• 재활치료과학
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• 제13권1호
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• pp.99-114
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• 2024

목적 : 본 연구에서는 정보통신기술(information and communication technology, ICT) 기반의 고령자를 위한 비대면 라이프스타일 프로그램을 개발하고 그 적용 가능성을 평가하였다. 연구방법 : 본 프로그램은 분석, 설계, 개발, 구현 및 평가 5단계로 구성된 ADDIE 모델을 기반으로 개발되었다. 5단계의 연구과정 동안 8단계를 거쳐 최종적으로 지역사회 고령자들을 대상으로 비대면 라이프 스타일 프로그램이 수행되었다. 결과 : 프로그램 분석 결과, 대상자들의 우울 증상과 외로움이 유의하게 감소한 것으로 나타났고 삶의 질 점수가 증가함을 확인할 수 있었다. 결론 : 본 연구를 통해 개발된 ICT 기반의 비대면 라이프스타일 프로그램은 고령자들이 성공적인 노화를 위한 생활 방식을 더 잘 이해하도록 동기부여하는 데 도움이 되었다.

• Journal of Ginseng Research
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• 제47권5호
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• pp.627-637
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• 2023

Background: Damage to the healthy intestinal epithelial layer and regulation of the intestinal immune system, closely interrelated, are considered pivotal parts of the curative treatment for inflammatory bowel disease (IBD). Plant-based diets and phytochemicals can support the immune microenvironment in the intestinal epithelial barrier for a balanced immune system by improving the intestinal microecological balance and may have therapeutic potential in colitis. However, there have been only a few reports on the therapeutic potential of plant-derived exosome-like nanoparticles (PENs) and the underlying mechanism in colitis. This study aimed to assess the therapeutic effect of PENs from Panax ginseng, ginseng-derived exosome-like nanoparticles (GENs), in a mouse model of IBD, with a focus on the intestinal immune microenvironment. Method: To evaluate the anti-inflammatory effect of GENs on acute colitis, we treated GENs in Caco2 and lipopolysaccharide (LPS) -induced RAW 264.7 macrophages and analyzed the gene expression of proinflammatory cytokines and anti-inflammatory cytokines such as TNF-α, IL-6, and IL-10 by real-time PCR (RT-PCR). Furthermore, we further examined bacterial DNA from feces and determined the alteration of gut microbiota composition in DSS-induced colitis mice after administration of GENs through 16S rRNA gene sequencing analysis. Result: GENs with low toxicity showed a long-lasting intestinal retention effect for 48 h, which could lead to effective suppression of pro-inflammatory cytokines such as TNF-α and IL-6 production through inhibition of NF-κB in DSS-induced colitis. As a result, it showed longer colon length and suppressed thickening of the colon wall in the mice treated with GENs. Due to the amelioration of the progression of DSS-induced colitis with GENs treatment, the prolonged survival rate was observed for 17 days compared to 9 days in the PBS-treated group. In the gut microbiota analysis, the ratio of Firmicutes/Bacteroidota was decreased, which means GENs have therapeutic effectiveness against IBD. Ingesting GENs would be expected to slow colitis progression, strengthen the gut microbiota, and maintain gut homeostasis by preventing bacterial dysbiosis. Conclusion: GENs have a therapeutic effect on colitis through modulation of the intestinal microbiota and immune microenvironment. GENs not only ameliorate the inflammation in the damaged intestine by downregulating pro-inflammatory cytokines but also help balance the microbiota on the intestinal barrier and thereby improve the digestive system.

