• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.6
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• pp.591-597
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• 2013

Because most existing non-Newtonian models are not suitable for application to the lattice Boltzmann method, theoretical and numerical studies in this regard remain challenging. In this study, the hydrokinetic (HK) model was modified and applied to a 3D sudden contraction-expansion channel flow, and the characteristics of the HK model flow were evaluated to generate non-trivial predictions in three-dimensional strong shear flows. The HK model is very efficient for application to the lattice Boltzmann method because it utilizes the shear rate and relaxation time. However, the simulation would be unstable in a high shear flow field because the local relaxation time sharply decreases with an increase in the shear rate in a strong shear flow field. In the HK model, it may become necessary to truncate the relaxation time and non-dimensional parameter to obtain stable numerical results.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.26 no.6
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• pp.567-579
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• 1993

The response of sea levels to a typhoon in the north Japanese coast in the Japan Sea is investigated by using hourly ses level data($1966{\sim}1986$) and a numerical shallow water model with high resolution($5'{\times}5'$). The observed sea level analysis shows (1) progressive waves exist between Simonoseki(SS) and Maizuru(MZ) with the mean phase speed of about 4 m/s during the passage of the typhoon, (2) the phase speed between Sasebo(SB) and HK(Hakata) is slower(about 1.7 m/s), and (3) the maximum sea level at HK is achieved about 0.5 day later than that of SS. In many aspects, the numerical model results correspond well to the above observed features. In the model the progressive waves are identified as a topographic wave with the phase speed of about 4 m/s. Before the typhoon passes through the Korea Strait/ the Tsushima Strait, the wave propagations along the Japanese coast are significantly influenced by the southwestward coastal jet induced by the wind stress parallel to the coast. The waves start to propagate northeastward along the coast when the coastal jet is weakened.

• Journal of Internet Computing and Services
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• v.15 no.1
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• pp.125-134
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• 2014

As the social media which was simple communication media is activated on account of twitter and facebook, it's usability and importance are growing recently. Although many companies are making full use of its the capacity of information diffusion for marketing, the adverse effects of this capacity are growing. Because social network is formed and communicates based on friendships and relationships, the spreading speed of the spam and mal-ware is very swift. In this paper, we draw parameters affecting malicious data diffusion in social network environment, and compare and analyze the diffusion capacity of each parameters by propagation experiment with XSS Worm and Koobface Worm. In addition, we discuss the structural characteristics of social network environment and then proposed malicious data propagation model based on parameters affecting information diffusion. n this paper, we made up BA and HK models based on SI model, dynamic model, to conduct the experiments, and as a result of the experiments it was proved that parameters which effect on propagation of XSS Worm and Koobface Worm are clustering coefficient and closeness centrality.

• Korean Journal of Plant Resources
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• v.31 no.2
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• pp.95-101
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• 2018

Doxorubicin is a anti-cancer drugs that interferes with the growth and spread of cancer cells in human body. Doxorubicin is used to treat different types of cancers that affect the ovary, thyoid and lungs, but induced side effect such as nephrotoxicity and cardiotoxicity. Thus, we investigated that the effect of iridin on doxorubicin-induced necrosis in HK-2 cells, a human proximal tubule cell. To confirm effect of iridin on doxorubicin-induced necrosis, HK-2 cells are treated with $10{\mu}M$ doxorubicin and $80{\mu}M$ iridin. $80{\mu}M$ iridin reduced $10{\mu}M$ doxorubicin-induced necrosis, the mitochondrial over activation and caspase-3 activation. However, iridin reduces anti-cancer effect of doxorubicin such as PARP1 and caspase-3 activation, checkpoint proteins (CDK4 and CDK6) in NCI-H1129 cells (Human non-small cell lung cancer cell). In HCT-116 cells (Human colorectan cancer cell), iridin do not increased protein expression of CDK4 and CDK6 decreased by doxorubicin. Results indicate that treatment of iridin was diminished doxorubicin-induced necrosis in HK-2 cells. However, iridin was decreased anti-cancer effect of doxorubicin on NCI-H1229, but not HCT-116. Thus, further experiment are required to iridin treatment on various cancer cells and animal models because effect of iridin different cell type.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.4
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• pp.421-431
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• 2023

