Browse > Article

The Effect of Phospholipase $A_2$ Herbal-acupuncture on Neurotransmitters against Middle Cerebral Artery Occulsion Rats.  

Kim Sung Min (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Hanny University)
Jung Tae Young (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Hanny University)
Leem Seong Cheol (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Hanny University)
Seo Jeong Chul (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Hanny University)
Han Sang Won (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Hanny University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.5, 2004 , pp. 1322-1330 More about this Journal
Abstract
This experimental studies were performed in order to prove the effect of Phospholipase A₂(PLA₂) Herbal-acupuncture by using rats that had neuronal damage due to the Middle Cerebral Artery Occulsion(MCAO). We observed the change of extracellular concentrations(μM) Of dopamine, DOPAC, HVA, HIAA, glutamate, aspartate, GABA, glysine, taurine, alanine, and tyrosine as extracted by vivo microdialysis, in the PLA₂ Herbal-acupuncture administrated rats(240-260g, Sprague-Dawley) subjected to the MCAO. The dialysates were extracted three times before the MCAO and six times after the MCAO every 20 minutes, and ana lysed by highperformance liquid chromatography(HPLC). PLA₂ Herbal-acupuncture significantly inhibited glutamate and tyrosine which are stimulant neurotransmitters at brain ischemia, and it significantly decreased glycine, GABA, taurine, and alanine which are inhibitory neurotransmitters at brain ischemia. PLA₂ Herbal-acupuncture may prevent delayed neuronal death(DND) in selectively vulnerable focal areas of the brain effectively.
Keywords
Phospholipase A₂(PLA₂); Herbal-acupuncture; Middle Cerebral Artery Occulsion(MCAO); Neurotransmitters;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kynurenine hydroxylase inhibitors reduce ischemic brain damage /
[ Cozzi A;Carpenedo R;Moroni F. ] / J. Cereb Blood Flow Metab.
2 Energy metabolism in delayed neuronal death of CA1 neurons of hippocampal following transient ischemia in the gerbil /
[ Arai H;Passonneau JV;Lust WD. ] / Brain Dis.   ScienceOn
3 Lesions of the local coeruleus system aggregate ischemic damage in the rat brain /
[ Blomqvist P;Lindvall O;Wielloch T. ] / Neurosci. Lett.   ScienceOn
4 Prevention of delayed neuronal death in gerbil hippocampus by iron channel blockers /
[ Iijima K;Kogure K. ] / Stroke
5 Delayed neuronal death in the gerbil hippocampus following ischemia /
[ Kirino T. ] / Brain Res.   ScienceOn
6 /
[ 沈全魚(外) ] / 中風證治
7 /
[ 叢法滋 ] / 腦病的中醫論治
8 /
[ Raymond D. Adams(外) ] / 아담스 신경과학
9 /
[ 金永錫 ] / 臨床中風學
10 /
[ 全國韓醫科大學 心系內科學敎室 ] / 全國韓醫科大學 心系內科學敎室
11 /
[ 陳輝 ] / 實用中醫腦病學
12 봉독요법의 최신연구동향에 대한 고찰 /
[ 김지영(외) ] / 大韓鍼灸學會誌
13 /
[ 全國韓醫科大學 鍼灸經穴學敎室 ] / 鍼灸學(上)
14 /
[ 廓賀齡 ] / 內科急症治療學
15 In vivo models of cerebral ischemia: Effects of parenterally administered NMDA receptor glycine site antagonists /
[ Warner DS;Martin H;Ludwig P;McAllister A;Keana JFW;Weber E. ] / J. Cereb. Blood flow Metab.
16 Dynamics of extracellula metabolites in the striatum after middle cerebral artery occlusion in the rat monitored by intercerebral microdialysis /
[ Hillered L;Hallstrom A;Segersvard S;Persson L.;Ungerstedt U. ] / J. Cereb. Blood Flow Metab.
17 Microdialysis in the study of extracellular levels of amino acids in the rat brain /
[ Tossman U;Ungerstedt U. ] / Acta. Phys. Scand.   ScienceOn
18 Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion /
[ Nagasawa H.;Kogure K. ] / Stroke
19 An essential role for lysophosphatidylcholine in the inhibition of platelet aggregation by secretory hospholipase A2 /
[ Yuan Y(et al.) ] / Blood
20 A peptide from the venom of the Honey Bee /
[ Assen E(et al.) ] / Brit. Pharmscol.
21 PLA(2) dependence of diaphragm mitochondrial formation of reactive oxygenspecies /
[ Nethery D;Callahan LA;Stofan D;Mattera R;DiMarco A.;Supinski G ] / J. Appl Physiol.
