• Journal of Microbiology and Biotechnology
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• v.31 no.1
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• pp.51-62
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• 2021

Here, we investigated the prebiotic and antioxidant effects of Actinidia arguta sprout water extract (AASWE) on lipopolysaccharide (LPS)-induced cognitive deficit mice. AASWE increased viable cell count, titratable acidity, and acetic acid production in Lactobacillus reuteri strain and showed a cytoprotective effect on LPS-induced inflammation in HT-29 cells. We assessed the behavior of LPS-induced cognitive deficit mice using Y-maze, passive avoidance and Morris water maze tests and found that administration of AASWE significantly improved learning and memory function. The AASWE group showed antioxidant activity through downregulation of malondialdehyde levels and upregulation of superoxide dismutase levels in brain tissue. In addition, the AASWE group exhibited activation of the cholinergic system with decreased acetylcholinesterase activity in brain tissue. Furthermore, AASWE effectively downregulated inflammatory mediators such as phosphorylated-JNK, phosphorylated-NF-κB, TNF-α and interleukin-6. The major bioactive compounds of AASWE were identified as quercetin-3-O-arabinopyranosyl(1→2)-rhamnopyranosyl(1→6)-glucopyranose, quercetin-3-O-apiosyl(1 → 2)-galactoside, rutin, and 3-caffeoylquinic acid. Based on these results, we suggest that AASWE not only increases the growth of beneficial bacteria in the intestines, but also shows an ameliorating effect on LPS-induced cognitive impairment.

• Journal of The Korean Association For Science Education
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• v.22 no.4
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• pp.837-850
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• 2002

In an attempt to accelerate the development of formal reasoning ability of students, 'Thinking Science' activities developed by the Cognitive Acceleration through Science Education(CASE) project were implemented to 841 students in 7th grade aged 12+ in six middle schools over a period of two years. Homogeneity between the CASE group and control group was tested with SRT II, while the improvement of formal reasoning ability of the students was tested with SRT VII. The results were analyzed by treatment, gender, and cognitive levels of the students. Statistically significant gains were shown in the CASE group compared with those in the control group. Cognitive level of girls in the CASE group significantly increased as compared with the control group, while there was moderate effect in boys. These results implied that the thinking science activities were effective in cognitive acceleration of girls aged 12+. It was shown that much more CASE students in pre or concrete operational level shifted to formal operational level as compared with the control group while there were significant effects in all levels (ES=0.31${\sim}$1.10) without showing any tendency.

• Proceedings of the Acoustical Society of Korea Conference
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• autumn
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• pp.41-44
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• 1999

본 논문에서는 PC 응용을 위한 고음질의 한국어 text-to-speech(TTS) 합성 시스템을 개발하였다. 개발된 시스템의 합성방식으로는 음의 고저 조절, 인접음 사이의 연결 처리 및 음색제어 등에서 기존의 PSOLA 방식에 비해 장점을 가지는 정현파 모델 기반의 방식을 채택하였고, 자연스러운 운율 모델링을 위하여 통계적 기법중의 하나인 Classification and regression tree(CART) 방법을 사용하였다. 또한 음소 경계의 불연속성 문제를 줄이기 위한 합성단위로 초성-중성 및 종성 단위를 사용하였고, 다양한 음색표현이 가능하도록 음색제어 기능을 갖추었다. 그리고, 표준 Speech Application Program Interface(SAPI)를 준용한 TTS engine 형태로 구현함으로써 PC 상에서의 응용 프로그램 개발 편의성을 높였다. 합성음의 청취평가 결과 음질의 우수성 및 음색제어 기능의 유효성을 확인할 수 있었다.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2005.05a
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• pp.154-157
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• 2005

