Browse > Article

Research of Traditional Herbal Medicines for Anti-inflammatory Effects - Focusing on in vitro experiments -  

Lee, Soo-Jin (Dept. of Physiology, College of Korean Medicine, Sangji University)
Publication Information
Journal of Haehwa Medicine / v.22, no.1, 2013 , pp. 37-48 More about this Journal
Abstract
This study aims to summarize and makes a reference of anti-inflammatory activities of herbal medicines. In this process, this review collated papers of anti-inflammation-focused studies using herbal medicines in Oriental medical journals since 2003. Finally 221 papers were included and the type of materials, the type and effective classification of herbal medicines, the type of cells used in the experiments and the action and mechanisms of herbal medicine were analysed. The herbal medicines having the effects of decreasing fire and tonifying and nourishment were used the most. Most herbal medicines in this study can decrease proinflammatory cytokines, NO and prostaglandin 2 (PGE 2) production, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by regulating of nuclear factor kappa B (NF-${\kappa}B$) and/or mitogen activated protein kinases (MAPKs).
Keywords
inflammation; anti-inflammation; herbal medicine;
Citations & Related Records
Times Cited By KSCI : 10  (Citation Analysis)
연도 인용수 순위
1 Kim S, Lee E, Lee H, Nam G, Kim H, Hwang S, Hwang S: Effect on Inflammatory-cytokines Production Inhibition and Analgesic Activity of Perilla Frutescens Extracts. Korean Journal of Oriental Physiology and Pathology 20(2): pp.414-419, 2006.
2 오형호 외. 만성질환 실태와 관리방안. 서울, 한국보건사회연구원, 2001.
3 Kim EJ, Kim GY: Regulation of Inflammatory Cytokine Production by Bee Venom in Rat Chondrocytes. Korean Journal of Oriental Physiology and Pathology 25(1): pp. 132-137, 2011.
4 Yoo S, Jeong S, Kim Y, Lim H, Jin S, Jeon W et al. Effects of Water and Ethanol Extracts from Ojeok-san on Inflammation and its Related Diseases. Korean Journal of Oriental Internal Medicine 33(4): pp.418-428, 2012.
5 전국한의과대학 본초학교수 공저. 본초학. 서울, 영림사, 1991.
6 허준 지음, 동의문헌연구실 옮김. 신대역동의 보감. 서울, 법인문화사, 2009.
7 Guo LY, Hung TM, Bae KH, Shin EM, Zhou HY, Hong YN, Kang SS, Kim HP: Anti-inflammatory Effects of Schisandrin Isolated from the Fruit of Schisandra Chinensis Baill. Eur J Pharmacol 591(1-3): pp.293-299, 2008.   DOI   ScienceOn
8 Bosca L, Zeini M, Traves PG, Hortelano S: Nitric Oxide and Cell Viability in Inflammatory Cells. Toxicology 2008(2): pp.249-258, 2005.
9 Hur I, Sim S, Kim K: Anti-inflammatory Effect of Various Solvent Extract from Atractylodes Japonica on Lipopolysaccharide -induced Inflammation in BV2 cells. The Joumal of Korean Oriental Medical Ophthalmology, Otolaryngology & Dermatology 20(2): pp.36-46, 2007.
10 Chung HY, Kim HJ, Kim KW, Choi JS, Yu BP: Molecular Inflammation Hypothesis of Aging Based on the Anti-aging Mechanism of Calorie Restriction. Micro Res Techinq 59: pp.264-272, 2002.   DOI   ScienceOn
11 Jin HZ, Lee JH, Lee D, Hong YS, Kim YH Lee JJ: Inhibitors of the LPS-induced NF-${\kappa}B$ Activation from Artemisia Sylvatica. Phytochemistry 65: pp.2247 -2253, 2004.   DOI   ScienceOn
12 Tsujii, M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN: Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells. Cell 93(5): pp.705-716, 1998.   DOI   ScienceOn
13 Cho H, Jung H, Lee J, Jo M, Jee S: Anti-inflammaory Effects of the MeOH Extract of Gentianae Macrophyllae Radix in vivo. The Joumal of Korean Oriental Medical Ophthalmology, Otolaryngology & Dermatology 22(3): pp.63-70, 2009.
14 Kim S, Kim K: The Effects of Ethanol Extract from Atractylodes Chinensis Rhizome on the Mast Cell-Mediated Inflammatory Responses. The Joumal of Korean Oriental Medical Ophthalmology, Otolaryngology & Dermatology 24(1): pp. 45-63, 2011.
15 Yoo YM, Joo SS, Lee SG, Lee DI. Potential Role of Anti-inflammation by Red Ginseng in Rat Microglia. Korean Journal of Oriental Physiology and Pathology 19(1): pp.242-245, 2005.
