• Journal of Korean Medicine Rehabilitation
• /
• v.18 no.1
• /
• pp.95-110
• /
• 2008

목 적 : 급성 및 만성 염증 질환은 iNOS에 의해서 생성된 과량의 NO와 관련이 있다. 따라서 이러한 질병 치료를 목적으로 NO 생성 억제물질 또는 iNOS 발현 차단물질을 개발할 가치가 있다. 본 연구는 대사 안정성을 개선시킨 dimethoxycurcumin (DiMC)이 활성화된 대식세포에서 NO 생성 및 iNOS 발현을 제어할 수 있는지 조사하였다. 방 법 : RAW264.7 세포를 DiMC (양쪽 방향성 고리에 각각 2개의 methoxy group을 가짐), curcumin (양쪽 방향성 고리에 각각 1개의 methoxy group을 가짐), bis-demethoxycurcumin (양쪽 방향성 고리에 methoxy group이 없음; BDMC) 및 tetrahydrocurcumin (양쪽 방향성 고리에 각각 1개의 methoxy group을 가지고 있지만 중앙 7개 탄소 사슬에 이중결합이 없음; THC)로 각각 전처리한 후에 LPS로 자극하였다. 이들 전처리 물질의 효과를 비교하기 위하여, NO 생성, iNOS 발현, NF-kB p65 인산화 및 p65 DNA-binding 활성을 조사하였다. 결 과 : DiMC, curcumin 및 BDMC는 NO 생성, iNOS 발현 및 NF-kB 활성을 억제하였으며, 그 세기에 있어서 DiMC가 가장 크게 관찰되었고 그 다음 curcumin 그리고 BDMC 순으로 관찰되었다. THC는 어떠한 활성도 보이지 못했다. 결 론 :DiMC는 NO 생성 억제, iNOS 발현 차단 및 NF-kB 비활성을 유도할 수 있음을 알 수 있었다. 이러한 효과는 연속된 이중결합 및 methoxy group의 증가와 관련이 있는 것으로 판단된다.

• Lettere Italiane
• /
• no.30
• /
• pp.205-229
• /
• 2010

L'italiano ha diverse forme di pronomi clitici che vengono distinti in genere, numero e persona a seconda del nome di partenza. Quando appare un pronome clitico, l'ordine delle parole nella frase cambia: dal tipo normale SVO si passa al tipo SOV come in coreano. I pronomi clitici hanno una caratteristica molto diversa rispetto sia a piena NP sia ad una NP debole, e non sono compatibili con questi NP all'interno della frase, il che significa che i pronomi clitici si muovono in posizione superficiale lasciando la loro posizione originale dopo il verbo. Osservando questo fenomeno (movimento clitico da [DP, VP] a [spec, AgrOP]) e analizzando in questa sede solo il caso del pronome diretto si è cercato di evidenziare le regole precise di tale movimento determinato da "Case licensing" e "feature checking." Seguendo e accettando pienamente la precedente analisi di Belletti(1999), in cui vengono proposte due vie di procedimento del movimento dentro il AgrOP (una è [spec, AgrOP]; l'altra, [Agro, AgrOP], propongo qui l'esistenza di un ordine preciso in tale movimento: nel caso in cui un pronome diretto prenda una via di [spec, AgrOP], 'V' si muove prima fino ad arrivare alla [Agro, AgrSP], poi, 'pro' prosegue la sua strada fino alla [pro, AgrSP], e alla fine, il pronome diretto sale fino alla [spec, TP] per formare la costruzione proclitica; nel caso in cui un pronome diretto prenda invece l'altra via di [Agro, AgrOP], 'pro' sale prima fino alla [spec, AgrSP] tramite il movimento 'spec to spec', successivamente il 'pronome diretto' si muove verso la [Agro, AgrSP], e infine 'V' si sposta verso la [Agro, AgrSP] per formare la costruzione enclitica.

