• Genomics & Informatics
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• v.11 no.4
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• pp.191-199
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• 2013

High-throughput next-generation sequencing (NGS) technology produces a tremendous amount of raw sequence data. The challenges for researchers are to process the raw data, to map the sequences to genome, to discover variants that are different from the reference genome, and to prioritize/rank the variants for the question of interest. The recent development of many computational algorithms and programs has vastly improved the ability to translate sequence data into valuable information for disease gene identification. However, the NGS data analysis is complex and could be overwhelming for researchers who are not familiar with the process. Here, we outline the analysis pipeline and describe some of the most commonly used principles and tools for analyzing NGS data for disease gene identification.

• The Plant Pathology Journal
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• v.36 no.3
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• pp.193-203
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• 2020

Volatile compounds (VOCs) are not only media for communication within a species but also effective tools for sender to manipulate behavior and physiology of receiver species. Although the influence of VOCs on the interactions among organisms is evident, types of VOCs and specific mechanisms through which VOCs work during such interactions are only beginning to become clear. Here, we review the fungal volatile compounds (FVOCs) and their impacts on different recipient organisms from perspective of distinct lifestyles of the filamentous fungi. Particularly, we discuss the possibility that different lifestyles are intimately associated with an ability to produce a repertoire of FVOCs in fungi. The FVOCs discussed here have been identified and analyzed as relevant signals under a range of experimental settings. However, mechanistic insight into how specific interactions are mediated by such FVOCs at the molecular levels, amidst complex community of microbes and plants, requires further testing. Experimental designs and advanced technologies that attempt to address this question will facilitate our understanding and applications of FVOCs to agriculture and ecosystem management.

• Language and Information
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• v.6 no.2
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• pp.171-185
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• 2002

I claim that the asymmetry of locality effects in wh-questions involving Complex Noun Phrase Island in Korean follows from the proposal for the asymmetric mode of scope taking between way (why) and the other wh-words in Korean as laid out in Choi (2002). 1 will show that the present proposal is superio. to the LF pied-piping approach in Nishigauchi (1990) and WH-structure pied-piping in von Stechow(1996) in that it does not have the fatal problem of wrong semantics in Nishigauchi and Subjacency violation problem in von Stechow. The crossed reading in examples involving Wh-island has an interesting implication for the mechanism of unselective binding, suggesting that Heim's (1982) quantifier indexing mechanism, which requires the local unselective binding of the indefinite by the unselective binder, may be too strong.

• Structural Engineering and Mechanics
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• v.7 no.6
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• pp.551-559
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• 1999

This paper presents some simple thinking on an age-old question that given a bridge of a certain span and loading, from the point of view of the structural efficiency, where should the bridge deck be positioned? Generally, this decision is made for other reasons than structural efficiency such as aesthetics and the analyst is often presented with a fait accompli. Using the recently invented Evolutional Structural Optimisation (ESO) method, it is possible to demonstrate that having the deck at different vertical locations can lead to a very different mass and shape for each structural form resembling cable-stayed and cable-truss bridges. By monitoring a performance index which is the function of stresses and volume of discretised finite elements, the best optimised structure can be easily determined and the bridge deck positioning problem can be efficiently solved without resorting to any complex analysis procedures.

• Bulletin of the Korean Mathematical Society
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• v.58 no.4
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• pp.795-814
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• 2021

In this paper, we study the transcendental meromorphic solutions for the nonlinear differential equations: fⁿ + P(f) = R(z)e^α(z) and fⁿ + P_*(f) = p₁(z)e^α₁(z) + p₂(z)e^α₂(z) in the complex plane, where P(f) and P_*(f) are differential polynomials in f of degree n - 1 with coefficients being small functions and rational functions respectively, R is a non-vanishing small function of f, α is a nonconstant entire function, p₁, p₂ are non-vanishing rational functions, and α₁, α₂ are nonconstant polynomials. Particularly, we consider the solutions of the second equation when p₁, p₂ are nonzero constants, and deg α₁ = deg α₂ = 1. Our results are improvements and complements of Liao ([9]), and Rong-Xu ([11]), etc., which partially answer a question proposed by Li ([7]).

• International Journal of Fluid Machinery and Systems
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• v.2 no.4
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• pp.295-302
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• 2009

The flow in the draft tube cone of Francis turbines operated at partial discharge is a complex hydrodynamic phenomenon where an incoming steady axisymmetric swirling flow evolves into a three-dimensional unsteady flow field with precessing helical vortex (also called vortex rope) and associated pressure fluctuations. The paper addresses the following fundamental question: is it possible to compute the circumferentially averaged flow field induced by the precessing vortex rope by using an axisymmetric turbulent swirling flow model? In other words, instead of averaging the measured or computed 3D velocity and pressure fields we would like to solve directly the circumferentially averaged governing equations. As a result, one could use a 2D axi-symmetric model instead of the full 3D flow simulation, with huge savings in both computing time and resources. In order to answer this question we first compute the axisymmetric turbulent swirling flow using available solvers by introducing a stagnant region model (SRM), essentially enforcing a unidirectional circumferentially averaged meridian flow as suggested by the experimental data. Numerical results obtained with both models are compared against measured axial and circumferential velocity profiles, as well as for the vortex rope location. Although the circumferentially averaged flow field cannot capture the unsteadiness of the 3D flow, it can be reliably used for further stability analysis, as well as for assessing and optimizing various techniques to stabilize the swirling flow. In particular, the methodology presented and validated in this paper is particularly useful in optimizing the blade design in order to reduce the stagnant region extent, thus mitigating the vortex rope and expending the operating range for Francis turbines.