16 Woo S, Jeong J, Shin H: Inhibitory Effects of Mori Fructus on the Peroxynitrite and Proinflammatory Proteins. Korean Journal of Oriental Physiology and Pathology 22(6): pp. 1475-1481, 2008.
17 Jung I, Song H: Obovatol Inhibits Inflammation Mediator Generation and Colon Carcinoma SW620, HCT116 Cell Growth Through Induction of Apoptotic Cell Death Via Inactivation of NF-${\kappa}B$. The Journal of Korea Acupuncture on Moxibustion Society 25(2): pp.75-89, 2008.
18 Zo C, Lee S, Kim D, Lee S, Song B: Regulatory Effect of Inflammatory Cytokines Secretion and Hypoxia -inducible Factor-1$\alpha$ Activation by Panax ginseng. Korean Journal of Oriental Physiology and Pathology 20(5): pp. 1327-1333, 2006.
19 Choi EK, Roh SS: Effects of YongdamSaganTangGamibang(YSTG) on the Inflammatory Reactions. The Joumal of Korean Oriental Medical Ophthalmology, Otolaryngology & Dermatology 17(2): pp.39-47, 2004.
20 You B, Kim H: Effect of Forsythiae Fructus Exract on the Release of Inflammatory Mediatorinduced by Lipopolysaccharide in RAW 264.7 Macrophage. Korean Journal of Oriental Physiology and Pathology 21(3): pp. 765-770, 2007.
21 Seo U, Lee J, Park J, Park Y: The Ethylacetate Extract of North Kangwhal (Ostericum koreanum) Attenuates the Inflammatory Responses in PMA/A23187 -stimulated Mast Cells. Korean Journal of Herbology 23(4): pp.81-89, 2008.
22 Seo B, Kim E, Park S, Jang M, Choi S, Lee E: Effects of Anemarrhenae Rhizoma on LPS-stimulated Expression of COX-2 and iNOS in mouse BV2 microglial cells. The Journal of Korea Acupuncture on Moxibustion Society 22(2): pp.155-162, 2005.
23 Yun J, Song Y, Lim H: Aqueous Extract of Anemarrhenae Rhizoma Suppresses Lipopolysaccharide-induced Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells. The Journal of Oriental Rehabilitation Medicine 16(4): pp.49-60, 2006.
24 Lim Y, Lyu J, Shin S, Lee S, Yoon H, Lyu S et al: Inhibitory Effects of Hwanggigunjung-tang on the secretion of PGE 2, NO and Cytokines in LPS-stimulated BV2 microglial Cells. The Joumal of Korean Oriental Medical Ophthalmology, Otolaryngology & Dermatology 20(2): pp.116-131, 2007.
25 Lee J, Park S: The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NF${\kappa}B$, JNK and p38 Pathway. The Journal of Sasang Constitutional Medicine 21(1): pp. 139-149, 2009.
26 Kim B, Lee Y, Kang K: Codonopsis Lanceolata Inhibits Inflammation through Regulation of MAPK in LPS-stimulated RAW264.7 cells. Korean Journal of Oriental Physiology and Pathology 24(1): pp.80-84, 2010.
27 Jeon W, Lee M, Lim H, Shin I, Kim Y, Jin S et al: Experimental Studies on the inflammation-$\gamma$elated diseases pharmacological effect of water and 70% ethanol extracts from Socheongnyong -tang. The Korean Journal of Oriental Medical Prescription 20(2): pp.13-28, 2012.
28 Hong SH, ChoiBT, Lee YT: Effect of Zibachunggan-tang on lipopolysaccharide -induced expression of NF-${\kappa}B$ downstream genes in HepG2 cell. Korean Journal of Oriental Physiology and Pathology 17(5): pp.1251-1256, 2003.
29 Kim SH, Seo SH, Hong SH: The effect of Gagamchunggan-tang on Iipoplysaccharide -induced expression of NK${\kappa}B$ downstream genes in HepG2 cell. Korean Journal of Oriental Internal Medicine 24(1): pp.113-122, 2003.
30 Kim JK, Kim YC, Lee JH, Woo HJ. The Effects of Injinchunggan-tang(Yinchenqinggan -tang) on Inflammatory Cytokine Gene Expression in Kupffer Cells. Korean Journal of Oriental Internal Medicine 25(1): pp. 46-58, 2004.
31 Han CW, Kim YC, Lee JH, Woo HJ: Effects of Chongyeal-sodok-yeum on chemokines expression in lung epithelial cells. Korean Journal of Oriental Internal Medicine 25(1): pp.59-70, 2004.