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Iron-fortified recombinant Saccharomyces cerevisiae producing Sus scrofa ferritin heavy-chain recovers iron deficiency in mice

  • Lim, Hwan;Kim, Jong-Taek;Kim, Myoung-Dong;Rhee, Ki-Jong;Jung, Bae Dong
    • Korean Journal of Veterinary Research
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    • v.52 no.4
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    • pp.263-268
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    • 2012
  • In this study, we produced iron-fortified yeast (Saccharomyces cerevisiae) producing Sus scrofa ferritin heavy-chain to provide iron supplementation in anemic piglets. We determined whether iron-ferritin accumulated in recombinant yeasts could improve iron deficiency in mice. C57BL/6 male mice exposed to Fe-deficient diet for 2 weeks were given a single dose of ferrous ammonium sulfate (FAS), ferritin-producing recombinant yeast (APO), or APO reacted with iron ($Fe^{2+}$) (FER). The bioavailability of recombinant yeasts was examined by measuring body weight gain, hemoglobin concentration and hematocrit value 1 week later. In addition, ferritin protein levels were evaluated by western blot analysis and iron stores in tissues were measured by inductively coupled plasma spectrometer. We found that anemic mice treated with FER exhibited increased levels of ferritin heavy-chain in spleen and liver. Consistently, this treatment restored the iron concentration in these tissues. In addition, this treatment significantly increased hemoglobin value and the hematocrit ratio. Furthermore, FER treatment significantly enhanced body weight gain. These results suggest that the iron-fortified recombinant yeast strain is bioavailable.

KRULL DIMENSION OF HURWITZ POLYNOMIAL RINGS OVER PRÜFER DOMAINS

  • Le, Thi Ngoc Giau;Phan, Thanh Toan
    • Bulletin of the Korean Mathematical Society
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    • v.55 no.2
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    • pp.625-631
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    • 2018
  • Let R be a commutative ring with identity and let R[x] be the collection of polynomials with coefficients in R. There are a lot of multiplications in R[x] such that together with the usual addition, R[x] becomes a ring that contains R as a subring. These multiplications are from a class of functions ${\lambda}$ from ${\mathbb{N}}_0$ to ${\mathbb{N}}$. The trivial case when ${\lambda}(i)=1$ for all i gives the usual polynomial ring. Among nontrivial cases, there is an important one, namely, the case when ${\lambda}(i)=i!$ for all i. For this case, it gives the well-known Hurwitz polynomial ring $R_H[x]$. In this paper, we completely determine the Krull dimension of $R_H[x]$ when R is a $Pr{\ddot{u}}fer$ domain. Let R be a $Pr{\ddot{u}}fer$ domain. We show that dim $R_H[x]={\dim}\;R+1$ if R has characteristic zero and dim $R_H[x]={\dim}\;R$ otherwise.

GRADED INTEGRAL DOMAINS AND PRÜFER-LIKE DOMAINS

  • Chang, Gyu Whan
    • Journal of the Korean Mathematical Society
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    • v.54 no.6
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    • pp.1733-1757
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    • 2017
  • Let $R={\oplus}_{{\alpha}{\in}{\Gamma}}R_{\alpha}$ be an integral domain graded by an arbitrary torsionless grading monoid ${\Gamma}$, ${\bar{R}}$ be the integral closure of R, H be the set of nonzero homogeneous elements of R, C(f) be the fractional ideal of R generated by the homogeneous components of $f{\in}R_H$, and $N(H)=\{f{\in}R{\mid}C(f)_v=R\}$. Let $R_H$ be a UFD. We say that a nonzero prime ideal Q of R is an upper to zero in R if $Q=fR_H{\cap}R$ for some $f{\in}R$ and that R is a graded UMT-domain if each upper to zero in R is a maximal t-ideal. In this paper, we study several ring-theoretic properties of graded UMT-domains. Among other things, we prove that if R has a unit of nonzero degree, then R is a graded UMT-domain if and only if every prime ideal of $R_{N(H)}$ is extended from a homogeneous ideal of R, if and only if ${\bar{R}}_{H{\backslash}Q}$ is a graded-$Pr{\ddot{u}}fer$ domain for all homogeneous maximal t-ideals Q of R, if and only if ${\bar{R}}_{N(H)}$ is a $Pr{\ddot{u}}fer$ domain, if and only if R is a UMT-domain.

