• Korean Journal of Fisheries and Aquatic Sciences
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• v.43 no.3
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• pp.270-276
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• 2010

This study estimated the heavy metal concentrations in octopus (Octopus minor) and conducted a food safety assessment of octopus. Octopus, a benthic cephalopod, was collected from the Seosan intertidal zone on the west coast of Korea. The samples were digested with acids, and then the cadmium (Cd), copper (Cu), and zinc (Zn) contents were analyzed using inductively coupled plasma mass spectrometry (ICP-MS). The Cd, Cu, and Zn range of concentrations in octopus were 0.06-19 (mean 5.8), 44-1,463 (mean 354.8), and 76-929 (mean 247.9) mg/kg on a dry weight basis, respectively. The concentrations of heavy metals were higher in the internal organs than in the mantle. Of the three heavy metals, copper had the highest concentrations in the internal organs because of the existence of hemocyanin bound with copper in octopus blood, whereas zinc had the highest concentrations in the mantle. No relationship between the concentration of heavy metals and biological parameters (length, weight, and sex) was found. The ratios (I/M) of the heavy metal concentrations in internal organs and mantle were highest for cadmium, although cadmium had much lower concentrations in the internal organs compared with copper and zinc. Considering the provisional tolerable weekly intake (PTWI) of the three heavy metals and the average intake of octopus per day, all three elements should have no adverse effects on humans.

• Journal of Environmental Science International
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• v.16 no.11
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• pp.1287-1293
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• 2007

To obtain the risk assessment of hazardous materials in Rehmanniae Radix Preparata, the residual pesticides and heavy metals in samples on the Korea and China are surveyed. Group I ($BHC-{\delta}$, $BHC-{\beta}$, Fenitrothion, Penthoate, Endosulfan-${\alpha}$, Dieldrin, Endosulfan-${\beta}$ and Endosulfan-sulfate), Group II (BHC-${\gamma}$, Aldrin, DDD, DDT-p,p Permethrin and Fenvalerate), Group III(BHC-${\alpha}$, Chlorpyrifos, Tolyfluanid, Captan and DDT-o,p) and Group IV(Quintozene, Vinclozolin, DDE and Chlorfenapyr) could analysed on gas chromatography-ECD for evaluation of residual pesticides. Qualified detection concentration on the GC-ECD are $0.45 ng/g{\sim}2.50 ng/g$. Group I, Group II, Group III and Group IV are not detected in Rehmanniae Radix Preparata on the Korea and China. Concentration of As, Cd and Pb in Rehmanniae Radix Preparata. on the Korea are 3.06%, 7.00% and 5.78% for Korea Food & Drug Administration(KFDA). Concentration of As, Cd and Pb in Rehmanniae Radix Preparata. on the China are 5.16%, 5.33% and 6.50% for Korea Food & Drug Administration(KFDA). The hazardous materials in Rehmanniae Radix Preparata on the Korea and China were verified the safety of the residual heavy metals and pesticides compare with Korea Food & Drug Administration (KFDA) advisory level.

• Korean journal of food and cookery science
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• v.26 no.6
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• pp.811-820
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• 2010

The purpose of this study was to investigate the practices for management manual development of Good Restaurants in order to apply Green Safety Management technology. A total of 128 restaurants in Seoul according to restaurant size and style were analyzed by SPSS (window ver. 12.0). Exactly 38.3% of those surveyed purchased manicured vegetables and seafood that generates less garbage; Korean restaurants displayed the lowest frequency of purchasing preprocessed foodstuff, and Japanese restaurants had the most refrigerators and thermometers and kept the refrigeration temperature the lowest. Exactly 56.5% of the restaurants sold large and small amounts of main menu separately; Chinese restaurants displayed the highest rate while Western restaurants displayed the lowest. Furthermore, only 7.3% of the restaurants were willing to sell either large or small amounts of the same menu item. Japanese style menu had the most number of side dishes (6.1) while Western style menu had the lowest (1.8). Most of the restaurants were equipped with containers for leftovers (87.4%), but the rate of customers who took out leftovers significantly differed depending on the style of restaurant (p<0.05).

