• Title/Summary/Keyword: Harmful Effects

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Effects of Lactobacillus acidophilus Intake on Microfloral Changes in Human Feces (Lactobacillus acidophilus의 섭취가 사람의 분변 균총에 미치는 영향)

  • Jung, Eun-Ji;Ahn, Young-Tae;Kim, Hyun-Uk
    • Korean Journal of Food Science and Technology
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    • v.31 no.6
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    • pp.1642-1647
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    • 1999
  • Twenty healthy adult volunteers (divided into two groups) were given with 100 mL of acidophilus milk, twice a day, containing $1{\times}10^8\;cfu/mL$ of Lactobacillus acidophilus SNUL 01 or SNUL 02 originated from healthy Korean adults. The floral changes of lactobacilli, Escherichia coli, and Clostridium perfringens surviving in the feces as well as the pH of the fecal material have been studied for three weeks. Initial pH of the fecal samples before taking acidophilus milk were about pH 7 and it has been decreased to about pH 5 when the acidophilus milk was given. Population of fecal lactobacilli increased from about $10^7\;cfu/g\;to\;10^8\;cfu/g$ of fecal material after 4 days of acidophilus milk intake and the high population of lactobacilli was maintained up to 21 days. Viable cells of the fecal E. coli and C. perfringens have been decreased from about $10^7{\sim}10^8\;cfu/g\;and\;10^5{\sim}10^6\;cfu/g\;to\;10^6\;cfu/g\;and\;10^3\;cfu/g$ of fecal material after 21 days, respectively. In conclusion, continuous intake of acidophilus milk made with L. acidophilus SNUL 01 and SNUL 02 helped maintaining normal intestinal microflora, suppress harmful microorganisms.

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Green Tea Polyphenol Epigallocatechine Gallate (EGCG) Prevented LPS-induced BV-2 Micoglial Cell Activation (BV-2 미세아교세포의 활성에 대한 녹차 유래 폴리페놀 EGCG의 억제 효과)

  • Park, Euteum;Chun, Hong Sung
    • Journal of Life Science
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    • v.26 no.6
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    • pp.640-645
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    • 2016
  • Microglial cells are immediately activated in the central nervous system in response to a variety of neuronal environmental changes, such as injuries or inflammation. In addition to the modulation of the intrinsic immune response, a key role of microglial cells is the phagocytosis of dying cells and cellular debris. In this study, the inhibitory effects of epigallocatechine-3-gallate (EGCG), a most abundant and active polyphenol component of green tea, on lipopolysaccharide (LPS)-induced microglial activation are determined. EGCG dose dependently suppressed LPS-induced nitric oxide production and the expression of inducible nitric oxide synthase (iNOS) in BV-2 microglial cells. EGCG are potent LPS-induced inhibitors of several pro-inflammatory cytokine expressions, such as TNF-α and IL-1β, in microglial cells. Furthermore, EGCG generally inhibits the induction of LPS-mediated microglial activation and potently inhibits the phagocytosis of LPS-stimulated BV2 microglia. Although the conditioned media from LPS-stimulated BV-2 cells caused the SN4741 cell death, that from the conditioned media of EGCG pretreated BV-2 cells did not diminish the viability of SN4741 cells. These results suggest EGCG, a green tea polyphenol, could be a promising available molecule for the modulation of harmful microglial activation.

Whitening Effect with Fruit and Whitening Toothpaste (과일 및 미백치약으로 처리한 치아의 미백효과)

  • Gong, Min-Ji;Kim, Se-Won;Kim, Sol-Ji;Ahn, Hyun-Joo;Chae, Woo-Ri;Hong, Seung-Ji;Nam, Seoul-Hee
    • Journal of the Korea Convergence Society
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    • v.8 no.9
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    • pp.127-133
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    • 2017
  • The purpose of this study is to confirm the effect of natural tooth whitening using fruits that can be easily accessed in real life by increasing interest in tooth whitening in modern society. Twenty premolar teeth were divided into five groups (n=4). Strawberry (A), lemon (B), banana skin (C), baking soda (D) and whitening toothpaste (E) were treated with a toothbrush on the enamel surface. The tooth surface was treated with a toothbrush at the same time for 3 minutes for breakfast, lunch, and dinner, then washed with sterile distilled water, and stored in saline solution. This procedure was repeated for 4 weeks, and the color change of teeth was observed at intervals of one week. After 4 weeks, there was a significant difference in tooth color change after 3 weeks(p<0.05). Among them, strawberry and lemon showed higer effects to whitening toothpaste. It is believed that strawberries and lemons have a higher whitening effect than whitening toothpaste. Whitening toothpaste may be replaced with a safe natural whitening effect using strawberries and lemons instead of chemical ingredients that may be harmful to human body.

