Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Study of Bio-absorbability and Bio-compatibility of Poly-L-lactic-acid Implant in Dogs

개에서 Poly-L-lactic-acid 이식물의 생분해성과 생체적합성에 관한 연구

  • Park, Po-Young (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Young-Ki (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Bahk, Jong-Yoon (Department of Urology, Gyeongsang Nationai University Medical School) ;
  • Park, Joung-Man (School of Materials Science & Engineering, Gyeongsang National University) ;
  • Koh, Phil-Ok (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Chang, Hong-Hee (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hee-Chun (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hyo-Jong (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Yeon, Seong-Chan (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • 박보영 (경상대학교 수의과대학 동물의학연구소) ;
  • 김영기 (경상대학교 수의과대학 동물의학연구소) ;
  • 박종윤 (경상대학교 의과대학) ;
  • 박종만 (경상대학교 공과대학) ;
  • 고필옥 (경상대학교 수의과대학 동물의학연구소) ;
  • 장홍희 (경상대학교 수의과대학 동물의학연구소) ;
  • 이희천 (경상대학교 수의과대학 동물의학연구소) ;
  • 이효종 (경상대학교 수의과대학 동물의학연구소) ;
  • 연성찬 (경상대학교 수의과대학 동물의학연구소)
  • Published : 2007.06.30
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Abstract

Bioabsorbable devices have been utilized and experimented in many aspects of orthopaedic surgery. Depending upon their constituent polymers, these materials can be tailored to provide sufficient rigidity to allow bone healing, retain mechanical strength for certain period of time, and then eventually begin to undergo degradation. The objective of this study was to estimate extent in which Poly-L-latic acid (PLLA) implants had bioabsorbability and biocompatibility with bone and soft tissue in dogs and also to develop bioabsorbable, biocompatible materials with the appropriate strength and degradation characteristics to allow for regular clinical use for treating orthopedic problems in humans as well as animals. Eighteen dogs were used as experimental animals and were inserted two types of PLLA implants. PLLA rods were inserted into subcutaneous tissue of back or the abdomen wall. And the rods were tested for material properties including viscosity, molecular weight, melting point, melting temperature, crystallinity, flexural strength, and flexural modulus over time. PLLA screws were inserted through cortical bone into bone marrow in the femur of the dogs and stainless steel screw was inserted in the same femur. Radiographs were taken after surgery to observe locations of screw. Histological variations including cortical bone response, muscular response, bone marrow response were analyzed over the time for 62weeks. The physical properties of PLLA rods had delicate balances between mechanical, thermal and viscoelastic factors. PLLA screws did not induce any harmful effects and clinical complications on bone and soft tissue for degradation period. These results suggest that PLLA implants could be suitable for clinical use.

Keywords

References

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