• The Korean Journal of Physiology and Pharmacology
• /
• v.27 no.4
• /
• pp.345-356
• /
• 2023

This study aimed to assess the effects of exogenous hydrogen sulfide (H₂S) on abdominal aorta coarctation (AAC) induced myocardial fibrosis (MF) and autophagy in rats. Forty-four Sprague-Dawley rats were randomly divided into control group, AAC group, AAC + H₂S group, and H₂S control group. After a model of rats with AAC was built surgically, AAC + H₂S group and H₂S group were injected intraperitoneally with H₂S (100 µmol/kg) daily. The rats in the control group and the AAC group were injected with the same amount of PBS. We observed that H₂S can improve left ventricular function and the deposition of myocardial collagen fibers, inhibit pyroptosis, down-regulate the expression of P-eif2α in myocardial tissue, and inhibit cell autophagy by activating the phosphatidylinositol 3-kinase (PI3K)/AKT1 signaling pathway (p < 0.05). In addition, angiotensin II (1 µM) H9c2 cardiomyocytes were injured in vitro experiments, and it was also observed that pyroptosis was inhibited after H₂S (400 µmol/kg) intervention, the expression of P-eif2α in cardiomyocytes was significantly down-regulated, and the PI3K/AKT1 signaling pathway was activated at the same time. Therefore, increasing the expression of P-eif2α reverses the activation of the PI3K/AKT1 signaling pathway by H₂S. In conclusion, these findings suggest that exogenous H₂S can ameliorate MF in rats with AAC by inhibiting pyroptosis, and the mechanism may be associated with inhibiting the phosphorylation of eif2α and activating the PI3K/AKT1 signaling pathway to inhibit excessive cell autophagy.

• Journal of Institute of Control, Robotics and Systems
• /
• v.10 no.3
• /
• pp.216-224
• /
• 2004

In this paper we address reliable output feedback control problem for a class of linear systems with actuator/sensor failures. An output feedback control method is proposed which stabilizes the plant and guarantees $H_\inftyt$-norm constraint against all admissible actuator/sensor failures. The controller can be obtainer by solving some LMls that cover all failure cases. Effectiveness of this controller is validated via a numerical example. This paper addresses reliable output feedback control problem for a class of linear systems with actuator/sensor failures. An output feedback control method is proposed which stabilizes the plant and guarantees $H_\inftyt$-norm constraint against all admissible actuator/sensor failures. The controller can be obtained by solving some LMls that cover all failure cases. Effectiveness of this controller is validated via numerical example.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.18 no.5
• /
• pp.198-202
• /
• 2004

This thesis proposes a robust controller introducing the H$_{\infty}$ control theory, one of the robust control theories that can obtain desired control performance while ensuring robustness for the uncertainty and disturbance contained in the power system. The performance of the designed controller is examined by extensive non-linear time domain simulation. Results show that the proposed H$_{\infty}$ controller is superior to that of the conventional controller.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.62 no.8
• /
• pp.1132-1137
• /
• 2013

This paper considers the $H_{\infty}$ control problem for networked control systems(NCSs). In order to solve the problem which comes from discontinuous control signal in NCSs, an approach that discontinuous control signals treat time-varying delayed continuous signals is applied to achieve $H_{\infty}$ stability of NCSs. In addition, randomly occurring packet losses and disturbances are considered by introducing stochastic variables with Bernoulli distribution. Based on Lyapunov stability theory, a new stability condition is obtained via linear matrix inequality formulation to find the $H_{\infty}$ controller which achieves the mean square stability of NCSs. Finally, the proposed method is applied to a numerical example in order to show the effectiveness of our results.

• Animal Bioscience
• /
• v.35 no.10
• /
• pp.1616-1627
• /
• 2022

Objective: This work was conducted to investigate the effects of oxidative stress on meat quality, mitochondrial function, calcium metabolism and ferroptosis of broilers. Methods: In this study, a total of 144 one-day-old male Ross 308 chicks were divided into 3 groups (control group, saline group, and hydrogen peroxide [H₂O₂] group) with 6 replicates of 8 broilers each. The study lasted for 42 d. The broilers in the saline and H₂O₂ groups were intraperitoneally injected with 0.75% saline and 10.0% H₂O₂ on the 16th and 37th day of the experimental period respectively, the injection volumes were 1.0 mL/kg of broiler body weight. On the 42nd day of the experimental period, two chicks were randomly selected from each cage, a total of thirty-six chicks were stunned by electric shock and slaughtered to collect breast muscle samples. Results: The H₂O₂ exposure reduced pH value, increased drip loss and shear force of breast meat (p<0.05), impaired the ultrastructure and function of mitochondria. The H₂O₂ exposure damaged the antioxidant system in mitochondria, excessive reactive oxygen species carbonylation modified calcium channels on mitochondria, which impaired the activities of key enzymes on calcium channel, resulted in the increased calcium concentration in cytoplasm and mitochondria (p<0.05). In addition, the H₂O₂ exposure increased the iron content and lipid peroxidation (p<0.05), which induced ferroptosis. Conclusion: Oxidative stress could impair meat quality by causing mitochondrial dysfunction, resulting in calcium metabolism disorder and ferroptosis.

