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Comparison of Clinical Development and Evaluation of Triple Antihypertensive Therapy in Advanced Foreign Countries  

Wang, So Young (Pharmaceutical Safety Bureau, Ministry of Food and Drug Safety)
Shon, Soo Jung (Drug Evaluation Department, National Institute of Food and Drug Safety Evaluation)
Um, Jung Yoon (Drug Evaluation Department, National Institute of Food and Drug Safety Evaluation)
Lim, Hwa Kyung (Drug Evaluation Department, National Institute of Food and Drug Safety Evaluation)
Lim, Sook (Drug Evaluation Department, National Institute of Food and Drug Safety Evaluation)
Kang, Seung Ho (Department of Applied Statistics, Yonsei University)
Lee, Sun Hee (Drug Evaluation Department, National Institute of Food and Drug Safety Evaluation)
Publication Information
Korean Journal of Clinical Pharmacy / v.23, no.3, 2013 , pp. 239-247 More about this Journal
Abstract
Background: Fixed drug combinations are formulations containing two or more active ingredients in a single dosage form. Such combination therapies are commonly applied to improve efficacy, reduce adverse events and replace co-administration, etc. National and international guidelines for hypertension treatment recommend addition of other classes of antihypertensive drugs rather than incremental dose of mono-therapy, when blood pressure is not adequately controlled. Thus, many dual combinations of antihypertensive drugs have been approved and pharmaceutical companies are recently interested in developing antihypertensive triple combinations. Clinical trial designs for the fixed combinations are various depending on the target patients, dosage and clinical endpoints. Thereby, further discussions for the clinical trials of antihypertensive triple therapies are required regarding the indication claimed. Conclusion: This article provides a review for the assessment of the label and medical reports of the clinical trials on antihypertensive triple therapies in advanced foreign countries.
Keywords
Antihypertensive drug; Triple combination therapies; Initial therapy; Add-on/switch therapy; Substitutional/replacement therapy;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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