• 대한지역사회영양학회지
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• 제11권6호
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• pp.707-713
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• 2006

The purpose of this study was to test whether moderate alcohol consumption has any positive effect on lowering blood pressure among Koreans. Study subjects were Korean adults 20 years or older (n=5,234) who participated in the 2001 Korean National Health and Nutrition Examination Survey (KNHANES). Analysis of variance and analysis of covariance were used to construct univariate and multivariate models relating alcohol consumption to blood pressure for the analysis. After adjustment for possible covariates, drinkers (regardless of drinking level) had significantly higher systolic and diastolic blood pressure, compared with never-drinker for male subjects. Diastolic and systolic blood pressures were also significantly elevated with the drinking frequency and amount of alcohol intake among male subjects. For the female subjects, only diastolic blood pressure was significantly associated with the alcohol consumption at multivariate model. however, low level alcohol consumption did not show any sign of lowing effects on blood pressure. The result implies that moderate alcohol consumption did not have any positive effect on lowering blood pressure among Koreans for either sex.

• Genomics & Informatics
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• 제9권3호
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• pp.102-113
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• 2011

C-terminal SRC kinase (CSK) is a ubiquitously expressed, cytosolic enzyme that phosphorylates and inactivates several SRC family protein tyrosine kinases. Recent genomewide association studies have implicated CSK in the regulation of blood pressure. The current study aim is to determine the blood pressure association of the genes regulated by CSK down-regulation. The CSK mRNA expression was downregulated in vascular smooth muscle cells using small interfering RNA (siRNA). CSK mRNA levels fell by 90% in cells that were treated with CSK siRNA; the RNA from these cells was examined by microarray using the Illumina HumanRef-8 v3 platform, which comprises 24,526 reference mRNA probes. On treatment with CSK siRNA, 19 genes were downregulated by more than 2-fold and 13 genes were upregulated by more than 2-fold. Three (CANX, SLC30A7, and HMOX1) of them revealed more than 3 fold differential expression. Interestingly, the HMOX1 SNPs were associated with diastolic blood pressure in the 7551 Koreans using Korea Association REsource data, and the result was supported by the other reports that HMOX1 linked to blood vessel maintenance. Among the remaining 29 differentially expressed genes, seven (SSBP1, CDH2, YWHAE, ME2, PFTK1, G3BP2, and TUFT1) revealed association with both systolic and diastolic blood pressures. The CDH2 gene was linked to blood pressures. Conclusively, we identified 32 differentially expressed genes which were regulated by CSK reduction, and two (HOMX1 and CDH2) of them might influence the blood pressure regulation through CSK pathway.

• Journal of Preventive Medicine and Public Health
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• 제24권2호
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• pp.161-170
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• 1991

The purpose of this study is to find the tracking of blood pressure in primary school-age children. A follow-up study was conducted from 1986 to 1990 on 330 first grade children attending primary schools in Kangwha County, Kyungki-Do. Basically we employed a linear regression model with random coefficients to figure out the relation between blood pressure changes and initial blood pressure. We obtained the following results ; 1. The mean blood pressures were increased grade went up in both sexs and were generally higher in female than male except for the systolic blood pressure at first grade. The size of difference was about 0.8 mmHg in mean systolic blood pressure and 1.5 mmHg in mean diastolic blood pressure. 2. The average annual increasing rates of systolic blood pressure were 2.5 mmHg in male and 3.1 mmHg in female respectively. For the diastolic blood pressure IV the average annual increasing rates were observed to be 3.0 mmHg in male and 2.9 mmHg in female respectively. Increasing rate of systolic blood pressure was significantly higher in female than male. 3. The adjusted regression coefficient of systolic blood pressure change on initial value was -0.11 in male and -0.13 in female and that coefficient of diastolic blood pressure change on initial value was -0.01 in male and -0.11 in female. This result shows that children with higher initial blood pressure do not pick up their blood pressure faster than others with lower initial blood pressure. There is no evidence of tracking of blood pressure in children. It is essential to find the earliest age having the tracking of blood pressure and we leave it for the further study.

