• IMMUNE NETWORK
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• v.13 no.5
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• pp.184-193
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• 2013

Co-signaling molecules are surface glycoproteins that positively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T cell receptor (TCR) signaling. In the past 10 years, the field of co-signaling research has been advanced by the understanding of underlying mechanisms of the immune modulation led by newly identified co-signaling molecules and the successful preclinical and clinical trials targeting co-inhibitory molecules called immune checkpoints in the treatment of autoimmune diseases and cancers. In this review, we briefly describe the characteristics of well-known B7 co-signaling family members regarding the expression, functions and therapeutic implications and to introduce newly identified B7 members such as B7-H5, B7-H6, and B7-H7.

• Biomedical Science Letters
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• v.28 no.4
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• pp.211-222
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• 2022

After more than two years of efforts to end the corona pandemic, a gradual recovery is starting in countries with high vaccination rates. Easing public health policies for a full-fledged post-corona era, such as lifting the mandatory use of outdoor mask and quarantine measures in entry have been considered in Korea. However, the continuous emergence of new variants of SARS-CoV-2 and limitations in vaccine efficacy still remain challenging. Fortunately, T cells and memory T cells, which are key components of adaptive immunity appear to contribute substantially in COVID-19 control. SARS-CoV-2 specific CD4⁺/CD8⁺ T cells are induced by natural infection or vaccination, and rapid induction and activation of T cells is mainly associated with viral clearance and attenuated clinical severity. In addition, T cell responses induced by recognition of a wide range of epitopes were minimally affected and conserved against the highly infectious subsets of omicron variants. Polyfunctional SARS-CoV-2 specific T cell memory including stem cell-like memory T cells were also developed in COVID-19 convalescent patients, suggesting long lasting protective T cell immunity. Thus, a robust T-cell immune response appears to serve as a reliable and long-term component of host protection in the context of reduced efficacy of humoral immunity and persistent mutations and/or immune escape.

• Journal of the Korean Chemical Society
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• v.48 no.1
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• pp.39-45
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• 2004

Acid amplifying copolymers are synthesized by the copolymerization of tert-butyl methacrylate(tBMA) with acid-sensitive functional group and 4-hydroxy-4'p-styrenesufonyloxyisopropylidene dicyclohexane(HSI) or 4-p-styrenesulfonyloxy-4'-tosyloxyisopropylidenedicyclohexane(STI) with acid-amplifying group as novel polymeric acid amplifying photoresists. Poly(HSI-co-tBMA) film and Poly(STI-co-tBMA) film as acid amplifying photoresists show reasonable thermal stability in the absence of an acid species. Poly(STI-co-tBMA) film exhibits 2X higher photosensitivity, whereas Poly(HSI-co-tBMA) film show 2X lower photosensitivity compared with ptBMA homopolymer. The attachment of acid-amplifying units to polymer backbones could provide a novel way to enhance the photosensitivity of acid-sensitive polymers depending on the structure of acid-amplifying units.

• Journal of the Korean Chemical Society
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• v.47 no.1
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• pp.59-66
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• 2003

The comb-type grafted polymer hydrogels, which composed of N-isopropylacrylamide monomer and oligo(N-isopropylacrylamide-co-tert-butylacrylamide) [oligo(NIPAAm-co-t-BAM)], were synthesized by redox polymerization in 5~10% methanol aqueous solution using ammonium peroxodisulfate (APS) at 4 oC for 24h. The lower critical solution temperatures (LCSTs) of the comb-type grafted hydrogels were decreased with increase of t-BAM content in the grafted copolymer. We observed the effect of crosslinker and concentration of oligo(NIPAAm-co-t-BAM) on the shrinking/swelling ratio of hydrogels. Changes of shrinking/swelling ratio were decreased with increase of concentration of crosslinker. The increase of grafted oligo(NIPAAm-co-t-BAM) in the hydrogel shows an fast changes of shrinking/ swelling rate. The comb-type grafted hydrogels are expected to be valuable for the sensing materials of time-temperature labels(TTLs).

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2019.05a
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• pp.227-228
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• 2019

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2017.10a
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• pp.205-206
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• 2017

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2017.05a
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• pp.283-284
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• 2017

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2017.05a
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• pp.231-232
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• 2017

• KIPS Transactions on Software and Data Engineering
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• v.4 no.9
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• pp.331-336
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• 2015

On the IoT-based sensor networks, users or sensor nodes must perform a Service Discovery (SD) procedure before access to the wanted service. Current approach uses a center-concentrated Resource Directory (RD) servers or P2P technique, but these can cause a point-of-failure or flooding of SD messages. In this paper, we proposes an improved SWoT SD approach for CoAP-based sensor networks, which integrates Social Web of Things (SWoT) concept to current CoAP-based SD approach that makes up for weak points of existing systems. This new approach can perform a function like a keyword or location-based search originated from SNS, which can enhances the usability. Finally, we implemented a real system to evaluate.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.17 no.2
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• pp.119-126
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• 2017

Developing the TCP/IP standard IBA which is higher organization of IETF decided to attach the TCP/IP protocol stack to small things, such as sensor. This means small object is also considered as on of the communication node, it has symbolic meaning that expand smart object has all five layer. Under this background, IoT/WoT configure the intelligent network between objects based on the internet to communication was introduced. Things has own IP address on IoT environment and are smart object that a lot of people communicate over the internet on Application Layer. In other words, IoT is that smart object are commercialized space. According to the interest of IoT, IETF establish CoAP for use as IoT protocol. CoAP is expected that standard protocols created by things is connected to the Internet protocol that can be used within a constrained environment. Accordingly, in this paper, we proposed Middleware API that can manage and collect the data of objects that connected CoAP network.