• Korean Circulation Journal
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• 제52권4호
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• pp.304-319
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• 2022

Background and Objectives: De-escalation of dual-antiplatelet therapy through dose reduction of prasugrel improved net adverse clinical events (NACEs) after acute coronary syndrome (ACS), mainly through the reduction of bleeding without an increase in ischemic outcomes. Whether the benefits of de-escalation are sustained in highly thrombotic conditions such as ST-elevation myocardial infarction (STEMI) is unknown. We aimed to assess the efficacy and safety of de-escalation therapy in patients with STEMI or non-ST-segment elevation ACS (NSTE-ACS). Methods: This is a pre-specified subgroup analysis of the HOST-REDUCE-POLYTECH-ACS trial. ACS patients were randomized to prasugrel de-escalation (5 mg daily) or conventional dose (10 mg daily) at 1-month post-percutaneous coronary intervention. The primary endpoint was a NACE, defined as a composite of all-cause death, non-fatal myocardial infarction, stent thrombosis, clinically driven revascularization, stroke, and bleeding events of grade ≥2 Bleeding Academic Research Consortium (BARC) criteria at 1 year. Results: Among 2,338 patients included in the randomization, 326 patients were diagnosed with STEMI. In patients with NSTE-ACS, the risk of the primary endpoint was significantly reduced with de-escalation (hazard ratio [HR], 0.65; 95% confidence interval [CI], 0.48-0.89; p=0.006 for de-escalation vs. conventional), mainly driven by a reduced bleeding. However, in those with STEMI, there was no difference in the occurrence of the primary outcome (HR, 1.04; 95% CI, 0.48-2.26; p=0.915; p for interaction=0.271). Conclusions: Prasugrel dose de-escalation reduced the rate of NACE and bleeding, without increasing the rate of ischemic events in NSTE-ACS patients but not in STEMI patients.

• Korean Circulation Journal
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• 제52권4호
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• pp.324-337
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• 2022

Background and Objectives: Identifying patients with high bleeding risk (HBR) is important when making decisions for antiplatelet therapy strategy. This study evaluated the impact of ticagrelor monotherapy after 3-month dual antiplatelet therapy (DAPT) according to HBR in acute coronary syndrome (ACS) patients treated with drug eluting stents (DESs). Methods: In this post-hoc analysis of the TICO trial, HBR was defined by 2 approaches: meeting Academic Research Consortium for HBR (ARC-HBR) criteria or Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent DAPT (PRECISE-DAPT) score ≥25. The primary outcome was a 3-12 months net adverse clinical event (composite of major bleeding and adverse cardiac and cerebrovascular events). Results: Of the 2,980 patients without adverse events during the first 3 months after DES implantation, 453 (15.2%) were HBR by ARC-HBR criteria and 504 (16.9%) were HBR by PRECISE-DAPT score. The primary outcome rate was higher in HBR versus non-HBR patients (by ARC-HBR criteria: hazard ratio [HR], 2.87; 95% confidence interval [CI], 1.76-4.69; p<0.001; by PRECISE-DAPT score: HR, 3.09; 95% CI, 1.92-4.98; p<0.001). Ticagrelor monotherapy after 3-month DAPT was associated with lower primary outcome rate than ticagrelor-based 12-month DAPT regardless of HBR by ARC-HBR criteria, with similar magnitudes of therapy effect for HBR and non-HBR patients (p-interaction=0.400). Results were consistent by PRECISE-DAPT score (p-interaction=0.178). Conclusions: In ACS patients treated with DESs, ticagrelor monotherapy after 3-month DAPT was associated with lower rate of adverse clinical outcomes regardless of HBR, with similar magnitudes of therapy effect between HBR and non-HBR.

• 대한치과보철학회지
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• 제52권2호
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• pp.82-89
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• 2014

