• 환경위생공학
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• 제18권3호통권49호
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• pp.11-20
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• 2003

There are two ways of reducing air pollution. One is the approach of the pollutant source control and the other one is the traffic demand decreasing approach. This study is focusing on the approach of land use planning and optimal location of urban facilities because those are the basic cause to generate transportation demands. So, the purpose of this study would be to analyze the changes of NOx and CO distribution on environmental air by functional hierarchy of urban roads and to make evaluation model of 'Transportation-Land Use -Air Pollution'. It will contribute to improve the air pollution level at same actual traffic generation according to different location.

• 한국정밀공학회지
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• 제16권5호통권98호
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• pp.124-131
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• 1999

DVD(Digital Versatile Disk) is the data storage media devised to make high storage density and high speed data input/output possible. For example, a whole length movie can be stored in a disk as large as a CD(Compact Disk). Therefore higher rotational speed and better accuracy in optical pick-up are required compared with the existing optical storage device. Without these operational functional requirements being satisfied DVD will lose its place as the high capacity storage device. This paper evaluated whether the currently developed DVD satisfies the requirements and provides improved methods with the Axiomatic Approach which is superb in evaluating and designing newly concepted designs.

• Industrial Engineering and Management Systems
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• 제15권4호
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• pp.432-445
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• 2016

A random profile is the result of a process, the output of which is a function instead of a scalar or vector quantity. In the nature of these objects, two main dimensions of "functionality" and "randomness" can be recognized. Valuable researches have been conducted to present control charts for monitoring such processes in which a regression approach has been applied by focusing on "randomness" of profiles. Performing other statistical techniques such as hypothesis testing for different parameters, comparing parameters of two populations, ANOVA, DOE, etc. has been postponed thus far, because the "functional" nature of profiles is ignored. In this paper, first, some needed theorems are proven with an applied approach, so that be understandable for an engineer which is unfamiliar with advanced mathematical analysis. Then, as an application of that, a statistical test is designed for mean of continuous random profiles. Finally, using experimental operating characteristic curves obtained in computer simulation, it is demonstrated that the presented tests are properly able to recognize deviations in the null hypothesis.

• Clinical and Experimental Pediatrics
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• 제49권2호
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• pp.129-135
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• 2006

Chronic recurrent abdominal pain is a common manifestation in children. Functional abdominal pain is the most common cause of chronic abdominal pain and can be diagnosed properly by the physician without the requirement of specific evaluation when there are no alarm symptoms or signs. Functional abdominal pain is categorized as functional dyspepsia, irritable bowel syndrome, functional abdominal pain, abdominal migraine, and aerophagia, according to the Rome II criteria for pediatric functional gastrointestinal disorders. New concepts on the pathogenesis of functional abdominal pain include brain-gut interaction, visceral hypersensitivity, gastrointestinal dysmotility, inflammation, autonomic dysfunction, genetic predisposition, and triggering factors including psycho-social stress.

• Communications for Statistical Applications and Methods
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• 제29권1호
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• pp.103-125
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• 2022

In this paper, we analyze the time series data of the case and death counts of COVID-19 that broke out in China in December, 2019. The study period is during the lockdown of Wuhan. We exploit functional data analysis methods to analyze the collected time series data. The analysis is divided into three parts. First, the functional principal component analysis is conducted to investigate the modes of variation. Second, we carry out the functional canonical correlation analysis to explore the relationship between confirmed and death cases. Finally, we utilize a clustering method based on the Expectation-Maximization (EM) algorithm to run the cluster analysis on the counts of confirmed cases, where the number of clusters is determined via a cross-validation approach. Besides, we compare the clustering results with some migration data available to the public.

• Korean Journal of Mathematics
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• 제17권3호
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• pp.331-340
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• 2009

We show the existence of nonconstant periodic solution for the nonlinear Hamiltonian systems with some nonlinearity. We approach the variational method. We use the critical point theory and the variational linking theory for strongly indefinite functional.

