• 한국콘텐츠학회논문지
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• 제16권10호
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• pp.766-779
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• 2016

본 연구는 세월호 참사 보도에 드러난 '가상성'을 중심으로 매개된 현실과 실제 현실의 간극을 조명하고자 기획되었다. 방송기자연합회 저널리즘 특별위원회는 한국 언론의 세월호 보도 양상을 가리켜 저널리즘의 침몰이라고 명명할 만큼 세월호 보도는 현실 반영에 커다란 문제점을 드러냈다. 언론 보도의 가상성이 문제가 되는 것은 실제 현실보다 보도된 현실, 즉 매개 표상들을 더욱 많이 접촉하고 경험할 때, 수용자는 '실제 현실'에 근거하여 행동하기보다는 '매개된 현실'로부터 받아들인 것을 실제 상황이라 여기고 이에 근거해 반응한다는데 있다. 많은 연구에서 매체의 수용자들은 매개현실을 실제 외부세계로 받아들이는 것으로 관찰된다. 본 연구는 선행연구와 사상사에서 다루어진 '가상' 개념에 대한 중요 담론을 검토하여 매개현실의 문제와 한계를 설명하고자 하였다. 매개현실의 가상성은 여론에 영향을 미칠 뿐만 아니라 권력의 사회화, 사회 통제, 사회주도권 개념들과도 쉽게 연결 지을 수 있었다.

• Journal of Korean Neurosurgical Society
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• 제46권4호
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• pp.346-350
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• 2009

Objective : The purpose of this study was to analyze in detail the relationship between outcome and time course of effect in medically refractory primary cervical dystonia (CD) with phasic type that was treated by bilateral globus pallidus internus (Gpi) deep brain stimulation (DBS). Methods : Six patients underwent bilateral implantation of DBS into the Gpi under the guide of microelectrode recording and were followed for $18.7{\pm}11.1$ months. The mean duration of the CD was $5.8{\pm}3.4$ years. The mean age at time of surgery was $54.2{\pm}10.2$ years. Patients were evaluated with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and relief scale using patient self-reporting. Results : The TWSTRS total scores improved by 64.5%, 65.5%, 75.8%, and 76.0% at 3, 6, 12 months, and at the last available follow-up after surgery, respectively. Statistically significant improvements in the TWSTRS scores were observed 3 months after surgery (p=0.028) with gradual improvement up to 12 months after surgery, thereafter, the improvement was sustained. However, there was no statistically significant difference between the scores at 3 and 12 months. Subjective improvement reported averaged $81.7{\pm}6.8%$ at last follow-up. Mild dysarthria, the most frequent adverse event, occurred in 3 patients. Conclusions : Our results show that the bilateral Gpi-DBS can offer a significant therapeutic effect from 3 months postoperatively in patients with primary CD with phasic type, without significant side effects.

• 대한한의학회지
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• 제36권1호
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• pp.33-44
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• 2015

Objectives: The aim of this study was to understand the characteristics of herbal-drug-associated adverse events (AEs) reported in the internet newspaper articles and to take a countermeasure against the safety issue of herbal drugs. Methods: We searched the internet newspaper articles published from 2010 to 2014 in the 3 major portal sites in Korea, NAVER, DAUM, and GOOGLE. Search terms were the Korean words equivalent of 'herbal drug' and 'side effects'. Informations on the type and characteristics of suspected herbal drugs, AEs, and the patient records were extracted from the articles reporting the herbal-drug-associated AE occurred in Korea. Results: From 8,806 articles, a total of 36 AEs were found. The most frequently reported age group was 20s, and women outnumbered men. Obesity was the most common cause of administration. Doctors of Korean medicine clinic were the most commonly referred prescribers and purchasing route (11 cases). The most frequently mentioned medicinal herb was Ephedra sinica (7 cases) and the most commonly reported AEs were abdominal pain (8 cases), dizziness (6 cases), diarrhea (5 cases), and vomiting (5 cases) were followed in order. Ten cases were judged as serious AEs, and the others were not. Conclusions: Current customers demand health care providers to offer them sufficient information on the safety of herbal drugs. To satisfy their requirements, physicians of Korean medicine should be able to explain, predict, prepare, recognize, and deal with the herbal-drug-associated AEs. We propose an establishment of pharmacovigilance system for herbal medicine, in which doctors of Korean medicine are participated as important personnel, to collect and analyze the related AEs and offer credible information on the safety of herbal drug.

