• Macromolecular Research
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• v.15 no.2
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• pp.100-108
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• 2007

Gene therapy has become a promising strategy for the treatment of genetically based diseases, such as cancer, which are currently considered incurable. A major obstacle in the field of cancer gene therapy is the development of a safe and efficient delivery system for therapeutic gene transfer. Non-viral vectors have attracted great interest, as they are simple to prepare, stable, easy to modify and relatively safe compared to viral vectors. In this review, an insight into the strategies developed for polyethylenimine (PEI)-based non-viral vectors has been provide, including improvement of the polyplex properties by incorporating hydrophilic spacer, poly(ethylene glycol) (PEG). Moreover, this review will summarize the strategies for the tumor targeting. Specifically, a targeted polymeric gene delivery system, PEI-g-PEG-RGD, will be introduced as an efficient gene delivery vector for tumor therapy, including its functional analysis both in vitro and in vivo.

• Proceedings of the IEEK Conference
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• 2003.11c
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• pp.86-89
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• 2003

In this paper, Self-Oscillating Mixer is designed by oscillator that was based on a general nonlinear input-output model for the subharmonic injection locked oscillator is analysed. We have designed and fabricated the Self-Oscillating Mixer for 5GHz by proposed subharmonic injection locked oscillator based frequency synthesizer structure that have characteristic of good frequency sensitivity, good phase noise. The design strategy leading to an optimized SILO with regards to its locking range is described and a test SOM circuit is demonstrated a 4dB conversion gain at 280MHz IF frequency from the carrier.

• Maritime Security
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• v.6 no.1
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• pp.1-35
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• 2023

The purpose of this study is to present the direction of development of our navy's response strategy through analysis at the ends, ways, and means level of the Chinese navy's offensive strategy for the West Sea. As a result of the analysis, at the ends level, the Chinese Navy's offensive strategy for the West Sea strategy is being linked to a grand strategy to protect maritime rights and achieve maritime power between the U.S. and China competition, at the ways level, the Chinese Navy is expected to create a foundation for the international community to recognize the West Sea as China's inland sea through "routine entry" and "exercise authority", and in case of emergency, it will try to secure sea control in the West Sea in a short period of time by blocking Korea's maritime transportation route based on the overwhelming preemptive attack capability of aircraft carriers. At the means level, it is accelerating the construction of aircraft carrier warfare units and improving its ability to engage long-range missiles. As a direction of development of the Korean Navy's response strategy in response to this, first, Establishment and Development of National Maritime Security Strategy in conjunction with the Korean Indo-Pacific Strategy. Second, it proposes the development of the concept of effective security operations for the east sea area of the West Sea intermediate line, and third, the development of the concept of combat performance and capacity building to strengthen survival and lethality.

• Journal of Power Electronics
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• v.14 no.2
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• pp.271-281
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• 2014

Fluctuating wind conditions necessitate the use of a variable speed wind turbine (VSWT) with a AC/DC/AC converter scheme in order to harvest the maximum power from the wind and to decouple the synchronous generator voltage and frequency from the grid voltage and frequency. In this paper, a combination of a three phase diode bridge rectifier (DBR) and a modified topology of the diode clamped multilevel inverter (DCMLI) has been considered as an AC/DC/AC converter. A control strategy has been proposed for the DCMLI to achieve the objective of grid interface of a wind power system together with local load compensation. A novel fixed frequency current control method is proposed for the DCMLI based on the level shifted multi carrier PWM for achieving the required control objectives with equal and uniform switching frequency operation for better control and thermal management with the modified DCMLI. The condition of the controller gain is derived to ensure the operation of the DCMLI at the fixed frequency of the carrier. The converter current injected into the distribution grid is controlled in accordance with the wind power availability. In addition, load compensation is performed as an added facility in order to free the source currents being fed from the grid of harmonic distortion, unbalance and a low power factor even though the load may be unbalanced, non-linear and of a poor power factor. The results are validated using PSCAD/EMTDC simulation studies.

• Journal of Power Electronics
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• v.12 no.4
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• pp.567-577
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• 2012

This paper introduces a new scheme to balance the DC bus voltages of a cascaded H-bridge converter which is used as a Distribution Static Synchronous Series Compensator (D-SSSC) in electrical distribution network. The aim of D-SSSC is to control the power flow between two feeders from different substations. As a result of different cell losses and capacitors tolerance the cells DC bus voltage can deviate from their reference values. In the proposed scheme, by individually modifying the reference PWM signal for each cell, an effective balancing procedure is derived. The new balancing procedure needs only the line current sign and is independent of the main control strategy, which controls the total DC bus voltages of cascaded H-bridge. The effect of modulation index variation on the capacitor voltage is analytically derived for the proposed strategy. The proposed method takes advantages of phase shift carrier based modulation and can be applied for a cascaded H-bridge with any number of cells. Also the system is immune to loss of one cell and the presented procedure can keep balancing between the remaining cells. Simulation studies and experimental results validate the effectiveness of the proposed method in the balancing of DC bus voltages.