• 대한간호학회지
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• 제32권5호
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• pp.633-642
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• 2002

The purpose of this study was to evaluate the effect of a Yoga program on decreasing blood pressure in elderly patients with essential hypertension and to suggest a yoga program effective as a nursing intervention tool to reduced blood pressure with increasing life satisfaction. Method: The subjects of this study were 24 elderly's essential hypertension, who practiced yoga by three times a week for 8 weeks. In order to evaluate the effect of the yoga program, blood pressure, physiological parameters (Total cholesterol, HDL, LDL, triglycerides) and level of life satisfaction were measured before and after the training. Collected date were analyzed by SPSSWIN program. Result: 1) There were significant reduction in systolic and diastolic blood pressure. 2) There were significant reductions in total cholesterol, LDL, triglycerides but no significant increased in HDL. 3) Blood pressure changes were time specific : Both of systolic and diastolic blood pressures were significantly reduced after 2weeks. 4) There was a significant increase in life satisfaction. Conclusion: The results proved that a yoga program was an effective nursing intervention to reduce blood pressure and to increased life satisfaction for elderly patients with essential hypertension.

• 대한지역사회영양학회지
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• 제7권2호
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• pp.232-244
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• 2002

This study investigated the correlation between health-related habits and the biochemical characteristics of the blood of Korean bus drivers. A total of 178 bus drivers working in the Masan area participated in this study. The general characteristics and health-related habits of the subjects were surveyed using a serf-administered questionnaire. The biochemical date were collected from regular health check-ups done through their workshop health insurance company in lune, 1999. The results were as follows : The average age of the subjects was 38 years, and 44.2% had a driving career of between 10 and 19 years. About 90% of the subjects ate irregularly, and 36% ate. health floods. Their rates of drinking, smoking and exercise were 74.6%, 83.6% and 70.8%, respectively. Their frequency of drinking was significantly increased as the length of their driving career increased (p < 0.001). Their levels of total serum cholesterol, in relation to the length of their driving career was significantly higher in the over 20 year group than in the below 10 year group (p < 0.05). Their systolic blood pressures, according to age, were significantly higher in the 51 to 60 age group than in the other groups (p < 0.05). Their total um cholesterol levels signiscantly increased with increasing age (p < 0.001). Their diastolic blood pressures (p < 0.001) and blood glucose levels (p < 0.05) were significantly higher among the subjects who drinking alcohol almost everyday, than among other subjects. Their systolic blood pressures who significantly increased with increasing frequency of their drinking (p < 0.001). The systolic blood pressure and diastolic blood pressure were positively related to age, the amount of drinking, the frequency of drinking and the obesity index, and negatively related to exercise and the duration of exercise. The hemoglobin was positively related to age, preference for a meat diet and the obesity index. The blood glucose was positively related to the amount of drinking, and the total serum cholesterol was positively related to age, length of driving career, period of smoking and the obesity index. The results of this study indicated that bus drivers need regular exercise, moderation of their drinking and smoking, and control of their body weights so as to prevent chronic diseases.

• Clinical and Experimental Pediatrics
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• 제51권9호
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• pp.998-1006
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• 2008

