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http://dx.doi.org/10.4110/in.2013.13.5.184

Emerging Co-signaling Networks in T Cell Immune Regulation  

Jung, Keunok (Department of Microbiology and Immunology, Advanced Cancer Research of Multiple Myeloma, Inje University College of Medicine)
Choi, Inhak (Department of Microbiology and Immunology, Advanced Cancer Research of Multiple Myeloma, Inje University College of Medicine)
Publication Information
IMMUNE NETWORK / v.13, no.5, 2013 , pp. 184-193 More about this Journal
Abstract
Co-signaling molecules are surface glycoproteins that positively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T cell receptor (TCR) signaling. In the past 10 years, the field of co-signaling research has been advanced by the understanding of underlying mechanisms of the immune modulation led by newly identified co-signaling molecules and the successful preclinical and clinical trials targeting co-inhibitory molecules called immune checkpoints in the treatment of autoimmune diseases and cancers. In this review, we briefly describe the characteristics of well-known B7 co-signaling family members regarding the expression, functions and therapeutic implications and to introduce newly identified B7 members such as B7-H5, B7-H6, and B7-H7.
Keywords
Co-signaling molecule; B7 family; Co-stimulation; Co-inhibition;
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