• Gut and Liver
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• v.12 no.6
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• pp.648-654
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• 2018

Background/Aims: Dual priming oligonucleotide-based multiplex polymerase chain reaction (DPO-based PCR) can detect the presence of clarithromycin resistance without culture. The aim of this study was to investigate the cost-effectiveness of DPO-based PCR for Helicobacter pylori eradication. Methods: From 2015 to 2016, medical records of patients who received H. pylori eradication therapy were analyzed. Patients were divided into two groups: tailored group patients who were treated based on DPO-based PCR and empirical group patients. Eradication rate and medical cost, including diagnostic tests, eradication regimens, and $^{13}C$-urea breath tests, were compared between the two groups. Cost for one successful eradication was calculated in each group. The expected cost of eradication for empirical treatment was investigated by varying the treatment duration and eradication rate. Results: A total of 527 patients were analyzed (tailored group 208, empirical group 319). The eradication success rate of the first-line therapy was higher in the tailored group compared to that in the empirical group (91.8% vs 72.1%, p<0.01). The total medical cost for each group was $114.8{\pm}14.1U.S.$ dollars (USD) and $85.8{\pm}24.4USD$, respectively (p<0.01). The total medical costs for each ultimately successful eradication in the tailored group and in the empirical group were 120.0 USD and 92.4 USD, respectively. The economic modeling expected cost of a successful eradication after a 7- or 14-day empirical treatment was 93.8 to 111.4 USD and 126.3 to 149.9 USD, respectively. Conclusions: Based on economic modeling, the cost for a successful eradication using DPO-based PCR would be similar or superior to the expected cost of a successful eradication with a 14-day empirical treatment when the first-line eradication rate is ${\leq}80%$.

• Journal of Information Technology Applications and Management
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• v.20 no.3
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• pp.129-141
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• 2013

When the formative construct is placed in the endogenous position, there are clear theoretical, mathematical, and empirical issues in model estimation. Nonetheless, scholars who have adopted structural equation modeling for empirical research and those who are engaged in debates on the viability of formative modeling fail to recognize the fundamental problems of employing formative measurement in the endogenous position. This manuscript is intended to set a corrective path by discussing three reasons why this frequented practice may be avoided in both theoretical and empirical research.

• East Asian mathematical journal
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• v.35 no.2
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• pp.217-237
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• 2019

This Modeling is a cyclical process of creating and modifying models of empirical situations to understand them better and improve decisions. The role of modeling and teaching mathematical modeling in school mathematics has received increasing attention as generating authentic learning and revealing the ways of thinking that produced it. In this paper and interactive lecture session, we will review a subset of the related literature, discuss benefits and challenges in teaching and learning mathematical modeling, and share our attempts to improve traditional textbook problems so that they can become more authentic modeling activities and implications for instruction and assessment as well as for research.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1830-1835
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• 2003

A novel index representing burden distribution form in the blast furnace is developed and index estimation model is built with an empirical modeling method to monitor inner condition of the furnace without expensive sensors. To find the best combination of index and modeling method, two candidates for the index and four modeling methods have been examined. Results have shown that 3-D index have more resolution in describing the distribution form than 1-D index and ANN model produces smallest RMSE due to nonlinearity between the indices and charging mode. Although ANN has shown the best prediction accuracy in this study, PLS can be a good alternative due to its advantages in generalization capability, consistency, simplicity and training time. The second best result of PLS in the prediction results supports this fact.

• Journal of KIISE:Computer Systems and Theory
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• v.33 no.1_2
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• pp.15-34
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• 2006

This paper introduces an empirical modeling technique. This technique uses a set of sample results which are collected from a few small scale simulations. Empirical models are developed by applying a couple of statistical estimation techniques to these samples. We built two types of models for cache miss rates in Symmetric Multiprocessor systems. One is for the changes of input data set size while the specification of target system is fixed. The other is for the changes of the number of processors in target system while the input data set size is fixed. To develop accurate models, we built individual model for every kind of cache misses for each shared data structure in a program. The final model is then obtained by integrating them. Besides, combined use of Least Mean Squares and Robust Estimations enhances the quality of models by minimizing the distortion due to outliers. Empirical modeling technique produces extremely accurate models without analysis on sample data. In addition, since only snail scale simulations are necessary, once a set of samples can be collected, empirical method can be adopted in any research areas. In 17 cases among 24 trials, empirical models present extremely low prediction errors below $1\%$. In the remaining cases, the accuracy is excellent, as well. The models sustain high quality even when the behavioral characteristics of programs are irregular and the number of samples are barely enough.