• Archives of Pharmacal Research
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• 제27권10호
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• pp.985-989
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• 2004

A functional divergency oriented synthetic approach to the azoninone (9-membered lactams), key intermediate for the indolizidine alkaloids library, using amide enolate induced aza-Claisen rearrangement has been achieved.

• 대한수학회보
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• 제8권1호
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• pp.9-15
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• 1971

The purpose of this note is to use primitive recursive functions and predicates similar to those presented by Davis [2] to show the well-known result first proved by Godel in [3] that the well-formed formulas of a pure functional calculus form a recursive set. The technique shown in this paper immediately suggests a unique approach to Theorem proving using a computer.

• 한국전문물리치료학회지
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• 제10권2호
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• pp.11-22
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• 2003

The purpose of this study was to analyze the effects of three different pelvic tilts on a sit-to-stand (STS) and to suggest a new assessment approach based on biomechanical analysis. The three difrent pelvic tilts were: (1) comfortable pelvic tilt sit-to-stand (CPT STS), (2) posterior pelvic tilt sit-to-stand (PPT STS) and (3) anterior pelvic tilt sit-to-stand (APT STS). To determine the onset time of muscle contraction surface electrodes were applied to the rectus femoris muscle (RF), vastus lateralis muscle (VL), biceps femoris muscle (BF), tibialis anterior muscle (TA), gastrocnemius muscle (GCM), and soleus muscle (SOL). The ICC was used for functional linkage analysis. The findings of this study were as follows. First, significant differences were found in kinematic variables and in muscle activation pattern among the three activities. Second, the results of functional integrated analysis revealed that recruited muscle activation patterns changed when the thigh-off was viewed as a reference point. Third, there were independent functional units between the thigh-off and the VL and between the thigh-off and the RF in the functional linkage analysis. The VL and RF acted as prime mover muscles, and more postural adjustment muscle recruitment was required as the demand of postural muscle control increased (PPT STS, APT STS, and CPT STS in order). In conclusion, the findings of this study suggest the following evaluative and therapeutic approach for STS activity. APT STS can be introduced for movement efficiency and functional advantage when abnormal STS is treated. However, excessive APT would change the muscle activation patterns of BF and SOL and require additional postural muscle control to cause abnormal control patterns.

• Molecules and Cells
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• 제44권7호
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• pp.500-516
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• 2021

Cardiac hypertrophic signaling cascades resulting in heart failure diseases are mediated by protein phosphorylation. Recent developments in mass spectrometry-based phosphoproteomics have led to the identification of thousands of differentially phosphorylated proteins and their phosphorylation sites. However, functional studies of these differentially phosphorylated proteins have not been conducted in a large-scale or high-throughput manner due to a lack of methods capable of revealing the functional relevance of each phosphorylation site. In this study, an integrated approach combining quantitative phosphoproteomics and cell-based functional screening using phosphorylation competition peptides was developed. A pathological cardiac hypertrophy model, junctate-1 transgenic mice and control mice, were analyzed using label-free quantitative phosphoproteomics to identify differentially phosphorylated proteins and sites. A cell-based functional assay system measuring hypertrophic cell growth of neonatal rat ventricle cardiomyocytes (NRVMs) following phenylephrine treatment was applied, and changes in phosphorylation of individual differentially phosphorylated sites were induced by incorporation of phosphorylation competition peptides conjugated with cell-penetrating peptides. Cell-based functional screening against 18 selected phosphorylation sites identified three phosphorylation sites (Ser-98, Ser-179 of Ldb3, and Ser-1146 of palladin) displaying near-complete inhibition of cardiac hypertrophic growth of NRVMs. Changes in phosphorylation levels of Ser-98 and Ser-179 in Ldb3 were further confirmed in NRVMs and other pathological/physiological hypertrophy models, including transverse aortic constriction and swimming models, using site-specific phospho-antibodies. Our integrated approach can be used to identify functionally important phosphorylation sites among differentially phosphorylated sites, and unlike conventional approaches, it is easily applicable for large-scale and/or high-throughput analyses.