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Optimization of the formulation for manufacturing of Bokbunja (Rubus coreanus Miquel)-black mulberry (Morus alba) herbal pill by D-optimal mixture design approach (D-optimal mixture design 이용 복분자-오디 환 제조 배합비 최적화)

  • Moon, Jin-Young;Hwang, Su-Jung;Eun, Jong-Bang
    • Korean Journal of Food Science and Technology
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    • v.53 no.2
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    • pp.174-180
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    • 2021
  • The optimal recipe for manufacturing composite honey-based herbal pills mainly comprising Rubus coreanus powder (RCP), black mulberry powder (BMP), and vitamin C was investigated. Honey-based herbal pills were prepared by mixing these powders, binding them with honey, and then forming a round shape. The experiment was designed based on the D-optimal mixture design, which included 12 experimental points with one replicate for three independent variables as follows: RCP (10~35%), BMP (10~35%), and vitamin C (5~10%). In addition, the dependent variables (total phenolic and flavonoid content and antioxidant activity) were measured and used to optimize the manufacturing conditions. The results showed that high amounts of RCP were correlated with high total flavonoid content, whereas the addition of high amounts of vitamin C resulted in higher antioxidant activity. In conclusion, an optimized formulation for the honey-based herbal pill was found to contain 35% RCP, 10% BMP, and 10% vitamin C.

A Study on the Competition of the World Women's Handball Championship Using Bigdata : Focused on the top 5 teams of the 2007-2019 World Women's Handball Championship (빅데이터를 활용한 여자핸드볼선수권대회 전력 비교 연구 -2007~2019년 세계여자핸드볼선수권대회 상위 5개팀과 대한민국을 중심으로-)

  • Kang, Yong-Gu;Kwak, Han-Pyong
    • Journal of Industrial Convergence
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    • v.19 no.1
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    • pp.147-158
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    • 2021
  • This study was conducted seven times from 2007 to the 2019 Women's World Handball Championships to analyze and strengthen the strength of the Korean women's handball team through the analysis of the top five countries' strengths. Among the 41 national teams participating in the World Women's Handball Championship, a total of five national teams, including the Netherlands, Norway, Russia, Spain, and France, were selected for the final study. Among the records provided by the International Handball Federation (IHF), the ranking was selected by analyzing the competition records of 41 participating countries, and technical statistics and frequency analysis were conducted using the SPSS/PC+ Ver21.0 program. based on the accumulated records of the top five women's handball competitions, handball attack and defense strategies that can make up for the inferiority in future physical conditions are needed and detailed follow-up studies are needed. Also, we hope to use it as a basic resource for improving the performance of Korean women's handball players and to play a key role in enhancing the level of women's handball at the 2021 Tokyo Olympics.

Morphological and Molecular Identification of Spirometra Tapeworms (Cestoda: Diphyllobothriidae) from Carnivorous Mammals in the Serengeti and Selous Ecosystems of Tanzania

  • Ndosi, Barakaeli Abdieli;Park, Hansol;Lee, Dongmin;Choe, Seongjun;Kang, Yeseul;Nath, Tilak Chandra;Bia, Mohammed Mebarek;Eamudomkarn, Chatanun;Jeon, Hyeong-Kyu;Eom, Keeseon S.
    • Parasites, Hosts and Diseases
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    • v.58 no.6
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    • pp.653-660
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    • 2020
  • Spirometra tapeworms (Cestoda: Diphyllobothriidae) collected from carnivorous mammals in Tanzania were identified by the DNA sequence analysis of the mitochondrial cytochrome c oxidase subunit 1 (cox1) and internal transcribed spacer 1 (ITS1), and by morphological characteristics. A total of 15 adult worms were collected from stool samples and carcasses of Panthera leo, Panthera pardus, and Crocuta crocuta in the Serengeti and Selous ecosystems of Tanzania. Three Spirometra species: S. theileri, S. ranarum and S. erinaceieuropaei were identified based on morphological features. Partial cox1 sequences (400 bp) of 10 specimens were revealed. Eight specimens showed 99.5% similarity with Spirometra theileri (MK955901), 1 specimen showed 99.5% similarity with the Korean S. erinaceieuropaei and 1 specimen had 99.5% similarity with Myanmar S. ranarum. Sequence homology estimates for the ITS1 region of S. theileri were 89.8% with S. erinaceieuropaei, 82.5% with S. decipiens, and 78.3% with S. ranarum; and 94.4% homology was observed between S. decipiens and S. ranarum. Phylogenetic analyses were performed with 4 species of Spirometra and 2 species of Dibothriocephalus (=Diphyllobothrium). By both ML and BI methods, cox1 and ITS1 gave well supported, congruent trees topology of S. erinaceieuropaei and S. theileri with S. decipiens and S. ranarum forming a clade. The Dibothriocephalus species were sisters of each other and collectively forming successive outgroups. Our findings confirmed that 3 Spirometra species (S. theileri, S. ranarum, and S. erinaceieuropaei) are distributed in the Serengeti and Selous ecosystems of Tanzania.