Approximate Life Cycle Assessment of Classified Products using Artificial Neural Network and Statistical Analysis in Conceptual Product Design (개념 설계 단계에서 인공 신경망과 통계적 분석을 이용한 제품군의 근사적 전과정 평가)

  • 박지형;서광규
    • Journal of the Korean Society for Precision Engineering
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    • v.20 no.3
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    • pp.221-229
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    • 2003
  • In the early phases of the product life cycle, Life Cycle Assessment (LCA) is recently used to support the decision-making fer the conceptual product design and the best alternative can be selected based on its estimated LCA and its benefits. Both the lack of detailed information and time for a full LCA fur a various range of design concepts need the new approach fer the environmental analysis. This paper suggests a novel approximate LCA methodology for the conceptual design stage by grouping products according to their environmental characteristics and by mapping product attributes into impact driver index. The relationship is statistically verified by exploring the correlation between total impact indicator and energy impact category. Then a neural network approach is developed to predict an approximate LCA of grouping products in conceptual design. Trained learning algorithms for the known characteristics of existing products will quickly give the result of LCA for new design products. The training is generalized by using product attributes for an ID in a group as well as another product attributes for another IDs in other groups. The neural network model with back propagation algorithm is used and the results are compared with those of multiple regression analysis. The proposed approach does not replace the full LCA but it would give some useful guidelines fer the design of environmentally conscious products in conceptual design phase.

New insights about coke deposition in methanol-to-DME reaction over MOR-, MFI- and FER-type zeolites

  • Migliori, Massimo;Catizzone, Enrico;Aloise, Alfredo;Bonura, Giuseppe;Gomez-Hortiguela, Luis;Frusteri, Leone;Cannilla, Catia;Frusteri, Francesco;Giordano, Girolamo
    • Journal of Industrial and Engineering Chemistry
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    • v.68
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    • pp.196-208
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    • 2018
  • The effect of channel-system of zeolite on methanol-to-DME reaction was studied. Results revealed that channels size and topology affect catalyst lifetime, type and location of coke precursors. FER and MFI showed the best resistance towards coke deposition, whilst fast deactivation was observed on MOR. Although the higher concentration and strength of acid sites, FER structure formed a lower coke amount, preferably located within the pores, while coke cluster deposited on the external surface of MOR. Analysis of acid sites distribution and strength was performed during deactivation-regeneration process. Coke location assessment was also supported by molecular simulations.

GRADED INTEGRAL DOMAINS IN WHICH EACH NONZERO HOMOGENEOUS IDEAL IS DIVISORIAL

  • Chang, Gyu Whan;Hamdi, Haleh;Sahandi, Parviz
    • Bulletin of the Korean Mathematical Society
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    • v.56 no.4
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    • pp.1041-1057
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    • 2019
  • Let ${\Gamma}$ be a nonzero commutative cancellative monoid (written additively), $R={\bigoplus}_{{\alpha}{\in}{\Gamma}}$ $R_{\alpha}$ be a ${\Gamma}$-graded integral domain with $R_{\alpha}{\neq}\{0\}$ for all ${\alpha}{\in}{\Gamma}$, and $S(H)=\{f{\in}R{\mid}C(f)=R\}$. In this paper, we study homogeneously divisorial domains which are graded integral domains whose nonzero homogeneous ideals are divisorial. Among other things, we show that if R is integrally closed, then R is a homogeneously divisorial domain if and only if $R_{S(H)}$ is an h-local $Pr{\ddot{u}}fer$ domain whose maximal ideals are invertible, if and only if R satisfies the following four conditions: (i) R is a graded-$Pr{\ddot{u}}fer$ domain, (ii) every homogeneous maximal ideal of R is invertible, (iii) each nonzero homogeneous prime ideal of R is contained in a unique homogeneous maximal ideal, and (iv) each homogeneous ideal of R has only finitely many minimal prime ideals. We also show that if R is a graded-Noetherian domain, then R is a homogeneously divisorial domain if and only if $R_{S(H)}$ is a divisorial domain of (Krull) dimension one.