Sewer deterioration models can offer important information on prediction of future condition of the asset to decision makers in their implementing sewer pipe networks management program. In this study, Markov chain model was used to estimate sewer deterioration trend based on the historical structural condition assessment data obtained by CCTV inspection. The data used in this study were limited to Hume pipe with diameter of 450 mm and 600 mm in three sub-catchment areas in city A, which were collected by CCTV inspection projects performed in 1998-1999 and 2010-2011. As a result, it was found that sewers in sub-catchment area EM have deteriorated faster than those in other two sub-catchments. Various main defects were to generate in 29% of 450 mm sewers and 38% of 600 mm in 35 years after the installation, while serious failure in 62% of 450 mm sewers and 74% of 600 mm in 100 years after the installation in sub-catchment area EM. In sub-catchment area SN, main defects were to generate in 26% of 450 mm sewers and 35% of 600 mm in 35 years after the installation, while in sub-catchment area HK main defects were to generate in 27% of 450 mm sewers and 37% of 600 mm in 35 years after the installation. Larger sewer pipes of 600 mm were found to deteriorate faster than smaller sewer pipes of 450 mm by about 12 years. Assuming that the percentage of main defects generation could be set as 40% to estimate the life expectancy of the sewers, it was estimated as 60 years in sub-catchment area SN, 42 years in sub-catchment area EM, 59 years in sub-catchment area HK for 450 mm sewer pipes, respectively. For 600 mm sewer pipes, on the other hand, it was estimated as 43 years, 34 years, 39 years in sub-catchment areas SN, EM, and HK, respectively.

• Journal of computational fluids engineering
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• v.19 no.4
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• pp.61-67
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• 2014

Since the most of the existing non-Newtonian models are not adequate to apply to the lattmce Boltzmann method, it is a challenging task from both the theoretical and the numerical points of view. In this research the hydro-kinetic model was modified and applied to the 3-D moving sphere in the circular channel flow and the characteristics of the shear thinning effect by the HK-model was evaluated and the condition of ${\Gamma}$ in the model was suggested for the stable simulation to generate non-trivial prediction in three dimension strong shear flows. On the wall boundaries of circular channel the curved wall surface treatment with constant velocity condition was applied and the bounceback condition was applied on the sphere wall to simulate the relative motion of the sphere. The condition is adequate at the less blockage than 0.7 but It may need to apply a multi-scale concept of grid refinement at the narrow flow region. to obtain the stable numerical results.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.41 no.3
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• pp.263-268
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• 2015

The purpose of this study was to investigate anti-melanogenesis effects of mulberry seed extracts (MSE). MSE inhibited melanogenesis in melan-a cells at $10{\mu}g/mL$ without cytotoxicity. Also, MSE decreased tyrosinase, tyrosinase-related protein-1 (TRP-1) protein expression in the melan-a cells. To identify the signaling pathway of MSE, the ability of MSE to influence extracellular signal-regulated protein kinase (ERK) activation was investigated. MSE induced ERK protein expression in a dose-dependent manner. In addition, MSE presented inhibition of the body pigmentation in vivo zebrafish model. These results suggest that MSE may be an effective anti-melanogenesis agent regulating the expression of ERK protein and melanogenic enzymes.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.95-95
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• 2022

남극에 상주하는 여러 과학기지 근처 해역에서 5 mm 이하의 크기를 가지는 미세플라스틱이 다량 발견되고 있으며, 그에 따라 과학기지에서 방출하는 방류수가 미세플라스틱의 지역 소스로 여겨지고 있다. 현재는 미세플라스틱의 오염 수준을 이해하는 정도에서 그쳤으며, 미세플라스틱의 물리적인 운송 메커니즘을 이해하고자 하는 시도는 상대적으로 부족한 실정이다. 남극 세종과학기지 근처에서도 미세플라스틱이 발견됨에 따라 본 연구에서는 과학기지 인근인 마리안 소만(Marian Cove)에서의 미세플라스틱 운송 메커니즘을 확인하고자 한다. 연구 대상 지역에서 미세플라스틱의 체류 시간은 짧기 때문에, 미세플라스틱에 생물오손 또는 풍화작용이 일어나기에는 충분하지 않은 시간이다. 따라서, 마리안 소만에서 발견된 미세플라스틱에 대해 연직 속도에 따라 확실히 가라앉는 그룹과 확실히 떠오르는 그룹으로 나누어 입자의 이송 메커니즘을 파악하였다. 해수 유동 모델과 파랑 모델을 결합하여 마리안 소만의 해수 흐름을 재현하였으며, 과학기지 방류 구 위치에서 방출된 미세플라스틱의 이송 경로는 라그랑지안 입자 추적(Lagrangian Particle Tracking) 방법을 이용하였다. 본 연구에서는 미세플라스틱의 궤적을 설명하기 위해 입자의 이송에 영향을 주는 힘을 결정할 수 있는 무차원 수 HK angle을 제안하였으며, 이를 이용하여 마리안 소만에서의 미세플라스틱 이송을 설명하였다. 대상 해역 내에서 확실히 떠오르는 그룹은 표층 흐름을 따라 해안선에 도달하였으며, 확실히 가라앉는 그룹은 방출 직후 빠르게 가라 앉으며 방출 위치 근처인 해저에 집적되었다. HK angle에 따르면, 마리안 소만의 연직 흐름이 강할 경우에는 미세플라스틱의 특성에 관계없이 해수 흐름을 따라 이송됨을 확인하였다. 더 나아가, 조석에 따라 미세플라스틱의 방출 시간을 달리하고, 방출 위치를 달리하여 모의함으로써 마리안 소만과 같이 작은 만에서 미세플라스틱 오염도를 줄이기 위한 적절한 방류수 방출 시간 및 위치를 제안하였다.