Quantitative analysis of glycerol concentration in red wine using Fourier transform infrared spectroscopy and chemometrics analysis

  • Joshi, Rahul;Joshi, Ritu;Amanah, Hanim Zuhrotul;Faqeerzada, Mohammad Akbar;Jayapal, Praveen Kumar;Kim, Geonwoo;Baek, Insuck;Park, Eun-Sung;Masithoh, Rudiati Evi;Cho, Byoung-Kwan
    • Korean Journal of Agricultural Science
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    • v.48 no.2
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    • pp.299-310
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    • 2021
  • Glycerol is a non-volatile compound with no aromatic properties that contributes significantly to the quality of wine by providing sweetness and richness of taste. In addition, it is also the third most significant byproduct of alcoholic fermentation in terms of quantity after ethanol and carbon dioxide. In this study, Fourier transform infrared (FT-IR) spectroscopy was employed as a fast non-destructive method in conjugation with multivariate regression analysis to build a model for the quantitative analysis of glycerol concentration in wine samples. The samples were prepared by using three varieties of red wine samples (i.e., Shiraz, Merlot, and Barbaresco) that were adulterated with glycerol in concentration ranges from 0.1 to 15% (v·v-1), and subjected to analysis together with pure wine samples. A net analyte signal (NAS)-based methodology, called hybrid linear analysis in the literature (HLA/GO), was applied for predicting glycerol concentrations in the collected FT-IR spectral data. Calibration and validation sets were designed to evaluate the performance of the multivariate method. The obtained results exhibited a high coefficient of determination (R2) of 0.987 and a low root mean square error (RMSE) of 0.563% for the calibration set, and a R2 of 0.984 and a RMSE of 0.626% for the validation set. Further, the model was validated in terms of sensitivity, selectivity, and limits of detection and quantification, and the results confirmed that this model can be used in most applications, as well as for quality assurance.

The Morpho-Climatic Characteristics of Stratified Slope Deposits in the Southwest Region of Haenam (해남 남서부지역의 Stratified Slope Deposit의 기후지형학적 특성)

  • PARK, Chul-Woong
    • Journal of The Geomorphological Association of Korea
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    • v.15 no.2
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    • pp.11-24
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    • 2008
  • Stratified slope was formed on the SSE-facing slope in the southwest region of Haenam, South Korea. Field and laboratory investigations into the geomorphology and sedimentology of stratified slope deposit that is inactive. Outcrops of this deposit show an alteration of coarse debris-supported matrix and tiny debris-supported matrix layers. Sedimentological analysis(particle-size analysis) indicates that this deposit is not fluvial process or only gravitation like rock-fall. Many clasts and fine materials on the slope is supposed to be product by congelifraction under Pleistocene periglacial climatic environment. Also The processes responsible for the genesis of this deposit probably are to move downward by gelifluction and to remove fine materials by slope wash in thawing cycle and in situ debris congelifraction on gelifluction slope. Now It is impossible to account for the time range of genesis(diurnal, seasonal). In conclusion, this stratified slope formed in cold and humid periglacial environmental in pleistocene, therefore, this slope is a periglacial relic landform, indicates that in south korea there was a cold and humid paleo-climate such as periglacial environmen.