연구 목적: 본 연구의 목적은 중합 과정 중 치과용 레진 시멘트의 점탄성 성질의 변화를 관찰하기 위한 것이다. 연구 재료 및 방법: 6 종류의 레진시멘트(Clearfil SA luting, Panavia F 2.0, Zirconite, Variolink N, RelyX Unicem clicker, RelyX U200)가 이번 실험에 사용되었다. AR1500 stress controlled rheometer를 이용해 $32^{\circ}C$에서 동적 시간 경과 시험(dynamic oscillation time sweep test)이 시행되었다. 각각의 레진시멘트의 전단 저장 계수(G'), 전단 손실 계수(G"), 손실 탄젠트(tan ${\delta}$), 변위량을 20분 동안 3번씩 반복 측정하였다. 측정 결과는 일원배치분석 및 Tukey's hoc test로 사후 검정을 시행하였다(${\alpha}$=0.05). 결과: 모든 레진 시멘트는 혼합 후 시간에 따라 G' 값이 증가하였고, 최종적으로 안정상태에 도달하였다. 실험 종료 시점에서 RelyX U200은 가장 높은 G'값을 나타냈고, RelyX Unicem (clicker type)과 Variolink N이 가장 낮은 G'값을 나타냈다. Tan ${\delta}$와 변위량은 일정 수준의 값을 유지하다가 G'이 증가하기 시작하는 시점에서 0에 도달하였다. 이는 변위량이 0에 도달하는 지점과 거의 일치하였으며, 그 시간은 6분 내외였다. 결론: 본 연구에서 RelyX U200은 다른 레진 시멘트와 비교하여 가장 오랜 시간 동안 소성을 유지하고, 경화 완료 후 가장 높은 강도(rigidity)를 보였다. 따라서 여러 개의 보철물을 동시에 합착해야 하는 경우에 RelyX U200이 유용할 것으로 사료된다.

• 지능정보연구
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• 제25권2호
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• pp.57-75
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• 2019

본 논문에서는 4차 산업혁명 핵심기술 중 가장 활발하게 산업화가 진행되고 있는 사물인터넷 산업을 대상으로 비즈모델 혁신방향 중심의 연구를 수행하였다. 글로벌 트렌드 분석을 위해 PEST분석을 활용하여 정책적, 경제적, 사회적, 기술적 이슈를 도출하였고, Gartner, International Data Corporation 등 ICT관련 조사 분석기관의 사물인터넷산업에 대한 미래전망을 제시하였는데, 사물인터넷은 인프라 및 플랫폼을 기반으로 산업인터넷(IIoT), 소물인터넷(IoST) 등으로 네트워크 기술경쟁이 이슈가 될 것으로 전망하였다. 4차 산업혁명으로 인해 급변하는 산업계에 대응하기 위해 기존의 비즈니스 모델 혁신을 위한 다양한 경영학적 방법론들을 검토하였고, '적용성', '민첩성', '다양성', '연계성' 4가지 기준을 가지고 전문가 설문조사를 수행하여 Business Model Canvas 모델이 비즈니스 모델 혁신 방법론으로 가장 적합하다는 AHP 분석결과를 도출하였다. Business Model Canvas는 비즈니스 모델 혁신을 위한 방법론으로 비교적 최근에 제시된 경영전략이며, 9개의 블록 접근 방식을 통해 비즈니스모델의 가치를 식별하며, 비즈니스의 4대 핵심 영역인 고객, 주문, 인프라, 사업타당성 분석 등을 포괄한다. 결론적으로 ICT융합산업 분야에서 어떠한 Business Model Canvas 모델을 방향으로 적용할지에 대한 고찰을 기술하였다.

• 대한치위생과학회지
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• 제1권1호
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• pp.23-36
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• 2018