• Journal of the Society of Naval Architects of Korea
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• v.48 no.2
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• pp.178-182
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• 2011

Generally in order to reduce the steel weight of stiffened plate, stiffener spaces tend to be narrow and the plate gets thin. However, it will involve more fabrication cost because it can lead to the increase of welding length and the number of structural members. In the yard, the design which is able to reduce the total fabrication cost is needed, although it requires more steel weight. The purpose of this study is to find optimum stiffener spaces to minimize the fabrication cost for the cargo tank of LPG Carriers. Global optimization methods such as ES(Evolution Strategy) and GA(Genetic Algorithm) are introduced to find a global optimum solution and the sum of steel material cost and labor cost is selected as main objective function. Convergence degree of both methods in according to the size of searching population is examined and an efficient size is investigated. In order to verify the necessity of the optimum design based on the cost, minimum weight design and minimum cost design are carried out.

• Journal of Korean Academy of Nursing Administration
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• v.16 no.1
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• pp.48-58
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• 2010

Purpose: The purpose of this study was to identify the effect of a mentoring program as a strategy for the retention of clinical nurses. Method: Research subjects were 20 mentors, 20 mentees and 22 clinical nurses for a control group of mentees. A mentoring program was developed by an expert committee and applied to the experimental group for six months. Data were collected at three and six months after the application of the program from September, 2008 to March, 2009. Data were analyzed using $x^$-test, t-test, Repeated Measures ANOVA, One-way ANOVA in SPSS/Win 15.0 Program. Results: Job satisfaction, organizational commitment, empowerment, and carrier commitment in the mentees of the experimental group were significantly higher than the nurses of the control group. Intention of resignation in mentees of the experimental group were significantly lower than the nurses of the control group. Also, there were significant interaction between the groups and the times of measurements in all variables. Conclusion: The mentoring program showed positive impact on the variables for maintenance of clinical nurses. Recommendation: Based on these findings, retention strategies using mentoring programs were recommended to reduce clinical nurses' resignation and improve the competency of clinical nurses that leads to the productivity of nursing organizations.

• Journal of Power Electronics
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• v.18 no.1
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• pp.70-80
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• 2018

A novel strategy based on a zero common mode voltage pulse-width modulation (ZCMV-PWM) technique and zero-sequence circulating current (ZSCC) feedback control is proposed in this study to eliminate ZSCCs between three-level neutral point clamped (NPC) voltage source inverters, with common AC and DC buses, that are operating in parallel. First, an equivalent model of ZSCC in a three-phase three-level NPC inverter paralleled system is developed. Second, on the basis of the analysis of the excitation source of ZSCCs, i.e., the difference in common mode voltages (CMVs) between paralleled inverters, the ZCMV-PWM method is presented to reduce CMVs, and a simple electric circuit is adopted to control ZSCCs and neutral point potential. Finally, simulation and experiment are conducted to illustrate effectiveness of the proposed strategy. Results show that ZSCCs between paralleled inverters can be eliminated effectively under steady and dynamic states. Moreover, the proposed strategy exhibits the advantage of not requiring carrier synchronization. It can be utilized in inverters with different types of filter.

• 대한공업교육학회지
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• v.44 no.1
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• pp.209-231
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• 2019

The purpose of this study was to extract the factors of core competency required for technology teachers and to analyze the educational needs for extracted core competency factors and to search for the application of core competencies in the in-service technology teachers education. This study was conducted by literature review, expert validation, and needs assessment method. The survey was conducted by 92 low-carrier technology teachers who participated in in-service technology teachers education for upgrading to first grade teacher certificate. Data were analyzed the factor analysis, needs assessment, and IPA analysis using SPSS 24. The core competencies with high education needs were selected by the score of the Borich formula and the IPA analysis. As a result of the study, 29 factors of core competencies were chosen as the priority: challenge, planning ability, decision making ability, future orientation, intellectual property utilization ability, communication ability, and creative thinking etc. Based on the conclusions of this study, I would suggest the following. It is to create a new in-service education program reflected on core competencies that have high educational needs of low-carrier technology teachers. In addition, a strategy that reflects core competencies methodically in existing in-service teachers education program is needed. Future research should be followed by research on curriculum design to enhance high needed core competencies of low-carrier technology teachers.

• Journal of Electrical Engineering and Technology
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• v.10 no.4
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• pp.1552-1557
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• 2015

The paper unleashes a new idea to arrive at reduced switch count topological structures configured in the form of a matrix for a cascaded Multi level inverter (CMLI). The theory encircles to minimize the number of switches involved in the conduction path and there from acclaim reduced input current distortion, lower switching losses and electromagnetic interference. The focus extends to standardize the number of power devices required for reaching different levels of output voltage from the same architecture. It includes appropriate pulse width modulation (PWM) strategy to generate firing pulses and ensure the desired operation of the power modules. The investigative study carries with it MATLAB based simulation and experimental results obtained using suitable prototypes to illustrate the viability of the proposed concept. The promising nature of the performance projects a new dimension in the use of single phase MLIs for renewable energy related applications.