• Ocean and Polar Research
• /
• v.36 no.3
• /
• pp.255-276
• /
• 2014

The dispute between China and Japan regarding $Di\grave{a}oy\acute{u}t\acute{a}i$ is believed to be quite similar to the controversy surrounding Dokdo in terms of historical and post-war processes except for the point that the phenomena of occupation is different with regard to Dokdo. China's claim to $Di\grave{a}oy\acute{u}t\acute{a}i$ is based on historical title and continuous use while the basis of Japan's claim is summarized as preoccupancy of ownerless land. Even though Japan acknowledges that China discovered $Di\grave{a}oy\acute{u}t\acute{a}i$, Japan claims that the act to establish sovereignty over the island from the standpoint of International Law was not taken by China. However, at that time, effective occupation was not an essential prerequisite for the acquisition of a territory. That is to say, from a legal perspective, the legal right for an area could be established based on the discovery of the land, and so it is thought that Japan is applying the current criteria of International Law in a manner that is inappropriate. When we review the post-war process, the San Francisco Peace Treaty does not directly mention $Di\grave{a}oy\acute{u}t\acute{a}i$. But based on the said treaty, we can note that Japan gave up all rights for the southern area that is north of the boundary line that equates to latitude $29^{\circ}$ and that includes the Ryuku Islands and $Di\grave{a}oy\acute{u}t\acute{a}i$. Of course, the provisions for the territory in the San Francisco Peace Treaty and its disposal are not the final factor for the judgment regarding dominium of $Di\grave{a}oy\acute{u}t\acute{a}i$. However, it seems clear that Japan's attitude and interpretation regarding the issues of $Di\grave{a}oy\acute{u}t\acute{a}i$, the Kuril Islands and Dokdo is problematic.

• Transactions on Electrical and Electronic Materials
• /
• v.14 no.6
• /
• pp.291-294
• /
• 2013

When subjected to a change in dimensions, the device performance decreases. Multi-gate SOI devices, viz. the Double Gate MOSFET (DG-MOSFET), are expected to make inroads into integrated circuit applications previously dominated exclusively by planar MOSFETs. The primary focus of attention is how channel engineering (i.e. Graded Channel (GC)) and gate engineering (i.e. Dual Insulator (DI)) as gate oxide) creates an effect on the device performance, specifically, leakage current ($I_{off}$), on current ($I_{on}$), and DIBL. This study examines the performance of the devices, by virtue of a simulation analysis, in conjunction with N-channel DG-MOSFETs. The important parameters for improvement in circuit speed and power consumption are discussed. From the analysis, DG-DI MOSFET is the most suitable candidate for high speed switching application, simultaneously providing better performance as an amplifier.

• Advances in nano research
• /
• v.5 no.1
• /
• pp.61-67
• /
• 2017

A semi-empirical approach to model the temperature effects on I-V characteristics of Carbon Nanotube Field Effect Transistors (CNTFETs) is proposed. The model includes two thermal parameters describing CNTFET behaviour in terms of saturation drain current and threshold voltage, whose values are extracted from the simulated and trans-characteristics of the device in different temperature conditions. Our results are compared with those of a numerical model online available, obtaining I-V characteristics comparable but with a lower CPU calculation time.

• Journal of Pharmacopuncture
• /
• v.12 no.3
• /
• pp.25-30
• /
• 2009

Objectives: To find the potential acupuncture points by using Trypan blue staining on the skin of rat and Nude mouse. Methods: 0.4% Trypan blue was applied to the skin of rat or Nude mouse previously treated by surfactant. Washing by warm saline was followed after enough application of trypan blue and surfactant. Frequency of Trypan blue application should be varied to the experimental animals' condition for visualizing significant spots. Results: Blue spots appeared roughly in symmetry along kidney meridian or stomach meridian. Several spots outside of kidney or stomach meridian were also observed; however, the detail stereoscopic images of those blue spots were slightly different according to the position blue-colored. DiI signals were visualized along blood vessel after DiI injection into the Trypan blue-visualized blue spots. Conclusion: Our method to visualize the potential acupuncture points as a blue spot on rat and Nude mouse skins may contribute to the next step for finding specific flowing channels among blue spots.