22 Failure to activate cytosolic phospholipase A2 causes TNF resistance in humanleukemic cells /
[ Wu YL;Jiang XR;Newland AC;Kelsey SM. ] / J. Immunol.
23 Role of oxygen free radicals in carcinogenesis and brain ischemia /
[ Floyd RA. ] / FASEB J.
24 Rapid postmortem increase in extracellular dopamine in the rat brain as assessed by brain microdialysis /
[ Vulto AG;Sharp T;Ungerstedt U;Versteeg DH. ] / J. Neurochem.
25 Elevation of neuroactive substances in the cortex of cats during prolonged focal ischemia /
[ Matsumoto K;Graf R;Rosner G;Taguchi J;Heiss WD. ] / J. Cereb Blood Flow Metab.
26 Effects of transient forebrain ischemia and pargyline on extracellular concentrations of dopamine, serotonin, and their metabolites in the rat striatum as determined by in vivo microdialysis /
[ Damsma G;Boisvert DP;Mudrick LA;Wenkstern D;Fibiger HC. ] / J. Neurochem.
27 Striatal dopamine in acute cerebral ischemia of stroke-resistant rats /
[ Kawano T;Tsutsumi K;Miyake H;Mori K. ] / Stroke
28 Metabolism of monoamine neurotransmitters in the evolution of infarction in ischemic striatum /
[ Weinberger J;Nieves-Rosa J. ] / J. Neural Transm.
29 /
[ 서유헌 ] / 신경전달물질
30 /
[ 許仁會(外) ] / 神經傳達物質 基礎와 臨床
31 Use of the Morris water maze and acoustic startle chamber to evaluate neurologic injury after asphxial arrest in rats /
[ Hickey RW;Akino M;Strausbaugh S;De Courtmn-Myers GM. ] / Pediatr. Res.   ScienceOn
32 Elevation of extracellular oncentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis /
[ Benveniste H;Drejer J. Schoousboe A. ] / J. Neurochem.
33 NMDA- receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurons /
[ MacDermott AB;Mayer ML;Wessbrook GL. ] / Nature
34 A glutamate release inhibitor, protects against focal cerebral ischemic damage /
[ Leach MJ;Swan JH;Eisenthal D;Dopson M;Nobbs M ] / Stroke
35 Amine-mediated toxicity. The effects of dopamine, norepinephrine, 5- hydroxytryptamine, 6-hydroxydopamine, ascorbate, glutathione and peroxide on the in vitro activities of creatine and adenylate kinases in the brain of the rat /
[ Maker HS;Weiss C;Brannan TS. ] / Neuropharmacology   ScienceOn
36 Comparative effect of transient global ischemia on extracellular level of glutamate, glycine, and gamma-aminobutyric acid in vulnerable and nonvulnerable brain regions in the rat /
[ Globus MY;Busto R;Martinez E;Valdes I;Dietrich WD;Ginsberg MD. ] / J. Neurochem.
37 Role for GABA in selective vulnerability in gerbils /
[ Sternau LL;Lust WD;Ricci AJ ] / Stroke
38 The effect of the glycine site-specific NMDA antagonist ACEA1021 on ischemic brain damage caused by acute subdural hematoma in the rat /
[ Tsuchida E;Bullock R. ] / J. Neurotrauma.   ScienceOn
39 Extracellular overflow of glutamate, aspartate, GABA and taurine in the cortex and basal ganglia of fetal lambs during hypoxia -ischemia /
[ Hagberg H;Andersson P;Kjellmer I;Thiringer K;Thordstein M. ] / Neurosci Lett.   ScienceOn
40 Blood-brain barrier taurine transport during osmotic stress and in focal cerebral ischemia /
[ Stummer W;Betz AL;Shakui P;Keep RF ] / J. Cereb Blood Flow Metab.
41 Role of glial cells for the basal and <TEX>$Ca^{2+}$</TEX>-dependent <TEX>$K^+$</TEX>-evoked release of transmitter amino acids investigated by microdialysis /
[ Paulsen RE;Fonnun F. ] / J. Neurochem.
42 Brain concentrations of kynurenic acid after a systemic neuroprotective dose in the gerbil model of global ischemia /
[ Salvati P;Ukmar G;Dho L;Rosa B;Cini M;Marconi M;Molinari A;Post C. ] / Prog Neuropsychopharmacol Biol Psychiatry   ScienceOn
43 Stimulation of protein-tyrosine phosphorylation in berbil hippocampus after global forebrain ischemia /
[ Yokota M;Sado TC;Miyaji K;Kawashima S;Suzuki K. ] / Neurosci Lett.