Comparative study between an intensive small group teaching and a 1-year clinical practice on OSCE

  • Kim, Sinjae;Park, Minhwan;Seo, Ji-Hyun;Woo, Hyang-Ok;Youn, Hee-Shang;Park, Jung Je;Jeon, Sea-Yuoug;Hwa, Jung Seok;Mullan, Patricia;Gruppen, Larry D.
    • Kosin Medical Journal
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    • v.33 no.2
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    • pp.181-190
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    • 2018
  • Objectives: Our school introduced a new curriculum based on faculty-directed, intensive, small-group teaching of clinical skills in the third-year medical students. To examine its effects, we compared the mean scores on an OSCE between the third- and fourth-year medical students. Methods: Third- and fourth-year students did rotations at the same five OSCE stations. They then completed a brief self-reporting questionnaire survey to examine the degree of satisfaction with new curriculum in the third-year students and clinical practice in the fourth-year students, as well as their perception of confidence and preparedness. We analyzed the OSCE data obtained from 158 students, 133 of whom also completed the questionnaire. Results: Mean OSCE scores on the breast examination and wet smear stations were significantly higher in the third-year group (P < 0.001). But mean OSCE scores of motor-sensory examination and lumbar puncture were significantly higher in the fourth-year group (P < 0.05). The mean OSCE scores had no significant correlation with satisfaction. In addition, the self-ratings of confidence had a high degree of correlation with satisfaction with new curriculum (r = 0.673) and clinical practice (r = 0.692). Furthermore, there was a moderate degree of correlation between satisfaction and preparedness in both groups (r = 0.403 and 0.449). Conclusions: There is no significant difference in the effect on the degree of clinical performance and confidence between an intensive-small group teaching and a 1-year clinical practice. If combined, intensive small group teaching and clinical practice would be useful to improve the degree of ability and confidence in medical students.

A Comparative Study on Precarious Labor Market in Korea and Japan: Gender and Occupational Division of Precarious work (한국과 일본의 불안정노동시장 비교연구: 불안정노동의 젠더적·직업계층적 분절)

  • Back, Seung Ho;AN, Juyoung;Lee, Sophia Seung-yoon
    • 한국사회정책
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    • v.24 no.2
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    • pp.1-29
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    • 2017
  • This study compares and analyzes precarious labor market in Korea and Japan in terms of gender and occupational class. Previous studies have analyzed precarious labor limited to the level of employment type such as non-standard workers. This study reconceptualizes precarious labor in terms of the combination of employment relations and income level. In addition. we analyzed whether there are differences in the characteristics of precarious labor between Korea and Japan. In order to analyze the labor market precariousness in Korea. we used data from the 17th Korea Labor Panel Survey (2014) and for Japan. we used the 9th (2012) data from the Keio Household Panel Survey. As a result. we could confirm the feminization of labor market precariousness and horizontal division by occupation in both Korea and Japan. Also. ordered logistic regression analysis showed that the more women. and those in their 60s or older. the less skilled service workers. or the manufacturing workers are likely to face labor market instability in both Korea and Japan. The results of this analysis reflect the fact that Korea and Japan have experienced similar changes in the labor market structure with institutionalized employment protection system based on male workers.

The Current Research Status of Complementary and Integrative Medicine in Practice-Based Research Networks: A Systematic Review (개원의중심연구망에서 수행된 보완통합의학 관련 연구 현황: 체계적 문헌고찰)

  • Won, Jiyoon;Han, Gajin;Kim, Yejin;Park, Jae Rang;Noh, Eunyoung;Ji, Yu-jin;Adams, Jon;Lee, Hyangsook
    • Korean Journal of Acupuncture
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    • v.37 no.4
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    • pp.209-230
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    • 2020
  • Objectives : Practice-Based Research Networks (PBRNs), collaborations of practitioners and academic researchers, have provided platforms for conducting research to address clinical questions generated from daily routine care. This review aimed to critically analyse articles from PBRNs that are related to complementary and integrative medicine (CIM) and to suggest future directions for a PBRN which is appropriate for Korean Medicine (KM). Methods : PubMed, PBRN registries in Agency for Healthcare Research and Quality and relevant PBRN websites were searched up to November 2019 for research articles from PBRNs that focused on CIM regardless of study design. Methodological quality of the included studies was assessed. The included studies were read in full, classified and summarised according to their topics. Results : A total of 51 articles published from 1998 through 2020 were included in this review. They were categorised into three principal themes based on research questions and findings: health services research (embracing researches examining characteristics of patients and CIM practitioners/practices, and communication between patients and practitioners); effectiveness and safety of CIM practices/interventions; and feasibility studies of instruments and interventions in PBRN settings. The study designs varied including surveys (n=30), prospective observational studies (n=6), 2ndary analyses of existing studies (n=7), protocols (n=7), retrospective chart review (n=1) and qualitative study (n=1). Quality of the included studies greatly varied. Conclusions : PBRNs can serve as a feasible platform for conducting practice-relevant research on KM and CIM. Considering growing demands on evidence-base for routine practice of KM amid various stakeholders, a PBRN in KM community and further researches nested within PBRN designs are warranted.

