• 한국지진공학회논문집
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• 제1권1호
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• pp.19-24
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• 1997

파형분석에 의한 영월지진의 본진과 두 여진에 대하여 연구하였다. 한국자원연구소(KIGAM)에서 제공된 지진기록의 파형분석을 위하여 12개의 가능한 파형에 대하여 주시곡선과 두 점을 잇는 파선추적이 사용되었다. 영월지진의 파형분석 결과는 다음과 같은 특성을 보여준다. 1) 본진(규모 4.5)에서는 Pn파형이 명확이 보이지만 두 여진(규모 3.8과 2.5)에서는 Pn파형이 보이지 않는다. 2) 두 여진에는 Pg 혹은 PmP파형이 초동파로 도착한다. 3) 비록 콘라드 불연속면이 실제로 존재하더라도 지진기록에서 콘라드면과 관계되는 파형을 구분하기가 어렵다. 4) 경상분지밖에 위치하는 구례(GRE) 관측소의 지진기록은 Pn파형의 도착시간, 주파수 등에서 경상분지 내에 위치하는 관측소의 기록과 비교할 때 차이를 보인다.

• Journal of Korean Neurosurgical Society
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• 제46권1호
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• pp.38-44
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• 2009

Objective : The authors studied the risk factors of silent cerebral microbleeds (MBs) and old hematomas (OHs) and their association with concurrent magnetic resonance (MR) imaging findings in the patients of intracerebral hemorrhages (ICHs). Methods : From April 2002 to June 2007, we retrospectively studied 234 patients of primary hemorrhagic stroke. All patients were evaluated with computed tomography (CT) and 3.0-tesla MR imaging studies within the first week of admission. MBs and OHs were assessed by using $T2^{\ast}$-weighted gradient-echo (GRE) MR imaging. The patients were divided into 2 groups, depending on whether or not they had two GRE lesions of chronic hemorrhages. A correlation between MBs and OHs lesions were also statistically tested. Lacunes and white matter and periventricular hyperintensities (WMHs, PVHs) were checked by T1- and T2-weighted spin-echo and fluid attenuated inversion recovery sequences. Variables on the clinical and laboratory data and MR imaging abnormalities were compared between both groups with or without MBs and OHs. Results : MBs were observed in 186 (79.5%) patients and a total of 46 OHs were detected in 45 (19.2%) patients. MBs (39.6%), OHs (80.4%), and ICHs (69.7%) were most commonly located in the ganglionic/thalamic region. Both MBs and OHs groups were more frequently related to chronic hypertension and advanced WMHs and PVHs. The prevalence and number of MBs were more closely associated with OHs groups than non-OH patients. Conclusion : This study clearly demonstrated the presence of MBs and OHs and their correlation with hypertension and cerebral white matter microangiopathy in the ICHs patients. Topographic correlation between the three lesions (MBs, OHs, and ICHs) was also noted in the deep thalamo-basal location.

• 전자공학회논문지
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• 제51권1호
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• pp.202-208
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• 2014

로봇 시스템에 작용하는 마찰력은 비선형 형태이며 특히 저속에서의 정밀 제어를 어렵게 만든다. 본 논문에서는 로봇 연구에서 자주 활용되고 있는 벤치마크 로봇 시스템의 단축 모델에 대한 동적 마찰 보상 문제를 다룬다. 마찰 모델은 동적 특성 및 다양한 효과를 나타낼 수 있도록 비선형 동적 모델인 LuGre 모델을 고려한다. 본 논문에서 제안하는 제어기는 두 부분으로 구성된다. 동적 마찰의 추정 및 보상을 위해 Dual 관측기 기반의 적응 제어기를 사용한다. 마찰 추정 오차 및 나머지 외란을 보상하기 위해 PI 관측기를 추가로 설계한다. 모의실험을 통해 비선형 동적 마찰이 벤치마크 로봇 시스템의 제어 성능에 미치는 영향을 확인하고 제안된 제어기를 사용함으로써 동적 마찰에 대한 제어 성능이 향상됨을 보인다.

• Molecules and Cells
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• 제39권8호
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• pp.631-638
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• 2016