• Journal of the Korean Academic Society of Industrial Cluster
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• v.2 no.1
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• pp.14-27
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• 2008

Ousters have become a key focus of interest and analysis over the last decade or so, informed by the work of the Harvard business economist Michael Porter. Recent research, however, suggests that the classic Porterian conception of clusters needs to be rethought. In particular, the idea that clusters are geogaphically bounded and integrated units whose primary link to the outside world is through the export of goods and services to global markets is highly Questionable, if not untenable. Relational approaches to clusters and regional development stress the importance of the wider networks and 'pipelines' through which knowledge is exchanged with key partners and collaborators located outside of the particular cluster in question. Rather than the main external links being those between leading firms and global markets, firms may engage in a range of global relations with collaborators and suppliers. This paper address the challenge of rethinking clusters in the light of the recent emphasis on global networks md connections, drawing on experience from m old industrial region in Western Europe Scotland. In assessing cluster experiences and initiatives in Scotland, I examine the development of the oil and gas and electronics clusters. In conclusion, I suggest that cluster initiatives me only likely to generate lasting benefits for the region in question if there is significant local ownership md control of key industries and clusters.

• Journal of Dental Anesthesia and Pain Medicine
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• v.17 no.3
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• pp.163-181
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• 2017

In the field of orofacial surgery, a red blood cell transfusion (RBCT) is occasionally required during double jaw and oral cancer surgery. However, the question remains whether the effect of RBCT during the perioperative period is beneficial or harmful. The answer to this question remains challenging. In the field of orofacial surgery, transfusion is performed for the purpose of oxygen transfer to hypoxic tissues and plasma volume expansion when there is bleeding. However, there are various risks, such as infectious complications (viral and bacterial), transfusion-related acute lung injury, ABO and non-ABO associated hemolytic transfusion reactions, febrile non-hemolytic transfusion reactions, transfusion associated graft-versus-host disease, transfusion associated circulatory overload, and hypersensitivity transfusion reaction including anaphylaxis and transfusion-related immune-modulation. Many studies and guidelines have suggested RBCT is considered when hemoglobin levels recorded are 7 g/dL for general patients and 8-9 g/dL for patients with cardiovascular disease or hemodynamically unstable patients. However, RBCT is occasionally an essential treatment during surgeries and it is often required in emergency cases. We need to comprehensively consider postoperative bleeding, different clinical situations, the level of intra- and postoperative patient monitoring, and various problems that may arise from a transfusion, in the perspective of patient safety. Since orofacial surgery has an especially high risk of bleeding due to the complex structures involved and the extensive vascular distribution, measures to prevent bleeding should be taken and the conditions for a transfusion should be optimized and appropriate in order to promote patient safety.

• Journal of the Korean Chemical Society
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• v.61 no.6
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• pp.378-387
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• 2017

In this study, we analyzed the causes of decrease in the number of students taking Chemistry ? in the College Scholastics Ability Test (CSAT) by analyzing the adequacy of the Chemistry I question in the CSAT and the recognition survey of students and teachers about the Chemistry I choice. We analyzed some questions in Chemistry I of the CSAT from the year 2014 to 2016. The questions were analyzed to determine whether they were appropriate to the curriculum content, achievement standard, and achievement level. The target of the survey for perception was 452 senior high school students and 68 science teachers. The result of the study showed that the questions in Chemistry I are somewhat difficult compared to the depth and achievement level required by the curriculum, and it also requires mathematical thinking ability. Students recognized the mathematical thinking and complex mathematical skills are needed to solve problems in Chemistry I. Teachers also thought that the choice of Chemistry I is unfavorable in aspect of meeting the minimum academic ability standard, and accordingly, they did not actively recommend students to take Chemistry I. Moreover, most of the teachers recognized that it is necessary to improve the direction of writing questions for Chemistry I. Therefore, setting questions that can be solved using chemical knowledge, not mathematical ability need to be addressed.

• Journal of the Korean association of regional geographers
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• v.13 no.5
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• pp.509-525
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• 2007

The aim of this study is to evaluate the governance system involved in the policy of upgrading the Seongseo industrial complex in Daegu city. The governance system was evaluated by four indicators; social legitimacy, reliability, expertness, and transparency. The major findings of this study are summarized as follows. It is expected that the Seongseo industrial complex upgrading policy would accelerate to upgrade the industry structure and competitiveness of the cluster. However, the firms of the cluster have a Question of reliability to the actors of initiating the policy. In this context, to raise the trust level the policy needs to turn towards making the communication channel among the stake-holders of the cluster more democratically and horizontally. It is also problematic to reveal the low degree of expertness of the policy's decision makers, the fragmented system of policy operation and a lack of information. Consequently, the policy is required to improve the transparency on the policy-making process, and to activate the participation of professional groups and civil society.