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Induction Chemotherapy Followed by Concurrent Chemoradiotherapy Versus Concurrent Chemoradiotherapy with or without Adjuvant Chemotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma: Meta-analysis of 1,096 Patients from 11 Randomized Controlled Trials

  • Liang, Zhong-Guo;Zhu, Xiao-Dong;Tan, Ai-Hua;Jiang, Yan-Ming;Qu, Song;Su, Fang;Xu, Guo-Zeng
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.1
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    • pp.515-521
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    • 2013
  • Purpose: To evaluate the efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy (the treatment group) versus concurrent chemoradiotherapy with or without adjuvant chemotherapy (the control group) for locoregionally advanced nasopharyngeal carcinoma. Methods: The search strategy included Pubmed, Embase, the Cochrane Library, China National Knowledge Internet Web, Chinese Biomedical Database and Wanfang Database. We also searched reference lists of articles and the volumes of abstracts of scientific meetings. All randomized controlled trials were included for a meta-analysis performed with RevMan 5.1.0. The Grading of Recommendations Assessment, Development, and Evaluation system (GRADE) was used to rate the level of evidence. Results: Eleven studies were included. Risk ratios of 0.99 (95%CI 0.72-1.36), 0.37 (95%CI 0.20-0.69), 1.08 (95%CI 0.84-1.38), 0.98 (95%CI 0.75-1.27) were observed for 3 years overall survival, 3 years progression-free survival, 2 years loco-regional failure-free survival and 2 years distant metastasis failure-free survival. There were no treatment-related deaths in either group in the 11 studies. Risk ratios of 1.90 (95%CI 1.24-2.92), 2.67 (95%CI 0.64-11.1), 1.04 (95%CI 0.79-1.37), 0.98 (95%CI 0.27-3.52) were found for grade 3-4 leukopenia, grade 3-4 thrombocytopenia, grade 3-4 mucous membrane, and grade 3-4 hepatic hematologic and gastrointestinal toxicity, the most significant toxicities for patients. Conclusion: Compared with the control group, induction chemotherapy followed by concurrent chemoradiotherapy was well tolerated but could not significantly improve prognosis in terms of overall survival, loco-regional failure-free survival or distant metastasis failure-free survival.

The Role of Meniscal Arrow in the Treatment of the Meniscal Tear (반월상 연골 파열의 치료에서 meniscal arrow의 역할)

  • Bae, Dae Kyung;Yim, Chang Moo;Jeong, Ki Woong
    • Journal of the Korean Arthroscopy Society
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    • v.3 no.1
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    • pp.24-29
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    • 1999
  • Purpose : The purpose of this paper is to analyze the clinical results after meniscal repair using meniscal arrow. Materials and Methods : Between May 1997 and Aug 1998, we repaired 22 tom menisci in 22 patients using meniscal arrows. There were nineteen males and three females with an average age of 27 years. There were longitudinal tear in 14 cases, Bucket-handle tear were 7 cases and horizontal tear was in 1 case. In 22 meniscus tears, 16 cases were associated with anterior cruciate ligament tear. Average number of meniscal arrow that was used were 2.5(ranged 1 to 4). Average follow-up period was 14.7 months(ranged 6 to 22 months). We evaluated the clinical results by the Tapper and Hoover's grading system. Results : There were excellent in 16 cases, good in 4 cases and fair in 2 cases on the clinical results. At the last follow up, the range of the motion of the knee joint were average 135 degrees(ranged 125 to 140 degrees). Mean time elapsed for meniscal repair were 25 minutes(ranged 15 to 40 minutes). Conclusion : Meniscal arrow has many advantages such as short operative time, easy fixation technique, and less neurovascular injury. We think that arthroscopic meniscal repair using meniscal arrow is effective treatment method in selected patient who have longitudinal, bucket-handle tear at the posterior hom associated with anterior cruciate ligament tear.