Measuring the Effectiveness of Teaching and Actual Condition of Internet Ethics of the Undergraduate Students (인터넷 윤리의식의 실태 분석 및 교육 효과 측정)

  • Kim, Tae-Hee;Kang, Moon-Seol
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.14 no.5
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    • pp.1257-1269
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    • 2010
  • The internet which is fast spread over all areas of our lives provides us with benefits of efficiency, productivity, and amusement; however, its features as an anonymous and non-face-to-face medium have raised a serious social issue of the collapse of internet ethics due to the abuse of it. Thereupon, the importance of internet ethics education has been highlighted to prevent side effects resulted from the internet and cultivate human-centered internet culture. In this paper, we suggests desirable methods for internet ethics education based on the investigation and analysis of the status of university freshmen's internet ethics. This research conducted a survey and analyzed its result after categorizing the status of internet ethics into the invasion of private information, invasion of intellectual property rights, harmful information, internet communication culture, cyber violence, internet addiction, and internet fraud. And based on the result of analyzing their internet ethics, this paper suggests desirable methods for internet ethics education. Next, internet ethics education was conducted by applying the proposed methods for internet ethics education, and its educational effect was evaluated. According to the result of verifying the educational effect measured statistically, it has proved that the suggested internet ethics education is effective to improve undergraduates' internet ethics.

Removal of Cobalt Ions by Precipitate Foam Flotation (침전 포말부선법에 의한 Cobalt Ion의 제거)

  • 정인하;이정원
    • Resources Recycling
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    • v.7 no.3
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    • pp.11-16
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    • 1998
  • Simulated waste liquid containing 50 ppm cobalt ion was t$\xi$sted by precipitate flotation using a sodium lauryl sulfate as a c collector. The effects of initial cobalt ion concentration, pH, surfactant concentration, flotation time, gas flow rate and foreign i ions on removal efficiency of cobalt ion were studied. Pretreatment of the waste liquid with 35% $H_2O_2$, prior to precipitate f flotation made shin of optimal flotation pH from the strong alkalinity to weak alkaline range and made a favorable flotation of c cobalt ion in wide range of pH. For the result of this experiment, 99.8% removal efficiency was obtained on the conditions of initial coball ion concentration 50 ppm, pH 9.5 gas flow rate 70 mllmin, flotation time 30 min. The simulate ion was fanned t to be the most harmful ion against removal of cobalt by precipitate flotation of the species which were tested The presence of 0.1 M of $SO_4^{2-}$ ion decreased remo,때 $\xi$폐iciency of cobalt to 90% while the cobalt were almost entirely removed in the a absence of sulfate ion.

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Arguments and Some Issues to be Considered for Building the New Administration Capital City in Korea (신 행정수도 건설의 논거와 과제)

  • 안성호
    • Journal of the Korean Geographical Society
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    • v.38 no.2
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    • pp.298-311
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    • 2003
  • Building the new administration capital city, one of presidential candidate Moo-Hyun Rho's election pledges, is now listed as a priority national policy agenda of the Participation Government. However, so many people's negative attitudes ranging from cynical skepticism to firm objections against the national policy agenda may threaten its smooth policy actualization. At this juncture, this paper attempts to present persuasive arguments and discuss some critical issues to be considered for building the new administration capital city successfully. The paper begins with taking a look at the current state of hyper-concentration of Seoul agglomeration area and its harmful effects, paints a vision of 'an evenly developed country as a whole' via illustrating the vision from the Swiss case, and reviews the performance of the precedent governments' reform measures for rectifying the hyper-concentration of Seoul agglomeration area. And then, the paper argues for building the new administration capital city as a potent solution to the problem of excessive concentration of activities in Seoul agglomeration area, as well as a driving force to spur the government to realize the Participation Government' enthusiastic vision: 'a decentralized and evenly developed country as a whole' and 'the hub country in the Northeast Asia'. In addition, the paper discusses the location of the new administration capital city in connection with the forthcoming national unification. Lastly, the paper deals with the important issues such as the procedure of people's approval, the population size and legal status of the new administration capital city, the relationship between building the new administration capital city and decentralization reform, etc.