• 대한의용생체공학회:의공학회지
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• 제41권1호
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• pp.35-41
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• 2020

In this study, we examined whether the systematic literature review method used in the field of evidence-based medicine could be used for post-market clinical evaluation of medical devices by modifying them to fit the regulatory perspective of medical devices in Korea. For this purpose, systematic literature review was modified and applied to conduct a clinical literature survey on the ophthalmic electrosurgical system(Trabectome^®, NeoMediX Corp) used for the treatment of glaucoma. A total of six documents were finally selected, and clinical safety and efficacy information on the indications of the ophthalmic electrosurgical system were effectively presented. In addition, general safety information and unexpected safety information could be distinguished through comparison with medical device adverse event reporting cases. The method used in this study is expected to be used in various ways throughout post-market medical device safety management system and for the purpose of regulation improvement, especially in the field of ophthalmic electrosurgical system.

• 한국임상약학회지
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• 제21권4호
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• pp.383-389
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• 2011

약물요법에 있어 약물이상반응은 환자의 사망률과 이환율에 영향을 미치는 중요한 요인이다. 약물이상반응 발생시 이를 신속히 보고하는 것과 함께 약물치료과정에서 일어날 수 있는 약물 관련부작용을 조기에 인지하고 능동적으로 조치함으로써 환자에게 가해지는 위해를 최소화하는 것 또한 실제 환자치료의 질적인 관리에서 중요한 부분이다. 본 연구에서는 의료기록의 전산화에 따른 전산데이터들을 활용한 약물이상반응감시방법 중 하나로 평가 받고 있는 Computerized surveillance system (CSS)에 대한 사례 연구들의 방법들을 비교해 보고, 제시된 관련 시그널들 중 약물이상반응을 능동적인 방법 즉 실시간 혹은 예방적으로 적용 가능한 시그널들을 찾아 정리해 보고자 하였다. 이를 위해 가장 대표적인 연구가 진행되었던 연구사례들을 분석하였고 약 20여 개의 시그널들을 선정하여 분야별로 제시하였다.

• Korean Chemical Engineering Research
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• 제49권4호
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• pp.387-392
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• 2011

생촉매인 효소의 기질선택성은 다양한 분야에서 유용하게 이용되고 있다. 그 중에서도 효소결합면역흡착검사(enzyme-linked immunosorbent assay, ELISA)는 항원항체의 결합을 항체와 공유결합된 효소의 반응으로 나타냄으로써 다양한 항원들의 진단을 가능케 했다. 하지만 기존의 효소결합면역흡착검사는 하나의 항체당 하나의 효소가 결합된 형태이기 때문에 감도(sensitivity)의 증가 폭에 그 한계가 있으며, 이를 극복하기 위한 방안으로 하나의 항체당 결합된 효소의 수를 증가시킴으로써 혁신적인 감도의 향상을 가져오는 연구가 진행되었다. 최근 나노바이오촉매(nanobiocatalyst, NBC) 접근방식을 이용한 효소활성의 안정화는 효소결합면역흡착검사의 감도 향상뿐만 아니라 그 성능의 안정성을 확보할 수 있는 연구결과로 이어지고 있다. 본 총설에서는 일반적인 효소결합면역흡착검사의 기본적인 원리와 감도향상을 위한 연구, 그리고 성능안정성(performance stability)을 향상시키기 위한 나노바이오촉매-결합면역흡착검사(Nanobiocatalyst-Linked Immunosorbent Assay, NBC-LISA)에 대하여 살펴보고자 한다.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1994년도 교수 연수회(역학)
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• pp.206-233
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• 1994

The Medical Research Council has for some years encouraged collaborative clinical trials in leukaemia and other cancers, reporting the results in the medical literature. One unreported result which deserves such publication is the development of the expertise to design and analyse such trials. This report was prepared by a group of British and American statisticians, but it is intended for people without any statistical expertise. Part!, which appears in this issue, discusses the design of such trials; Part II, which will appear separately in the January 1977 issue of the Journal, gives full instructions for the statistical analysis of such trials by means of life tables and the logrank test, including a worked example, and discusses the interpretation of trial results, including brief reports of particular trials. Both parts of this report are relevant to all clinical trials which study time to death, and would be equally relevant to clinical trials which study time to other particular classes of untoward event: first stroke, perhaps, or first relapse, metastasis, disease recurrence, thrombosis, transplant rejection, or death from a particular cause. Part I, in this issue, collects together ideas that have mostly already appeared in the medical literature, but Part II, next month, is the first simple account yet published for non-statistical physicians of how to analyse efficiently data from clinical trials of survival duration. Such trials include the majority of all clinical trials of cancer therapy; in cancer trials, however, it may be preferable to use these statistical methods to study time to local recurrence of tumour, or to study time to detectable metastatic spread, in addition to studying total survival. Solid tumours can be staged at diagnosis; if this, or any other available information in some other disease is an important determinant of outcome, it can be used to make the overall logrank test for the whole heterogeneous trial population more sensitive, and more intuitively satisfactory, for it will then only be necessary to compare like with like, and not, by chance, Stage I with Stage III.

