• Journal of the korean academy of Pediatric Dentistry
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• v.49 no.3
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• pp.300-309
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• 2022

This study aimed to evaluate the effects of two ginsenoside Rb1 (G-Rb1) loaded films on oral wound healing. Two types of G-Rb1 films, G-Rb1 loaded carboxymethyl cellulose (GCMC) film and G-Rb1 loaded hyaluronic acid (GHA) film, were developed. A total of 36 Sprague-Dawley rats were divided into 3 groups: control, GCMC, and GHA. After wound formation on midpalate, the control group was left without treatment, whereas the experimental groups had films attached. The specimen was analyzed clinically and histologically after 7 and 21 days. For clinical analysis, the area of incompletely re-epithelialized wound was measured. For histological analysis, the distance between the margins of the wound (soft tissue gap) was measured and the percentage of the collagen-stained area on the specimen was calculated. In clinical and soft tissue gap analysis, the GCMC group presented improved healing compared to the GHA group and the control at day 7 (p < 0.05). And, both GCMC (9.74 ± 10.12%) and GHA groups (19.50 ± 14.47%) presented greater collagen-positive pixels compared to control (0.89 ± 1.60%) at day 7 (p < 0.05). However, there were no differences in these parameters among the groups on day 21. Therefore, G-Rb1 loaded films improved oral wound healing.

• The Academic Congress of Korean Shoulder and Elbow Society
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• 2008.03a
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• pp.178-178
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• 2008

In order to improve static stability and healing of reattached labrum, we combined the advantages of suture bridge and transosseous technique. Using the conventional 3 portal for anterior instability, check stability of bony Bankart and preparation of glenoid bed in 3 way including removal, reshaping or mobilization of bony fragment. Two anchors were inserted to the superior and inferior portion and medial edge of bony Bankart lesion. It usually corresponded to the area of IGHL. Medial mattress sutures were applied around IGHL complex to get enough depth of glenoid coverage using suture hook. Make 3.5mm pushlock anchor hole to the articular edge of glenoid cartilage. Proximal suture bridge was applied at first and then distal suture bridge was inserted to mobilize the labrum in proximal direction. These construction can provide more stable labral repair with wide contact and compression in case of deficient bony stability. It not only avoids technical disadvantage of point contact with anchor fixation, but also decreasing gap formation through cross compression of labrum that couldn't gain even with the transosseous fixation which affords linear compression effect. Additional bony stability could be gained if the the bony fragment was mobilized to the glenoid margin with potential healing bed or reshaped for the good contact with reattached labrum.

• Journal of Haehwa Medicine
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• v.28 no.2
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• pp.41-47
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• 2019

Objectives : Atopic dermatitis is an irritable skin disease accompanying rash and itching leading to impaired skin barrier. ATO-ALL is an ethanol extract of natural products comprising 12 herbs and effective on atopic dermatitis. In this study, we aimed to propose that the effect of ATO-ALL on skin regeneration in human keratinocyte cell line, HaCaT cells. Methods : To evaluate the skin regenerating effects of ATO-ALL, scratch wound healing assay, bromodeoxyuridine (BrdU) assay, and propidum iodide (PI) assay were performed using cultured HaCaT cell line. Result : Scratch wound healing assay showed that ATO-ALL was able to enhance the gap filling activity more than 2-fold at 7 ppm concentration compared with control group. BrdU assay demonstrated that ATO-ALL treatment increased the de novo cell proliferation in a dose-dependent manner. Finally, PI assay indicated that the cell cycle of HaCaT cells was modulated by ATO-ALL treatment. Conclusions : These results suggested that ATO-ALL may have skin regenerating effects by increasing cell proliferation via cell cycle regulation. Taken together, ATO-ALL is supposed to have a potential on regeneration of damaged skin or functional disease including atopic dermatitis.