본 연구는 한국어를 학습한 경험이 없는 일본인의 한국어 치경폐쇄음 세 음소 범주(/ㄷ/, /ㄸ/, /ㅌ/)에 대한 지각 학습이 양순폐쇄음 세 음소(/ㅂ/. /ㅃ/, /ㅍ/) 지각에 미치는 효과를 검토하였다. 김윤현과 김정오 (2005)는 일본인들이 지각 학습과제에서 한국어 치경폐쇄음 세 범주를 구분할 때 기식성. 긴장성과 같은 변별 자질에 선택주의 하게 됨을 시사하는 결과를 얻었다. 치경음에 대한 지각 학습으로 적절한 단서에 선택주의 하게 되었다면, 같은 지각 차원에 따라 세 범주로 구분되는 양순음의 경우에도 치경폐쇄음 학습 후 음성자극들을 옳게 범주화를 할 것이다. 실험 결과, 치경폐쇄음 자극(/다/, /따/, /타/)만으로 이루어진 동일-상이판단 학습 과제에서 치경폐쇄음 파악의 정확율은 29.1%(표준오차=3.02) 증가하였고, 조음 위치의 변화에 따른 음향적 차이에도 불구하고 양순폐쇄음의 정반응율도 15.8%(표준오차=3.27)의 향상을 보였다. 이 전이효과는 치경음 지각 학습 때문에 일본인들이 폐쇄음의 세 음소 범주를 구분하는 적절한 지각 차원에 선택주의하게 되었음을 시사한다.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2005.05a
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• pp.255-260
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• 2005

번역 메모리(Translation Memory)는 오늘날 기계번역에 있어 통계기반 접근법이나 형태-통사적 접근법 모두에 있어 가장 중요한 요소로 평가되고 있다. 그러나 번역 메모리는 언어의 자질 및 각 용례를 통합적으로 관리해야 하며, 이를 기계가 자동으로 처리해주어야 하는 어려움이 있다. 최근에는 이러한 문제점을 해결하기 위해 다국적 기업을 중심으로 기계보조번역(Computer Aided Translation) 환경에 대한 연구가 활발히 이루어지고 있으나, 언어적인 특성 보다는 번역 메모리의 저장/대치적 측면에서 주요 연구가 이루어지고 있다. 이 논문에서는 번역 메모리 정보가 보다 높은 재사용성을 보이기 위해서는 다양한 언어자질값을 담을 수 있어야 한다고 보고, 이를 효율적으로 관리/구축할 수 있는 기계보조번역 워크벤치의 framework을 제시한다. 언어분석을 위한 대상언어로는 교역 및 기술 측면에서 영어, 일어, 중국어 다음으로 영향력이 높은 불어를 채택하며, 기존 기계보조번역 방식에 대한 고찰을 통해 개선된 번역 메모리 관리, 자동분석/번역 모듈 및 협업(collaboration) 방안에 대해 소개하고, 향후 발전방향에 대해 논의한다.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2010.05a
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• pp.48-54
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• 2010

INTRODUCTION Interaction between temporal events at the millisecond level is important for visual and tactile interaction. OBJECT The aim of the present study is to identify any neural signature, as reflected in event-related potentials (ERP), for the integrative processes when the two sensory modalities are stimulated in synchrony as opposed to when they are stimulated separately. METHOD The basic strategy was to compare ERP signals obtained with simultaneous visual and tactile stimulation with a linear summation of ERP patterns obtained with each modality stimulated separately. Condition were presented, paired with various stimulus-onset-asynchronies (SOA) ranging from - 300 ms (tactile-first) to 300 ms (visual-first), and in trials where only one modality was stimulated alone. RESULT A positive deviation was located in observed ERP at C4 electrode (contralateral to the stimulated hand) at 200-400 ms, in comparison to the predicted ERP. The deviation was present at all SOAs other than -300ms (tactile-first) and 300 ms (visual-first). There was also a positive deviation at occipital leads at the 50-ms SOA (visual-first) trials. DISCUSSION It suggested that neural signatures of cross-modal integration occur within a limited time-window. The deviations were specifically localized at the contralateral somatosensory and visual cortices, indicating that the integration happens at or before the level of the primary cortices.

• Molecules and Cells
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• v.42 no.11
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• pp.739-746
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• 2019

Significant knowledge about the pathophysiology of Alzheimer's disease (AD) has been gained in the last century; however, the understanding of its causes of onset remains limited. Late-onset AD is observed in about 95% of patients, and APOE4-encoding apolipoprotein E4 (ApoE4) is strongly associated with these cases. As an apolipoprotein, the function of ApoE in brain cholesterol transport has been extensively studied and widely appreciated. Development of new technologies such as human-induced pluripotent stem cells (hiPSCs) and CRISPR-Cas9 genome editing tools have enabled us to develop human brain model systems in vitro and readily manipulate genomic information. In the context of these advances, recent studies provide strong evidence that abnormal cholesterol metabolism by ApoE4 could be linked to AD-associated pathology. In this review, we discuss novel discoveries in brain cholesterol dysregulation by ApoE4. We further elaborate cell type-specific roles in cholesterol regulation of four major brain cell types, neurons, astrocytes, microglia, and oligodendrocytes, and how its dysregulation can be linked to AD pathology.