Study of Bio-absorbability and Bio-compatibility of Poly-L-lactic-acid Implant in Dogs (개에서 Poly-L-lactic-acid 이식물의 생분해성과 생체적합성에 관한 연구)

  • Park, Po-Young;Kim, Young-Ki;Bahk, Jong-Yoon;Park, Joung-Man;Koh, Phil-Ok;Chang, Hong-Hee;Lee, Hee-Chun;Lee, Hyo-Jong;Yeon, Seong-Chan
    • Journal of Veterinary Clinics
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    • v.24 no.2
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    • pp.182-191
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    • 2007
  • Bioabsorbable devices have been utilized and experimented in many aspects of orthopaedic surgery. Depending upon their constituent polymers, these materials can be tailored to provide sufficient rigidity to allow bone healing, retain mechanical strength for certain period of time, and then eventually begin to undergo degradation. The objective of this study was to estimate extent in which Poly-L-latic acid (PLLA) implants had bioabsorbability and biocompatibility with bone and soft tissue in dogs and also to develop bioabsorbable, biocompatible materials with the appropriate strength and degradation characteristics to allow for regular clinical use for treating orthopedic problems in humans as well as animals. Eighteen dogs were used as experimental animals and were inserted two types of PLLA implants. PLLA rods were inserted into subcutaneous tissue of back or the abdomen wall. And the rods were tested for material properties including viscosity, molecular weight, melting point, melting temperature, crystallinity, flexural strength, and flexural modulus over time. PLLA screws were inserted through cortical bone into bone marrow in the femur of the dogs and stainless steel screw was inserted in the same femur. Radiographs were taken after surgery to observe locations of screw. Histological variations including cortical bone response, muscular response, bone marrow response were analyzed over the time for 62weeks. The physical properties of PLLA rods had delicate balances between mechanical, thermal and viscoelastic factors. PLLA screws did not induce any harmful effects and clinical complications on bone and soft tissue for degradation period. These results suggest that PLLA implants could be suitable for clinical use.

Pulling Force and Manure Spreading Characteristic of Tractor-drawn Animal Slurry Manure Sub-soil Injector (가축분뇨액비 지중살포기의 견인력 및 살포 특성)

  • Choe K. J;Lee S. H.;Ryu B. K.;Oh K. Y.;Park H. J.;Lee S. T.
    • Journal of Animal Environmental Science
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    • v.11 no.1
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    • pp.25-34
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    • 2005
  • The study aimed to develop a tractor drawn animal slurry manure sub-soil injector for arable land and thus, can reduce the waste management cost through effective treatment and utilization of animal slurry manure. The application of animal slurry manure to agricultural land will probably be one of the most effective ways to enrich the soil with vital nutrients. However, some existing slurry manure spenders are not suitable in the field because of their adverse effects to the environment. Based on this premise, a prototype was designed and assembled using 5 sub-soiling standards attached to the sin injector device. The traction force of the Prototype measured in the depth of 10 cm and 15 cm from the ground surface of a paddy field was 1,062 kgf and 1,214 kgf, respectively. A unique feature of the machine was that there was an equal volume of slurry manure flowing from each delivery pipe and regulated by a pressurized container that was likewise synchronized with the speed of the tractor The sub-soiling manure injection system can mitigate or reduce the harmful emission of obnoxious gases and malodor during the injection operation.