목 적 : 소아 고혈압은 성별, 연령별, 신장별 수축기 또는 이완기 혈압이 95 백분위수 이상으로, 진동식 자동 혈압계에 의한 소아 혈압치는 일부 연령에서만 보고되어 있고, 최근 6세 이하의 어린 소아에서 보고가 적다. 이에 저자들은 진동식 자동 혈압계를 이용하여 신생아부터 6세 이하의 정상 소아를 대상으로 성별, 연령별, 신장 백분위수별 수축기 및 이완기 혈압을 측정하여 정상 혈압치 및 혈압 백분위수 곡선을 구하여 우리나라 소아의 고혈압 진단과 치료에 도움이 되고자 본 연구를 실시하였다. 방 법 : 서울 시내 6세 이하의 어린이 6,690명(남아 3,545명, 여아 3,145명)을 대상으로 진동식 자동 혈압계(Dinamap, Procare-200, GE, USA)를 이용하여 수축기 혈압과 이완기 혈압을 각각 두 차례에 걸쳐 측정하였으며, 이를 이용하여 연령별, 성별 평균 혈압을 구하고, 신장 5, 10, 25, 50, 75, 90, 95 백분위수에 따른 50, 90, 95, 99 백분위수의 혈압을 산출하였고 혈압 백분위수 곡선을 구하였다. 수축기 혈압과 이완기 혈압은 성별 고정효과모형을 적용하여 선형회귀모형에서 회귀계수와 표준편차를 구하였다. 결 과 : 남아와 여아 모두에서 연령이 증가함에 따라 수축기 혈압과 이완기 혈압이 점차 증가하였다. 남아와 여아 모두 동일한 신장 백분위수를 가진 어린이들이 연령이 증가함에 따라서 수축기 혈압과 이완기 혈압 모두 증가하는 양상을 보였다. 남아와 여아 모두 동일한 연령대에서 신장이 커질수록 수축기 혈압과 이완기 혈압 모두 증가하는 양상을 보였다. 결 론 : 진동식 자동 혈압계를 이용하여 서울지역 6세 이하 어린이의 성별, 연령 및 신장 백분위수에 따른 혈압 백분위수를 구하였다. 이번 연구 자료가 6세 이하의 고혈압을 진단하고 치료하는데 큰 도움이 되리라 생각한다. 앞으로 고혈압 진단과 치료를 위해서는 서울시가 아닌 우리나라 전국 소아를 대상으로 한 대규모 연구가 필요하다.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권1호
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• pp.11-18
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• 2022

Background: The vasoconstrictive effect of epinephrine in local anesthetics affects the heart, which leads to hesitation among dentists in injecting local anesthetics into patients with cardiovascular disease. Due to its vasoconstrictive effects, the present study investigated the effects of vasopressin administration on cardiac function in rats. Methods: Experiment 1 aimed to determine the vasopressin concentration that could affect cardiac function. An arterial catheter was inserted into the male Wistar rats. Next, 0.03, 0.3, and 3.0 U/mL arginine vasopressin (AVP) (0.03V, 0.3V, and 3.0V) was injected into the tongue, and the blood pressure was measured. The control group received normal saline only. In Experiment 2, following anesthesia infiltration, a pressure-volume catheter was placed in the left ventricle. Baseline values of end-systolic elastance, end-diastolic volume, end-systolic pressure, stroke work, stroke volume, and end-systolic elastance were recorded. Next, normal saline and 3.0V AVP were injected into the tongue to measure their effect on hemodynamic and cardiac function. Results: After 3.0V administration, systolic blood pressures at 10 and 15 min were higher than those of the control group; they increased at 10 min compared with those at baseline. The diastolic blood pressures at 5-15 min were higher than those of the control group; they increased at 5 and 10 min compared with those at baseline. The preload decreased at 5 and 10 min compared to that at baseline. However, the afterload increased from 5 to 15 min compared with that of the control group; it increased at 10 min compared with that at baseline. Stroke volume decreased at 10 and 15 min compared with that of the control group; it decreased from 5 to 15 min compared with that at baseline. Stroke work decreased from 5 to 15 min compared with that of the control group; it decreased from 5 to 15 min compared with that at baseline. Conclusion: Our results showed that 3.0 U/mL concentration of vasopressin resulted in increased blood pressure, decreased stroke volume and stoke work, decreased preload and increased afterload, without any effect on myocardial contractility.

