• Biomolecules & Therapeutics
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• v.29 no.2
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• pp.154-165
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• 2021

This study aimed to investigate whether the antidiabetic drugs dipeptidyl peptidase 4 (DPP4) inhibitors such as evogliptin and sitagliptin affect the membrane DPP4 (mDPP4) enzymatic activity and immune function of T helper1 (Th1) cells in terms of cytokine expression and cell profiles. The mDPP4 enzymatic activity, cytokine expression, and cell profiles, including cell counts, cell viability, DNA synthesis, and apoptosis, were measured in pokeweed mitogen (PWM)-activated CD4+CD26+ H9 Th1 cells with or without the DPP4 inhibitors, evogliptin and sitagliptin. PWM treatment alone strongly stimulated the expression of mDPP4 and cytokines such as interleukin (IL)-2, IL-10, tumor necrosis factor-alpha, interferon-gamma, IL-13, and granulocyte-macrophage colony stimulating factor in the CD4+CD26+ H9 Th1 cells. Evogliptin or sitagliptin treatment potently inhibited mDPP4 activity in a dose-dependent manner but did not affect either the cytokine profile or cell viability in PWM-activated CD4+CD26+ H9 Th1 cells. These results suggest that, following immune stimulation, Th1 cell signaling pathways for cytokine expression function normally after treatment with evogliptin or sitagliptin, which efficiently inhibit mDPP4 enzymatic activity in Th1 cells.

• Management & Information Systems Review
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• v.33 no.2
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• pp.37-61
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• 2014

This research is to study presenteeism of members of a organization. It factually verifies how the job stress perceived by the members affect on presenteeism and examines factors to alleviate presenteeism, in addition, tests moderating effects based on the core self-evaluations and team climate. Research results reveal, first of all, that influencing relationship which job stress increases presenteeism exists. Second, core self-evaluations control the relationship between job stress and presenteeism, which means the stronger subconscious to oneself is the more it relieve the relationship between job stress and presenteeism. Third, team climate partially contolled the relationship between job stress and presenteeism. Atmosphere with clearer performance responsibility has better controlling effect to alleviate the relationship between job stress and presenteeism. Within the team climate, subordinate variables determine the effect on the presenteeism relationship. Significances and limitations of this research was discussed at the last.

• Korean Journal of Microbiology
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• v.27 no.3
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• pp.169-175
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• 1989

To study the role of mutant precore region in expression and secretion of hapatitis B viral core antigen, we have cloned core antigen gene(HBc) with or without precore region in geterologous expression vectors containing SV40 promoter, yeast promoter, and lambda $P_{L}$ promoter. In COS cells transfected with plasmid containing C-gene with precore region, antigens were detected in both cell extract and cultured medium. However, in the cells transfected with plasmids containing C-gene without precore or with mutated precore region by one nucleotide (T) addition at the nucleotide 1,821, HBcAg was detected only in cell extracts. These results support that the mutation by one nucleotide addition shifted the initiation codon of precore region to 53 nucleotides upward and the elongated precore region also played a major role in the secretion of HBcAg in mammalian cells. In the case of yeast and E. coli, HBcAg was detected only in cell extracts in spite of the presence of precore region, which suggest that precore region could not affect HBcAg secretion in these system.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.1
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• pp.78-84
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• 2017

Objective: The aim of this study was to examine shifts in the composition of the bacterial population in the intestinal tracts (ITs) of weaning piglets by antibiotic treatment using high-throughput sequencing. Methods: Sixty 28-d-old weaning piglets were randomly divided into two treatment groups. The Control group was treated with a basal diet without antibiotics. The Antibiotic group's basal diet contained colistin sulfate at a concentration of 20 g per ton and bacitracin zinc at a concentration of 40 g per ton. All of the pigs were fed for 28 days. Then, three pigs were killed, and the luminal contents of the jejunum, ileum, cecum, and colon were collected for DNA extraction and high-throughput sequencing. Results: The results showed that the average daily weight gain of the antibiotic group was significantly greater (p<0.05), and the incidence of diarrhea lower (p>0.05), than the control group. A total of 812,607 valid reads were generated. Thirty-eight operational taxonomic units (OTUs) that were found in all of the samples were defined as core OTUs. Twenty-one phyla were identified, and approximately 90% of the classifiable sequences belonged to the phylum Firmicutes. Forty-two classes were identified. Of the 232 genera identified, nine genera were identified as the core gut microbiome because they existed in all of the tracts. The proportion of the nine core bacteria varied at the different tract sites. A heat map was used to understand how the numbers of the abundant genera shifted between the two treatment groups. Conclusion: At different tract sites the relative abundance of gut microbiota was different. Antibiotics could cause shifts in the microorganism composition and affect the composition of gut microbiota in the different tracts of weaning piglets.

• Restorative Dentistry and Endodontics
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• v.37 no.4
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• pp.207-214
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• 2012

Objectives: This study evaluated the influence of chlorhexidine (CHX) on the microtensile bonds strength (${\mu}TBS$) of resin core with two adhesive systems to dentin in endodontic cavities. Materials and Methods: Flat dentinal surfaces in 40 molar endodontic cavities were treated with self-etch adhesive system, Contax (DMG) and total-etch adhesive system, Adper Single Bond 2 (3M ESPE) after the following surface treatments: (1) Priming only (Contax), (2) CHX for 15 sec + rinsing + priming (Contax), (3) Etching with priming (Adper Single Bond 2), (4) Etching + CHX for 15 sec + rinsing + priming (Adper Single Bond 2). Resin composite build-ups were made with LuxaCore (DMG) using a bulk method and polymerized for 40 sec. For each condition, half of specimens were submitted to ${\mu}TBS$ after 24 hr storage and half of them were submitted to thermocycling of 10,000 cycles between $5^{\circ}C$ and $55^{\circ}C$ before testing. The data were analyzed using ANOVA and independent t-test at a significance level of 95%. Results: CHX pre-treatment did not affect the bond strength of specimens tested at the immediate testing period, regardless of dentin surface treatments. However, after 10,000 thermocycling, all groups showed reduced bond strength. The amount of reduction was greater in groups without CHX treatments than groups with CHX treatment. These characteristics were the same in both self-etch adhesive system and total-etch adhesive system. Conclusions: 2% CHX application for 15 sec proved to alleviate the decrease of bond strength of dentin bonding systems. No significant difference was shown in ${\mu}TBS$ between total-etching system and self-etching system.

