• Journal of The Korean Association of Information Education
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• v.25 no.6
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• pp.961-972
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• 2021

In this study, an educational program was developed so that artificial intelligence could be used as a transdisciplinary convergence education with other disciplines. The main educational content is designed for 8 hours using machine learning to help students understand the molecular structure dealt with in high school chemistry. The program developed in this study calculated the I-CVI (Item Content Validity Index) value through expert review, and as a result, none of the items were rejected with a score of .80 or higher. Because the program of this study combines the content elements of the chemistry subject and the information (artificial intelligence) subject academically, it is expected that the learner will be able to increase the convergence talent literacy. In addition, since it is not required to secure a additional number of hours for this educational program, the burden on teachers may be low.

• Human Ecology Research
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• v.60 no.2
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• pp.289-302
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• 2022

This study examined the effect of private educational expenditure on adolescent depression and somatic symptoms. The sample comprised 2,589 first-grade middle-school students who completed the 2018 Korea Children and Youth Panel Survey. Data were analyzed using ANOVA (the generalized linear model), multiple regression, and quantile regression analysis. The principal results were as follows. First, 15.15% of adolescents reported depression symptoms, and 15.57% reported somatic symptoms. Second, levels of depression were significantly different among classes with a different level of private educational expenditure. Third, depression level was significantly negatively associated with private educational expenditure, in that the higher the private educational expenditure, the lower the depression level. Fourth, the effect of private educational expenditure on adolescent depression was significant at the 70~90th quantile regression, suggesting that private educational expenditure was associated with a higher level of depression symptoms. The results indicate that private education was viewed as a consumption commodity rather than a complementary educational practice or investment in human capital. Private education as a commodity might induce the highly developed and costly private education market. In turn, there is an increased financial burden for education at one end of the social-economic continuum and depression caused by relative deprivation at the other end.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.1
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• pp.33-40
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• 2021

Recently, antibody-drug conjugates (ADCs) are used to deliver efficient cytotoxic payloads selectively in cancer cells. In the designing of an ADC, the antibody is connected to a toxic payload via a covalent linker, which helps to solubilizes the typical hydrophobic payload as well as stabilizes the linkage over circulation. The development of the linkers for the antibody drug conjugate is still in demand. Initially, the acid, disulfide, and cathepsin-sensitive ADCs attracted considerable attention for the delivery of a potent cytotoxic payload but suffer from instability in human and mouse plasma with a short half-life. In addition, It also suffer from a solubility issue that induces aggregation, which is the major problem in their development. ADCs associated with sulfatase and phosphatase cleavable linker are highly soluble due to the anionic nature of sulfate and phosphate groups. The ADCs also showed high stability in human and mouse plasma. Therefore, to overcome these limitations, sulfatase and phosphatase cleavable linkers were developed. This review focuses on the recently reported advantages of sulfatase and phosphatase cleavable linkers for ADCs.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.85-91
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• 2021

Selective amino acid conjugation of bulky antibodies is a valuable asset for real-time diagnosis and therapy. However, selective conjugation incorporating a chelate-bearing radioactive atom into an antibody without affecting its immunoreactivity is a challenging task. A bifunctional chelator (BFC), a selective amino acid-targeting probe, and a linker have been developed to overcome this problem. Here, we report the synthesis of a novel propylene cross-bridged chelator (PCB)-1,8-N,N'-bis-(carboxymethyl)-1,4,8,11-tetraazacyclotetradecane (TE2A)-luminol BFC via a click reaction and radiolabel it with a ⁶⁴Cu ion for tyrosine-selective conjugation of trastuzumab. In the initial optimization study, we tried different oxidative addition conditions such as electro-oxidation, hemin, horseradish peroxidase, iodogen tube, chloramine-T, and iodo beads. In this study, up to 82% of ⁶⁴Cu-PCB-TE2A-luminol was conjugated with the antibody in an iodo bead-catalyzed oxidative addition reaction with an isolated yield of 24.4%.