• Journal of Food Hygiene and Safety
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• v.14 no.3
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• pp.293-304
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• 1999

The purpose of this study was to evaluate the microbiological quality, and to assure the hygienic safety of the food production in the university food service facility located in Seoul in accordance with the Hazard Analysis Critical Control Point(HACCP) concepts. In the hygienic state assessment of kitchen, it has revealed that it was very important to remove water from the kitchen floor and to establish standard method for disinfection of cooking utensils. And foodservice workers were required to have training program for the safe handling of food and utensils since they did treat food without hygienic gloves. The kitchen layout had to be improved because the near distance of table with heating unit and shelf might cause the growth of microorganisms when prepared food was kept on the shelf. In terms of the timetemperature measurement and microbiological quality assessment during each of the food production phases, most of sengchae (raw vegetable dish) and namul (cooked vegetable dish) were treated within danger zone for food safeness ($5~60^{\circ}C$). It has shown that the microbiological quality of raw materials was very much inferior at the time of receiving based on the TPC($10^{5}~10^{7}$), coliform($10^{3}~1O^{6}$), which was not acceptable level(TPC:$10^{6}$, coliform:$10^{3}$) suggested by Solberg. Microbiological growth has increased in the both of sengchae and namul considerably during most of food production phase. Therefore, it is extremely important to reduce holding and serving time and to avoid treating food within the danger zone for food safeness. In addition, the prevention of cross-contamination during mixing the ingredients with improper equipments and with insanitary treatments by workers was also important to keep the food safety in this speciqic university foodservice facility.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.4
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• pp.90-98
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• 2021

Since 2017, the Occupational Safety and Health Act has been fully applied to school food services, and risk assessments have been implemented since 2019. The introduction was slow compared to other industries and was evaluated by non-professional nutritionists, so there was a limit to establishing the system. All schools under the Seoul Metropolitan Office of Education apply the KRAS every year in accordance with the OSH Act for school foodservice and a notice from the Ministry of Employment and Labor. A risk assessment is applied according to legal regulations. On the other hand, the effectiveness of risk assessment has been questioned because the frequency and intensity criteria of the risk are qualitative and subjective. Based on the accident statistics of catering workers, the frequency and intensity criteria of risk were presented quantitatively and objectively, and a risk assessment was conducted by applying a new calculation standard for some work during the catering service and compared with current risk assessment results. The risk was increased, and the improved effectiveness was confirmed by the specific suggestions for improvement. Thus, the pilot evaluation for the entire food service should be expanded, and the feasibility confirmed. The pilot evaluation should be applied to all schools to enhance the effectiveness and operability of the risk assessment.

• The Korean Journal of Pesticide Science
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• v.17 no.4
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• pp.302-306
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• 2013

We report the dietary exposure to rotenone in the Korean population and children (1-18) through consumption of lettuce and cucumber. To obtain the residue data, we analyzed using the GC-NPD and HPLC-DAD method. Rotenone residues in samples were as follows; lettuce 0.16-1.15, cucumber < 0.001-0.006. The average dietary intake was determined using result from the 2009 Korea National Health and Nutrition Examination Survey Data. The risk index (RI) was calculated using rotenone residues and dietary intakes. The lettuce and cucumber showed the highest at 18.41%, 0.00, respectively. RI fell below 100 of %RfD showing no risks in these vegetables. Therefore, the risk assessment on the detected rotenone was evaluated as safe level.

• Analytical Science and Technology
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• v.33 no.5
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• pp.215-223
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• 2020

