• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.30 no.5
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• pp.380-390
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• 2004

Bone healing plays an important role in orthognathic and craniofacial surgery. Bone tissue repair and regeneration are regulated by an array of growth and morphogenetic factors. Bone formation and remodeling require continuous generation of osteoprogenitor cells from bone marrow stromal cells, which generate and respond to a variety of growth factors with putative roles in hematopoiesis and mesenchymal differentiation. In this study, the efficacy of a single application of hepatocyte growth factor to promote bone regeneration in 5-mm experimental calvarial defects of adult male rats was assessed histologically and immunohistochemically. The result of the experimental site were compared with those of the contralateral contral side. None of the control and experimental bone defects demonstrated complete bone closure. Bone regeneration was found close th the margine and central part of the defects. At 1, 2 weeks, there were found much significant cellural mitotic activity and many inflammatory cells and osteoblasts on the experimental site than control site. At 4, 6 weeks, new bone apposition was founded in both site but, more apposition was seen at experimental site. At 8, 12 weeks, also, some differences was found that more apposition of new bone and collagen fiber was seen on experimental site. Our results have some possibility that HGF do a early positive role to repair the bone defect. More study will be needed.

• Nutrition Research and Practice
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• v.9 no.4
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• pp.343-349
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• 2015

BACKGROUND/OBJECTIVES: Fermentation of dietary fiber results in production of various short chain fatty acids in the colon. In particular, butyrate is reported to regulate the physical and functional integrity of the normal colonic mucosa by altering mucin gene expression or the number of goblet cells. The objective of this study was to investigate whether butyrate modulates mucin secretion in LS174T human colorectal cells, thereby influencing the adhesion of probiotics such as Lactobacillus and Bifidobacterium strains and subsequently inhibiting pathogenic bacteria such as E. coli. In addition, possible signaling pathways involved in mucin gene regulation induced by butyrate treatment were also investigated. MATERIALS/METHODS: Mucin protein content assay and periodic acid-Schiff (PAS) staining were performed in LS174T cells treated with butyrate at various concentrations. Effects of butyrate on the ability of probiotics to adhere to LS174T cells and their competition with E. coli strains were examined. Real time polymerase chain reaction for mucin gene expression and Taqman array 96-well fast plate-based pathway analysis were performed on butyrate-treated LS174T cells. RESULTS: Treatment with butyrate resulted in a dose-dependent increase in mucin protein contents in LS174T cells with peak effects at 6 or 9 mM, which was further confirmed by PAS staining. Increase in mucin protein contents resulted in elevated adherence of probiotics, which subsequently reduced the adherent ability of E. coli. Treatment with butyrate also increased transcriptional levels of MUC3, MUC4, and MUC12, which was accompanied by higher gene expressions of signaling kinases and transcription factors involved in mitogen-activated protein kinase (MAPK) signaling pathways. CONCLUSIONS: Based on our results, butyrate is an effective regulator of modulation of mucin protein production at the transcriptional and translational levels, resulting in changes in the adherence of gut microflora. Butyrate potentially stimulates the MAPK signaling pathway in intestinal cells, which is positively correlated with gut defense.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.3
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• pp.667-673
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• 2015

A laser diode(LD) has been studied in many fields what medical, industrial processing, sensor, advertising equipment, printing equipment. And the LD is being used in industry. However, LD will require precision handling. Therefore, the actual use of LD is limited to areas of specialization. In this study, attend to the characteristics of the LD what weak to electrostatic and physical impact, current and heat. And will make a sample module that use comfortably a various wavelength LD. Furthermore, Furthermore, through the printing CTP(Computer to Plate) equipment used the 128-channel LD-Driver, compares it with a 64-channel CTP device about the print speed and resolution. And will solved the problem of delay between the dot and the dot. Finally, consider the potential of the 256-channel LD-Driver.

• Korean Journal of Optics and Photonics
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• v.14 no.5
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• pp.504-508
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• 2003

We present a new point-diffraction interferometer, which has been devised for the three-dimensional profile measurement of light scattering rough surfaces. The interferometer system has multiple sources of two-point-diffraction and a CCD camera composed of an array of two-dimensional photodetectors. Each diffraction source is an independent two-point-diffraction interferometer made of a pair of single-mode optical fibers, which are housed in a ceramic ferrule to emit two spherical wave fronts by means of diffraction at their free ends. The two spherical wave fronts then interfere with each other and subsequently generate a unique fringe pattern on the test surface. A He-Ne source provides coherent light to the two fibers through a 2${\times}$l optical coupler, and one of the fibers is elongated by use of a piezoelectric tube to produce phase shifting. The xyz coordinates of the target surface are determined by fitting the measured phase data into a global model of multilateration. Measurement has been performed for the warpage inspection of chip scale packages (CSPs) that are tape-mounted on ball grid arrays (BGAs) and backside profile of a silicon wafer in the middle of integrated-circuit fabrication process. When a diagonal profile is measured across the wafer, the maximum discrepancy turns out to be 5.6 ${\mu}{\textrm}{m}$ with a standard deviation of 1.5 ${\mu}{\textrm}{m}$.

• Korean Journal of Optics and Photonics
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• v.14 no.5
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• pp.509-514
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• 2003

Mach-Zehnder interferometric wavelength converters with monolithically integrated semiconductor optical amplifiers (SOA's) have been fabricated and characteristics of wavelength conversion at 10 Gb/s have been investigated for wavelength span of 40 nm. The devices have been achieved by using a butt-joint combination of buried ridge structure type SOA's and passive waveguides. In the integration, a new method has been applied that removes p+InP cladding layer leading to high propagation loss and forms simultaneously the current blocking and the cladding layer using undoped InP. The module packaging has been achieved by using a titled fiber array for effective coupling into the tilted waveguide in the wavelength converter. Using the module, wavelength conversion with power penalty lower than 1 ㏈ at 10 Gb/s has been demonstrated for wavelength span of 40 nm. In addition, it is show that the module can provide 2R (re-amplification, re-shaping) operation by demonstrating the conversion with the negative penalty.

