• Applied Microscopy
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• v.19 no.2
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• pp.99-118
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• 1989

The cardiotoxic effects of acute and chronic administration of adriamycin (ADR) were evaluated in A/J Swiss albino mice. In acute studies, male mice received intravenous ADR, 5mg or 15mg/kg per day for 3 or 1day and were sacrifice 12 hours later. Because the glutathione-glutathione peroxidase system is major pathway for free radical detoxication, glutathione levels and glutathione peroxidase activity was measured. In acute studies, ADR-treated mice exhibited significantly decreased levels(p<0.05) of total glutathione and unchanged levels of oxidized glutathione and percentage of oxidized glutathione. The earliest myocardial fine structural alterations included swelling and degeneration of mitochondria and dilatation of sarcoplasmic reticulum at all dosage of acute models. In chronic studies, mice received 5mg/kg ADR once a week for up to 16 weeks. Levels of total and reduced glutathione were decreased significantly(p<0.01) and oxidized glutathione and percentage of oxidized glutathione were increased significantly (p<0.05). Chronic myocardial lesions included perinuclear vacuolization, seperation of myofibrils and the fasciae adherens of intercalated disc and hypercontraction band within myocyte. Glutathione peroxidase activity reduced significantly (p<0.01) in any group of acute and chronic ADR-treated animals. Test for lipid peroxidation(malondialdehyde) was increased significantly(P<0.01). Thus, we conclude 1) ADR significantly lowers glutathione levels in heart tissue, and 2) cellular damage progress produced by alteration of this system in mouse models of ADR cardiotoxicity. These results suggest that the glutathione-glutathione peroxidase system may be involved in the modulation of ADR-induced cardiotoxicity.

• Journal of Communications and Networks
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• v.13 no.6
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• pp.664-677
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• 2011

In order to control interference and improve spectrum efficiency in the femtocell and macrocell overlaid system (FMOS), we propose a joint frequency bandwidth dynamic division, clustering and power control algorithm (JFCPA) for orthogonal-frequency-division-multiple access-based downlink FMOS. The overall system bandwidth is divided into three bands, and the macro-cellular coverage is divided into two areas according to the intensity of the interference from the macro base station to the femtocells, which are dynamically determined by using the JFCPA. A cluster is taken as the unit for frequency reuse among femtocells. We map the problem of clustering to the MAX k-CUT problem with the aim of eliminating the inter-femtocell collision interference, which is solved by a graph-based heuristic algorithm. Frequency bandwidth sharing or splitting between the femtocell tier and the macrocell tier is determined by a step-migration-algorithm-based power control. Simulations conducted to demonstrate the effectiveness of our proposed algorithm showed the frequency-reuse probability of the FMOS reuse band above 97.6% and at least 70% of the frequency bandwidth available for the macrocell tier, which means that the co-tier and the cross-tier interference were effectively controlled. Thus, high spectrum efficiency was achieved. The simulation results also clarified that the planning of frequency resource allocation in FMOS should take into account both the spatial density of femtocells and the interference suffered by them. Statistical results from our simulations also provide guidelines for actual FMOS planning.

• Current Optics and Photonics
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• v.1 no.4
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• pp.412-420
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• 2017

Multinucleated bone resorptive osteoclasts differentiate from bone marrow-derived monocyte/macrophage precursor cells. During osteoclast differentiation, mononuclear pre-osteoclasts change their morphology and biochemical characteristics. In this study, Raman spectroscopy with multivariate techniques such as Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA) were used to extract biochemical information related to various cellular events during osteoclastogenesis. This technique allowed for label-free and noninvasive monitoring of differentiating cells, and clearly discriminated four different time points during osteoclast differentiation. The Raman band intensity showed significant time-dependent changes that increased up to day 4. The results of Raman spectroscopy agreed with results from atomic force microscopy (AFM) and tartrate-resistant acid phosphatase (TRAP) staining, a conventional biological assay. Under AFM, normal spindle-like mononuclear pre-osteoclasts became round and smaller at day 2 after treatment with a receptor activator of nuclear $factor-{\kappa}B$ ligand and they formed multinucleated giant cells at day 4. Thus, Raman spectroscopy, in combination with PCA-LDA, may be useful for noninvasive label-free quality assessment of cell status during osteoclast differentiation, enabling more efficient optimization of the bioprocesses.

• Molecules and Cells
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• v.19 no.3
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• pp.428-435
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• 2005

This study was carried out to assess the potential of SSR markers for variety identification by comparing SSR markers and morphological traits in tests of distinctiveness, uniformity, and stability (DUS) of pepper (Capsicum annuum L.) varieties. Twenty-seven SSR markers were polymorphic in 66 pepper varieties, revealing a total of 89 alleles. Average polymorphism information content (PIC) value was 0.529, ranging from 0.03 to 0.877. Cluster analysis of the band patterns separated the varieties into three groups corresponding to varietal types. Morphological trait-based clustering showed some degree of similarity to dendrogram topologies based on the SSR index. However, no significance correlation was found between the SSR and morphological data. SSR markers could be used to complement a DUS test of a candidate variety and to select complimentary varieties by pre-screening existing varieties in the context of protecting new varieties of pepper.