• Journal of Digital Convergence
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• v.10 no.11
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• pp.433-439
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• 2012

This article aims at developing Mind Healing Program for university students, whose anxiety and depression are getting serious. Reality therapy was experimented total 10 times(one time per week), which was the revision and supplement of Woo(1994)'s reality therapy program. It consists of introducing program and self, understanding 5 mind desires, identifying obstacles of conversation, learning efficient communication skills, controling irrational expectation of others, recognizing mind gap, problems of choice and responsibility, nurturing mind, etc. The effectiveness of this program was verified through a model whose research variants were participation motivation, participation satisfaction, and mental health. Direct effects of participation motivation, participation satisfaction, and mental health were less satisfactory than indirect effects of the time when program satisfaction is a variant. It is concluded that mental health of participants is getting better when more satisfactory program should be provided, rather than motivation of simple participation.

• Journal of Korean Dental Science
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• v.7 no.2
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• pp.58-65
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• 2014

Purpose: This study was performed to evaluate the effect of chitosan combined with absorbable gelatin compressed sponge on the expression of osteoblastic differentiation marker genes during the healing of rat extraction socket. Materials and Methods: Twenty-four male Wistar rats were used. In control group, the extraction socket was closed with suture. In chitosan group, the socket was filled with chitosan combined with Gelfoam (Pharmacia & Upjohn Co.) and closed with suture. In each group, the animals were sacrificed at 3 days, 1 week, 2 weeks, and 4 weeks postoperatively. The expression of osteoblastic differentiation marker genes, including BSP, OCN, Runx2, and Col1 were quantified by real-time polymerase chain reaction. Result: Compared to control group, the mRNA level of BSP in chitosan group increased significantly at 2 weeks after extraction and the level of OCN decreased significantly at 3 days and 4 weeks after extraction (P<0.05). The mRNA levels of OCN, Runx2, and Col1 in chitosan group increased slightly at 2 weeks after extraction, but there was no statistical difference between groups. Conclusion: The results indicate that chitosan has some effects on the expression of osteogenic genes during the healing of extraction sockets.

• Clinics in Shoulder and Elbow
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• v.11 no.2
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• pp.82-89
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• 2008

Ideal rotator cuff repair is to maintain high fixation strength and minimize gap formation for optimizing the environment of biologic healing of tendon to bone. Among the current repair techniques, the suture bridge technique is superior to single- or double-row repair in ultimate load to failure, gap formation, restoring anatomical footprint and achieving pressurized contact area. The suture bridge technique also minimizes gap formation and has rotational and torsional resistances allowing early rehabilitation. However, despite superior biomechanical characteristics of the suture bridge technique, there is no evidence that these mechanical advantages result in better clinical outcomes. Furthermore, there is no difference in failure rates between the double-row repair and suture bridge techniques. An appropriate repair technique should be determined based on tear size and pattern and tendon quality.

• 대한치주과학회:학술대회논문집
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• 2007.11a
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• pp.117-118
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• 2007

• 대한치주과학회:학술대회논문집
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• 2007.11a
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• pp.146-147
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• 2007

• Clinics in Shoulder and Elbow
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• v.20 no.2
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• pp.105-112
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• 2017

Rotator cuff tears commonly affect the shoulder joints. Despite developments in surgical techniques and instrumentation, the treatment of massive rotator cuff tears remains challenging. The problems associated with rotator cuff repairs, such as inferior mechanical properties and high retear rates are yet to be solved. Recently, patch augmentation has been suggested as an alternative treatment because it can reinforce mechanical properties at the initial stage of healing and reduce gap formation. The purpose of this article was to comprehensively summarize the concepts and the consensus surrounding patch augmentation and evaluate the clinical and anatomical outcomes after patch augmentation for massive rotator cuff tears.

• Journal of Korea Artificial Intelligence Association
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• v.1 no.2
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• pp.7-13
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• 2023

In this paper, Depression is a mental disorder characterized by a lack of enthusiasm and feelings of sadness, which significantly impairs daily functioning. In 2018, there was an increase in book sales in the essay genre, particularly the popularity of "healing essays." This trend is seen as challenging the negative image and prejudices associated with depression. In 2021, a significant rise in the proportion of 20-year-old patients with depression is attributed to factors like job-related stress, interpersonal issues, and financial burdens. Additionally, there is a strong correlation between depression and suicidal thoughts, particularly among individuals who have experienced feelings of depression. Despite the increasing prevalence of depression among young adults, research in this area is lacking. To address this gap, statistical tools such as logistic regression and chi-squared tests are employed. The analysis reveals various independent variables associated with feelings of depression, shedding light on the relationships between these factors.