• 한국전통의학지
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• 제15권1호
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• pp.113-127
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• 2006

Objectives: This study was produced to examine the effects of moxibustion that had been played important role to traditional oriental medical treatment on disease. Recently, it was reported that moxi-tar which is generated in the process of moxibustion as burning combustibles decreased nitric oxide(NO) and inducible NO synthase (iNOS) generation in cellular experiments. Methods: Carrageenan-induced arthritis rat model was used to test the effect of moxi-tar as a chronic pain model. Diluted moxi-tar was single injected in several acupoints or combined with electroacupuncture (l ms, 2 Hz, and 2 mA) into contralateral ST36 acupoint for 30 min to assess the synergic effects. After the treatment, behavioral tests measuring stepping force were periodically conducted during the next 12 hours. Endogenous NO and iNOS, cyclooxygenase-2 (COX-2), and c-Fos protein expression in the spinal cord were examined on a rat model of carrageenan-induced arthritis. Results : After the induction of arthritis, rats subsequently showed a reduced stepping force of the affected limb for at least the next 4 days. The reduced stepping force of the limb was presumably due to a painful knee, since oral injection of indomethacin produced temporary improvement of weight bearing. Maxi-tar produced significant improvement of stepping force of the hindlimb affected by the arthritis lasting at least 9 hours. The magnitude of this improvement was equivalent to that obtained after an oral injection of 3 mg/kg of indomethacin and this improvement of stepping force was interpreted as an analgesic effect. Maxi-tar produced the improvement of stepping force of the affected hindlimb in a dose-dependent manner. Both NO production and iNOS, COX-2 protein expression increased by arthritis were suppressed by maxi-tar. Moxi-tar on combination with electroacupuncture (EA) produced more powerful and longer lasting improvement of stepping force of the hindlimb affected by the arthritis than either moxi-tar or EA did. Conclusion : The present study suggest that maxi-tar produces a potent analgesic effect on the chronic knee arthritis pain model in the rat and that moxi-tar-induced analgesia modulate endogenous NO through the suppression of iNOS/COX-2 protein expression.

• 패션비즈니스
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• 제23권2호
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• pp.48-61
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• 2019

The objective of this study was to derive a list of creative thinking techniques applied with the requirements of the appropriate technique for the task of fashion design development among the process of fashion product planning. This was done through the analysis of thinking techniques by the type of thinking and idea method. Also, the study presented how each creative thinking technique derived is applied to the task of developing fashion design. The scope of the study was 'Fashion Design Development Task', which corresponds to the design sketch of a fashion item based on the seasonal design concept derived through the fashion design planning stage. Research on the thinking techniques consisted largely of the process of idea thinking, the elements of creative thinking, the patterns and types of thinking. Four studies by Makoto, Michalko, De Bono, and Cox suggesting that the patterns and types of thinking techniques were analyzed for the purpose of this study as empirical studies through FGI of a group of five fashion experts. The analysis results showed that the thinking techniques suitable for the development of fashion design were derived from the technique of fractionation, attributive listing, scamper, morphological analysis, mind mapping, lotus blossom, pattern language, provocative operation, and forced connection. In particular, it can be confirmed that the scamper was treated as an efficient and practical technique in the many studies.

• 동의생리병리학회지
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• 제16권5호
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• pp.1048-1054
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• 2002

Silsosangami(SSG) is a formula of oriental medicines as an effective biological response modifier for augmenting host homeostasis of body circulation. Also SSG has been known to have an anti-diabetic activity and anti-platelet aggregation activity. The present study was undertaken to examine the effects of a new SSG on murine macrophage and human neutrophil functions as well as on several enzymes relevant to the inflammatory process. The results of the present study indicate that SSG exerts anti-inflammatory effects related to the inhibition of neutrophil functions and of PGE2 production, which could be due to a decreased expression of and COX-2.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1171-1174
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• 2005

Manufacturing capability at the micro or nano scale production field is requested strongly in view of parts and product miniaturization. Miniaturized parts and products will introduce lots of benefits in terms of high precision functionality and low energy consumption. This paper presents the results of micro milling machine tool development for micro machining process. Finite element analysis has been performed to know the relationship between design dimensional variables and structural stiffness in terms of static, dynamic, thermal aspects. Performance evaluation through machining has been tested and discussed for achievable machining characteristics.