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Quality Improvement in Patient Care Services : Obstacles and Approaches (진료의 질관리에 대한 시론 -장애와 접근-)

  • 한달선
    • Health Policy and Management
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    • v.2 no.2
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    • pp.112-130
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    • 1992
  • Patient care services are provided to individual patients in response to their health needs produced by illnesses or injuries. The services are often addressed to very serious conditions, and also they constitute the most expensive component of health care services. Therefore, the importance of quality is emphasized, but there are many indications that patient care quality is far from a satisfactory state in most of the countries. Based upon this observation, it is attempted to examine obstacles and approaches to quality improvement in patient care services. In doing so, following Taguchi's(1986) definition of product quality, quality of patient care services is conceived of as better when the less is the sociental loss attributalbe to variability of intended function and harmful side effects they emhibit after being delivered. Some distinguishing features of medical care sector pose difficulties in implementing effective quality improvement programs in patient care services. Nevertheless, newly proposed method of quality management, based on industrial quality management approach, seems to have a great deal of potential to effectively cope with such difficulties. This method, unlike the traditional approach to quality assurance, focuses on total organisational processes, not individuals, as the obproach to quality assurance, focuses on total organizational processes, not individuals, as the objects of quality improvement; variation, not comparison with standards, in quality measurement; and continuous improvement, not removing only bad quality care, as an ideal. Prerequisite to a successful use of any quality mangement method is motivating providers to improve quality. Conceivable approaches for such motivation are self-regulation, external controls and promotion of competition. Since these approaches are not mutually exclusive, they may be employed in an appropriate combination. In Korea, medical care providers are now functioning under the circumstances where they have little reason for making efforts to improve quality of their services. Once these circumstantial conditions are changed to exert pressures on providers to improve quality, the use of adequate quality management method becomes an issue. In this connection, much attention shoould be directed to the newly proposed method described above. In all these efforts for improving quality of patient care services, health insurance would be able to play a pivotal role. Poviders of medical care, buth indiciduals and organizations, are usually very responsive to the measures that affect their financing, and thus health insurance can be a strong instrument for motivationg providers to improve quality. Also, the insurance continuously acquires data on patient care, which could be processed to produce information required to effective quality control.

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Human and Animal Disease Biomarkers and Biomonitoring of Deoxynivalenol and Related Fungal Metabolites as Cereal and Feed Contaminants (곡물 및 사료오염 데옥시니발레놀 및 대사체에 의한 인축질환 연계 생체지표 및 바이오모니터링)

  • Moon, Yuseok;Kim, Dongwook
    • Journal of Food Hygiene and Safety
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    • v.29 no.2
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    • pp.85-91
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    • 2014
  • Deoxynivalenol (DON) and related trichothecene mycotoxins are extensively distributed in the cereal-based food and feed stuffs worldwide. Recent climate changes and global grain trade increased chance of exposure to more DON and related toxic metabolites in poorly managed production systems. Monitoring the biological and environmental exposures to the toxins are crucial in protecting human and animals from toxicities of the hazardous contaminants in food or feeds. Exposure biomarkers including urine DON itself are prone to shift to less harmful metabolites by intestinal microbiota and liver metabolic enzymes. De-epoxyfication of DON by gut microbes such as Eubacterium strain BBSH 797 and Eubacterium sp. DSM 11798 leads to more fecal secretion of DOM-1. By contrast, most of plant-derived DON-glucoside is also easily catabolized to free DON by gut microbes, which produces more burden to body. Phase 2 hepatic metabolism also contributes to the glucuronidation of DON, which can be useful urine biomarkers. However, chemical modification could be very typical depending on the anthropologic or genetic background, luminal bacteria, and hepatic metabolic enzyme susceptibility to the toxins in the diet. After toxin exposure, effect biomarkers are also important in estimating the linkage and mechanisms of foodborne diseases in human and animal population. Most prominent adverse effects are demonstrated in the DON-induced immunological and behavioral disorders. For instance, acutely elevated interleukin-8 from insulted gut exposed to dietaty DON is a dominant clinical biomarker in human and animals. Moreover, subchronic exposure to the toxins is associated with high levels of serum IgA, a biological mediator of IgA nephritis. In particular, anorexia monitoring using mouse models are recently developed to monitor the biological activities of DON-induced feed refusal. It is also mechanistically linked to alteration of serotoin and peptide YY, which are promising biomarkers of neurological disorders by the toxins. As animal-alternative biomonitoring, huamn enterocyte-based assay has been developed and more realistic gut mimetic models would be useful in monitoring the effect biomarkers in resposne to toxic contaminants in the future investigations.