• 한국철도학회논문집
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• 제11권4호
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• pp.404-409
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• 2008

본 논문은 크게 두 가지 내용을 담고 있다. 하나는 기 개발된 철도 인간신뢰도분석 방법(R-HRA)의 개정에 관한 내용이며, 다른 하나는 개정된 R-HRA 방법에 기반한 R-HRA 지원 시스템의 개발이다. 개정된 R-HRA 방법은 분석자간 일관성을 유지하기 위한 직무분석 지침의 제공과 영향인자의 분류에 특징을 두고 있으며, R-HRA 지원 시스템은 인간신뢰도분석을 위한 정보의 수집, 내 외적 오류유형을 포함한 정성적 오류분석, 오류확률의 정량화, 전체 분석결과의 문서화 작업 등을 지원하고 있다. 개정된 R-HRA 방법과 지원 소프트웨어는 철도 사고 시나리오에서 발생 가능한 인적오류 가능성을 효과적이고 효율적으로 분석할 수 있도록 지원할 수 있을 것으로 기대된다.

• 한국항행학회논문지
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• 제22권4호
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• pp.288-294
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• 2018

항공기의 엔터테인먼트 시스템은 고정된 모니터를 사용하는 대신에 승객 개인의 휴대용 전자기기를 사용하는 형태로 그 패러다임이 바뀌었다. 이로 인해 기내 설비는 간소해진 반면 휴대용 전자기기들의 전기 충전으로 안전에 대한 리스크는 증가되었다. 송신 기능이 없는 개인 휴대전자기기와 달리 와이파이 기능이 있는 전자기기(T-PED)의 사용이 허용되고 기내에서 배터리의 충전도 요구된다. 본 연구에서는 기내 무선 환경과 엔터테인먼트 서비스의 변화에 따른 영향을 조사하기 위해 NASA 항공안전보고시스템을 이용하여 기내 전자기기 사용 관련 자료를 분석하였다. 이를 기초로 하여, 항공기 안전관리 관점에서 비행 중에 발생된 객실 전자장비나 승객 휴대용 전자기기(특히 스마트폰)로 인한 이벤트 발생 사례를 공유하여 개인용 전자기기의 위험성을 분석하였다. 이러한 분석을 위해 잠재적 위해요인의 식별과 리스크 평가 작업이 수행되었으며, 최종적으로 휴대용 전자기기의 안전한 사용을 위한 리스크 완화 전략이 제시되었다.

• Allergy, Asthma & Respiratory Disease
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• 제6권6호
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• pp.315-321
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• 2018

Purpose: Radiocontrast media are widely used in medical imaging to improve diagnostic accuracy. However, studies on the adverse reactions of radiocontrast media in children are limited. We aimed to describe the characteristics of adverse reactions to radiocontrast media among children who had a computed tomography scan or magnetic resonance imaging in a tertiary university hospital. Methods: We retrospectively collected data on adverse reactions to radiocontrast media by the reporting system of a tertiary university hospital. We selected data from children under the age of 19 from July 2011 to December 2017 and analyzed their characteristics. We focused mainly on the characteristics of the index case which is defined by the first adverse event of each subject. Results: During the period, a total of 88,050 radiocontrast media-enhanced imaging studies were performed and 184 cases of adverse reactions were reported. A total of 71 were identified as index cases. Forty-nine (69.0%) were male and the mean age was $12.7{\pm}3.2$ years. The incidence of radiocontrast media-related adverse reactions was 0.09% and severe reactions were 0.002%. The most common clinical feature was skin manifestations (54.9%), followed by gastrointestinal symptoms (40.8%) and neuropsychiatric symptoms (7.4%). Conclusion: Adverse reactions to radiocontrast media rarely occur in children and the incidence of severe reactions is low. Most reactions are mild and are related to the skin and gastrointestinal system. This report would provide good evidence for establishing a management strategy in children scheduled for imaging studies using radiocontrast media.