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The Contents of Emergency Treatment Practice Conducted by Emergency Medical Technician and Related Factors (일부 응급구조사들의 응급처치 시행내용과 관련 요인)

  • Jeong, Sang-Gil;Kim, Ki-Soon;Cho, Soo-Hyung;Kang, Myung-Geun;Han, Mi-Ah
    • Journal of agricultural medicine and community health
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    • v.34 no.3
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    • pp.346-358
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    • 2009
  • Objectives: A study was conducted by analysing the contents and frequency of emergency treatment practiced by emergency medical technicians(EMTs) in emergency situations and contains related factors. Methods: The study subjects included 80 EMTs who participated in ongoing education classes during the period from June 25th to June 26th, 2008. the survey included 53 EMTs employed within 119 first aid teams in fire stations in both a metropolitan city and a medium-sized city. From the survey results relation between frequency of emergency treatment and subjects characteristics explored statistically including t-test, X2 test, Pearson correlation and finally stepwise multiple regression. Results: The most frequent procedure by EMTs checking vital signs. The statistically significant related factors overall of the 23 items of emergency treatment frequency was the working area and the grading of EMT certification. In contrast, significant related factors with frequency of IV linkage were found to be the subjects gender, institution employed and the importance of recognizing the item. The statistically significant related factors of that of ECG monitoring was the gender of respondents. Conclusions: To keep the appropriate frequency of emergency treatment by EMT, active efforts to promote their individual importance and confidence cognition are necessary, especially towards males and persons who have 2nd class certification. Moreover, EMTs who work in small cities must be supported.

The Clinical Observation on 3 Cases of Facial Palsy Following Microvascular Decompression in Hemifacial Spasm Patients (편측안면경련 환자에서 미세혈관 감압수술 후 발생한 구안와사 환자 3례)

  • Kim, Jong-In;Choi, Yang-Sik;Kim, Haeng-Beom;Kim, Joo-Hee;Lee, Ro-Min;Kim, Kun-Hyung;Lee, Jae-Dong;Kang, Sung-Keel;Koh, Hyung-Kyun
    • Journal of Acupuncture Research
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    • v.23 no.6
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    • pp.229-238
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    • 2006
  • Background and Objetive : The aim of this study is to report 3 cases of facial palsy following microvascular decompression in hemifacial spasm patients. It is a rare disease, with few research on the effect of acupuncture therapy on it. Material and Method : We selected 3 cases of facial palsy following microvascular decompression in hemifacial spasm patients, among patients who visited the Facial palsy Clinic of Kyunghee Oriental Medical Center. We treated them with acupuncture therapy(ST6, ST4, BL2, TE17, GV24, GV14, and Ex-HN4 of the healthy side, and LI4 and ST36 of both sides) and aroma therapy. After treatment we observed and checked any changes within clinical symptoms using the House-Brackmann Grade and the Yanagihara's Unweighted Grading System. Result and Conclusion : 1. All three cases were of hemifacial spasm patients who had facial palsy following microvascular decompression. The patients visited 27 months(Case1), 2 months(Case2) and 7 months(Case 3) after the surgery respectively. 2. Period of time till complete recovery is 23 months(Case1), 8 months(Case2) and 3 month (Case3) respectively. 3. All three cases had symptoms of sequelae: retraction of mouth toward the healthy side and involuntary spasm of lips. The later the initiation of treatment after the sugery, the more severe symptoms of sequelae.

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Clinical Characteristics and Treatment Effects of Shoulder Pain Patients Admitted to a Korean Medicine Hospital Based on MRI Findings (한방병원에 입원한 견통 환자들의 MRI소견에 따른 임상적 특징, 한방치료 효과에 대한 비교고찰)

  • Lim, Su Jin;Jun, Jae Yun;Lee, Chong Whan;Kim, Hae Sol;Kim, Ho Sun;Bae, Young Hyun;Ahn, Ji Hoon
    • Journal of Acupuncture Research
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    • v.31 no.4
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    • pp.109-119
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    • 2014
  • Objectives : The aim of this study is to observe clinical characteristics and treatment outcomes of inpatients admitted to a Korean medicine hospital for shoulder pain based on magnetic resonance imaging(MRI) findings. Methods : 28 patients with MRI data were included. Data on MRI findings, duration of pain, and treatment effects were collected. To measure treatment outcomes, verbal numerical rating scale(VNRS), range of motion(ROM), and a clinical condition grading system were used. Results : 1. The patient population was 75.0 % female and 39.3 %(n=11) belonged to the 51~60-year-old age group. In the under 40 population, 1 or less MRI findings were found. 2. As for the type of disorder, 82.1 % of the patients were diagnosed with 'Supraspinatus lesion', 39.3 % with 'subacromial-subdeltoid(SA-SA) bursitis', and 28.6 % with 'Adhesive capsulitis' 3. Numerous correlations could be made between duration of pain and MRI findings. 'rotator cuff full thickness tear' was more prevalent in acute shoulder pain patients, and 'Adhesive capsulitis' in chronic patients. 4. VNRS and ROM at the time of discharge had significantly improved as compared to VNRS and ROM at the time of admission. 5. As for correlation between MRI findings and clinical condition grade, patients diagnosed with 'rotator cuff partial tear' reported to be in 'good' condition or better whereas those with 'rotator cuff full thickness tear' reported to be in 'fair' condition or worse. Conclusions : Patients admitted to a Korean Medicine hospital for shoulder pain had varying degrees of severity as shown on MRI. Almost all lesions responded well to Korean medicine treatment.