Glutathione peroxidase 3 (GPx3), an antioxidant enzyme, acts as a modulator of redox signaling, has immunomodulatory function, and catalyzes the detoxification of reactive oxygen species (ROS). GPx3 has been identified as a tumor suppressor in many cancers. Although hyper-methylation of the GPx3 promoter has been shown to down-regulate its expression, other mechanisms by which GPx3 expression is regulated have not been reported. The aim of this study was to further elucidate the mechanisms of GPx3 regulation. GPx3 gene analysis predicted the presence of ten glucocorticoid response elements (GREs) on the GPx3 gene. This result prompted us to investigate whether GPx3 expression is regulated by the glucocorticoid receptor (GR), which is implicated in tumor response to chemotherapy. The corticosteroid dexamethasone (Dex) was used to examine the possible relationship between GR and GPx3 expression. Dex significantly induced GPx3 expression in H1299, H1650, and H1975 cell lines, which exhibit low levels of GPx3 expression under normal conditions. The results of EMSA and ChIP-PCR suggest that GR binds directly to GRE 6 and 7, both of which are located near the GPx3 promoter. Assessment of GPx3 transcription efficiency using a luciferase reporter system showed that blocking formation of the GR-GRE complexes reduced luciferase activity by 7-8-fold. Suppression of GR expression by siRNA transfection also induced down-regulation of GPx3. These data indicate that GPx3 expression can be regulated independently via epigenetic or GR-mediated mechanisms in lung cancer cells, and suggest that GPx3 could potentiate glucocorticoid (GC)-mediated anti-infla-mmatory signaling in lung cancer cells.

• 한국정보과학회논문지:정보통신
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• 제29권1호
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• pp.31-39
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• 2002

VPN이란 공중망에서의 물리적인 구성과 무관하게 논리적으로 폐쇄된 사용자 집단을 구성하여 각종 통신 서비스를 제공하는 기술이다. 이러한 VPN을 구성하기 위해 IP/IP, GRE, L2TP, MPLS 등 다양한 기술들이 제시되었고, 그 중에서 MPLS를 이용한 방식이 다른 기술에서는 제공하기 어려운 QoS, 보안, 관리 유지 등을 제공하는데 많은 장점을 갖고 있다. 본 논문에서는 기존의 라우터 제조업체들에서 제안된 Network 기반 VPN 즉, PE 라우터(Provider Edge Label Switch Router) 기반 MPLS VPN과는 달리 CE 라우터(Customer Edge LSR) 기반의 MPLS VPN 방식을 제시하였다. PE 라우터 기반 MPLS VPN에서의 단점을 보완하기 위해 CE 라우터 기반 MPLS VPN 제어 요소 및 동작 절차를 지역(Customer) 네트웍과 망사업자(Provider) 네트웍에서의 MPLS Edge 라우터를 기반하여 설계하였고, PE 라우터 기반의 MPLS VPN과 CE 라우터 기반의 MPLS VPN의 성능을 비교하였다.

• Genomics & Informatics
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• 제21권4호
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• pp.52.1-52.10
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• 2023

Accurate and efficient microbial diagnosis is crucial for effective molecular diagnostics, especially in the field of human healthcare. The gold standard equipment widely employed for detecting specific microorganisms in molecular diagnosis is quantitative real-time polymerase chain reaction (qRT-PCR). However, its limitations in low metagenomic DNA yield samples necessitate exploring alternative approaches. Digital PCR, by quantifying the number of copies of the target sequence, provides absolute quantification results for the bacterial strain. In this study, we compared the diagnostic efficiency of qRT-PCR and digital PCR in detecting a particular bacterial strain (Staphylococcus aureus), focusing on skin-derived DNA samples. Experimentally, specific primer for S. aureus were designed at transcription elongation factor (greA) gene and the target amplicon were cloned and sequenced to validate efficiency of specificity to the greA gene of S. aureus. To quantify the absolute amount of microorganisms present on the skin, the variable region 5 (V5) of the 16S rRNA gene was used, and primers for S. aureus identification were used to relative their amount in the subject's skin. The findings demonstrate the absolute convenience and efficiency of digital PCR in microbial diagnostics. We suggest that the high sensitivity and precise quantification provided by digital PCR could be a promising tool for detecting specific microorganisms, especially in skin-derived DNA samples with low metagenomic DNA yields, and that further research and implementation is needed to improve medical practice and diagnosis.

• Investigative Magnetic Resonance Imaging
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• 제22권1호
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• pp.1-9
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• 2018