• Journal of The Korean Astronomical Society
• /
• v.37 no.5
• /
• pp.315-322
• /
• 2004

Several arguments have been presented in the literature to support the connection between radio halos and cluster mergers. The spectral index distributions of the halos in A665 and A2163 provide a new strong confirmation of this connection, i.e. of the fact that the cluster merger plays an important role in the energy supply to the radio halos. Features of the spectral index (flattening and patches) are indication of a complex shape of the radiating electron spectrum, and are therefore in support of electron reacceleration models. Regions of flatter spectrum are found to be related to the recent merger. In the undisturbed cluster regions, instead, the spectrum steepens with the distance from the cluster center. The plot of the integrated spectral index of a sample of halos versus the cluster temperature indicates that clusters at higher temperature tend to host halos with flatter spectra. This correlation provides further evidence of the connection between radio emission and cluster mergers.

• Applied Chemistry for Engineering
• /
• v.10 no.1
• /
• pp.6-11
• /
• 1999

Dialkylamine (di-)nitrobenzoates as vapor corrosion inhibitor were synthesized with dialkylamines and (di-)nitrobenzoic acids. The compounds were analyzed by elemental analyzer, FT-IR and $^1H$-NMR spectrophotometer. Corrosion inhibition of synthetic compounds and additives [$(NH_4)_2CO_3$, $NaHCO_3$] against ferrous and non-ferrous metal was investigated by potentiostatic method [1% (w/v) corrosion inhibitor in 1M $Na_2SO_4$ aqueous solution] respectively. For corrosion inhibition of ferrous metal, dialkylamine 4-nitrobenzoates were better inhibitor than dialkylamine 3, 5-dinitrobenzoates, the passivating current density ($i_p$) of dialkylamine 4-nitrobenzoate was shown $4.78mA/cm^2$. While, for non-ferrous metal, dialkylamine 3, 5-dinitrobenzoates were better, those of dipropylamine 3, 5-dinitrobenzoate and hexamethyleneimine 3, 5-dinitrobenzoate were shown 36 and $37mA/cm^2$. Additive effect of $(NH_4)_2CO_3$ and $NaHCO_3$ for corrosion inhibition of ferrous metal was excellent but that of non-ferrous metal was not. Optimum ratios of diethylamine 4-nitrobenzoate with $(NH_4)_2CO_3$ and $NaHCO_3$ were 4 : 6 and 5 : 5 (V/V), and passivating current densities ($i_p$) of the mixtures were shown 0.26 and $0.85mA/cm^2$, respectively.

• Journal of Communications and Networks
• /
• v.7 no.1
• /
• pp.29-35
• /
• 2005

This paper deals with the problem of multiuser detection over a direct-sequence code-division multiple access (DS-CDMA) channel with incomplete channel state informations (I-CSI). We devise and assess two novel recursive detectors based on the expectation conditional maximization (ECM) algorithm and the generalized likelihood ratio (GLR) principle, respectively. Both receivers entail an affordable computational complexity. Moreover, the performance assessment, conducted via Monte Carlo techniques, shows that they achieve satisfactory performance levels and outperform linear detectors.

• Journal of Korean Tunnelling and Underground Space Association
• /
• v.6 no.4
• /
• pp.357-365
• /
• 2004

Tunnel portals are often located in areas where the risk of rock fall and/or detachement of rock fragments from rocky slopes is high. In this case it is necessary to design the portals so as to protect the road (i.e. using an artificial tunnel) or to instal structures that are able to intercept falling blocks on the slope. This paper deals with the design problems of these structures and includes a special analysis of net fences which have undergone a remarkable technological improvement over recent years.