• Journal of Institute of Control, Robotics and Systems
• /
• v.20 no.1
• /
• pp.6-11
• /
• 2014

Repetitive control is a specialized control scheme to track and/or attenuate a periodic reference trajectory and/or disturbance. Most researches about repetitive control have been performed in the frequency domain. Recently, several approaches to deal with repetitive control systems in the state space are developed by representing a q filter as a state-space equation. This paper presents a design method of a repetitive control system in the state space to satisfy $H_{\infty}$ performance. The overall system is composed of a plant, a repetitive controller, and a state-feedback controller, which can be converted to a standard form used in $H_{\infty}$ control. A LMI (Linear Matrix Inequality)-based stability condition is derived for fixed state-feedback gains. Under a given q filter, another LMI condition is derived to improve $H_{\infty}$ performance and is employed to find state-feedback gains by solving an optimization problem. Finally, to verify the feasibility of the proposed method, a numerical example is demonstrated.

• Journal of Institute of Control, Robotics and Systems
• /
• v.13 no.10
• /
• pp.1000-1006
• /
• 2007

This paper presents an LMI-based method to design a saturated state-feedback $H_2$ controller for uncertain systems with actuator saturation. Specifically, the paper proposes a sufficient condition such that the system under norm-bounded uncertainties and actuator saturation is asymptotically stable and the $H_2$-norm of the system has an upper-bound. The resulting condition is further utilized to solve a convex optimization problem specified in the context of $H_2$-norm minimization, whose solution yields a saturated $H_2$ controller. A numerical example is presented to show the effectiveness of the proposed method.

• Journal of Sensor Science and Technology
• /
• v.29 no.6
• /
• pp.382-387
• /
• 2020

Hydrogen (H₂) is considered as a new clean energy resource for replacing petroleum because it produces only H₂O after the combustion process. However, owing to its explosive nature, it is extremely important to detect H₂ gas in the ambient atmosphere. This has triggered the development of H₂ gas sensors. 2-dimensional (2D) graphene has emerged as one of the most promising candidates for chemical sensors in various industries. In particular, graphene exhibits outstanding potential in chemoresistive gas sensors for the detection of diverse harmful gases and the control of indoor air quality. Graphene-based chemoresistive gas sensors have attracted tremendous attention owing to their promising properties such as room temperature operation, effective gas adsorption, and high flexibility and transparency. Pristine graphene exhibits good sensitivity to NO₂ gas at room temperature and relatively low sensitivity to H₂ gas. Thus, research to control the selectivity of graphene gas sensors and improve the sensitivity to H₂ gas has been performed. Noble metal decoration and metal oxide decoration on the surface of graphene are the most favored approaches for effectively controlling the selectivity of graphene gas sensors. Herein, we introduce several strategies that enhance the sensitivity of graphene gas sensors to H₂ gas.

• Journal of Institute of Control, Robotics and Systems
• /
• v.14 no.3
• /
• pp.254-262
• /
• 2008

In this paper, we propose an adaptive neural dynamic surface control (DSC) approach with $H_{\infty}$ tracking performance for full dynamics of nonlinear flight systems. It is assumed that the model uncertainties such as structured and unstrutured uncertainties, and external disturbances influence the nonlinear aircraft model. In our control system, self recurrent wavelet neural networks (SRWNNs) are used to compensate the model uncertainties of nonlinear flight systems, and an adaptive DSC technique is extended for the disturbance attenuation of nonlinear flight systems. All weights of SRWNNs are trained on-line by the smooth projection algorithm. From Lyapunov stability theorem, it is shown that $H_{\infty}$ performance nom external disturbances can be obtained. Finally, we present the simulation results for a nonlinear six-degree-of-freedom F-16 aircraft model to confirm the effectiveness of the proposed control system.

• Journal of Aerospace System Engineering
• /
• v.2 no.3
• /
• pp.1-6
• /
• 2008

The tilt rotor aircraft has the flight characteristics which takes off vertically like a helicopter and flies forward like an airplane. Especially, the transition process from a helicopter to an airplane mode requires not only the mixing of control inputs but also the stability and controllability augmentation system(SCAS) in order to keep the safe flight because there are compound flight dynamic characteristics of a helicopter and an airplane including non-linearity, uncertainty. This paper describes the design of SCAS in a lateral motion for the tilt rotor aircraft based on the $H_{\infty}$ control method, which was performed from mathematical model with weighting matrix based on the relationship between the $H_{\infty}$ norm and the sensitivity function. Through simulation analysis for the controller designed on the $H_{\infty}$ control theory, it was shown that this method may be applied to the control design of the tilt rotor aircraft.