical therapy and so on) were not performed at all. We evaluated the patient through Visual Analogue Scale(VAS) and Digital Infrared Thermal Imaging(DITI). Results : After 2 or 3 times of treatment, the patient showed that clinical symptoms and VAS were lessened and there was a change of temperature in DITI. Conclusions : According to the results, Scolopendrid Herbal-Acupuncture may have anti-inflammatory effects. But further studies are required to prove the exact effect.

• 대한약침학회지
• /
• 제9권1호
• /
• pp.127-137
• /
• 2006

Objective : This experiment was conducted to evaluate inhibitory effects against hepatic metastasis by cultivated wild ginseng Herbal Acupuncture. Methods : Colon26-L5 carcinoma cells were injected through hepatic portal vein to induce hepatic metastatic cancer. After treated cultivated wild ginseng Herbal Acupuncture and investigated various kinds of cytokine level using cytokine chip. Results : 1. Mice treated with cultivated wild ginseng Herbal Acupuncture reduced the level of $IL-l{\alpha}$, $IL-{\beta}$, and $TNF-{\alpha}$ compared to the control group. 2. Mice treated with cultivated wild ginseng Herbal Acupuncture was not showed significant change in the level of IL-4, IL-l0, IL-12 and $INF-{\gamma}$ compared to the control group. 3. Observing the level of various kinds of cytokine, cultivated wild ginseng Herbal Acupuncture was suppressed pro-inflammatory cytokine. These findings indicate cultivated wild ginseng Herbal Acupuncture is possible to use the inflammatory disease and futher studies carry out for the explanation of anticancer mechanism.