Adipocyte differentiation inhibition, whitening, antibacterial and antioxidant activities of extracts from Aloe vera by-product (알로에 베라 가공 부산물 추출물의 지방세포 분화억제, 미백, 항균 및 항산화 활성)

  • Lee, Seong-Hun;Eun, Chang-Ho;Baek, Jin-Hong;Kim, In-Jung
    • Journal of Applied Biological Chemistry
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    • v.64 no.2
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    • pp.171-176
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    • 2021
  • Aloe has been widely used as a cosmetic and medicinal plant. Until now, several effects such as antioxidant, anti-cancer, anti-diabetic, immunity and whitening of aloe gel extract have been reported, but research on aloe by-products occurring in food processing has not been actively conducted. In this study, we investigated whether the aloe by-product extract from food processing could be used as a functional biomaterial. Cytotoxicity was not seen in both the mixer and press extracts. Inhibition of 3T3-L1 adipocyte differentiation was detected only in the mixer extract and not in the press. It was confirmed that hyaluronic acid accumulation and tyrosinase inhibition increased according to the treatment concentration of the mixer extract. The antimicrobial activity of the mixer extract was observed in the Porphyromonas gingivalis strain, but not in the Streptococcus mutans strain. Antioxidant activity through DPPH and SOD analysis increased with the concentration of the mixer extract. In summary, it was confirmed that the mixer extract of aloe by-products has the effect of inhibiting adipocyte differentiation, moisturizing, whitening, and antioxidant, suggesting the possibility of using it as a functional bio-material for health drinks or beauty masks.

Laser methane detector-based quantification of methane emissions from indoor-fed Fogera dairy cows

  • Kobayashi, Nobuyuki;Hou, Fujiang;Tsunekawa, Atsushi;Yan, Tianhai;Tegegne, Firew;Tassew, Asaminew;Mekuriaw, Yeshambel;Mekuriaw, Shigdaf;Hunegnaw, Beyadglign;Mekonnen, Wondimeneh;Ichinohe, Toshiyoshi
    • Animal Bioscience
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    • v.34 no.8
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    • pp.1415-1424
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    • 2021
  • Objective: Portable laser methane detectors (LMDs) may be an economical means of estimating CH4 emissions from ruminants. We validated an LMD-based approach and then used that approach to evaluate CH4 emissions from indigenous dairy cows in a dryland area of Ethiopia. Methods: First, we validated our LMD-based approach in Simmental crossbred beef cattle (n = 2) housed in respiration chambers and fed either a high- or low-concentrate diet. From the results of the validation, we constructed an estimation equation to determine CH4 emissions from LMD CH4 concentrations. Next, we used our validated LMD approach to examine CH4 emissions in Fogera dairy cows grazed for 8 h/d (GG, n = 4), fed indoors on natural-grassland hay (CG1, n = 4), or fed indoors on Napier-grass (Pennisetum purpureum) hay (CG2, n = 4). All the cows were supplemented with concentrate feed. Results: The exhaled CH4 concentrations measured by LMD were linearly correlated with the CH4 emissions determined by infrared-absorption-based gas analyzer (r2 = 0.55). The estimation equation used to determine CH4 emissions (y, mg/min) from LMD CH4 concentrations (x, ppm m) was y = 0.4259x+38.61. Daily CH4 emissions of Fogera cows estimated by using the equation did not differ among the three groups; however, a numerically greater milk yield was obtained from the CG2 cows than from the GG cows, suggesting that Napier-grass hay might be better than natural-grassland hay for indoor feeding. The CG1 cows had higher CH4 emissions per feed intake than the other groups, without significant increases in milk yield and body-weight gain, suggesting that natural-grassland hay cannot be recommended for indoor-fed cows. Conclusion: These findings demonstrate the potential of using LMDs to valuate feeding regimens rapidly and economically for dairy cows in areas under financial constraint, while taking CH4 emissions into consideration.