Mechanical Properties of Alkali-Activated Slag-Based Concrete Using Lightweight Aggregates (경량골재를 사용한 알칼리 활성 슬래그 콘크리트의 역학적 특성)

  • Yang, Keun-Hyeok;Oh, Seung-Jin;Song, Jin-Gyu
    • Journal of the Korea Concrete Institute
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    • v.20 no.3
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    • pp.405-412
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    • 2008
  • Six alkali-activated (AA) concrete mixes were tested to explore the significance and limitations of developing an environmental friendly concrete. Ground granulated blast-furnace slag and powder typed sodium silicate were selected as source material and an alkaline activator, respectively. The main parameter investigated was the replacement level of lightweight fine aggregate to the natural sand. Workability and mechanical properties of lightweight AA concrete were measured: the variation of slump with time, the rate of compressive strength development, the splitting tensile strength, the moduli of rupture and elasticity, the stress-strain relationship, the bond resistance and shrinkage strain. Test results showed that the compressive strength of lightweight AA concrete sharply decreased when the replacement level of lightweight fine aggregate exceeded 30%. In particular, the increase in the discontinuous grading of lightweight aggregate resulted in the deterioration of the mechanical properties of concrete tested. The measured properties of lightweight AA concrete were also compared, wherever possible, with the results obtained from the design equations specified in ACI 318-05 or EC 2, depending on the relevance, and the results predicted from the empirical equations proposed by Slate et al. for lightweight ordinary Portland cement concrete. The stress-strain curves of different concrete were compared with predictions obtained from the mathematical model proposed by Tasnimi. The measured mechanical properties of lightweight AA concrete generally showed little agreement with the predictions obtained from these equations.

Shape Improvement and Optimum Gradation of Dry Processed Bottom Ash for Lightweight Mortar (경량 모르터용 건식공정 바텀애시의 입형 개선 효과와 최적 입도)

  • Choi, Hong-Beom;Kim, Jin-Man;Sun, Jung-Soo;Han, Dong-Yeop
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.3 no.1
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    • pp.7-14
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    • 2015
  • The aim of this research is suggesting dry processed bottom ash as a new and economical source of lightweight aggregate for mortar and concrete. The dry process of bottom ash is an advance method of water-free and no chloride because only cooled down by double dry conveyer belt systems. Furthermore, because of relatively slow cooling down process helps burning up the remaining carbon in bottom ash. Using this dry process bottom ash, to evaluate the feasibility of using as a lightweight aggregate for mortar and concrete, two-phase of experiments were conducted: 1) improving shape of the bottom ash, and 2) controlling grade of the bottom ash. From the first phase of experiment, additional abrasing process was conducted for round shape bottom ash, hence improved workability and compressive strength was achieved while unit weight was increased comparatively. Based on the better shape of bottom ash, from the second phase, various grades were adopted on cement mortar, standard grade showed the most favorable results on fresh and hardened properties. It is considered that the results of this research contribute on widening sustainable method of using bottom ash based on the dry process and increasing value of bottom ash as a lightweight aggregate for concrete.