• Journal of Life Science
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• v.21 no.9
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• pp.1214-1218
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• 2011

We investigated the fruits of Rubus crataegifolius Bge, a plant which has been traditionally used in Korea in phytotherapy, to describe antioxidant materials from plant sources. R. crataegifolius fruits were extracted with methanol and further fractionated into n-hexane, diethyl ether, and ethyl acetate. The antioxidant activity of each fraction and the residue was assessed using a 1,1-diphenyl-2-picrylhydrazyl (DPPH), $H_2O_2$ radical scavenging method, and their cytotoxicity on human primary kerationcyte (HK) was determined by an MTS assay. The R. crataegifolius fruit methanol extract showed strong antioxidant activity (75.04%, 50%) compared with vitamin C (79.9%, 54.1%) by the DPPH, and $H_2O_2$ method, respectively. The measured activity from the subsequent extracts of the methanol extract were 20.3% for n-hexane fraction (HF), 68.8% for diethyl ether fraction (DF), 67.1% for ethyl acetate fraction (EF), and 67.1% for the residue fraction (RE) by DPPH and 2.2% for HF, 1.6% for DF, 10% for EF, and 50% for the RE by $H_2O_2$ assay. An oxidative stress model of HK was established under a suitable concentration (1 mM). The cell viability of the RE treated group increased and the percentage of apoptotic cells decreased at concentrations of 0.005-0.02% RE compared with the $H_2O_2$ treated group. Fruit extracts of the medicinal plant R. crataegifolius showed potent antioxidant activity and the ability to relieve cell damage from $H_2O_2$ induced injury to HK.

• Journal of Plant Biotechnology
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• v.46 no.3
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• pp.165-171
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• 2019

Marker-assisted backcrossing (MABC) is useful for selecting an offspring with a highly recovered genetic background for a recurrent parent at early generation to various crops. Moreover, marker-assisted backcrossing (MABC) along with marker-assisted selection (MAS) contributes immensely to overcome the main limitation of the conventional breeding and it accelerates recurrent parent genome (RPG) recovery. In this study, we were employed to incorporate rin gene(s) from the donor parent T13-1084, into the genetic background of HK13-1151, a popular high-yielding tomato elite inbred line that is a pink color fruit, in order to develop a rin HK13-1084 improved line. The recurrent parent genome recovery was analyzed in early generations of backcrossing using SNP markers obtained from genotyping-by-sequencing analysis. From the $BC_1F_1$ and $BC_2F_1$ plants, 3,086 and 4868 polymorphic SNP markers were obtained via GBS analysis, respectively. These markers were present in all twelve chromosomes. The background analysis revealed that the extent of RPG recovery ranged from 56.7% to 84.5% and from 87.8% to 97.8% in $BC_1F_1$ and $BC_2F_1$ generations, respectively. In this study, No 5-1 with 97.8% RPG recovery rate among $BC_2F_1$ plants was similar to HK13-1151 strain in the fruit shape. Therefore, the selected plants were fixed in $BC_2F_2$ generation through selfing. MAS allowed identification of the plants that are more similar to the recurrent parent for the loci evaluated in the backcross generations. MABC can greatly reduce breeding time as compared to the conventional backcross breeding. For instance, MABC approach greatly shortened breeding time in tomato.