• Korean Institute of Interior Design Journal
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• v.23 no.2
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• pp.62-70
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• 2014

In the knowledge and information society of 21st century, 'Creativity' which is the core of national competitiveness and an important foundation for the development of the country has been emphasized on the importance of it. As a result, the convergence educational programs, as known as STEAM (science, technology, engineering, arts, mathematics) became more and more needed to children for cultivating creativity. As a follow-up study on STEAM program combining robotics and design for children developed by Design Promotion Committee of KIID, this study intends to modify and reanalyze the program and to seize the educational effectiveness of the groups of university students as mentors and children as mentees, The results are as follows; First, although the importance of STEAM education is highlighted, short-term educational programs tend to consist of only the contents of each field: design or science. Second, pre-training and mentoring were helpful to both mentors and children. Third, Children expanded the perception of STEAM concept and increased their interests in career. Mentors recognized the importance and the necessity of STEAM education, and were very satisfied with team activities which gave a new experience of working with other field of people. Therefore, this program provide to children an experience of logical thinking, having interests on uninterested field, and encouraging teamwork. Also, it provides to mentors a chance to develop their potential and experience, and set up a new vision for future.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.8 no.2
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• pp.151-156
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• 2022

Liposomes are bilayered particles that are surrounded by an aqueous solvent with amphiphilic substances such as phospholipids. Liposomes have the potential to overcome the limitations of physiochemical properties of existing drugs, and are therefore widely used in research for the treatment of many diseases, especially cancer. Currently, there are many liposome manufacturing methods that use various lipids and amphiphiles. Among them, the thin film-hydration method is a traditional and very simple method to prepare liposomes by hydrating a dry lipid film in an aqueous solvent, which has been widely used in the laboratory until recently. Recently, approaches to new nuclear imaging agents and radiotherapy by loading radioactive isotopes inside liposomes have been actively studied. In this review, we would like to discuss considerations for preparing liposomes using the thin film-hydration method.

• Journal of the Korea Convergence Society
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• v.9 no.12
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• pp.393-400
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• 2018

This study was to verify the effects of education in expression activity and various convergence education found in the class scene of one elementary school man teather to research of qualitative pattern and analyzes how it is expanded. This study were made through two class participation observation and six video analysis. In addition, we measured in-depth interviews of participants and students, a 10-week jump band training program, and applied a step-by-step physical activity program to enhance creative expressiveness. Based on the results of the study, the conclusions are as follows. First, It was found that the Jump-band training positively affects the students' speed, agility, and cardiopulmonary endurance. Second, It was found that the application of the step-by-step physical expression activity program had a positive effect on the students themselves. Third, It was found that it has an educational effect on the whole life of students beyond the curriculum and the field by attempting various fusion education. Based on this study, we propose the educational effects of the pre - curricular activities and the convergence lessons in elementary school during the follow - up research.

• Journal of the Korea Society of Computer and Information
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• v.15 no.11
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• pp.83-90
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• 2010

In this paper, we developed the program related green growth based Educational-Robot in the framework of Convergence for the community child welfare centers' children who are in poverty and broken homes as the way to enhance the competitiveness about education and a solution to cope with actively about the main tasks of the state for human resources in the future. Through the program developed, it has been verified the impact on the energy saving attitude. According to this result, it has been proved that convergence study program linked green growth for children of community welfare child center is effective to energy saving attitude. Through it, it is expected to help to meet the educational needs of the community child welfare centers' children.

• Journal of Fisheries and Marine Sciences Education
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• v.29 no.3
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• pp.822-833
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• 2017

The purpose of this study is to propose a company-centered apprenticeship educational program to secure professional manpower in the ship repair industry. There are various efforts to secure professional manpower across industries. However, it is very rare in the ship repair industry. In this study, we analyzed the educational program implemented by Research Institute of Medium & Small Shipbuilding(RIMS) with considering their problems. We also studied the apprenticeship education for improving a few problems of RIMS's program. As a result, we presented the new educational program by integrating the concept of apprenticeship education into the current educational program with two main points as belows. 1) the necessity of the convergence with a company-centered apprenticeship education. 2) the necessity of a training program with a focus on the global market environment.

• Journal of Fashion Business
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• v.27 no.3
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• pp.150-165
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• 2023

The purpose of this study is to propose a fashion design creativity convergence education program based on creative thinking that can be effectively used to create a creative fashion design in the fashion education field, and to verify the suitability of this program and its effectiveness in improving creativity. To this end, a fashion design creative convergence program combining divergent thinking and convergence thinking was designed, and an experimental study was conducted among college students in the fashion design department. Creativity evaluation was conducted by evaluating students' creative ability and creativity of fashion design results. In addition, an open survey was conducted to collect learners' opinions on the suitability of the program and the convergence process of divergent and convergent thinking. As a result of this study, it was found that the fashion design creative convergence education program based on creative thinking improves the creative competency of major learners of fashion design and is the learning performance competency in the process of producing creative results. This study is meaningful as it is a basic study that proposes a fashion design education program to foster the creative competency of fashion design majors, and is expected to be used in various ways in the educational field.