This research has been conducted from June 1, 2017 to August 25, 2017 for the dental hygienists working in Busan and Gyeongnam area, to provide necessary basic data for the purpose of revision of the relating laws from the analysis of their understanding and perspective on such laws through 262 subjects' questionnaire. Its analysis of their perspectives are as follows. 1. The common characteristics of the subjects are that 40.1% of them are under 25, and their working period was under three years with the 38.9%, and as for their marital status, 70.2% were single, the final education of 80.2% were associated degrees. Their working areas are centered in Gyeongsangnam-do province with 91.2%, the workplace type is for the dental clinic with 80.2%. 2. The comparison of the view point of the medical(technician) law according to the characteristics of the research subjects differed only whether or not the completion of the education, and as a result of the comparison according to the characteristics of those subjects understanding the details of the medical(technician) law, there was a significant difference saying "the current law has clear job description" depending on the working area or "the job duty is definite" depending on the job experience and job details. As for those saying "the job duty is definite", there was also significant difference depending upon marital status, final education and work details. There was no significant difference in all characteristics from findings of the necessity of legal system according to the subjects not understanding the medical(technician) law. 3. As a result of comparing the necessity of the medical(technician) law according to the characteristics of the research subjects, it was found that all the subjects accepted the necessity of the medical law revision including the dental hygienist in the medical person. The "necessity of the professional dental hygienist system" showed a significant difference depending upon the final education and medical institution type. Among the triggering factors in its amendment, there showed significant difference in the "cooperation of other organizations" and "solution of medical law problems" only in the final education. 4. As a result of comparison of the needs of the medical(technician) law revision according to the characteristics of the research subjects, it was found that the significant traits related to the age and job details showed "Legal responsibility would be increased" when the medical law is revised, in case that "it will help broaden the job extension", there showed a significant difference in career, final education, and working institution, and job details. "Legal protection is possible" showed significant difference except the age group and working area, and "it help the system settlement" showed in the final education. There was a significant difference in career, final education, and job details that "I can regulate the education and field practice", and the same in "my status will be improved" depending upon the final education, work area, and job details. Accordingly, in this research, for the establishment of more professional and comprehensive dental health service as suggested from the demand and necessity toward the medical(technician) Law by the dental hygienists.

• 대한치과보철학회지
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• 제52권4호
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• pp.312-316
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• 2014

목적: 본 연구에서는 지르코니아 수복물의 접착에 사용되는 레진 시멘트의 파괴인성을 측정하고 각 레진 시멘트의 다양한 수중 보관 기간이 파괴 인성에 미치는 영향에 관하여 알아보고자 하였다. 재료 및 방법: 세가지 종류의 레진 시멘트(Panavia F2.0, Clearfil SA luting, Zirconite)를 사용하여 single edge notched 형태의 시편($3mm{\times}6mm{\times}25mm$)을 제작하였다. 각 시편은 $37^{\circ}C$ 증류수에서 1일 (대조군), 30일, 90일, 180일 동안 보관하였다 (n=5). 만능시험기를 이용하여 0.1 mm/s 속도로 삼점굽힘 시험을 시행하고, 파절 시의 최대하중으로 파괴인성($K_{IC}$)을 계산하였다. 측정값은 일원분산분석과 다중분석을 위한 $Scheff{\acute{e}}$ test를 사용하였고, 유의수준은 0.05로 하였다. 결과: 대조군에서 Panavia F2.0가 $3.41{\pm}0.64MN{\cdot}m^{-1.5}$로 가장 높은 $K_{IC}$를 보였으며 Zirconite가 $3.07{\pm}0.41MN{\cdot}m^{-1.5}$, Clearfil SA luting이 $2.58{\pm}0.30MN{\cdot}m^{-1.5}$으로 가장 낮은 $K_{IC}$를 보였으나, 재료간에 유의성 있는 차이는 없었다. 수중보관 기간이 증가함에 따라 Panavia F2.0의 값은 감소였고, Clearfil SA luting과 Zirconite는 증가하였으나, 통계적으로 유의한 차이를 보이지 않았다. 결론: 지르코니아 수복물 전용 레진 시멘트의 파괴인성은 다른 일반 시멘트에 비해 대체로 높으며, 이러한 파괴인성은 수중 보관에 영향을 받지 않는다.

• 대한치과보철학회지
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• 제53권4호
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• pp.325-329
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• 2015