• International journal of advanced smart convergence
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• v.4 no.1
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• pp.11-17
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• 2015

Fouling in heat exchanger becomes a major problem of dairy industry and it increases the production cost. These are lost productivity, additional energy, additional equipment, chemical, manpower, and environmental impact. Fouling also introduces the risk of food safety due to the improper heating temperature which allow the survival of pathogenic bacteria in milk, introducing biofilm formation of pathogenic bacteria in equipments and spreading the pathogenic bacteria to milk. The aim of this study is to determine the fouling rate during pasteurization process in heat exchanger of pasteurized milk produced by Village Cooperative Society (KUD) "X" in Malang, East Java Indonesia by using empirical modeling. The fouling rate is found as $0.3945^{\circ}C/h$ with the heating process time ranged from 0 to 2 hours and temperature difference (hot water inlet temperature and milk outlet temperature) ranged from 0.654 to $1.636^{\circ}C$. The fouling rate depends on type and characteristics of heat exchangers, time and temperature of process, milk type, age of milk, seasonal variations, the presence of microorganism and more. This results will be used to plan Cleaning In Place (CIP) and to design the control system of pasteurization process in order to maintain the milk outlet temperature as standard of pasteurization.

• Journal of the Korean Society of Propulsion Engineers
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• v.24 no.6
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• pp.143-154
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• 2020

The mathematical modeling applying experimental coefficients to a conventional model was validated through the hydraulic test for the components and the full system of a small-sized liquid rocket engine's propellant supply system. According to the simulations, pressures difference for the fluid resistance components and the pump were mainly predicted. In order to improve the modeling accuracy, the loss coefficients obtained by the empirical method were applied to the modeling. Based on the governing equation of the flow or the well known empirical equation, the method of deriving the empirical coefficients was summarized and the coefficients were presented for the commercial products used in this study. The prediction results by modeling were in good agreement with the experimental data. Through the comparison with the experimental data, the factors affecting the accuracy of the simulation were analyzed and improving methods of the accuracy was proposed.

• Journal of Electrical Engineering and Technology
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• v.12 no.2
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• pp.937-943
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• 2017

To design an automatic steering controller with high performance for autonomous vehicle, it is necessary to have a precise model of the lateral dynamics with respect to the steering command input. This paper presents an empirical modeling of the steering system for an autonomous vehicle. The steering system here is represented by three individual transfer function models: a steering wheel actuator model from the steering command input to the steering angle of the shaft, a dynamic model between the steering angle and the yaw rate of the vehicle, and a dynamic model between the steering command and the lateral deviation of vehicle. These models are identified using frequency response data. Experiments were performed using a real vehicle. It is shown that the resulting identified models have been well fitted to the experimental data.

• Journal of Korean Elementary Science Education
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• v.41 no.4
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• pp.673-689
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• 2022

To understand seasonal changes it is necessary to understand the relationship between celestial bodies in a three-dimensional space, and to this end, modeling activities in which students directly construct, use, evaluate, and modify three-dimensional models are important. In this study, the process of elementary school students using globes and light bulbs to model Earth's motion in a three-dimensional space as a cause of seasonal changes was analyzed. Seventeen sixth graders participated in the modeling process. After exploring phenomena and concepts related to seasonal change, students constructed models using globes and bulbs and used them to explain seasonal changes. Video data recording students' modeling process, students' activity sheets, and transcripts of post-interview were used as research data, and data triangulation was conducted. The modeling level analysis framework was also developed based on previous studies. In particular, the framework was developed in detail in this study in consideration of the concept of Earth's motion as well as understanding model and implementing modeling. In the final analysis framework, the 3D modeling level was classified from level 1 to level 3, and student performance that may appear at each level was specified. As a result of the study, there were two main levels of modeling using globes for elementary school students to explain seasonal changes. The rotation and tilt of the axis of rotation and revolution of the earth were considered but the level at which empirical evidence was not used (level 2), the level at which empirical evidence was used to explain seasonal chages (level 3). However, even when students use empirical evidence, it did not lead to the construction of a scientific model. In this study, the cause was explored in relation to the characteristics of the tool used for modeling.

• Industrial Engineering and Management Systems
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• v.7 no.3
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• pp.245-256
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• 2008

In order to cope with the ill-defined problem of human behavior being immanent uncertainty, several methodologies have been studied in game theoretic, social psychological and political science frameworks. As methods to arrange system elements systematically and draw out the consenting structural model concretively, ISM, FSM and DEMATEL based on graph theory etc. have been proposed. In this paper, we propose a modified structural modeling method to recognize the nature of problem. We introduce the statistical method to adjust the establishment levels in group decision situation. From this, it will become possible to obtain effectively and smoothly the structural model of group members in comparison with the traditional methods. Further we propose a procedure for achieving the consenting structural model of group members based on the structural modeling method. By applying the method to recognize the nature of ill-defined problems, it will be possible to solve the given problem effectively and rationally. In order to inspect the effectiveness of the method, we conduct a practical problem as an empirical study: "Behavior analysis of passengers for the Joban line of East Japan Railway Company after new railway service of Tsukuba Express opened".