Indices for Quality Evaluation by Physicochemical and Chemoenzymatic Method in Red seabream, Pagrus major (물리 및 효소화학적 방법에 의한 참돔, Pagrus major의 품질판정 지표 설정)

  • 심길보;배진한;정호진;여해경;김태진;조영제
    • Journal of Aquaculture
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    • v.17 no.3
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    • pp.228-232
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    • 2004
  • This study evaluates red seabream quality using physicochemical and chemoenzymatic indices. Breaking strength was correlated with moisture content and lipid content of red seabram by a precedent experiment. Moisture content (X$_1$), lipid content (X$_2$) and breaking strength (Y) were optimized with multiple regression as, Y= -2.53539+0.05544X$_1$-0.00161X$_2$. To test the equation, red seabream (n=13) were randomly purchased and measured moisture content, lipid content and breaking strength. The calculated breaking strength using the equation was similar to breaking strength measured using Rheo meter. Adenylate energy charge (AEC), a general biochemical index of stress, values of all sample were higher than 0.8 expect two fish. Fish's condition was a good. The equation developed in this study predicts breaking strength with moisture and lipid content measured. Moreover the equation may be used in grading cultured red seabream with calculated breaking strength. Grade according to breaking strength, when it came to over 1.4 kg, was measured as high grade; when it came to below 1.2 kg, was measured as low grade. Grade according to AEC, when it came to over 0.8, was measured as high grade.

The Correlation Among the Activity of Daily Living, the Manual Ability and the Gross Motor Function (뇌성마비 아동의 일상생활활동 수행능력과 사물조작기능, 대동작기능의 상관관계 연구)

  • Ko, Yu-Jeong
    • The Journal of Korean Academy of Sensory Integration
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    • v.10 no.1
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    • pp.11-20
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    • 2012
  • Objective : The purpose of this study is intended to provide useful information about the disability evaluation indicators, the Modified Barthel Index (MBI) as a measurement tool for assessing the ability to perform activities of daily living through the correlation between the Modified Barthel Index (MBI) and the Manual Ability Classification System (MACS), and Gross Motor Function Classification System (GMFCS). Methods : The subject was 82 children with cerebral palsy. The validity was aexamined by calculation of correlation between the Modified Barthel Index (MBI), the Manual Ability Classification System (MACS) and Gross Motor Function Classification System (GMFCS). Results : There were a good significant correlation between the MBI and MACS (r = -.765, p <0.001), the MBI and the GMFCS (r = -.851, p < 0.001) and the MACS and the GMFCS (r = .615, p <0.001). Conclusion : The close correlation between the MBI that is used as the basis of grading cerebral palsy and high reliability and validity of the MACS, GMFCS suggest that disability evaluation indicators, the MBI could be useful for children with disabilities.

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A Comparison Study on the Method of Pollution Evaluation of Water Quality in the Stream (하천 수질의 오염도평가 방법의 비교 연구)

  • Lee, Ho-Beom;Lee, Jung-Ki;Shin, Dae-Yewn
    • Journal of Environmental Health Sciences
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    • v.31 no.5 s.86
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    • pp.398-403
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    • 2005
  • This study is undertaken to find the optimal method to make the decision on the degree of water pollution by comparison of K-WQI, KOE-WQI that is made for index with the water quality index and water quality environment standard of the Frame Act on Environment Policy as the result of survey for water quality reality on the major point of the Yeongsan river from 2002 to 2004. The water quality of major rivers has some differences depending on seasons. however, under the water quality standard by the $BOD_5$ density, most of rivers displayed the water quality level of $II{\sim}III$ grading, and on K-WQI that is classified by indexing for 10 categories of pH, DO, $BOD_5,\;COD,\;SS,\;T-N,\;NH_3-N,\;NO_{3^-}$ N, T-P, and E-Coli and classified into 5 groups from 100 points to 40 points, they displayed the score distribution of the first grade in water quality for $85{\sim}100$ points to the second grade in water quality for $70{\sim}84$ points. On KOE-WQI that is classified by indexing for 5 categories of pH, DO, $BOD_5$, COD and T-coli and classified into 5 groups from 90 points or above for outstanding and 29 points or below for very bad, and the water quality distribution is made ranged from the first grade in water quality for 90 points or more to the third grade in water quality for $69{\sim}50$ points. In addition, for the contribution of the water quality decline, the Environmental standard has significant dependency on the $BOD_5$ density, with K-WQI contributing in various water quality decline depending on the environment around the river area of $BOD_5,\;T-N,\;NH_3-N,\;NO_3-N,\;T-P$, and E-Coli, and KOE-WQI acting os the factor contributing to lower the water quality decline by $BOD_5$, COD, and T-coli. As such, the current water quality environment standard has high dependency on $BOD_5$ and KOE-WQI excludes some nitrogen and phosphorus that considers the river environment that the grade in water quality is set by some category, and K-WQI reflected well of the ecology environment of rivers with the diversity of the assessment factor as well as to have the low dependency of specific factor to be objective.