Optimum Parameter and Performance Analysis of Outer Loop Power Control in IMT-2000 (IMT-2000 외부회로 전력제어의 최적변수 및 성능 분석)

  • 이재성;장영민;전기준;임순용
    • Proceedings of the IEEK Conference
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    • 2000.11a
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    • pp.121-124
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    • 2000
  • In IMT-2000 systems, the outer loop dynamically adjusts the target SIR so that adequate performance in terms of the frame error rate(FER) and the true quality measure is achieved. This paper utilizes an analytic model lot outer loop power control(OLPC) adjusting the target SIR in IMT-2000. The analytic model is based on the discrete-time Markov chain as voice traffic SIR. It is described that the model can be used to find the optimum step size in voice traffic for fast fading environments. The optimum step size influences the performance of OLPC: As the step size decreases, the average target SIR increases and average FER decreases.

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ON Φ-FLAT MODULES AND Φ-PRÜFER RINGS

  • Zhao, Wei
    • Journal of the Korean Mathematical Society
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    • v.55 no.5
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    • pp.1221-1233
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    • 2018
  • Let R be a commutative ring with non-zero identity and let NN(R) = {I | I is a nonnil ideal of R}. Let M be an R-module and let ${\phi}-tor(M)=\{x{\in}M{\mid}Ix=0\text{ for some }I{\in}NN(R)\}$. If ${\phi}or(M)=M$, then M is called a ${\phi}$-torsion module. An R-module M is said to be ${\phi}$-flat, if $0{\rightarrow}{A{\otimes}_R}\;{M{\rightarrow}B{\otimes}_R}\;{M{\rightarrow}C{\otimes}_R}\;M{\rightarrow}0$ is an exact R-sequence, for any exact sequence of R-modules $0{\rightarrow}A{\rightarrow}B{\rightarrow}C{\rightarrow}0$, where C is ${\phi}$-torsion. In this paper, the concepts of NRD-submodules and NP-submodules are introduced, and the ${\phi}$-flat modules over a ${\phi}-Pr{\ddot{u}}fer$ ring are investigated.

POWER SERIES RINGS OVER PRÜFER v-MULTIPLICATION DOMAINS

  • Chang, Gyu Whan
    • Journal of the Korean Mathematical Society
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    • v.53 no.2
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    • pp.447-459
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    • 2016
  • Let D be an integral domain, {$X_{\alpha}$} be a nonempty set of indeterminates over D, and $D{\mathbb{[}}\{X_{\alpha}\}{\mathbb{]}_1}$ be the first type power series ring over D. We show that if D is a t-SFT $Pr{\ddot{u}}fer$ v-multiplication domain, then $D{\mathbb{[}}\{X_{\alpha}\}{\mathbb{]}}_{1_{D-\{0\}}}$ is a Krull domain, and $D{\mathbb{[}}\{X_{\alpha}\}{\mathbb{]}}_1$ is a $Pr{\ddot{u}}fer$ v-multiplication domain if and only if D is a Krull domain.

A NEW CHARACTERIZATION OF PRÜFER v-MULTIPLICATION DOMAINS

  • CHANG, GYU WHAN
    • Korean Journal of Mathematics
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    • v.23 no.4
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    • pp.631-636
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    • 2015
  • Let D be an integral domain and w be the so-called w-operation on D. In this note, we introduce the notion of *(w)-domains: D is a *(w)-domain if $(({\cap}(x_i))({\cap}(y_j)))_w={\cap}(x_iy_j)$ for all nonzero elements $x_1,{\ldots},x_m$; $y_1,{\ldots},y_n$ of D. We then show that D is a $Pr{\ddot{u}}fer$ v-multiplication domain if and only if D is a *(w)-domain and $A^{-1}$ is of finite type for all nonzero finitely generated fractional ideals A of D.