• KIPS Transactions on Software and Data Engineering
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• v.1 no.1
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• pp.69-74
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• 2012

Many internet users attempt to focus on the issues which have posted on social network services in a very short time. When some social big issue or event occurred, it will affect the number of comments and retweet on that day in twitter. In this paper, we propose the method of extracting core events based on timeline analysis, sentiment feature and retweet information in twitter data. To validate our method, we have compared the methods using only the frequency of words, word frequency with sentiment analysis, using only chi-square method and using sentiment analysis with chi-square method. For justification of the proposed approach, we have evaluated accuracy of correct answers in top 10 results. The proposed method achieved 94.9% performance. The experimental results show that the proposed method is effective for extracting core events in twitter corpus.

• Korean Journal of Applied Biomechanics
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• v.31 no.4
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• pp.297-307
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• 2021

Objective: The aim of this study was to analyze kinetic variables between thermotherapy and dynamic warm-up during drop-landing. Method: Twenty male healthy subjects (Age: 21.85 ± 1.90 years, Height: 1.81 ± 0.06 cm, Weight: 68.5 ± 7.06 kg) underwent three treatments applied on the thermotherapy of femoral muscles and a dynamic warm-up. The thermotherapy was performed for 15 minutes while sitting in a chair using an electric heating pad equipped with a temperature control device. Dynamic warm-up performed 14 exercise, a non-treatment was sitting in a chair for 15 minutes. Core temperature measurements of all subjects were performed before landing at a height of 50 cm. During drop-landing, core temperature, joint angle, moment, work of the sagittal plane was collected and analyzed. All analyses were performed with SPSS 21.0 and for repeated measured ANOVA and Post-hoc was Bonferroni. Results: Results indicated that Thermotherapy was increased temperature than other treatments (p = .000). During drop-landing, hip joint of dynamic warm-up was slower for angular velocity (p < .005), and left ankle joint was fastest than other treatments (p = .004). Maximum joint moment of dynamic warm-up was smaller for three joints (hip extension: p = .000; knee flexion/extension: p = .001/.000; ankle plantarflexion: p = .000). Negative work of dynamic warm-up was smaller than other treatments (p = .000). Conclusion: In conclusion, the thermotherapy in the local area doesn't affect the eccentric contraction of the thigh. The dynamic warm-up treatment minimized the joint moment and negative work of the lower joint during an eccentric contraction, it was confirmed that more active movement was performed than other treatment methods.

• Journal of Digital Convergence
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• v.19 no.6
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• pp.11-21
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• 2021

The aim of this study is to examine the effectiveness of learning by running an extracurricular program to make effective learning of unfamiliar and difficult programming education possible for students in the humanities. Analysis of learning-related data for one semester of lectures that were collected from 70 humanities students in departments A and B, data collected from a creative convergence app development contest extracurricular program, and data obtained through a questionnaire show that extracurricular program activities affect academic performance. The results of the core competency diagnosis test for students that was conducted before and after participating in the curriculum showed that core competencies improved for both A and B departments after participating in the curriculum. This study shows that extracurricular program activities can help individuals improve their abilities, while also providing customized guidance to reclusive students to improve their academic performance. By carrying out customized coaching for each department to develop apps related to the major field rather than general apps, we hope for improvements in ability to solve problems by converging with the major field, computational thinking, and creative thinking, in the future.

• Convergence Security Journal
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• v.22 no.5
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• pp.81-87
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• 2022

The purpose of this paper is to take a look the effect of the physical security level of companies possessing national core technology on security performance and work efficiency. To this end, a survey was set out for about 200 security officers for a month. In the survey, the independent variable was physical security level, the parameter was security performance, and the dependent variable was work efficiency. Reliability analysis, validity analysis, discriminant validity analysis, etc. were analyzed for causality through SPSS. As a result, "Physical Security Level ⇒ Security Performance, Security Performance ⇒ Work Efficiency" was adopted, but "Physical Security Level ⇒ Work Efficiency" was rejected. Therefore, it was found that the physical security level affects work efficiency through security performance, which is a parameter. However, it was found that the physical security level did not directly affect work efficiency. In order to improve work efficiency in the future, improving security performance should be a priority.

• Journal of Convergence for Information Technology
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• v.12 no.2
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• pp.54-62
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• 2022

This exploratory study aims to identify effect on core nursing competency of nursing students who experienced convergence practice due to COVID-19. The subjects of this study surveyed 123 senior nursing students in U city with a structured self-report questionnaire analyzed by the SPSS 22.0 software, t-test, One-way ANOVA, correlation, and multiple regression analysis. The average scores for nursing competence scale, self-directed learning ability, learning satisfaction, learning outcomes were 3.99, 3.71, 4.11 and 4.25 out of 5.00. The factors affecting of students' nursing competencies were self-directed learning ability, learning outcomes with 29 percent being explained by these variables. Learning satisfaction did not affect core nursing competency. Through this study we found that high quality educational environment should be prepared to improve these limitations. it is considered that a clear and systematic standard for the educational environment and evaluation of clinical practice is needed.