The objectives of the present study were to assess the oxidative stability of South Korean n-3 (omega-3 fatty acid) supplements carried out from 2018 to 2019 and evaluate the influence of product characteristics on oxidative safety. A total of 76 n-3 supplements were analysed for oxidation safety by four markers, including acid value (AV), primary oxidation (peroxide value, PV), secondary oxidation (p-anisidine value, pAV) and total oxidation value (TOTOX). Among the supplements tested, 5.3 %, 55.3 %, 28.9 % and 46.1 % exceeded the international voluntary recommended levels for AV, PV, pAV and TOTOX, respectively. Purity (%) of products, remainder of expiration date (suggested shelf life), package in press through package (PTP) and products with additives had statistically significant differences oxidation assessment levels (p < 0.05). In addition, n-3 group found in Algae oil had significantly lower AV levels than the group that did not, and product with Alaska pollack oil, had significantly higher pAV levels than without group (p < 0.05). The high oxidation status of South Korean n-3 products in the present study could not be considered a public health problem right now. However, the levels of oxidation may affect a lot the efficacy and safety of using n-3 supplements. Thus, current oxidation safety limits should be reestablished by regulatory bodies to ensure the safety and efficacy of n-3 supplements, so that the standards could be applied to the products available to consumers.

• Korean Journal of Clinical Pharmacy
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• v.23 no.3
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• pp.239-247
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• 2013

Background: Fixed drug combinations are formulations containing two or more active ingredients in a single dosage form. Such combination therapies are commonly applied to improve efficacy, reduce adverse events and replace co-administration, etc. National and international guidelines for hypertension treatment recommend addition of other classes of antihypertensive drugs rather than incremental dose of mono-therapy, when blood pressure is not adequately controlled. Thus, many dual combinations of antihypertensive drugs have been approved and pharmaceutical companies are recently interested in developing antihypertensive triple combinations. Clinical trial designs for the fixed combinations are various depending on the target patients, dosage and clinical endpoints. Thereby, further discussions for the clinical trials of antihypertensive triple therapies are required regarding the indication claimed. Conclusion: This article provides a review for the assessment of the label and medical reports of the clinical trials on antihypertensive triple therapies in advanced foreign countries.

• Korean Journal of Environmental Agriculture
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• v.31 no.1
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• pp.37-44
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• 2012

BACKGROUND: Many edible mushrooms are known to accumulate high levels of heavy metals. This research was focused on health risk assessment to investigate the mushrooms in Korea, arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) contaminations in edible mushrooms in cultivated areas were investigated, and health risk was assessed through dietary intake of mushrooms. METHODS AND RESULTS: The heavy metals in mushrooms were analyzed by ICP/MS after acid digestion. Probabilistic health risk were estimated by Monte-Carlo simulation techniques. The average contents of As, Cd, Pb, and Hg were $0.035{\pm}0.042$ mg/kg, $0.017{\pm}0.020$ mg/kg, $0.043{\pm}0.013$ mg/kg, and $0.004{\pm}0.004$ mg/kg, respectively. The results showed that contents of Cd and Pb did not exceed maximum residual levels established by European Uion regulation (Cd 0.20 mg/kg and Pb 0.30 mg/kg). For health risk assessment, estimated intakes in all age populations did not exceed the provisional tolerable daily intake of As and Hg, provisional tolerable monthly intake of Cd, provisional tolerable weekly intake of Pb. The Hazard Index (HI) were ranged from $0.03{\times}10^{-4}{\sim}0.01{\times}10^{-3}$ for As, $0.02{\times}10^{-3}{\sim}0.81{\times}10^{-3}$ for Cd, $0.06{\times}10^{-3}{\sim}0.38{\times}10^{-3}$ for Pb, and $0.08{\times}10^{-4}{\sim}0.14{\times}10^{-3}$ for Hg at general population. CONCLUSION: The HI from the ratio analysis between daily exposure and safety level values was less than 1.0. This results demonstrated that human exposure to heavy metals through dietary intake of mushrooms might not cause adverse effect.

• Journal of Food Hygiene and Safety
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• v.18 no.3
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• pp.107-112
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• 2003

Probabilistic exposure assessment has been recognized as an important tool in microbial risk assessment, because of obtained the desired results to characterize of variability and uncertainty associated with the microbial hazards. In addition, it will be provided much more actuality information than the point-estimate approaches. In this study, we present methodology using mathematical probability distribution in exposure assessment and estimating of contamination level of Listeria monocytogenes in meat and meat products as a case study. The result of estimation contaminatin level was mean ($50^{th}$ percentile) -4.08 Log CFU/g minimum ($5^{th}$ percentile) -4.88 Log CFU/g, maximum ($95^{th}$ percentile) -3.56 Log CFU/g.