목적: 본 연구에서는 임상에서 사용되는 몇 가지 레진 시멘트의 혼합 후 부하를 가하기까지의 시간에 따른 피막도의 변화를 비교하고, 혼합 후 작업 시간과 레진 시멘트의 피막도의 관계를 알아 보고자 하였다. 재료 및 방법: 네 종류의 레진 시멘트(Panavia F2.0, Clearfil SA Luting, Zirconite, RelyX U200)를 제조사의 지시대로 혼합한 후 두 장의 투명한 Mylar matrix strip 사이에 소량의 시멘트를 넣고 다양한 시간 간격(20, 40, 60, 80, 100, 120, 140, 160, 180, 200초) 후에 50 N의 부하를 가하고 광중합을 시행하였다. 각 시점에서의 피막도는 $1{\mu}m$ 단위까지 측정 가능한 디지털 피막도 측정기를 이용하여 각 시편 당 세 번씩 측정하여 평균값을 구하였으며, 선형회귀분석을 통하여 시간에 따른 측정값의 변화를 알아 보았다. 또한 Wilcoxon 검정을 사용하여 각 측정값과 제조사에서 제시한 작업 시간을 유의수준 0.05로 비교 분석하였다 ($\alpha$=.05). 결과: 본 연구에 사용된 모든 레진 시멘트에서 혼합 후 부하를 가하기까지 걸린 시간과 피막도는 선형회귀분석 결과 양의 상관관계를 갖는 일차함수적 패턴을 보였다. ISO기준에 따라 피막도가 $50{\mu}m$가 되는 시점까지의 시간은 각 레진 시멘트의 제조사가 제시한 작업 시간과 차이가 있었으나 통계적인 유의성은 없었다. 결론: 레진 시멘트의 피막도는 작업 시간의 증가에 따라 증가한다. 임상에서의 레진 시멘트의 작업 시간은 제조사에서 제시한 작업 시간과 차이가 있을 수 있다.

• 한국동물위생학회지
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• 제36권4호
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• pp.263-272
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• 2013

Consistent information on the chemical composition and its seasonal variation of goat udder half milk is limited in Korea. The objective of this study was to analyze the seasonal variation of the chemical composition of goat milk to take establish various parameters into consideration on the pricing of the goat milk. Variations in chemical composition, somatic cell count (SCC) and bacterial count of 1,038 udder half milk samples from 650 heads raised in 7 farms of Jeonnam province were determined by season. Fat, protein, lactose, non-fat solids, milk urea nitrogen (MUN), pH, SCC and bacterial counts were also analyzed. The average composition of the milk was: fat $3.80{\pm}1.36%$, protein $3.23{\pm}0.80%$, lactose $4.39{\pm}0.54%$, total solids $12.18{\pm}1.80%$, non-fat solids $8.38{\pm}0.80%$, and milk urea nitrogen $28.44{\pm}5.00mg/dL$. The average pH was $6.81{\pm}0.24$. The average of SCC and bacterial counts were $2.54{\pm}4.60{\times}10^6cells/mL$ and $1.25{\pm}3.76{\times}10^5CFU/mL$, respectively. Chemical composition, pH, SCC and bacterial counts of dairy goat milk varied widely during the lactation period and by season. The fat concentration was the lowest in spring ($3.39{\pm}1.53%$) and the highest in autumn and winter ($3.98{\pm}1.30%$ and $3.98{\pm}1.48%$). Protein concentration was the lowest during summer ($2.92{\pm}0.48%$) and the highest in winter ($2.92{\pm}0.48%$). Lactose concentration was the lowest in autumn ($4.24{\pm}0.41%$) and the highest in spring ($4.58{\pm}0.35%$). The lowest total solid value was obtained in the spring season ($11.75{\pm}1.80%$) which was then increased in winter ($12.85{\pm}1.96%$). Non-fat solid concentration was the lowest in summer ($8.07{\pm}0.64%$) and the highest in autumn ($8.94{\pm}0.82%$). MUN concentration was the highest in summer ($8.07{\pm}0.64%$), and the pH concentration was the highest in spring at $6.93{\pm}0.27%$. Seasonal variation of SCC and bacterial count were the lowest in spring ($0.94{\pm}1.54{\times}10^6cells/mL$ and $0.22{\pm}0.61{\times}10^5CFU/mL$, respectively) and was the highest in winter ($3.95{\pm}7.14{\times}10^6cells/mL$ and $2.23{\pm}5.54{\times}10^4CFU/mL$, respectively).