• 혜화의학회지
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• 제22권1호
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• pp.37-48
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• 2013

This study aims to summarize and makes a reference of anti-inflammatory activities of herbal medicines. In this process, this review collated papers of anti-inflammation-focused studies using herbal medicines in Oriental medical journals since 2003. Finally 221 papers were included and the type of materials, the type and effective classification of herbal medicines, the type of cells used in the experiments and the action and mechanisms of herbal medicine were analysed. The herbal medicines having the effects of decreasing fire and tonifying and nourishment were used the most. Most herbal medicines in this study can decrease proinflammatory cytokines, NO and prostaglandin 2 (PGE 2) production, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by regulating of nuclear factor kappa B (NF-${\kappa}B$) and/or mitogen activated protein kinases (MAPKs).

• Journal of the Korean Statistical Society
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• 제36권1호
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• pp.57-76
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• 2007

Kriging is a nonparametric regression method used in geostatistics for estimating curves and surfaces for spatial data. It may come as a surprise that the Kriging estimator, normally derived as the best linear unbiased estimator, is also the solution of a particular variational problem. Thus, Kriging estimators can also be interpreted as generalized smoothing splines where the roughness penalty is determined by the covariance function of a spatial process. We build off the early work by Silverman (1982, 1984) and the analysis by Cox (1983, 1984), Messer (1991), Messer and Goldstein (1993) and others and develop an equivalent kernel interpretation of geostatistical estimators. Given this connection we show how a given covariance function influences the bias and variance of the Kriging estimate as well as the mean squared prediction error. Some specific asymptotic results are given in one dimension for Matern covariances that have as their limit cubic smoothing splines.

• Journal of the Korean Data and Information Science Society
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• 제12권2호
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• pp.125-143
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• 2001

We, in this paper, propose a kernel estimator of hazard ratio with censored survival data. The uniform consistency and asymptotic normality of the proposed estimator are proved by using counting process approach. In order to assess the performance of the proposed estimator, we compare the kernel estimator with Cox estimator and the generalized rank estimators of hazard ratio in terms of MSE by Monte Carlo simulation. Two examples are illustrated for our results.

• Bulletin of the Korean Chemical Society
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• 제29권2호
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• pp.389-392
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• 2008

High purity carbon nano fibers/tubes (CNF/Ts) which contain 97% pure graphitic carbon are prepared by a new catalytic method. These carbon nano fibers/tubes are ready to use without any further purification. The striking feature of this method is the production of carbon nano fibers/tubes of narrow distribution range. The developed catalytic method also produces pure hydrogen. An additional advantage of this catalytic method is that catalyst can be reused without reactivation. Ni:Cu catalyst system is embodied into SCHOTT-DURAN filter disc of large pore size (40-100 mm). Due to the production of hydrogen in the reaction catalyst stability is enhanced and deactivation process is considerably slowed down.

• 호남수학학술지
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• 제9권1호
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• pp.113-119
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• 1987

Random variables $X_1$, $X_1$, ..., $X_m$ are said to be weakly associated if whenever $\pi$ is a permutation of {1, 2,..., m}, $1{\leq}k<m$, and f: $R^{k}{\rightarrow}R$, g: $R^{m-k}{\rightarrow}R$ are coordinatewise nondecreasing functions then Cov $[f(X_{x(1)},...,\;X_{\pi(k)},\;g(X_{x(k+1)},...,\;X_{x(m)})]{\geq}0$, whenever the covariance is defined. An infinite collection of random variables is weakly associated if every finite subcollection is weakly associated. The basic properties of weak association and central limit theorem for weakly associated random variables are derived. We also extend this idea to point random fields and prove that a Cox process with a stationary weakly associated intensity rardom measure is weakly associated. Another inequalities and the fact that positive correlated normal random variables are weakly associated are also proved.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.185.2-185.2
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• 2003

The typical approach of virtual screening is to prepare a 3D database and dock each member to the receptor, and carry out a post-analysis to make a final selection of compounds to be tested. The biological test of these compounds leads to 'hit'. The size of the 3D database is rate-determining factor because the docking process is still time-consuming method. The number of compounds for biological testing is cost-determining factor because the materials used in the test are cost-consuming. The use of the representative subsets derived from the entire database help reduce runtime of docking procedure. (omitted)