• Journal of Communications and Networks
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• v.18 no.3
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• pp.364-374
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• 2016

With vast amounts of spectrum available in the millimeter wave (mmWave) band, small cells at mmWave frequencies densely deployed underlying the conventional homogeneous macrocell network have gained considerable interest from academia, industry, and standards bodies. Due to high propagation loss at higher frequencies, mmWave communications are inherently directional, and concurrent transmissions (spatial reuse) under low inter-link interference can be enabled to significantly improve network capacity. On the other hand, mmWave links are easily blocked by obstacles such as human body and furniture. In this paper, we develop a multi-hop relaying transmission (MHRT) scheme to steer blocked flows around obstacles by establishing multi-hop relay paths. In MHRT, a relay path selection algorithm is proposed to establish relay paths for blocked flows for better use of concurrent transmissions. After relay path selection, we use a multi-hop transmission scheduling algorithm to compute near-optimal schedules by fully exploiting the spatial reuse. Through extensive simulations under various traffic patterns and channel conditions, we demonstrate MHRT achieves superior performance in terms of network throughput and connection robustness compared with other existing protocols, especially under serious blockage conditions. The performance ofMHRT with different hop limitations is also simulated and analyzed for a better choice of the maximum hop number in practice.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.12 no.7
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• pp.1086-1093
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• 2001

A new linearization technique for RF high-power amplifiers(HPAs) using n-th order error signal generator (ESGn) is proposed. The n-th order ESG generates an error signal based on the complex envelope transfer characteristics of the HPA, which is combined at the output of the HPA. Therefore, the higher-order nonlinearlities are not affected by the ESG$\_$n/ and the stability of the linearized system is guaranteed due to the inherent open-loop configuration. Moreover, the output delay loss can be avoided, because the error signal is generated with the input signal of the HPA. The IMD(intermodulation distortion) improvement obtained applying the ESG$\_$7/ to 5 W class A HPA in cellular band demonstrates the feasibility of the proposed postdistortion system.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.42 no.3
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• pp.577-584
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• 2017

Long Term Evolution device-to-device (LTE D2D) is a key technology to mitigate data traffic load in a cellular system. It facilitates direct data exchange between neighboring users, which is preceded by D2D discovery. Each device advertises its presence to neighboring devices by broadcasting its discovery message. In this paper, we develop a mathematical analysis to assess the probability that discovery messages are successfully transmitted at the D2D discovery stage. We make use of stochastic geometry for modeling spatial statistics of nodes in a two dimensional space. It reflects signal to noise plus interference ratio (SINR) degradation due to resource collision and in-band emission, which leads to the discovery message reception probability being modeled as a function of the distance between the transmitter and the receiver. Numerical results verify that the newly developed analysis accurately estimates discovery message reception probabilities of nodes at the D2D discovery stage.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2006.05a
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• pp.981-985
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• 2006

Wibro is stand for Wireless Broadband Internet called as Portable Internet, Wireless Broadband Internet or Wireless High-Speed Internet. This provides hish-speed internet service anytime, anywhere, from anyone and device with seamless mobility and the band is located between Mobile phone and wireless LAN. Wibro service should support handover to maintain connection continuously in movement because the service is based on If system which is different from cellular system. Current Mitre Mobility system and general Mobile If system has got a problem of delayed speed and lost packets during handover. IETF protocol has been proposed for minimizing this problem and its standardization is under process, mainly focused on Mip4, Mip6 and Mipshop WG. This article studies and analyzes an effective method of minimizing handover delay to improve the problem of WiBro system and its revitalization & outlook.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.18 no.2
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• pp.289-294
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• 2014

In this paper, we investigate the user scheduling, transmit beamforming, and receive beamforming of uplink space division multiple access (SDMA) systems where multiple users are allowed to transmit their signal to a base station (BS) using the same frequency band simultaneously. The BS performs a receive beamforming using the predetermined pseudo-random pattern and select users with a specific criterion. Especially, in this paper, we propose the threshold-based transmit power control, in which a user decrease its transmit power according if its generating interference to other users's signal is larger than a predetermined threshold. Assuming that the TDD system is used, the channel state information (CSI) can be obtained at each user from pilot signals from the BS. Simulation results show that the proposed technique significantly outperforms the existing user scheduling algorithms.

• Proceedings of the KAIS Fall Conference
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• 2010.05a
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• pp.18-23
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• 2010

4$\times$4 Butler Matrix structure has been presented in this paper. It can passes the signal with equal power level and phase difference in the 824MHz to 894MHz frequency of the cellular band. Conventional Butler Matrix was implemented as a single layer substrate structure, but in this paper, we use multi-layer substrate structure and eventually we could get it reduced in size than others. We also used the LTCC coupler to reduce the size effectively, instead of using $90^{\circ}$ hybrid coupler composed of microstrip structure. we used Designer V3.5 Ansoft HFSS V11 for design of 4$\times$4 Butler matrix. Finally, we get good agreements between simulation and experimental results.