Purpose: This study was designed to optimize the flip angle (FA) and scan timing of the hepatobiliary phase (HBP) using the 3D T1-weighted, gradient-echo (GRE) imaging with controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) technique on gadoxetic acid-enhanced 3T liver MR imaging. Materials and Methods: Sixty-two patients who underwent gadoxetic acid-enhanced 3T liver MR imaging were included in this study. Four 3D T1-weighted GRE imaging studies using the CAIPIRINHA technique and FAs of $9^{\circ}$ and $13^{\circ}$ were acquired during HBP at 15 and 20 min after intravenous injection of gadoxetic acid. Two abdominal radiologists, who were blinded to the FA and the timing of image acquisition, assessed the sharpness of liver edge, hepatic vessel clarity, lesion conspicuity, artifact severity, and overall image quality using a five-point scale. Quantitative analysis was performed by another radiologist to estimate the relative liver enhancement (RLE) and the signal-to-noise ratio (SNR). Statistical analyses were performed using the Wilcoxon signed rank test and one-way analysis of variance. Results: The scores of the HBP with an FA of $13^{\circ}$ during the same delayed time were significantly higher than those of the HBP with an FA of $9^{\circ}$ in all the assessment items (P < 0.01). In terms of the delay time, images at the same FA obtained with a 20-min-HBP showed better quality than those obtained with a 15-min-HBP. There was no significant difference in qualitative scores between the 20-min-HBP and the 15-min-HBP images in the non-liver cirrhosis (LC) group except for the hepatic vessel clarity score with $9^{\circ}$ FA. In the quantitative analysis, a statistically significant difference was found in the degree of RLE in the four HBP images (P = 0.012). However, in the subgroup analysis, no significant difference in RLE was found in the four HBP images in either the LC or the non-LC groups. The SNR did not differ significantly in the four HBP images. In the subgroup analysis, 20-min-HBP imaging with a $13^{\circ}$ FA showed the highest SNR value in the LC-group, whereas 15-min-HBP imaging with a $13^{\circ}$ FA showed the best value of SNR in the non-LC group. Conclusion: The use of a moderately high FA improves the image quality and lesion conspicuity on 3D, T1-weighted GRE imaging using the CAIPIRINHA technique on gadoxetic acid, 3T liver MR imaging. In patients with normal liver function, the 15-min-HBP with a $13^{\circ}$ FA represents a feasible option without a significant decrease in image quality.

• 융합신호처리학회논문지
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• 제16권4호
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• pp.149-155
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• 2015

치아 임플란트는 구강 내에 위치하여 목, 뇌 기저부와 안면부 MR 영상에 영향을 미친다. MR 검사에 사용되어지는 자장의 비균일성은 주로 주파수 부호화 방향으로 신호강도의 변화 및 기하학적인 왜곡으로 인공물을 발생시킨다. 본 연구는 치아 임플란트에 의한 왜곡 정도를 자기공명영상의 신호대 잡음비(singal to noise ratio:SNR)를 평가하여 임플란트 영향 정도를 확인하고자 하였다. 이를 위하여 인체와 유사하게 지방, 근육, 물로 구성된 돼지고기 팬텀을 이용하여 신호대 잡음비를 측정하고, 실험을 위해 제작한 고정형 물 팬텀을 이용하여 신호대 잡음비를 측정하여 치아 임플란트 재료 종류에 따른 신호대 잡음비의 크기를 비교 분석하였다. 돼지고기 팬텀의 Brushite, HSA, Metal, RBM 은 T1 SE에서 2.76, 2.22, 1.88, 1.57 이었고, T2 FLAIR에서 1.88, 1.78, 1.65, 1.79, T2 FSE에서 2.28, 2.25, 2.88, 2.05 T2 GRE에서 2.74, 1.94, 1.67, 1.48의 신호대 잡음비가 측정되었다. 고정형 물 팬텀의 Brushite, HSA, Metal, RBM 은 T1 SE에서 1.93, 1.87, 1.93, 2.06, T2 FLAIR에서 1.83, 1.76, 1.82, 1.92 T2 FSE에서 1.85, 1.79, 7.86, 1.97 T2 GRE는 1.97, 1.93, 1.99, 2.06의 신호대 잡음비가 측정되었다. 이러한 결과를 고려해 볼 때, 치아 임플란트의 재료를 선택할 경우 환자와 치과 의사는 치아의 수복이 주된 목적이지만 여러 분야의 검사에 미치는 영향도 고려해야한다. 또한 환자의 치아 임플란트 재료에 따라 검사 프로토콜을 선택하는데 이 연구 결과가 기초자료로 활용될 수 있다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2009년도 제40회 하계학술대회
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• pp.1640_1641
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• 2009

Dynamic friction and force ripple are the most predominant factors that affect the positioning accuracy of permanent magnet synchronous motor(PMSM) servo drives system, and it is desirable to compensate them in finite time with a continuous control law. In this paper, based on LuGre dynamic friction model, a robust adaptive skidding mode controller is proposed to compensate the nonlinear effect of friction and force ripple. The controller scheme consists of a PD component and a robust adaptive sliding mode controller for estimating the unknown system parameter. Using Lyapunov stability theorem, asymptotic stability analysis and position tracking performance are guaranteed. Simulation results well verify the feasibility and the effectiveness of the proposed scheme for high0precision motion trajectory tracking.

• 전기학회논문지P
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• 제59권2호
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• pp.163-172
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• 2010

A robust positioning control system has been studied using a friction parameter observer and a recurrent fuzzy neural network based on the sliding model. To estimate a nonlinear friction parameters of the LuGre friction model, a dual friction model-based observer is introduced. In addition, an approximating method for a system uncertainty has been developed using a recurrent fuzzy neural network technique to improve positioning performance. Experimental results have been presented to validate the performance of a proposed intelligent compensation scheme.