• Journal of The Korean Association For Science Education
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• v.22 no.1
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• pp.12-21
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• 2002

The purpose of this study is to understand middle school students' levels of cognitive conflict for the students provided quantitative demonstration and qualitative demonstration after the pre-test. 297 middle school students were selected from one school in Pusan. Action-reaction problem of mechanics and electric bulbs in parallel problem of electricity were used in the demonstration and the pre-test. Students' cognitive conflict levels were investigated using the developed items by Kwon(1999) et al. We compared cognitive conflict levels between quantitative demonstration group and qualitative demonstration group. In addition to, we compared cognitive conflict levels between students who changed their preconceptions and the students who adhered to their preconceptions. We investigated correlation between levels of faith with preconceptions and cognitive conflict levels. The study generated the following results. First, students who selected incorrect choice in pre-test showed the higher levels of cognitive conflict in quantitative demonstration group than qualitative demonstration group and students who selected correct choice in pre-test showed higher levels of cognitive conflict in qualitative demonstration group than quantitative demonstration group. Second, students who changed their preconceptions were higher levels of cognitive conflict than students who adhered their preconceptions. Third, students who selected incorrect choice in pre-test showed positive correlation between levels of faith with preconceptions and levels of cognitive conflict, and students who selected incorrect choice in pre-test showed negative correlation between levels of faith with preconceptions and levels of cognitive conflict.

• Korean Journal of Cognitive Science
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• v.4 no.2
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• pp.5-28
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• 1994

In this thesis we attempt to analyze modern Korean poetic texts in the franmeworks of text limgisitics and cognitive pragmatics. Both frameworks describe and explai human verbal communicantion in terms of congnitive information-processing procedures.By utilizing analytical devices provided by seven standards of textuality we can analyze any type of text,especially in terms of the cognitive operations underlying the production and reception processes.It is clamed in cognitive pragmatic framework that human ostensive inforential communication is regulated by the Principle of Relevance.We claim that the relevance-based framework of pragmatics provides evidence and rationale for those cognitive operations identified in the text linguistic framework. poetic texts involve every kind of cognitive strategies and processing procedures underlying human verbal communication.So,if modern Korean poetic texts are satisfactorily analyzed by text linguistics and cognitive pragmatics,it means that both frameworks are very useful tools for analyzing texts and that all the other text types which are less complicated than poetic text will also be analyzed by these frameworks. Researchers of poetry,and poets,are sensitive to poetic effects.They feel more of poeticity while reading poetic texts than ordinary readers do.However,these researchers or poets sometimes give different interpretation of a single poetic text.The interpretation of poetry cannot be anything,because poets write poems with particular intertions and do not just throw them out so as to be interpreted at ramdom.This thesis suggersts that the poeticity felt by the reader can be described and accounted for in a scientific way.In other words,text linguistics and cognitive pragmatics enable the researchers of poetry to become objective in interpreting poetic texts. It will be clearly shown that we have to see poetic texts from a cognitive perspective,since they are by-products of cognitive processing performed by discourse participants.

• Journal of The Korean Association For Science Education
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• v.29 no.8
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• pp.886-897
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• 2009

One of useful strategies to change students' misconceptions into scientific conceptions in physics is the cognitive conflict strategy, the main point of which is to arouse cognitive conflicts by presenting anomalous phenomena to students. However, it has been reported that students experienced cognitive conflicts while expecting or reasoning results of an experiment before confronting an anomalous phenomenon. Therefore, we have examined how much students' cognitive conflicts were aroused before presenting an anomalous phenomenon. Then, we investigated the effects of the cognitive conflicts aroused prior to the students' confrontation with an anomalous phenomenon, both on the cognitive conflicts occurring after the students' confrontation with it, and on the students' conceptual changes. This study was performed during regular classes about light-source and weightlessness concepts. Subjects from two different middle schools in Pusan took part in the study. Preconceptions, degrees of cognitive conflicts before and after confronting anomalies, and postconceptions were checked during the classes. Then, delayed postconceptions were also checked in 3 weeks. As a result, the degree of cognitive conflicts before confronting an anomaly was as much as the degree of cognitive conflicts after it. There was significant correlation between both conflicts. Also the degree of cognitive conflicts before confronting an anomaly was a main factor in predicting the conceptual changes, while both conflicts had been related separately to the conceptual changes.