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http://dx.doi.org/10.15230/SCSK.2015.41.3.263

Melanogenesis Inhibitory Activities of Mulberry Seed Ethanol Extracts  

Jeong, Yong Tae (HK bio, business incubator, Daegu Haany University)
Kang, Min Ju (HK bio, business incubator, Daegu Haany University)
Kim, Jin Hee (College of herbal Bio-Industry, Daegu Haany University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.41, no.3, 2015 , pp. 263-268 More about this Journal
Abstract
The purpose of this study was to investigate anti-melanogenesis effects of mulberry seed extracts (MSE). MSE inhibited melanogenesis in melan-a cells at $10{\mu}g/mL$ without cytotoxicity. Also, MSE decreased tyrosinase, tyrosinase-related protein-1 (TRP-1) protein expression in the melan-a cells. To identify the signaling pathway of MSE, the ability of MSE to influence extracellular signal-regulated protein kinase (ERK) activation was investigated. MSE induced ERK protein expression in a dose-dependent manner. In addition, MSE presented inhibition of the body pigmentation in vivo zebrafish model. These results suggest that MSE may be an effective anti-melanogenesis agent regulating the expression of ERK protein and melanogenic enzymes.
Keywords
Mulberry seed; melanogenesis; melan-a; zebrafish; ethanol extract;
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Times Cited By KSCI : 4  (Citation Analysis)
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