• 대한간호학회지
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• 제40권5호
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• pp.686-694
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• 2010

Purpose: This study was done to examine the effects of moxibustion on physiological indices, such as 24-hr blood pressure, pulse pressure, and pulse rate, and autonomic nervous symptoms among adults with prehypertension. Methods: Participants were adults whose systolic and diastolic blood pressures were in the prehypertension stage and were not under treatment for the condition. Both experimental and control group consisted of 13 participants who were taking classes on acupuncture and moxibustion at a private institute. The experimental group received moxibustion once a day for 15 min, at least 5 days a week for 8 weeks. The results were analyzed using $x^2$-test, t-test, Fisher's exact test, Wilcoxon rank sum test and repeated measures ANOVA with the SAS program. Bonferroni correction method was adopted for multiple comparisons. Results: No significant change was observed in the 24-hr systolic and diastolic blood pressure between the two groups. Differences in the 24-hr pulse pressure and pulse rate were also not significant. However, significant decreases in headache, symptoms of flushing and fatigue were observed in the experimental group. Conclusion: The results suggest that moxibustion contributes to alleviating symptoms such as headache, flushing and fatigue associated with the autonomic nervous system among adults with prehypertension.

• 생명과학회지
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• 제28권2호
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• pp.187-194
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• 2018

표고버섯으로부터 유래한 eritadenine (EA)은 혈중 low density lipoprotein (LDL), triglyceride (TG), phospholipid를 감소시키는 물질이다. 최근 저희 연구팀은 in vitro 연구에서 EA가 angiotensin converting enzyme (ACE)의 활성을 저해함을 밝혔다. 본 연구에서는 EA와 EA 함유한 표고버섯균사체 고체배양 효소추출물(EA-LEMCEE)이 본태성 고혈압 쥐 SHR의 혈압을 낮추었음을 보고한다. EA 및 EA-LEMSCEE는 인체 탯줄 혈관내피세포 EA.hy926 세포의 ACE 활성을 억제하였다. EA-LEMSCEE는 SHR의 수축기 및 이완기 혈압을 Control 처리구에 비해 유의성 있게 낮추어 처리 5주에는 Positive control인 captopril (CP) 처리와 비슷한 혈압감소 효과를 나타내었다. EA-LEMCE는 LEMSCEE에 비해 수축기 및 이완기 혈압을 감소시켰지만 유의성은 없었다. EA- LEMSCEE는 renin과 ACE 활성을 Control 처리에 비해 유의성 있게 억제하였고, angiotensin II (Ang II) 함량을 감소시켜, 처리 5주 후에 이러한 CP의 효과와 유사하였다. 또한 EA-LEMCEE는 LEMCEE에 비해 유의성 있게 renin 및 ACE 활성을 억제하였고 및 Ang II 함량을 감소시켰다. 이와 같은 결과는 EA 및 EA-LEMCEE는 본태성 고혈압 SHR의 renin과 ACE 활성을 억제하여 혈압을 낮추었고, EA 및 EA-LEMSCEE는 인체 고혈압을 낮출 수 있음을 의미한다.

• 한국컴퓨터정보학회논문지
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• 제28권11호
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• pp.155-160
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• 2023

본 논문은 광혈류신호를 이용하여 혈압을 예측하는 방법을 제시한다. 제시한 방법은 먼저, 광혈류신호를 측정한 후, 전처리 과정을 통해 아티펙트를 제거하고 학습을 위한 신호를 얻는다. 그리고 혈압에 영향을 주는 몸무게와 키를 부가 정보로 측정한다. 다음으로, 인공지능 알고리즘을 통해 광혈류신호, 키, 그리고 몸무게를 입력변수로 학습하여 수축기와 이완기 혈압을 추정하도록 시스템을 구축한다. 구축된 시스템은 사전에 입력된 키와, 몸무게, 그리고 측정한 광혈류신호를 가지고 수축기와 이완기 혈압을 예측한다. 제안한 방법은 무구속 방식으로 피검자의 키와 몸무게, 그리고 심장 및 혈관의 상태를 반영하는 광혈류신호를 입력받아 실시간, 연속적으로 혈압 예측이 가능하다. 본 연구에서 제시한 인공지능 기반 혈압예측시스템의 유용성을 확인하기 위해 측정한 혈압과 예측한 혈압의 비교를 통해 결과의 유용성을 확인한다.