• Journal of Animal Environmental Science
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• v.20 no.3
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• pp.117-124
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• 2014

The objectives were to assess the use of near-infrared reflectance spectroscopy (NIRS) as a tool for estimating nutrient compositions of corn kernel, and to apply an NIRS-based indium gallium arsenide array detector to the system for collecting spectra and analyzing calibration equations using equipments designed for field application. Partial Least Squares Regression (PLSR) was employed to develop calibration equations based on representative data sets. The kennard-stone algorithm was applied to induce a calibration set and a validation set. As a result, the method for structuring a calibration set significantly affected prediction accuracy. The prediction of chemical composition of corn kernel resulted in the following (kennard-stone algorithm: relative) moisture ($R^2=0.82$, RMSEP=0.183), crude protein ($R^2=0.80$, RMSEP=0.142), crude fat ($R^2=0.84$, RMSEP=0.098), crude fiber ($R^2=0.74$, RMSEP=0.098), and crude ash ($R^2=0.81$, RMSEP=0.048). Result of this experiment showed the potential of NIRS to predict the chemical composition of corn kernel.

• Journal of the Korean Ceramic Society
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• v.41 no.7
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• pp.528-533
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• 2004

Macroporous SiC with pore size 84∼658 nm and mesoporous SiC with pore size 15∼65 nm were respectively prepared by infiltrating low viscosity preceramic polymer solutions into the various sacrificial templates obtained by natural sedimentation or centrifuge of 20∼700 nm silica sol, which were subsequently etched off with HF after pyrolysis at 1000∼140$0^{\circ}C$ in an argon atmosphere. Three-dimensionally long range ordered macroporous SiC ceramics derived from polymethylsilane (PMS) showed surface area 584.64$m^2$g$^{-1}$ when prepared with 112nm silica sol and at 140$0^{\circ}C$, whereas mesoporous SiC from polycarbosilane (PCS) exhibited the highest surface area 619.4 $m^2$g$^{-1}$ with random pore array when prepared with 20-30 nm silica sol and at 100$0^{\circ}C$. Finally, tile pore characteristics of porous SiC on the types of silica sol, polymers and pyrolytic conditions were interpreted with the analytical results of SEM, TEM, and BET instruments.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.1
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• pp.51.1-51.1
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• 2014

DOTIFS is a new multi-object Integral Field Spectrograph (IFS) being designed and fabricated by the Inter-University Center for Astronomy and Astrophysics, Pune, India, (IUCAA) for the Cassegrain side port of the 3.6m Devasthal Optical Telescope (DOT). The telescope is constructed by the Aryabhatta Research Institute of Observational Sciences, Nainital (ARIES). Its main scientific objectives are the physics and kinematics of the ionized gas, star formation and H II regions in nearby galaxies. It is a novel instrument in terms of multi-IFU, built in deployment system, and high throughput. It consists of one magnifier, 16 integral field units (IFUs), and 8 spectrographs. Each IFU is comprised of a microlens array and 144 optical fibers, and has $7.4^{\prime\prime}{\times}8.7^{\prime\prime}$ field of view with 144 spaxel elements with a sampling of 0.8" hexagonal aperture. The IFUs can be deployed on the telescope side port over an 8' diameter focal plane by x-y actuators. 8 Identical, all refractive, dedicated fiber spectrographs will produce 2,304 R~1800 spectra over 370-740nm wavelength range with single exposure. Currently, conceptual and baseline design review had been done, and is in the critical design phase with a review planned for later this year. Some of the components have already arrived. The instrument will see its first light in 2015.

• Journal of Biomedical Engineering Research
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• v.21 no.3 s.61
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• pp.233-237
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• 2000

In general. fiber-optic medical endoscopes are made from glass step index (SI) fibers. These endoscopes have limitations in both image quality and mechanical properties. In particular. the image resolution of the SI endoscopes is limited to about 5$\mu$m. In this study the image resolution of plastic graded index (GRIN) super-resolution image guides with pixel sizes from 7 to 2.5 $\mu$m were measured and compared with those of 91ass SI image guides. There is an improvement in resolution of the plastic GRIN image guides as the microfiber diameter is reduced from 7 $\mu$m to 2.5 $\mu$m. The measured resolution of plastic GRIN image guide with 2.5 $\mu$m microfibers is more than a factor of two higher than that of g1ass SI image guide with 5$\mu$m microfibers. This new design of optical systems could have a major impact on a wide array of future optical systems used in defense. industrial, and medical applications.

• Journal of the Society of Naval Architects of Korea
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• v.46 no.6
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• pp.667-674
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• 2009

The researches on the development of composite material underwater vehicle propeller have been actively attempted for the reduction of radiation noise with outstanding damping effects. Composite material propellers have almost been designed and produced by the foreign experts, and it is difficult to obtain the related informations about their flow, vibration, material characteristics because they are treated as the secrets with close relationship to the military technology, especially in the case of underwater vehicles. For the security of domestic manufacture of composite material propeller and the comparison and examination of its performance and radiation noise characteristics with those of German CONTUR composite material propeller, two propellers were self-produced according to the fiber weaving and array using compressible molding process and their self performances and radiation noise characteristics were measured. The mean fluctuations of blade tip of self-produced composite material propeller were increased and the radiation noises in the low frequency band were reduced compared to those of CONTUR, which could be estimated as the change of material characteristics and also be thought to be used for the future research informations.